Kelvin K Leung

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint Automated quantification of caudate atrophy by local registration of serial MRI: evaluation and application in Huntington's disease
    Nicola Z Hobbs
    Dementia Research Centre, UCL Institute of Neurology, University College London, UK
    Neuroimage 47:1659-65. 2009
  2. pmc Robust atrophy rate measurement in Alzheimer's disease using multi-site serial MRI: tissue-specific intensity normalization and parameter selection
    Kelvin K Leung
    Dementia Research Centre DRC, Institute of Neurology, University College London, London, UK
    Neuroimage 50:516-23. 2010
  3. doi request reprint Consistent multi-time-point brain atrophy estimation from the boundary shift integral
    Kelvin K Leung
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Neuroimage 59:3995-4005. 2012
  4. pmc Brain MAPS: an automated, accurate and robust brain extraction technique using a template library
    Kelvin K Leung
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Neuroimage 55:1091-108. 2011
  5. ncbi request reprint Increasing power to predict mild cognitive impairment conversion to Alzheimer's disease using hippocampal atrophy rate and statistical shape models
    Kelvin K Leung
    Centre for Medical Image Computing, University College London, WC1E 6BT, UK
    Med Image Comput Comput Assist Interv 13:125-32. 2010
  6. pmc Comparison of phantom and registration scaling corrections using the ADNI cohort
    Matthew J Clarkson
    Dementia Research Centre, University College London, Institute of Neurology, London, UK
    Neuroimage 47:1506-13. 2009
  7. ncbi request reprint A framework for using diffusion weighted imaging to improve cortical parcellation
    Matthew J Clarkson
    Centre for Medical Image Computing, University College London, WC1E 6BT, UK
    Med Image Comput Comput Assist Interv 13:534-41. 2010
  8. pmc Automated cross-sectional and longitudinal hippocampal volume measurement in mild cognitive impairment and Alzheimer's disease
    Kelvin K Leung
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK Centre for Medical Image Computing, University College London, Gower Street, London, WC1E 6BT, UK
    Neuroimage 51:1345-59. 2010
  9. pmc Using manifold learning for atlas selection in multi-atlas segmentation
    Albert K Hoang Duc
    Centre for Medical Image Computing, University College London, London, United Kingdom
    PLoS ONE 8:e70059. 2013
  10. pmc The value of hippocampal and temporal horn volumes and rates of change in predicting future conversion to AD
    Kate E Macdonald
    Dementia Research Centre, UCL Institute of Neurology, London, UK
    Alzheimer Dis Assoc Disord 27:168-73. 2013

