Emmanuel D Levy

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. pmc 3D complex: a structural classification of protein complexes
    Emmanuel D Levy
    Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom
    PLoS Comput Biol 2:e155. 2006
  2. pmc Evolution of protein complexes by duplication of homomeric interactions
    Jose B Pereira-Leal
    Instituto Gulbenkian de Ciencia, Apartado 14, Oeiras, Portugal
    Genome Biol 8:R51. 2007
  3. pmc Probabilistic annotation of protein sequences based on functional classifications
    Emmanuel D Levy
    Computational Genomics Group, The European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge CB10 1SD, UK
    BMC Bioinformatics 6:302. 2005
  4. doi request reprint Evolution and dynamics of protein interactions and networks
    Emmanuel D Levy
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Curr Opin Struct Biol 18:349-57. 2008
  5. ncbi request reprint PiQSi: protein quaternary structure investigation
    Emmanuel D Levy
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, United Kingdom
    Structure 15:1364-7. 2007
  6. pmc Cellular crowding imposes global constraints on the chemistry and evolution of proteomes
    Emmanuel D Levy
    Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom
    Proc Natl Acad Sci U S A 109:20461-6. 2012
  7. pmc Assembly reflects evolution of protein complexes
    Emmanuel D Levy
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Nature 453:1262-5. 2008
  8. pmc Physicochemical principles that regulate the competition between functional and dysfunctional association of proteins
    Sebastian Pechmann
    Department of Chemistry, University of Cambridge, Cambridge, United Kingdom
    Proc Natl Acad Sci U S A 106:10159-64. 2009
  9. doi request reprint Homomeric protein complexes: evolution and assembly
    A J Venkatakrishnan
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Biochem Soc Trans 38:879-82. 2010
  10. pmc The origins and evolution of functional modules: lessons from protein complexes
    Jose B Pereira-Leal
    MRC Laboratory of Molecular Biology Hills Road, Cambridge CB2 2QH, UK
    Philos Trans R Soc Lond B Biol Sci 361:507-17. 2006

Detail Information

Publications12

  1. pmc 3D complex: a structural classification of protein complexes
    Emmanuel D Levy
    Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom
    PLoS Comput Biol 2:e155. 2006
    ..Our classification, available as a database and Web server at http://www.3Dcomplex.org, will be a starting point for future work aimed at understanding the structure and evolution of protein complexes...
  2. pmc Evolution of protein complexes by duplication of homomeric interactions
    Jose B Pereira-Leal
    Instituto Gulbenkian de Ciencia, Apartado 14, Oeiras, Portugal
    Genome Biol 8:R51. 2007
    ..The mechanisms driving the emergence and evolution of these modules are still unclear. Here we investigate the evolutionary origins of protein complexes, modules in physical protein-protein interaction networks...
  3. pmc Probabilistic annotation of protein sequences based on functional classifications
    Emmanuel D Levy
    Computational Genomics Group, The European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge CB10 1SD, UK
    BMC Bioinformatics 6:302. 2005
    ..Most automatic approaches developed to date rely on the identification of clusters of homologous proteins and the mapping of new proteins onto these clusters, which are expected to share functional characteristics...
  4. doi request reprint Evolution and dynamics of protein interactions and networks
    Emmanuel D Levy
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Curr Opin Struct Biol 18:349-57. 2008
    ..Finally, we discuss recently developed methods that will improve this picture in the future...
  5. ncbi request reprint PiQSi: protein quaternary structure investigation
    Emmanuel D Levy
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, United Kingdom
    Structure 15:1364-7. 2007
    ..PiQSi is accessible at http://www.PiQSi.org/...
  6. pmc Cellular crowding imposes global constraints on the chemistry and evolution of proteomes
    Emmanuel D Levy
    Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom
    Proc Natl Acad Sci U S A 109:20461-6. 2012
    ..Remarkably, the effects observed are consistently larger in E. coli and S. cerevisiae than in H. sapiens, suggesting that promiscuous protein-protein interactions may be freer to accumulate in the human lineage...
  7. pmc Assembly reflects evolution of protein complexes
    Emmanuel D Levy
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Nature 453:1262-5. 2008
    ..Our model of self-assembly allows reliable prediction of evolution and assembly of a complex solely from its crystal structure...
  8. pmc Physicochemical principles that regulate the competition between functional and dysfunctional association of proteins
    Sebastian Pechmann
    Department of Chemistry, University of Cambridge, Cambridge, United Kingdom
    Proc Natl Acad Sci U S A 106:10159-64. 2009
    ..These results indicate that functional and dysfunctional association of proteins are promoted by similar forces but also that they are closely regulated by the presence of specific interactions that stabilize native states...
  9. doi request reprint Homomeric protein complexes: evolution and assembly
    A J Venkatakrishnan
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Biochem Soc Trans 38:879-82. 2010
    ..Also, we briefly discuss the pathway of their assembly in solution...
  10. pmc The origins and evolution of functional modules: lessons from protein complexes
    Jose B Pereira-Leal
    MRC Laboratory of Molecular Biology Hills Road, Cambridge CB2 2QH, UK
    Philos Trans R Soc Lond B Biol Sci 361:507-17. 2006
    ..We also provide a perspective on the evolutionary mechanisms driving the growth of other modular cellular networks such as transcriptional regulatory and metabolic networks...
  11. doi request reprint A simple definition of structural regions in proteins and its use in analyzing interface evolution
    Emmanuel D Levy
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    J Mol Biol 403:660-70. 2010
    ..This analysis and conclusions will help understand the notion of promiscuity in protein-protein interaction networks...
  12. pmc CORRIE: enzyme sequence annotation with confidence estimates
    Benjamin Audit
    Laboratoire Joliot Curie and Laboratoire de Physique, CNRS UMR5672, Ecole Normale Superieure, Lyon Cedex 07, France
    BMC Bioinformatics 8:S3. 2007
    ..The CORRIE server is available at: http://www.genomes.org/services/corrie/...