Tim P Levine
Affiliation: University College London
- A protein pair with PIPs insideTim P Levine
UCL Institute of Ophthalmology, University College London, London EC1V 9EL, UK
Structure 21:1070-1. 2013..In this issue of Structure, Tong and colleagues find that the yeast OSBP homolog, Osh3, binds PI(4)P but not sterol, supporting the view that PI(4)P regulation, not sterol transport, is the key activity for OSBP homologs. ..
- The product of C9orf72, a gene strongly implicated in neurodegeneration, is structurally related to DENN Rab-GEFsTimothy P Levine
Department of Cell Biology, UCL Institute of Ophthalmology, Bath St, London EC1V 9EL, UK
Bioinformatics 29:499-503. 2013..Although a plausible mechanism for disease is that aberrant C9ORF72 mRNA poisons splicing, it is important to determine the cellular function of C9ORF72, about which nothing is known...
- Lipid traffic: Osh4p makes an unexpected exchangeTim P Levine
Institute of Ophthalmology, University College London, London EC1V 9EL, England, UK
J Cell Biol 195:927-9. 2011..This finding helps explain some previously published studies and also indicates that lipid/sterol exchange could contribute to establishing a sterol gradient in cells...
- A lipid transfer protein that transfers lipidTim P Levine
University College London Institute of Ophthalmology, London EC1V 9EL, England, UK
J Cell Biol 179:11-3. 2007..Godi, G. West, J. Bielawski, C.C. Chuang, A.C. van der Spoel, et al. 2007. Nature. 449:62-67) agree that four-phosphate adaptor protein 2 (FAPP2) transfers glucosylceramide (GlcCer), a lipid that takes an unexpectedly circuitous route...
- Inter-organelle membrane contact sites: through a glass, darklyTim Levine
Division of Cell Biology, UCL Institute of Ophthalmology, Bath St, London EC1V 9EL, UK
Curr Opin Cell Biol 18:371-8. 2006..Further work will be needed to test whether these lipid transfer proteins act when anchored at inter-organelle contact sites...
- Short-range intracellular trafficking of small molecules across endoplasmic reticulum junctionsTim Levine
Division of Cell Biology, Institute of Ophthalmology, Bath Street, London EC1V 9EL, UK
Trends Cell Biol 14:483-90. 2004..In the light of these advances, I hypothesize that the endoplasmic reticulum has a central role in the trafficking of lipids and ions by forming a network of MCSs with most other intracellular organelles...
- Annexin A2 at the interface between F-actin and membranes enriched in phosphatidylinositol 4,5,-bisphosphateMatthew J Hayes
Division of Cell Biology, UCL Institute of Ophthalmology, University College London, 11 43 Bath Street, London EC1V 9EL, UK
Biochim Biophys Acta 1793:1086-95. 2009..These observations are consistent with a role for annexin A2 as an actin nucleator on PI(4,5)P2-enriched membranes...
- Endoplasmic reticulum: one continuous network compartmentalized by extrinsic cuesTim Levine
Division of Cell Biology, Institute of Ophthalmology, 11 43 Bath Street, London EC1V 9EL, UK
Curr Opin Cell Biol 17:362-8. 2005....
- SSD: sterol-sensing directTim Levine
Division of Cell Biology, Institute of Ophthalmology, Bath Street, London EC1V 9EL, United Kingdom
Dev Cell 7:152-3. 2004..New biochemical studies of this domain demonstrate direct high-affinity binding of the sterol-sensing domain to sterol...
- Lipid traffic: floppy drives and a superhighwayJoost C M Holthuis
Department of Membrane Enzymology, Institute of Biomembranes, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
Nat Rev Mol Cell Biol 6:209-20. 2005..These include transbilayer flip-flop mechanisms and transfer across narrow gaps between the endoplasmic reticulum and other organelles, with the endoplasmic reticulum functioning as a superhighway along which lipids can rapidly diffuse...