Detail Information

Publications19

  1. ncbi request reprint Automated quantification of caudate atrophy by local registration of serial MRI: evaluation and application in Huntington's disease
    Nicola Z Hobbs
    Dementia Research Centre, UCL Institute of Neurology, University College London, UK
    Neuroimage 47:1659-65. 2009
    ..We describe and evaluate an automated technique based on a local registration and boundary shift integral (BSI) approach at the caudate-CSF and caudate-white matter boundaries; caudate boundary shift integral (CBSI)...
  2. pmc Robust atrophy rate measurement in Alzheimer's disease using multi-site serial MRI: tissue-specific intensity normalization and parameter selection
    Kelvin K Leung
    Dementia Research Centre DRC, Institute of Neurology, University College London, London, UK
    Neuroimage 50:516-23. 2010
    ..001) when using KN-BSI instead of classic-BSI. We concluded that KN-BSI offers more robust brain atrophy measurement than classic-BSI and substantially reduces sample sizes needed in clinical trials...
  3. doi request reprint Consistent multi-time-point brain atrophy estimation from the boundary shift integral
    Kelvin K Leung
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Neuroimage 59:3995-4005. 2012
    ..Either improved interpolation or symmetric registration alone can greatly reduce this bias, and our proposed method combining both aspects shows no significant bias in any of the four experiments...
  4. pmc Brain MAPS: an automated, accurate and robust brain extraction technique using a template library
    Kelvin K Leung
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Neuroimage 55:1091-108. 2011
    ..In conclusion, MAPS had relatively high accuracy and low variability compared to HWA, BET and BSE in MR scans with and without atrophy...
  5. ncbi request reprint Increasing power to predict mild cognitive impairment conversion to Alzheimer's disease using hippocampal atrophy rate and statistical shape models
    Kelvin K Leung
    Centre for Medical Image Computing, University College London, WC1E 6BT, UK
    Med Image Comput Comput Assist Interv 13:125-32. 2010
    ..We demonstrate increased statistical power to classify 86 MCI converters and 128 MCI stable subjects using the hippocampal atrophy rates calculated by the boundary shift integral within these ROIs...
  6. pmc Comparison of phantom and registration scaling corrections using the ADNI cohort
    Matthew J Clarkson
    Dementia Research Centre, University College London, Institute of Neurology, London, UK
    Neuroimage 47:1506-13. 2009
    ..Furthermore, based upon the atrophy rates in the AD subjects in this study, sample size requirements would be approximately 10-12% lower with (either) correction for voxel scaling than if no correction was used...
  7. ncbi request reprint A framework for using diffusion weighted imaging to improve cortical parcellation
    Matthew J Clarkson
    Centre for Medical Image Computing, University College London, WC1E 6BT, UK
    Med Image Comput Comput Assist Interv 13:534-41. 2010
    ..This work introduces a framework to investigate the relationship between structure and function, with no a-priori knowledge of specific regions of interest...
  8. pmc Automated cross-sectional and longitudinal hippocampal volume measurement in mild cognitive impairment and Alzheimer's disease
    Kelvin K Leung
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK Centre for Medical Image Computing, University College London, Gower Street, London, WC1E 6BT, UK
    Neuroimage 51:1345-59. 2010
    ..MAPS-HBSI required the lowest sample sizes (78 subjects) for a hypothetical trial. In conclusion, the MAPS and MAPS-HBSI methods give accurate and reliable volumes and atrophy rates across the clinical spectrum from healthy aging to AD...
  9. pmc Using manifold learning for atlas selection in multi-atlas segmentation
    Albert K Hoang Duc
    Centre for Medical Image Computing, University College London, London, United Kingdom
    PLoS ONE 8:e70059. 2013
    ....
  10. pmc The value of hippocampal and temporal horn volumes and rates of change in predicting future conversion to AD
    Kate E Macdonald
    Dementia Research Centre, UCL Institute of Neurology, London, UK
    Alzheimer Dis Assoc Disord 27:168-73. 2013
    ..023) and that the TH expansion rate is more predictive than the TH volume (P=0.036). Prodromal atrophy rates may be useful predictors of future conversion to sporadic AD from amnestic MCI...
  11. pmc Vascular and Alzheimer's disease markers independently predict brain atrophy rate in Alzheimer's Disease Neuroimaging Initiative controls
    Josephine Barnes
    Dementia Research Centre, Department of Neurodegenerative Disease, University College London Institute of Neurology, London, UK
    Neurobiol Aging 34:1996-2002. 2013
    ..There was no evidence of independent effects of WMH or CSF measures on BSI in AD. These data support findings that vascular damage is associated with increased brain atrophy in the context of AD pathology in pre-dementia stages...
  12. pmc Atrophy rates in asymptomatic amyloidosis: implications for Alzheimer prevention trials
    K Abigail Andrews
    Dementia Research Centre, University College London, London, United Kingdom
    PLoS ONE 8:e58816. 2013
    ..We conclude that hippocampal atrophy may be a feasible outcome measure for secondary prevention studies in asymptomatic amyloidosis...
  13. pmc Automated Template-Based Hippocampal Segmentations from MRI: The Effects of 1.5T or 3T Field Strength on Accuracy
    Kate E Macdonald
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    Neuroinformatics 12:405-12. 2014
    ..5T and 3T but with a wider CI for their ratios. This study supports the use of our automated hippocampal voluming methods, developed using 1.5T images, with 3T images. ..
  14. pmc Cerebral atrophy in mild cognitive impairment and Alzheimer disease: rates and acceleration
    Kelvin K Leung
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, UK
    Neurology 80:648-54. 2013
    ..To quantify the regional and global cerebral atrophy rates and assess acceleration rates in healthy controls, subjects with mild cognitive impairment (MCI), and subjects with mild Alzheimer disease (AD)...
  15. doi request reprint A comparison of voxel and surface based cortical thickness estimation methods
    Matthew J Clarkson
    Centre for Medical Image Computing, The Engineering Front Building, University College London, London WC1E 6BT, UK
    Neuroimage 57:856-65. 2011
    ..Finally we assessed longitudinal performance and concluded that currently FreeSurfer provides the most plausible measure of change over time, with further work required for voxel based methods...
  16. pmc Gray matter atrophy rate as a marker of disease progression in AD
    Valerie M Anderson
    Department of Neuroinflammation, UCL Institute of Neurology, Queen Square, London, UK
    Neurobiol Aging 33:1194-202. 2012
    ..Jacobian integration could be useful for measuring GM atrophy rate in Alzheimer's disease as a marker of disease progression and treatment efficacy...
  17. pmc APOE ε4 is associated with disproportionate progressive hippocampal atrophy in AD
    Emily N Manning
    Dementia Research Centre, UCL Institute of Neurology, London, United Kingdom
    PLoS ONE 9:e97608. 2014
    ....
  18. ncbi request reprint Volume changes in Alzheimer's disease and mild cognitive impairment: cognitive associations
    Matthew C Evans
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    Eur Radiol 20:674-82. 2010
    ..To assess the relationship between MRI-derived changes in whole-brain and ventricular volume with change in cognitive scores in Alzheimer's disease (AD), mild cognitive impairment (MCI) and control subjects...
  19. ncbi request reprint Automatic quantification of changes in bone in serial MR images of joints
    Kelvin K Leung
    University College London, London, UK
    IEEE Trans Med Imaging 25:1617-26. 2006
    ..But the global bone volume was found to be fluctuating over time. Finally, we compare our findings with histology of the subjects and the manual segmentation of bone lesions...