Manja Lehmann

Summary

Affiliation: University College London
Country: UK

Publications

  1. doi request reprint Cortical thickness and voxel-based morphometry in posterior cortical atrophy and typical Alzheimer's disease
    Manja Lehmann
    Dementia Research Centre, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
    Neurobiol Aging 32:1466-76. 2011
  2. doi request reprint Atrophy patterns in Alzheimer's disease and semantic dementia: a comparison of FreeSurfer and manual volumetric measurements
    Manja Lehmann
    Dementia Research Centre, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Neuroimage 49:2264-74. 2010
  3. doi request reprint Global gray matter changes in posterior cortical atrophy: a serial imaging study
    Manja Lehmann
    Dementia Research Centre, UCL Institute of Neurology, University College London, London, UK
    Alzheimers Dement 8:502-12. 2012
  4. pmc Posterior cerebral atrophy in the absence of medial temporal lobe atrophy in pathologically-confirmed Alzheimer's disease
    Manja Lehmann
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, UK
    Neurobiol Aging 33:627.e1-627.e12. 2012
  5. pmc Visual assessment of posterior atrophy development of a MRI rating scale
    Esther L G E Koedam
    Department of Neurology and Alzheimer Centre, VU University Medical Centre, PO Box 7057, 1007 MB, Amsterdam, The Netherlands
    Eur Radiol 21:2618-25. 2011
  6. doi request reprint Reduced cortical thickness in the posterior cingulate gyrus is characteristic of both typical and atypical Alzheimer's disease
    Manja Lehmann
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, UK
    J Alzheimers Dis 20:587-98. 2010
  7. doi request reprint An event-based model for disease progression and its application in familial Alzheimer's disease and Huntington's disease
    Hubert M Fonteijn
    Centre for Medical Image Computing, University College London, Gower Street, WC1E 6BT, London, UK
    Neuroimage 60:1880-9. 2012
  8. doi request reprint Visualizing the emergence of posterior cortical atrophy
    Jonathan Kennedy
    Dementia Research Centre, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Neurocase 18:248-57. 2012
  9. doi request reprint Basic visual function and cortical thickness patterns in posterior cortical atrophy
    Manja Lehmann
    Dementia Research Centre, UCL Institute of Neurology, University College London, London WC1N 3BG, UK
    Cereb Cortex 21:2122-32. 2011
  10. pmc Impairments of auditory scene analysis in Alzheimer's disease
    Johanna C Goll
    Dementia Research Centre, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
    Brain 135:190-200. 2012

