Tim P Levine

Summary

Affiliation: University College London
Country: UK

Publications

  1. pmc Discovery of new Longin and Roadblock domains that form platforms for small GTPases in Ragulator and TRAPP-II
    Timothy P Levine
    Division of Cell Biology UCL Institute of Ophthalmology London, UK
    Small Gtpases 4:62-9. 2013
  2. pmc Analysis of the key elements of FFAT-like motifs identifies new proteins that potentially bind VAP on the ER, including two AKAPs and FAPP2
    Veronika Mikitov√°
    Department of Cell Biology, University College London Institute of Ophthalmology, London, United Kingdom
    PLoS ONE 7:e30455. 2012
  3. pmc Lowe Syndrome protein OCRL1 supports maturation of polarized epithelial cells
    Adam G Grieve
    Department of Cell Biology, UCL Institute of Ophthalmology, London, United Kingdom
    PLoS ONE 6:e24044. 2011
  4. pmc Inheritance of cortical ER in yeast is required for normal septin organization
    Christopher J R Loewen
    Division of Cell Biology, University College London Institute of Ophthalmology, London EC1V 9EL, England, UK
    J Cell Biol 179:467-83. 2007
  5. doi request reprint A twoferase for lipid transfer at ER-golgi contact sites
    Tim P Levine
    Division of Cell Biology, UCL Institute of Ophthalmology, Bath Street, London EC1V 9EL, UK Electronic address
    Dev Cell 27:369-70. 2013
  6. pmc A protein pair with PIPs inside
    Tim P Levine
    UCL Institute of Ophthalmology, University College London, London EC1V 9EL, UK
    Structure 21:1070-1. 2013
  7. pmc The product of C9orf72, a gene strongly implicated in neurodegeneration, is structurally related to DENN Rab-GEFs
    Timothy P Levine
    Department of Cell Biology, UCL Institute of Ophthalmology, Bath St, London EC1V 9EL, UK
    Bioinformatics 29:499-503. 2013
  8. pmc A lipid transfer protein that transfers lipid
    Tim P Levine
    University College London Institute of Ophthalmology, London EC1V 9EL, England, UK
    J Cell Biol 179:11-3. 2007
  9. ncbi request reprint Short-range intracellular trafficking of small molecules across endoplasmic reticulum junctions
    Tim Levine
    Division of Cell Biology, Institute of Ophthalmology, Bath Street, London EC1V 9EL, UK
    Trends Cell Biol 14:483-90. 2004
  10. pmc Lipid traffic: Osh4p makes an unexpected exchange
    Tim P Levine
    Institute of Ophthalmology, University College London, London EC1V 9EL, England, UK
    J Cell Biol 195:927-9. 2011

