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Genomes and Genes | Nick R LeslieSummaryAffiliation: University of Dundee Country: UK Publications
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Publications
The redox regulation of PI 3-kinase-dependent signalingNick R Leslie
Division of Molecular Physiology, School of Life Sciences, University of Dundee, Wellcome Trust Biocentre, Dundee, United Kingdom
Antioxid Redox Signal 8:1765-74. 2006....
The PTEN and Myotubularin Phosphoinositide 3-Phosphatases: Linking Lipid Signalling to Human DiseaseNicholas R Leslie
Division of Cell Signalling and Immunology, Wellcome Trust Biocentre, College of Life Sciences, University of Dundee, Dow Street, DD1 5EH, Dundee, Scotland, United Kingdom
Subcell Biochem 58:281-336. 2012..This chapter will discuss these two classes of phosphatases, covering what is known about their biochemistry, their functions at the cellular and whole body level and their influence on human health...- Redox regulation of phosphatase functionN R Leslie
Division of Cell Signalling, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
Biochem Soc Trans 32:1018-20. 2004..Future studies should give us a clearer picture of the role of phosphatase inactivation in cellular behaviour and explain how specificity is achieved in redox signalling... - The regulation of cell migration by PTENN R Leslie
Division of Molecular Physiology, University of Dundee, Dundee DD1 5EH, Scotland, UK
Biochem Soc Trans 33:1507-8. 2005..Here, we discuss the role of PTEN in the regulation of cell migration... 
Analysis of the cellular functions of PTEN using catalytic domain and C-terminal mutations: differential effects of C-terminal deletion on signalling pathways downstream of phosphoinositide 3-kinaseN R Leslie
Division of Signal Transduction Therapy, Department of Biochemistry, University of Dundee, Dundee DD1 5EH, U K
Biochem J 346:827-33. 2000..They also identify a mutation, similar to mutations that occur in some human tumours, which removes the effect of PTEN on membrane ruffling but not that on PKB...
PtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migrationNick R Leslie
Division of Molecular Physiology, University of Dundee, Dundee, DD1 5EH, Scotland, United Kingdom
Curr Biol 17:115-25. 2007..PTEN also possesses a protein phosphatase activity, the role of which is less well characterized...- Understanding PTEN regulation: PIP2, polarity and protein stabilityN R Leslie
Division of Molecular Physiology, College of Life Sciences, University of Dundee, James Black Centre, Dundee, Scotland, UK
Oncogene 27:5464-76. 2008.... - P-REX2a driving tumorigenesis by PTEN inhibitionNick R Leslie
Division of Molecular Physiology, College of Life Sciences, University of Dundee, The James Black Centre, Dow Street, Dundee, DD1 5EH, UK
Sci Signal 2:pe68. 2009..This suggests that aberrant control of PTEN by P-REX2a may represent a key tumorigenic mechanism, in agreement with recent studies supporting the pathological relevance of several other proposed PTEN regulators... - Non-genomic loss of PTEN function in cancer: not in my genesNick R Leslie
Division of Molecular Physiology, College of Life Sciences, University of Dundee, Wellcome Trust Biocentre, Dow Street, Dundee DD1 5EH, UK
Trends Pharmacol Sci 32:131-40. 2011..Here we discuss these multiple mechanisms of PTEN regulation. We also put into context recent proposals that changes in this regulation can drive tumour development and address the accompanying evidence for their clinical significance... - PTEN function: how normal cells control it and tumour cells lose itNick R Leslie
Division of Cell Signalling, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
Biochem J 382:1-11. 2004.... - PTEN: The down side of PI 3-kinase signallingNick R Leslie
Division of Cell Signalling, School of Life Sciences, Medical Sciences Institute, University of Dundee, DD1 5EH Scotland, Dundee, UK
Cell Signal 14:285-95. 2002..There also remains the vexing question of whether any of PTEN's cellular functions reflect its evolutionary roots as a member of the protein tyrosine phosphatase superfamily... - Targeting mutants of PTEN reveal distinct subsets of tumour suppressor functionsN R Leslie
Division of Signal Transduction Therapy, Department of Biochemistry, University of Dundee, Dundee DD1 5EH, Scotland, UK
