Tim P Levine

Summary

Affiliation: University College London
Country: UK

Publications

  1. doi request reprint A twoferase for lipid transfer at ER-golgi contact sites
    Tim P Levine
    Division of Cell Biology, UCL Institute of Ophthalmology, Bath Street, London EC1V 9EL, UK Electronic address
    Dev Cell 27:369-70. 2013
  2. pmc A protein pair with PIPs inside
    Tim P Levine
    UCL Institute of Ophthalmology, University College London, London EC1V 9EL, UK
    Structure 21:1070-1. 2013
  3. pmc The product of C9orf72, a gene strongly implicated in neurodegeneration, is structurally related to DENN Rab-GEFs
    Timothy P Levine
    Department of Cell Biology, UCL Institute of Ophthalmology, Bath St, London EC1V 9EL, UK
    Bioinformatics 29:499-503. 2013
  4. pmc Lipid traffic: Osh4p makes an unexpected exchange
    Tim P Levine
    Institute of Ophthalmology, University College London, London EC1V 9EL, England, UK
    J Cell Biol 195:927-9. 2011
  5. pmc A lipid transfer protein that transfers lipid
    Tim P Levine
    University College London Institute of Ophthalmology, London EC1V 9EL, England, UK
    J Cell Biol 179:11-3. 2007
  6. ncbi request reprint Inter-organelle membrane contact sites: through a glass, darkly
    Tim Levine
    Division of Cell Biology, UCL Institute of Ophthalmology, Bath St, London EC1V 9EL, UK
    Curr Opin Cell Biol 18:371-8. 2006
  7. ncbi request reprint Short-range intracellular trafficking of small molecules across endoplasmic reticulum junctions
    Tim Levine
    Division of Cell Biology, Institute of Ophthalmology, Bath Street, London EC1V 9EL, UK
    Trends Cell Biol 14:483-90. 2004
  8. doi request reprint Annexin A2 at the interface between F-actin and membranes enriched in phosphatidylinositol 4,5,-bisphosphate
    Matthew J Hayes
    Division of Cell Biology, UCL Institute of Ophthalmology, University College London, 11 43 Bath Street, London EC1V 9EL, UK
    Biochim Biophys Acta 1793:1086-95. 2009
  9. ncbi request reprint Endoplasmic reticulum: one continuous network compartmentalized by extrinsic cues
    Tim Levine
    Division of Cell Biology, Institute of Ophthalmology, 11 43 Bath Street, London EC1V 9EL, UK
    Curr Opin Cell Biol 17:362-8. 2005
  10. ncbi request reprint SSD: sterol-sensing direct
    Tim Levine
    Division of Cell Biology, Institute of Ophthalmology, Bath Street, London EC1V 9EL, United Kingdom
    Dev Cell 7:152-3. 2004

Detail Information

Publications11

  1. doi request reprint A twoferase for lipid transfer at ER-golgi contact sites
    Tim P Levine
    Division of Cell Biology, UCL Institute of Ophthalmology, Bath Street, London EC1V 9EL, UK Electronic address
    Dev Cell 27:369-70. 2013
    ....
  2. pmc A protein pair with PIPs inside
    Tim P Levine
    UCL Institute of Ophthalmology, University College London, London EC1V 9EL, UK
    Structure 21:1070-1. 2013
    ..In this issue of Structure, Tong and colleagues find that the yeast OSBP homolog, Osh3, binds PI(4)P but not sterol, supporting the view that PI(4)P regulation, not sterol transport, is the key activity for OSBP homologs. ..
  3. pmc The product of C9orf72, a gene strongly implicated in neurodegeneration, is structurally related to DENN Rab-GEFs
    Timothy P Levine
    Department of Cell Biology, UCL Institute of Ophthalmology, Bath St, London EC1V 9EL, UK
    Bioinformatics 29:499-503. 2013
    ..Although a plausible mechanism for disease is that aberrant C9ORF72 mRNA poisons splicing, it is important to determine the cellular function of C9ORF72, about which nothing is known...
  4. pmc Lipid traffic: Osh4p makes an unexpected exchange
    Tim P Levine
    Institute of Ophthalmology, University College London, London EC1V 9EL, England, UK
    J Cell Biol 195:927-9. 2011
    ..This finding helps explain some previously published studies and also indicates that lipid/sterol exchange could contribute to establishing a sterol gradient in cells...
  5. pmc A lipid transfer protein that transfers lipid
    Tim P Levine
    University College London Institute of Ophthalmology, London EC1V 9EL, England, UK
    J Cell Biol 179:11-3. 2007
    ..Godi, G. West, J. Bielawski, C.C. Chuang, A.C. van der Spoel, et al. 2007. Nature. 449:62-67) agree that four-phosphate adaptor protein 2 (FAPP2) transfers glucosylceramide (GlcCer), a lipid that takes an unexpectedly circuitous route...
  6. ncbi request reprint Inter-organelle membrane contact sites: through a glass, darkly
    Tim Levine
    Division of Cell Biology, UCL Institute of Ophthalmology, Bath St, London EC1V 9EL, UK
    Curr Opin Cell Biol 18:371-8. 2006
    ..Further work will be needed to test whether these lipid transfer proteins act when anchored at inter-organelle contact sites...
  7. ncbi request reprint Short-range intracellular trafficking of small molecules across endoplasmic reticulum junctions
    Tim Levine
    Division of Cell Biology, Institute of Ophthalmology, Bath Street, London EC1V 9EL, UK
    Trends Cell Biol 14:483-90. 2004
    ..In the light of these advances, I hypothesize that the endoplasmic reticulum has a central role in the trafficking of lipids and ions by forming a network of MCSs with most other intracellular organelles...
  8. doi request reprint Annexin A2 at the interface between F-actin and membranes enriched in phosphatidylinositol 4,5,-bisphosphate
    Matthew J Hayes
    Division of Cell Biology, UCL Institute of Ophthalmology, University College London, 11 43 Bath Street, London EC1V 9EL, UK
    Biochim Biophys Acta 1793:1086-95. 2009
    ..These observations are consistent with a role for annexin A2 as an actin nucleator on PI(4,5)P2-enriched membranes...
  9. ncbi request reprint Endoplasmic reticulum: one continuous network compartmentalized by extrinsic cues
    Tim Levine
    Division of Cell Biology, Institute of Ophthalmology, 11 43 Bath Street, London EC1V 9EL, UK
    Curr Opin Cell Biol 17:362-8. 2005
    ....
  10. ncbi request reprint SSD: sterol-sensing direct
    Tim Levine
    Division of Cell Biology, Institute of Ophthalmology, Bath Street, London EC1V 9EL, United Kingdom
    Dev Cell 7:152-3. 2004
    ..New biochemical studies of this domain demonstrate direct high-affinity binding of the sterol-sensing domain to sterol...
  11. ncbi request reprint Lipid traffic: floppy drives and a superhighway
    Joost C M Holthuis
    Department of Membrane Enzymology, Institute of Biomembranes, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
    Nat Rev Mol Cell Biol 6:209-20. 2005
    ..These include transbilayer flip-flop mechanisms and transfer across narrow gaps between the endoplasmic reticulum and other organelles, with the endoplasmic reticulum functioning as a superhighway along which lipids can rapidly diffuse...