Nick R Leslie

Summary

Affiliation: University of Dundee
Country: UK

Publications

  1. ncbi request reprint The redox regulation of PI 3-kinase-dependent signaling
    Nick R Leslie
    Division of Molecular Physiology, School of Life Sciences, University of Dundee, Wellcome Trust Biocentre, Dundee, United Kingdom
    Antioxid Redox Signal 8:1765-74. 2006
  2. pmc Suppression of cellular proliferation and invasion by the concerted lipid and protein phosphatase activities of PTEN
    L Davidson
    Division of Molecular Physiology, College of Life Sciences, University of Dundee, Dundee, UK
    Oncogene 29:687-97. 2010
  3. doi request reprint PTEN: an intercellular peacekeeper?
    Nick R Leslie
    Division of Cell Signalling and Immunology, College of Life Sciences, University of Dundee, James Black Centre, Dundee DD1 5EH, UK
    Sci Signal 5:pe50. 2012
  4. doi request reprint The PTEN and Myotubularin Phosphoinositide 3-Phosphatases: Linking Lipid Signalling to Human Disease
    Elizabeth M Davies
    Division of Cell Signalling and Immunology, Wellcome Trust Biocentre, College of Life Sciences, University of Dundee, Dow Street, DD1 5EH, Dundee, Scotland, United Kingdom
    Subcell Biochem 58:281-336. 2012
  5. ncbi request reprint Redox regulation of phosphatase function
    N R Leslie
    Division of Cell Signalling, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Biochem Soc Trans 32:1018-20. 2004
  6. ncbi request reprint The regulation of cell migration by PTEN
    N R Leslie
    Division of Molecular Physiology, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem Soc Trans 33:1507-8. 2005
  7. pmc PtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migration
    Nick R Leslie
    Division of Molecular Physiology, University of Dundee, Dundee, DD1 5EH, Scotland, United Kingdom
    Curr Biol 17:115-25. 2007
  8. doi request reprint Understanding PTEN regulation: PIP2, polarity and protein stability
    N R Leslie
    Division of Molecular Physiology, College of Life Sciences, University of Dundee, James Black Centre, Dundee, Scotland, UK
    Oncogene 27:5464-76. 2008
  9. doi request reprint P-REX2a driving tumorigenesis by PTEN inhibition
    Nick R Leslie
    Division of Molecular Physiology, College of Life Sciences, University of Dundee, The James Black Centre, Dow Street, Dundee, DD1 5EH, UK
    Sci Signal 2:pe68. 2009
  10. doi request reprint Non-genomic loss of PTEN function in cancer: not in my genes
    Nick R Leslie
    Division of Molecular Physiology, College of Life Sciences, University of Dundee, Wellcome Trust Biocentre, Dow Street, Dundee DD1 5EH, UK
    Trends Pharmacol Sci 32:131-40. 2011

