Donald J Lehmann

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. doi request reprint Association of the aromatase gene with Alzheimer's disease in women
    Helen T Butler
    Genomics Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Neurosci Lett 468:202-6. 2010
  2. doi request reprint Transferrin and HFE genes interact in Alzheimer's disease risk: the Epistasis Project
    Donald J Lehmann
    Oxford Project to Investigate Memory and Ageing, University Department of Physiology, Anatomy and Genetics, Oxford, UK
    Neurobiol Aging 33:202.e1-13. 2012
  3. pmc Replication by the Epistasis Project of the interaction between the genes for IL-6 and IL-10 in the risk of Alzheimer's disease
    Onofre Combarros
    Neurology Service and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Marqués de Valdecilla University Hospital University of Cantabria, 39008 Santander, Spain
    J Neuroinflammation 6:22. 2009
  4. pmc The synergy factor: a statistic to measure interactions in complex diseases
    Mario Cortina Borja
    , Sevilla, Spain
    BMC Res Notes 2:105. 2009
  5. pmc The dopamine β-hydroxylase -1021C/T polymorphism is associated with the risk of Alzheimer's disease in the Epistasis Project
    Onofre Combarros
    Neurology Service and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Marqués de Valdecilla University Hospital University of Cantabria, 39008 Santander, Spain
    BMC Med Genet 11:162. 2010
  6. ncbi request reprint Association of butyrylcholinesterase K variant with cholinesterase-positive neuritic plaques in the temporal cortex in late-onset Alzheimer's disease
    D J Lehmann
    Oxford Project to Investigate Memory and Ageing OPTIMA, Department of Clinical Neurology, University of Oxford, UK
    Hum Genet 106:447-52. 2000
  7. doi request reprint The vitamin D receptor gene is associated with Alzheimer's disease
    Donald J Lehmann
    Oxford Project to Investigate Memory and Ageing OPTIMA, University Department of Pharmacology, Oxford OX1 3QT, UK
    Neurosci Lett 504:79-82. 2011
  8. pmc Apolipoprotein E epsilon4 and impaired episodic memory in community-dwelling elderly people: a marked sex difference. The Hordaland Health Study
    D J Lehmann
    OPTIMA, Oxford Centre for Gene Function, University Laboratory of Physiology, Parks Road, Oxford OX1 3PT, UK
    J Neurol Neurosurg Psychiatry 77:902-8. 2006
  9. ncbi request reprint Large meta-analysis establishes the ACE insertion-deletion polymorphism as a marker of Alzheimer's disease
    Donald J Lehmann
    The Oxford Project to Investigate Memory and Ageing OPTIMA, Department of Pharmacology, University of Oxford, Oxford, United Kingdom
    Am J Epidemiol 162:305-17. 2005
  10. ncbi request reprint Association of the androgen receptor CAG repeat polymorphism with Alzheimer's disease in men
    D J Lehmann
    Oxford Project to Investigate Memory and Ageing, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, UK
    Neurosci Lett 340:87-90. 2003