Collaborators

Detail Information

Publications18

  1. pmc Discovery of new Longin and Roadblock domains that form platforms for small GTPases in Ragulator and TRAPP-II
    Timothy P Levine
    Division of Cell Biology UCL Institute of Ophthalmology London, UK
    Small Gtpases 4:62-9. 2013
    ..We discovered two yeast Ragulator subunits, and also a new LD in TRAPPC10 that may explain the Rab11-GEF activity ascribed to TRAPP-II. ..
  2. pmc Analysis of the key elements of FFAT-like motifs identifies new proteins that potentially bind VAP on the ER, including two AKAPs and FAPP2
    Veronika Mikitov√°
    Department of Cell Biology, University College London Institute of Ophthalmology, London, United Kingdom
    PLoS ONE 7:e30455. 2012
    ..Defining how much variation is tolerated in FFAT-like motifs is a preliminary step prior to the identification of the full range of VAP interactors...
  3. pmc Lowe Syndrome protein OCRL1 supports maturation of polarized epithelial cells
    Adam G Grieve
    Department of Cell Biology, UCL Institute of Ophthalmology, London, United Kingdom
    PLoS ONE 6:e24044. 2011
    ..A role of OCRL1 in junctions of polarized cells may explain the pattern of organs affected in Lowe Syndrome...
  4. pmc Inheritance of cortical ER in yeast is required for normal septin organization
    Christopher J R Loewen
    Division of Cell Biology, University College London Institute of Ophthalmology, London EC1V 9EL, England, UK
    J Cell Biol 179:467-83. 2007
    ..This perturbation leads to a delay in the transition through G2, activating the Saccharomyces wee1 kinase (Swe1) and the morphogenesis checkpoint. Thus, we identify a mechanism involved in sensing the distribution of ER...
  5. doi request reprint A twoferase for lipid transfer at ER-golgi contact sites
    Tim P Levine
    Division of Cell Biology, UCL Institute of Ophthalmology, Bath Street, London EC1V 9EL, UK Electronic address
    Dev Cell 27:369-70. 2013
    ....
  6. pmc A protein pair with PIPs inside
    Tim P Levine
    UCL Institute of Ophthalmology, University College London, London EC1V 9EL, UK
    Structure 21:1070-1. 2013
    ..In this issue of Structure, Tong and colleagues find that the yeast OSBP homolog, Osh3, binds PI(4)P but not sterol, supporting the view that PI(4)P regulation, not sterol transport, is the key activity for OSBP homologs. ..
  7. pmc The product of C9orf72, a gene strongly implicated in neurodegeneration, is structurally related to DENN Rab-GEFs
    Timothy P Levine
    Department of Cell Biology, UCL Institute of Ophthalmology, Bath St, London EC1V 9EL, UK
    Bioinformatics 29:499-503. 2013
    ..Although a plausible mechanism for disease is that aberrant C9ORF72 mRNA poisons splicing, it is important to determine the cellular function of C9ORF72, about which nothing is known...
  8. pmc A lipid transfer protein that transfers lipid
    Tim P Levine
    University College London Institute of Ophthalmology, London EC1V 9EL, England, UK
    J Cell Biol 179:11-3. 2007
    ..Godi, G. West, J. Bielawski, C.C. Chuang, A.C. van der Spoel, et al. 2007. Nature. 449:62-67) agree that four-phosphate adaptor protein 2 (FAPP2) transfers glucosylceramide (GlcCer), a lipid that takes an unexpectedly circuitous route...
  9. ncbi request reprint Short-range intracellular trafficking of small molecules across endoplasmic reticulum junctions
    Tim Levine
    Division of Cell Biology, Institute of Ophthalmology, Bath Street, London EC1V 9EL, UK
    Trends Cell Biol 14:483-90. 2004
    ..In the light of these advances, I hypothesize that the endoplasmic reticulum has a central role in the trafficking of lipids and ions by forming a network of MCSs with most other intracellular organelles...
  10. pmc Lipid traffic: Osh4p makes an unexpected exchange
    Tim P Levine
    Institute of Ophthalmology, University College London, London EC1V 9EL, England, UK
    J Cell Biol 195:927-9. 2011
    ..This finding helps explain some previously published studies and also indicates that lipid/sterol exchange could contribute to establishing a sterol gradient in cells...
  11. ncbi request reprint Inter-organelle membrane contact sites: through a glass, darkly
    Tim Levine
    Division of Cell Biology, UCL Institute of Ophthalmology, Bath St, London EC1V 9EL, UK
    Curr Opin Cell Biol 18:371-8. 2006
    ..Further work will be needed to test whether these lipid transfer proteins act when anchored at inter-organelle contact sites...
  12. doi request reprint Annexin A2 at the interface between F-actin and membranes enriched in phosphatidylinositol 4,5,-bisphosphate
    Matthew J Hayes
    Division of Cell Biology, UCL Institute of Ophthalmology, University College London, 11 43 Bath Street, London EC1V 9EL, UK
    Biochim Biophys Acta 1793:1086-95. 2009
    ..These observations are consistent with a role for annexin A2 as an actin nucleator on PI(4,5)P2-enriched membranes...
  13. ncbi request reprint Endoplasmic reticulum: one continuous network compartmentalized by extrinsic cues
    Tim Levine
    Division of Cell Biology, Institute of Ophthalmology, 11 43 Bath Street, London EC1V 9EL, UK
    Curr Opin Cell Biol 17:362-8. 2005
    ....
  14. pmc Regulation of mitochondrial morphogenesis by annexin A6
    Marcin Chlystun
    Department of Cell Biology, University College London, Institute of Ophthalmology, London, United Kingdom
    PLoS ONE 8:e53774. 2013
    ..Our results suggest that anxA6 inhibits Drp1 activity, and that Ca(2+)-binding to anxA6 relieves this inhibition to permit Drp1-mediated mitochondrial fission...
  15. pmc Annexin 2 binding to phosphatidylinositol 4,5-bisphosphate on endocytic vesicles is regulated by the stress response pathway
    Matthew J Hayes
    Division of Cell Biology, Institute of Ophthalmology, University College London, 11 43 Bath Street, London EC1V 9EL, United Kingdom
    J Biol Chem 279:14157-64. 2004
    ..These results establish a novel phospholipid-binding specificity for annexin 2 consistent with a role in mediating the interaction between the macropinosome surface and the polymerized actin tail...
  16. ncbi request reprint SSD: sterol-sensing direct
    Tim Levine
    Division of Cell Biology, Institute of Ophthalmology, Bath Street, London EC1V 9EL, United Kingdom
    Dev Cell 7:152-3. 2004
    ..New biochemical studies of this domain demonstrate direct high-affinity binding of the sterol-sensing domain to sterol...
  17. ncbi request reprint Lipid traffic: floppy drives and a superhighway
    Joost C M Holthuis
    Department of Membrane Enzymology, Institute of Biomembranes, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
    Nat Rev Mol Cell Biol 6:209-20. 2005
    ..These include transbilayer flip-flop mechanisms and transfer across narrow gaps between the endoplasmic reticulum and other organelles, with the endoplasmic reticulum functioning as a superhighway along which lipids can rapidly diffuse...