Collaborators

Detail Information

Publications36

  1. ncbi request reprint The redox regulation of PI 3-kinase-dependent signaling
    Nick R Leslie
    Division of Molecular Physiology, School of Life Sciences, University of Dundee, Wellcome Trust Biocentre, Dundee, United Kingdom
    Antioxid Redox Signal 8:1765-74. 2006
    ....
  2. pmc Suppression of cellular proliferation and invasion by the concerted lipid and protein phosphatase activities of PTEN
    L Davidson
    Division of Molecular Physiology, College of Life Sciences, University of Dundee, Dundee, UK
    Oncogene 29:687-97. 2010
    ..Our data provide a novel tool to address the significance of PTEN's separable lipid and protein phosphatase activities and suggest that both activities suppress proliferation and together suppress invasion...
  3. doi request reprint PTEN: an intercellular peacekeeper?
    Nick R Leslie
    Division of Cell Signalling and Immunology, College of Life Sciences, University of Dundee, James Black Centre, Dundee DD1 5EH, UK
    Sci Signal 5:pe50. 2012
    ....
  4. doi request reprint The PTEN and Myotubularin Phosphoinositide 3-Phosphatases: Linking Lipid Signalling to Human Disease
    Elizabeth M Davies
    Division of Cell Signalling and Immunology, Wellcome Trust Biocentre, College of Life Sciences, University of Dundee, Dow Street, DD1 5EH, Dundee, Scotland, United Kingdom
    Subcell Biochem 58:281-336. 2012
    ..This chapter will discuss these two classes of phosphatases, covering what is known about their biochemistry, their functions at the cellular and whole body level and their influence on human health...
  5. ncbi request reprint Redox regulation of phosphatase function
    N R Leslie
    Division of Cell Signalling, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Biochem Soc Trans 32:1018-20. 2004
    ..Future studies should give us a clearer picture of the role of phosphatase inactivation in cellular behaviour and explain how specificity is achieved in redox signalling...
  6. ncbi request reprint The regulation of cell migration by PTEN
    N R Leslie
    Division of Molecular Physiology, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem Soc Trans 33:1507-8. 2005
    ..Here, we discuss the role of PTEN in the regulation of cell migration...
  7. pmc PtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migration
    Nick R Leslie
    Division of Molecular Physiology, University of Dundee, Dundee, DD1 5EH, Scotland, United Kingdom
    Curr Biol 17:115-25. 2007
    ..PTEN also possesses a protein phosphatase activity, the role of which is less well characterized...
  8. doi request reprint Understanding PTEN regulation: PIP2, polarity and protein stability
    N R Leslie
    Division of Molecular Physiology, College of Life Sciences, University of Dundee, James Black Centre, Dundee, Scotland, UK
    Oncogene 27:5464-76. 2008
    ....
  9. doi request reprint P-REX2a driving tumorigenesis by PTEN inhibition
    Nick R Leslie
    Division of Molecular Physiology, College of Life Sciences, University of Dundee, The James Black Centre, Dow Street, Dundee, DD1 5EH, UK
    Sci Signal 2:pe68. 2009
    ..This suggests that aberrant control of PTEN by P-REX2a may represent a key tumorigenic mechanism, in agreement with recent studies supporting the pathological relevance of several other proposed PTEN regulators...
  10. doi request reprint Non-genomic loss of PTEN function in cancer: not in my genes
    Nick R Leslie
    Division of Molecular Physiology, College of Life Sciences, University of Dundee, Wellcome Trust Biocentre, Dow Street, Dundee DD1 5EH, UK
    Trends Pharmacol Sci 32:131-40. 2011
    ..Here we discuss these multiple mechanisms of PTEN regulation. We also put into context recent proposals that changes in this regulation can drive tumour development and address the accompanying evidence for their clinical significance...
  11. pmc PTEN function: how normal cells control it and tumour cells lose it
    Nick R Leslie
    Division of Cell Signalling, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Biochem J 382:1-11. 2004
    ....
  12. pmc Analysis of the cellular functions of PTEN using catalytic domain and C-terminal mutations: differential effects of C-terminal deletion on signalling pathways downstream of phosphoinositide 3-kinase
    N R Leslie
    Division of Signal Transduction Therapy, Department of Biochemistry, University of Dundee, Dundee DD1 5EH, U K
    Biochem J 346:827-33. 2000
    ..They also identify a mutation, similar to mutations that occur in some human tumours, which removes the effect of PTEN on membrane ruffling but not that on PKB...
  13. ncbi request reprint PTEN: The down side of PI 3-kinase signalling
    Nick R Leslie
    Division of Cell Signalling, School of Life Sciences, Medical Sciences Institute, University of Dundee, DD1 5EH Scotland, Dundee, UK