Collaborators

Detail Information

Publications14

  1. doi request reprint Association of the aromatase gene with Alzheimer's disease in women
    Helen T Butler
    Genomics Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Neurosci Lett 468:202-6. 2010
    ..In the hippocampus, it is upregulated in postmenopausal women and is lowered in AD. These sex-specific results are therefore plausible. However, our results now need to be replicated in a larger dataset...
  2. doi request reprint Transferrin and HFE genes interact in Alzheimer's disease risk: the Epistasis Project
    Donald J Lehmann
    Oxford Project to Investigate Memory and Ageing, University Department of Physiology, Anatomy and Genetics, Oxford, UK
    Neurobiol Aging 33:202.e1-13. 2012
    ..We therefore suggest that iron overload may be a causative factor in the development of AD. Treatment for iron overload might thus be protective in some cases...
  3. pmc Replication by the Epistasis Project of the interaction between the genes for IL-6 and IL-10 in the risk of Alzheimer's disease
    Onofre Combarros
    Neurology Service and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Marqués de Valdecilla University Hospital University of Cantabria, 39008 Santander, Spain
    J Neuroinflammation 6:22. 2009
    ....
  4. pmc The synergy factor: a statistic to measure interactions in complex diseases
    Mario Cortina Borja
    , Sevilla, Spain
    BMC Res Notes 2:105. 2009
    ..It can be applied to primary or summarised data, e.g. published data. It can be used with any type of susceptibility factor, provided the data are dichotomised. Novel features include power estimation and meta-analysis...
  5. pmc The dopamine β-hydroxylase -1021C/T polymorphism is associated with the risk of Alzheimer's disease in the Epistasis Project
    Onofre Combarros
    Neurology Service and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Marqués de Valdecilla University Hospital University of Cantabria, 39008 Santander, Spain
    BMC Med Genet 11:162. 2010
    ..We therefore examined the associations with AD of the DBH -1021T allele and of the above interactions in the Epistasis Project, with 1757 cases of AD and 6294 elderly controls...
  6. ncbi request reprint Association of butyrylcholinesterase K variant with cholinesterase-positive neuritic plaques in the temporal cortex in late-onset Alzheimer's disease
    D J Lehmann
    Oxford Project to Investigate Memory and Ageing OPTIMA, Department of Clinical Neurology, University of Oxford, UK
    Hum Genet 106:447-52. 2000
    ..009). We consider three potential explanations for these findings: that the K variant binds more readily to plaque constituents, that it promotes fibril formation or that it induces aberrant neurite growth...
  7. doi request reprint The vitamin D receptor gene is associated with Alzheimer's disease
    Donald J Lehmann
    Oxford Project to Investigate Memory and Ageing OPTIMA, University Department of Pharmacology, Oxford OX1 3QT, UK
    Neurosci Lett 504:79-82. 2011
    ..05. These associations are biologically plausible and are consistent with a role for vitamin D in AD. Nevertheless, we consider this to be a hypothesis-generating study, which needs to be replicated in a larger dataset...
  8. pmc Apolipoprotein E epsilon4 and impaired episodic memory in community-dwelling elderly people: a marked sex difference. The Hordaland Health Study
    D J Lehmann
    OPTIMA, Oxford Centre for Gene Function, University Laboratory of Physiology, Parks Road, Oxford OX1 3PT, UK
    J Neurol Neurosurg Psychiatry 77:902-8. 2006
    ..Among elderly people without dementia, the apolipoprotein E epsilon4 allele (APOE4) has been associated with cognitive deficit, particularly in episodic memory, but few reports are available on whether this association differs by sex...
  9. ncbi request reprint Large meta-analysis establishes the ACE insertion-deletion polymorphism as a marker of Alzheimer's disease
    Donald J Lehmann
    The Oxford Project to Investigate Memory and Ageing OPTIMA, Department of Pharmacology, University of Oxford, Oxford, United Kingdom
    Am J Epidemiol 162:305-17. 2005
    ..This interaction warrants further investigation...
  10. ncbi request reprint Association of the androgen receptor CAG repeat polymorphism with Alzheimer's disease in men
    D J Lehmann
    Oxford Project to Investigate Memory and Ageing, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, UK
    Neurosci Lett 340:87-90. 2003
    ..5, 95% confidence intervals: 1.2-5.0) in men, but not in women. This association appeared stronger in early-onset AD (< 65 years). We conclude that this AR polymorphism is of potential relevance to the risk of AD in men...
  11. ncbi request reprint Using meta-analysis to explain the diversity of results in genetic studies of late-onset Alzheimer's disease and to identify high-risk subgroups
    D J Lehmann
    Oxford Project to Investigate Memory and Ageing OPTIMA, Radcliffe Infirmary, Oxford, UK
    Neuroscience 108:541-54. 2001
    ..This analysis leads to the identification of a potentially high-risk group: over 75 year old male carriers of both apolipoprotein E epsilon4 and butyrylcholinesterase K variant...
  12. ncbi request reprint HLA class I, II & III genes in confirmed late-onset Alzheimer's disease
    D J Lehmann
    Oxford Project to Investigate Memory and Ageing OPTIMA, University Department of Pharmacology, Oxford OX1 3QT, UK
    Neurobiol Aging 22:71-7. 2001
    ....
  13. doi request reprint Butyrylcholinesterase K variant associated with higher enzyme activity in the temporal cortex of elderly patients
    Andrea Tasker
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Neurosci Lett 442:297-9. 2008
    ..Linear regression analysis, controlling for gender, diagnosis, age at death and study centre, showed that the number of BCHE-K alleles was associated with increasing BuChE activity (p=0.009)...