Detail Information

Publications23

  1. doi request reprint Cortical thickness and voxel-based morphometry in posterior cortical atrophy and typical Alzheimer's disease
    Manja Lehmann
    Dementia Research Centre, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
    Neurobiol Aging 32:1466-76. 2011
    ..These distinct patterns of atrophy may have diagnostic utility. In a clinical context, a relatively spared medial temporal lobe in the presence of posterior parietal atrophy may imply PCA, and should not discount AD...
  2. doi request reprint Atrophy patterns in Alzheimer's disease and semantic dementia: a comparison of FreeSurfer and manual volumetric measurements
    Manja Lehmann
    Dementia Research Centre, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Neuroimage 49:2264-74. 2010
    ....
  3. doi request reprint Global gray matter changes in posterior cortical atrophy: a serial imaging study
    Manja Lehmann
    Dementia Research Centre, UCL Institute of Neurology, University College London, London, UK
    Alzheimers Dement 8:502-12. 2012
    ..However, differential longitudinal atrophy patterns are not well understood...
  4. pmc Posterior cerebral atrophy in the absence of medial temporal lobe atrophy in pathologically-confirmed Alzheimer's disease
    Manja Lehmann
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, UK
    Neurobiol Aging 33:627.e1-627.e12. 2012
    ..These results underline the importance of considering PA in AD diagnosis, particularly in younger patients where medial temporal atrophy may be less conspicuous...
  5. pmc Visual assessment of posterior atrophy development of a MRI rating scale
    Esther L G E Koedam
    Department of Neurology and Alzheimer Centre, VU University Medical Centre, PO Box 7057, 1007 MB, Amsterdam, The Netherlands
    Eur Radiol 21:2618-25. 2011
    ..To develop a visual rating scale for posterior atrophy (PA) assessment and to analyse whether this scale aids in the discrimination between Alzheimer's disease (AD) and other dementias...
  6. doi request reprint Reduced cortical thickness in the posterior cingulate gyrus is characteristic of both typical and atypical Alzheimer's disease
    Manja Lehmann
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, UK
    J Alzheimers Dis 20:587-98. 2010
    ..Reduced cortical thickness in the posterior cingulate gyrus is characteristic of AD pathology in patients with typical and atypical clinical presentations of AD, and may assist a clinical distinction of AD pathology from FTLD pathology...
  7. doi request reprint An event-based model for disease progression and its application in familial Alzheimer's disease and Huntington's disease
    Hubert M Fonteijn
    Centre for Medical Image Computing, University College London, Gower Street, WC1E 6BT, London, UK
    Neuroimage 60:1880-9. 2012
    ..The model and its formulation extend naturally to a wide range of other diseases and developmental processes and accommodate cross-sectional and longitudinal input data...
  8. doi request reprint Visualizing the emergence of posterior cortical atrophy
    Jonathan Kennedy
    Dementia Research Centre, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Neurocase 18:248-57. 2012
    ..Based on the clinical, neuropsychological and neuroimaging features, a diagnosis of PCA was made. The present case represents a unique opportunity to study and visualize the evolution of PCA from the very earliest symptomatic stages...
  9. doi request reprint Basic visual function and cortical thickness patterns in posterior cortical atrophy
    Manja Lehmann
    Dementia Research Centre, UCL Institute of Neurology, University College London, London WC1N 3BG, UK
    Cereb Cortex 21:2122-32. 2011
    ..However, there was also a lot of overlap in their patterns of cortical thinning. These findings suggest that different presentations of PCA represent points in a continuum of phenotypical variation...
  10. pmc Impairments of auditory scene analysis in Alzheimer's disease
    Johanna C Goll
    Dementia Research Centre, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
    Brain 135:190-200. 2012
    ..This work suggests a basis for understanding a class of clinical symptoms in Alzheimer's disease and for delineating cognitive mechanisms that mediate auditory scene analysis both in health and in neurodegenerative disease...
  11. ncbi request reprint An event-based disease progression model and its application to familial Alzheimer's disease
    Hubert M Fonteijn
    Centre for Medical Image Computing, Department of Computer Science, University College London, UK
    Inf Process Med Imaging 22:748-59. 2011
    ..We show progression of neuronal atrophy on a much finer level than previous studies, while confirming progression patterns from pathological studies, and integrate clinical events into the model...
  12. doi request reprint The language profile of posterior cortical atrophy
    Sebastian J Crutch
    Dementia Research Centre, Box 16, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    J Neurol Neurosurg Psychiatry 84:460-6. 2013
    ..Characterising and quantifying the aphasia associated with PCA is important for clarifying diagnostic and selection criteria for clinical and research studies...
  13. doi request reprint Visual ratings of atrophy in MCI: prediction of conversion and relationship with CSF biomarkers
    Manja Lehmann
    Dementia Research Centre, UCL Institute of Neurology, London, UK
    Neurobiol Aging 34:73-82. 2013
    ..These findings suggest both that posterior atrophy may predict conversion to AD in late-onset MCI, and that there may be differential relationships between CSF biomarkers and regional atrophy patterns...
  14. doi request reprint Patterns of cortical thickness according to APOE genotype in Alzheimer's disease
    Leticia GutiƩrrez-Galve
    Dementia Research Centre, Institute of Neurology, University College London UCL, London WC1N 3BG, UK
    Dement Geriatr Cogn Disord 28:476-85. 2009
    ..We aimed to assess the influence of APOE genotype on cortical thickness and regional brain volumes in AD (Alzheimer's disease)...
  15. pmc Posterior cortical atrophy
    Sebastian J Crutch
    Dementia Research Centre, Institute of Neurology, University College London, London, UK
    Lancet Neurol 11:170-8. 2012
    ..Greater awareness of the syndrome and agreement over the correspondence between syndrome-level and disease-level classifications are needed to improve diagnostic accuracy, clinical management, and the design of research studies...
  16. pmc Early-onset Alzheimer disease clinical variants: multivariate analyses of cortical thickness
    Gerard R Ridgway
    Dementia Research Centre, UCL Institute of Neurology, University College London, London, UK
    Neurology 79:80-4. 2012
    ....
  17. doi request reprint Head size, age and gender adjustment in MRI studies: a necessary nuisance?
    Josephine Barnes
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Neuroimage 53:1244-55. 2010
    ..Division of all volumes by head size is unlikely to be adequate owing to their non-proportional relationship...
  18. pmc Auditory object cognition in dementia
    Johanna C Goll
    Dementia Research Centre, Institute of Neurology, University College London, 8 11 Queen Square, London WC1N 3BG, United Kingdom
    Neuropsychologia 49:2755-65. 2011
    ..The findings provide evidence for separable stages of auditory object analysis and separable profiles of impaired auditory object cognition in different dementia syndromes...
  19. doi request reprint Fast free-form deformation using graphics processing units
    Marc Modat
    Centre for Medical Image Computing, Department of Medical Physics and Bioengineering, University College London, London, UK
    Comput Methods Programs Biomed 98:278-84. 2010
    ..This technology could be of significant utility in time-critical applications such as image-guided interventions, or in the processing of large data sets...
  20. doi request reprint Abnormal visual phenomena in posterior cortical atrophy
    Sebastian J Crutch
    Dementia Research Centre, Department of Neurodegeneration, UCL Institute of Neurology, University College London, UK
    Neurocase 17:160-77. 2011
    ..This study contributes to the growing characterisation of PCA whose atypical early visual symptoms are often heterogeneous and frequently under-recognised...
  21. doi request reprint Shining a light on posterior cortical atrophy
    Sebastian J Crutch
    Dementia Research Centre, UCL Institute of Neurology, London, UK
    Alzheimers Dement 9:463-5. 2013
    ....
  22. pmc Magnetic resonance imaging evidence for presymptomatic change in thalamus and caudate in familial Alzheimer's disease
    Natalie S Ryan
    Dementia Research Centre, Box 16 National Hospital for Neurology and Neurosugery, Queen Square, London WC1N 3BG, UK
    Brain 136:1399-414. 2013
    ..It may be owing to their dense connectivity that imaging changes are seen first in the thalamus and striatum, which then progress to involve other regions in a vulnerable neuronal network...
  23. doi request reprint Does registration of serial MRI improve diagnosis of dementia?
    Josephine Barnes
    Dementia Research Centre, UCL Institute of Neurology, London, UK
    Neuroradiology 52:987-95. 2010
    ..We aimed to assess the value of a second MR scan in the radiological diagnosis of dementia...