Affiliation: University of Oxford
Wang Y, Tsui H, Ke Y, Shi Y, Li Y, Davies L, et al
. Pak1 is required to maintain ventricular CaÂ²âº homeostasis and electrophysiological stability through SERCA2a regulation in mice. Circ Arrhythm Electrophysiol. 2014;7:938-48 pubmed publisher
..These findings indicate that Pak1 is required to maintain ventricular Ca(2+) homeostasis and electrophysiological stability and implicate Pak1 as a novel regulator of cardiac SERCA2a through a transcriptional mechanism. ..
Egom E, Bae J, Capel R, Richards M, Ke Y, Pharithi R, et al
. Effect of sphingosine-1-phosphate on L-type calcium current and Ca(2+) transient in rat ventricular myocytes. Mol Cell Biochem. 2016;419:83-92 pubmed publisher
..Thus the results indicate that S1P attenuates ?-adrenergic stress-induced alteration of intracellular Ca(2+) release and L-type Ca(2+) channel current at least in part via Pak1-PP2A-mediated signalling. ..
Yu S, Li G, Huang C, Lei M, Wu L. Late sodium current associated cardiac electrophysiological and mechanical dysfunction. Pflugers Arch. 2018;470:461-469 pubmed publisher
..This review discusses the roles of endogenous and enhanced INaL in arrhythmogenesis and mechanical dysfunction, and the basic and clinical research of INaL inhibitors. ..