Biochem J 357:427-35. 2001..Our data show that deregulation of PKB is not a universal feature of tumours carrying PTEN mutations and implicate other processes that may be deregulated in these tumours... - Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolasesNick R Leslie
Division of Cell Signalling, School of Life Sciences, The University of Dundee, Dundee, DD1 5EH, UK
BMC Biochem 3:20. 2002..The human genome contains at least 18 genes for Nudix hydrolase enzymes. Many have similar functions to one another. In order to understand their roles in cell physiology, these proteins must be characterised... - Redox regulation of PI 3-kinase signalling via inactivation of PTENNick R Leslie
Division of Cell Signalling, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
EMBO J 22:5501-10. 2003..These results may have significant implications for the many cellular processes in which PtdIns(3,4,5)P(3) and oxidants are produced concurrently... - Ubiquitination of PTEN (phosphatase and tensin homolog) inhibits phosphatase activity and is enhanced by membrane targeting and hyperosmotic stressHelene Maccario
Division of Molecular Physiology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom
J Biol Chem 285:12620-8. 2010..Our data indicate that ubiquitination may represent a regulated mechanism of direct reversible control over the PTEN enzyme... - Localization of agonist-sensitive PtdIns(3,4,5)P3 reveals a nuclear pool that is insensitive to PTEN expressionYvonne Lindsay
Division of Molecular Physiology, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK
J Cell Sci 119:5160-8. 2006..These data have important implications for the versatility of PI 3-kinase signaling and for the proposed functions of PTEN in the nucleus... - PTEN M-CBR3, a versatile and selective regulator of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5). Evidence for Ins(1,3,4,5,6)P5 as a proliferative signalElaine A Orchiston
Division of Cell Signalling, Faculty of Life Sciences, MSI WTB complex, Dow St, The University of Dundee, Dundee DD1 5EH, United Kingdom
J Biol Chem 279:1116-22. 2004..Our results, together with previously published data, suggest that Ins(1,3,4,5,6)P5 has a role in proliferation... - PTEN protein phosphatase activity correlates with control of gene expression and invasion, a tumor-suppressing phenotype, but not with AKT activityPriyanka Tibarewal
Division of Cell Signalling and Immunology, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK
Sci Signal 5:ra18. 2012..Finally, we identified a tumor-derived PTEN mutant selectively lacking protein phosphatase activity, indicating that in some circumstances the regulation of invasion and not that of AKT can correlate with PTEN-mediated tumor suppression... - Differential redox regulation within the PTP superfamilySarah H Ross
Division of Molecular Physiology, College of Life Sciences, University of Dundee, Dundee, UK
Cell Signal 19:1521-30. 2007..Our results show that sensitivity to reversible oxidation is not a necessary characteristic of the PTPs and imply that such sensitivity has evolved as a regulatory mechanism for some of this large family, but not others... - PTEN is destabilized by phosphorylation on Thr366Helene Maccario
Division of Molecular Physiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
Biochem J 405:439-44. 2007..Our data support a model in which the phosphorylation of Thr366 plays a role in destabilizing the PTEN protein... - Use of Akt inhibitor and a drug-resistant mutant validates a critical role for protein kinase B/Akt in the insulin-dependent regulation of glucose and system A amino acid uptakeCharlotte J Green
Division of Molecular Physiology, James Black Centre, College of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom
J Biol Chem 283:27653-67. 2008.... - The tumour-suppressor function of PTEN requires an N-terminal lipid-binding motifSteven M Walker
Division of Cell Signalling, School of Life Sciences, University of Dundee, MSI WTB complex, Dow Street, Dundee DD1 5EH, UK
Biochem J 379:301-7. 2004..Our results establish a requirement for the conserved N-terminal motif of PTEN for correct membrane orientation, cellular activity and tumour-suppressor function... - A novel leptin signalling pathway via PTEN inhibition in hypothalamic cell lines and pancreatic beta-cellsKe Ning
Neurosciences Institute, Division of Pathology and Neuroscience, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