    Cell Signal 14:285-95. 2002
    ..There also remains the vexing question of whether any of PTEN's cellular functions reflect its evolutionary roots as a member of the protein tyrosine phosphatase superfamily...
  14. pmc Redox regulation of PI 3-kinase signalling via inactivation of PTEN
    Nick R Leslie
    Division of Cell Signalling, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    EMBO J 22:5501-10. 2003
    ..These results may have significant implications for the many cellular processes in which PtdIns(3,4,5)P(3) and oxidants are produced concurrently...
  15. pmc Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases
    Nick R Leslie
    Division of Cell Signalling, School of Life Sciences, The University of Dundee, Dundee, DD1 5EH, UK
    BMC Biochem 3:20. 2002
    ..The human genome contains at least 18 genes for Nudix hydrolase enzymes. Many have similar functions to one another. In order to understand their roles in cell physiology, these proteins must be characterised...
  16. pmc Targeting mutants of PTEN reveal distinct subsets of tumour suppressor functions
    N R Leslie
    Division of Signal Transduction Therapy, Department of Biochemistry, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem J 357:427-35. 2001
    ..Our data show that deregulation of PKB is not a universal feature of tumours carrying PTEN mutations and implicate other processes that may be deregulated in these tumours...
  17. pmc Ubiquitination of PTEN (phosphatase and tensin homolog) inhibits phosphatase activity and is enhanced by membrane targeting and hyperosmotic stress
    Helene Maccario
    Division of Molecular Physiology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom
    J Biol Chem 285:12620-8. 2010
    ..Our data indicate that ubiquitination may represent a regulated mechanism of direct reversible control over the PTEN enzyme...
  18. ncbi request reprint PTEN M-CBR3, a versatile and selective regulator of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5). Evidence for Ins(1,3,4,5,6)P5 as a proliferative signal
    Elaine A Orchiston
    Division of Cell Signalling, Faculty of Life Sciences, MSI WTB complex, Dow St, The University of Dundee, Dundee DD1 5EH, United Kingdom
    J Biol Chem 279:1116-22. 2004
    ..Our results, together with previously published data, suggest that Ins(1,3,4,5,6)P5 has a role in proliferation...
  19. ncbi request reprint Localization of agonist-sensitive PtdIns(3,4,5)P3 reveals a nuclear pool that is insensitive to PTEN expression
    Yvonne Lindsay
    Division of Molecular Physiology, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK
    J Cell Sci 119:5160-8. 2006
    ..These data have important implications for the versatility of PI 3-kinase signaling and for the proposed functions of PTEN in the nucleus...
  20. doi request reprint PTEN protein phosphatase activity correlates with control of gene expression and invasion, a tumor-suppressing phenotype, but not with AKT activity
    Priyanka Tibarewal
    Division of Cell Signalling and Immunology, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK
    Sci Signal 5:ra18. 2012
    ..Finally, we identified a tumor-derived PTEN mutant selectively lacking protein phosphatase activity, indicating that in some circumstances the regulation of invasion and not that of AKT can correlate with PTEN-mediated tumor suppression...
  21. ncbi request reprint Differential redox regulation within the PTP superfamily
    Sarah H Ross
    Division of Molecular Physiology, College of Life Sciences, University of Dundee, Dundee, UK
    Cell Signal 19:1521-30. 2007
    ..Our results show that sensitivity to reversible oxidation is not a necessary characteristic of the PTPs and imply that such sensitivity has evolved as a regulatory mechanism for some of this large family, but not others...
  22. pmc PTEN is destabilized by phosphorylation on Thr366
    Helene Maccario
    Division of Molecular Physiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Biochem J 405:439-44. 2007
    ..Our data support a model in which the phosphorylation of Thr366 plays a role in destabilizing the PTEN protein...
  23. pmc The tumour-suppressor function of PTEN requires an N-terminal lipid-binding motif
    Steven M Walker
    Division of Cell Signalling, School of Life Sciences, University of Dundee, MSI WTB complex, Dow Street, Dundee DD1 5EH, UK
    Biochem J 379:301-7. 2004
    ..Our results establish a requirement for the conserved N-terminal motif of PTEN for correct membrane orientation, cellular activity and tumour-suppressor function...
  24. doi request reprint Use of Akt inhibitor and a drug-resistant mutant validates a critical role for protein kinase B/Akt in the insulin-dependent regulation of glucose and system A amino acid uptake
    Charlotte J Green
