M Isabel Leite
Affiliation: University of Oxford
Santos E, Moreira I, Coutinho E, GonÃ§alves G, Lopes C, Lopes Lima J, et al
. Congenital myasthenic syndrome due to mutation in CHRNE gene with clinical worsening and thymic hyperplasia attributed to association with autoimmune-myasthenia gravis. Neuromuscul Disord. 2015;25:928-31 pubmed publisher
..The inexistence of other conditions that could potentially associate with thymic hyperplasia also supports the diagnosis of MG. ..
Nour M, Nakashima I, Coutinho E, Woodhall M, Sousa F, Revis J, et al
. Pregnancy outcomes in aquaporin-4-positive neuromyelitis optica spectrum disorder. Neurology. 2016;86:79-87 pubmed publisher
..Women who develop NMOSD and have multiple other autoimmune disorders have greater odds of preeclampsia, independent of NMOSD onset timing. ..
Hor J, Lim T, Cheng M, Chia Y, Wong C, Lim S, et al
. Thymoma-associated myasthenia gravis and LGI1-encephalitis, with nephrotic syndrome post-thymectomy. J Neuroimmunol. 2018;317:100-102 pubmed publisher
..Nephropathy in myasthenia patients with thymoma should be properly evaluated, as it is treatable with immunotherapy, and it may even occur post-thymectomy. ..
Santos E, Coutinho E, Martins da Silva A, Marinho A, Vasconcelos C, Taipa R, et al
. Inflammatory myopathy associated with myasthenia gravis with and without thymic pathology: Report of four cases and literature review. Autoimmun Rev. 2017;16:644-649 pubmed publisher
..The recognition of these neuromuscular co-morbidities contributes to (i) understanding their pathogenic mechanisms, (ii) developing better management approaches and (iii) further improving disease outcomes. ..
Hor J, Lim T, Chia Y, Ching Y, Cheah C, Tan K, et al
. Prevalence of neuromyelitis optica spectrum disorder in the multi-ethnic Penang Island, Malaysia, and a review of worldwide prevalence. Mult Scler Relat Disord. 2018;19:20-24 pubmed publisher
..Worldwide, Blacks seem to have the highest NMOSD prevalence. More studies in different geographical regions and ethnic groups will be useful to further inform about potential factors in NMOSD pathogenesis. ..