EMBO J 25:2377-87. 2006..These results demonstrate a critical role for PTEN in leptin signalling and indicate a mechanism by which leptin and insulin can produce PI3K dependent differential cellular outputs... - Detection of novel intracellular agonist responsive pools of phosphatidylinositol 3,4-bisphosphate using the TAPP1 pleckstrin homology domain in immunoelectron microscopyStephen A Watt
Division of Cell Biology and Immunology, School of Life Sciences, MSI/WTB Complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, U.K
Biochem J 377:653-63. 2004..These data suggest a role for PtdIns(3,4) P (2) in endomembrane function... - Small molecule antagonists of the sigma-1 receptor cause selective release of the death program in tumor and self-reliant cells and inhibit tumor growth in vitro and in vivoBarbara A Spruce
Department of Surgery and Molecular Oncology, The University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, UK
Cancer Res 64:4875-86. 2004..Release of a sigma receptor-mediated brake on apoptosis may offer a new approach to cancer treatment... - Metabolic switching of PI3K-dependent lipid signalsC P Downes
Division of Molecular Physiology, James Black Centre, College of Life Sciences, University of Dundee, Dundee, UK
Biochem Soc Trans 35:188-92. 2007..We suggest that concomitant inhibition of cysteine-dependent phosphatases, such as PTEN, with activation of SHIP2 functions as a metabolic switch to regulate independently the relative levels of PtdIns(3,4,5)P(3) and PtdIns(3,4)P(2)... - Acute regulation of the tumour suppressor phosphatase, PTEN, by anionic lipids and reactive oxygen speciesC P Downes
Division of Cell Signalling, School of Life Sciences, MSI WTB complex, University of Dundee, Dundee DD1 5EH, Scotland, U K
Biochem Soc Trans 32:338-42. 2004..This mechanism provides a novel means to stimulate phosphoinositide 3-kinase-dependent signalling pathways, which may be important in circumstances where PtdIns(3,4,5) P (3) and oxidants are produced concurrently... - Antagonism of PI 3-kinase-dependent signalling pathways by the tumour suppressor protein, PTENC P Downes
Division of Cell Signalling, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
Biochem Soc Trans 29:846-51. 2001.... - Migration Stimulating Factor (MSF) promotes fibroblast migration by inhibiting AKTIan R Ellis
Unit of Cell and Molecular Biology, The Dental School, College of Medicine, Dentistry and Nursing, University of Dundee, Park Place, Dundee DD1 4HR, UK
Cell Signal 22:1655-9. 2010..These data indicate that MSF promotes fibroblast migration, at least in part, by inhibiting the activity of AKT... - Stimulation of PI 3-kinase signaling via inhibition of the tumor suppressor phosphatase, PTENC Peter Downes
Division of Molecular Physiology, Faculty of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK
Adv Enzyme Regul 47:184-94. 2007 - TPIP: a novel phosphoinositide 3-phosphataseS M Walker
Division of Cell Signalling, School of Life Sciences, University of Dundee, MSI WTB complex, Dow Street, Dundee DD1 5EH, Scotland, UK
Biochem J 360:277-83. 2001..We suggest that TPIP alpha plays a role in regulating phosphoinositide signalling on the endoplasmic reticulum, and might also represent a tumour suppressor and functional homologue of PTEN in some tissues... - Hypomorphic mutation of PDK1 suppresses tumorigenesis in PTEN(+/-) miceJose R Bayascas
MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom
Curr Biol 15:1839-46. 2005.... - Loss of PTEN selectively desensitizes upstream IGF1 and insulin signalingJ Lackey
Division of Molecular Physiology, School of Life Sciences, University of Dundee, Dundee, Scotland, UK
Oncogene 26:7132-42. 2007.... - Suppression of cellular proliferation and invasion by the concerted lipid and protein phosphatase activities of PTENL Davidson
Division of Molecular Physiology, College of Life Sciences, University of Dundee, Dundee, UK
Oncogene 29:687-97. 2010..Our data provide a novel tool to address the significance of PTEN's separable lipid and protein phosphatase activities and suggest that both activities suppress proliferation and together suppress invasion... - The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteinsLaura S Harrington
Cancer Research UK Centre for Cell and Molecular Biology, The Institute of Cancer Research, 237 Fulham Rd, London SW3 6JB, England, UK
J Cell Biol 166:213-23. 2004..Our results argue that the low malignant potential of tumors arising from TSC1-2 dysfunction may be explained by the failure of TSC mutant cells to activate PI3K and its downstream effectors...