    Division of Molecular Physiology, James Black Centre, College of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom
    J Biol Chem 283:27653-67. 2008
    ....
  25. pmc A novel leptin signalling pathway via PTEN inhibition in hypothalamic cell lines and pancreatic beta-cells
    Ke Ning
    Neurosciences Institute, Division of Pathology and Neuroscience, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
    EMBO J 25:2377-87. 2006
    ..These results demonstrate a critical role for PTEN in leptin signalling and indicate a mechanism by which leptin and insulin can produce PI3K dependent differential cellular outputs...
  26. pmc Detection of novel intracellular agonist responsive pools of phosphatidylinositol 3,4-bisphosphate using the TAPP1 pleckstrin homology domain in immunoelectron microscopy
    Stephen A Watt
    Division of Cell Biology and Immunology, School of Life Sciences, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, U K
    Biochem J 377:653-63. 2004
    ..These data suggest a role for PtdIns(3,4) P (2) in endomembrane function...
  27. ncbi request reprint Small molecule antagonists of the sigma-1 receptor cause selective release of the death program in tumor and self-reliant cells and inhibit tumor growth in vitro and in vivo
    Barbara A Spruce
    Department of Surgery and Molecular Oncology, The University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, UK
    Cancer Res 64:4875-86. 2004
    ..Release of a sigma receptor-mediated brake on apoptosis may offer a new approach to cancer treatment...
  28. ncbi request reprint Antagonism of PI 3-kinase-dependent signalling pathways by the tumour suppressor protein, PTEN
    C P Downes
    Division of Cell Signalling, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Biochem Soc Trans 29:846-51. 2001
    ....
  29. ncbi request reprint Metabolic switching of PI3K-dependent lipid signals
    C P Downes
    Division of Molecular Physiology, James Black Centre, College of Life Sciences, University of Dundee, Dundee, UK
    Biochem Soc Trans 35:188-92. 2007
    ..We suggest that concomitant inhibition of cysteine-dependent phosphatases, such as PTEN, with activation of SHIP2 functions as a metabolic switch to regulate independently the relative levels of PtdIns(3,4,5)P(3) and PtdIns(3,4)P(2)...
  30. ncbi request reprint Acute regulation of the tumour suppressor phosphatase, PTEN, by anionic lipids and reactive oxygen species
    C P Downes
    Division of Cell Signalling, School of Life Sciences, MSI WTB complex, University of Dundee, Dundee DD1 5EH, Scotland, U K
    Biochem Soc Trans 32:338-42. 2004
    ..This mechanism provides a novel means to stimulate phosphoinositide 3-kinase-dependent signalling pathways, which may be important in circumstances where PtdIns(3,4,5) P (3) and oxidants are produced concurrently...
  31. doi request reprint Migration Stimulating Factor (MSF) promotes fibroblast migration by inhibiting AKT
    Ian R Ellis
    Unit of Cell and Molecular Biology, The Dental School, College of Medicine, Dentistry and Nursing, University of Dundee, Park Place, Dundee DD1 4HR, UK
    Cell Signal 22:1655-9. 2010
    ..These data indicate that MSF promotes fibroblast migration, at least in part, by inhibiting the activity of AKT...
  32. ncbi request reprint Stimulation of PI 3-kinase signaling via inhibition of the tumor suppressor phosphatase, PTEN
    C Peter Downes
    Division of Molecular Physiology, Faculty of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK
    Adv Enzyme Regul 47:184-94. 2007
  33. pmc TPIP: a novel phosphoinositide 3-phosphatase
    S M Walker
    Division of Cell Signalling, School of Life Sciences, University of Dundee, MSI WTB complex, Dow Street, Dundee DD1 5EH, Scotland, UK
    Biochem J 360:277-83. 2001
    ..We suggest that TPIP alpha plays a role in regulating phosphoinositide signalling on the endoplasmic reticulum, and might also represent a tumour suppressor and functional homologue of PTEN in some tissues...
  34. ncbi request reprint Hypomorphic mutation of PDK1 suppresses tumorigenesis in PTEN(+/-) mice
    Jose R Bayascas
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom
    Curr Biol 15:1839-46. 2005
    ....
  35. pmc Loss of PTEN selectively desensitizes upstream IGF1 and insulin signaling
    J Lackey
    Division of Molecular Physiology, School of Life Sciences, University of Dundee, Dundee, Scotland, UK
    Oncogene 26:7132-42. 2007
    ....
  36. pmc The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins
    Laura S Harrington
    Cancer Research UK Centre for Cell and Molecular Biology, The Institute of Cancer Research, 237 Fulham Rd, London SW3 6JB, England, UK
    J Cell Biol 166:213-23. 2004
    ..Our results argue that the low malignant potential of tumors arising from TSC1-2 dysfunction may be explained by the failure of TSC mutant cells to activate PI3K and its downstream effectors...