A R Lehmann

Summary

Affiliation: University of Sussex
Country: UK

Publications

  1. pmc ATR-mediated phosphorylation of DNA polymerase η is needed for efficient recovery from UV damage
    Thomas Gohler
    Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, England, UK
    J Cell Biol 192:219-27. 2011
  2. pmc A role for chromatin remodellers in replication of damaged DNA
    Atsuko Niimi
    Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, UK
    Nucleic Acids Res 40:7393-403. 2012
  3. doi DNA polymerases and repair synthesis in NER in human cells
    Alan R Lehmann
    Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, UK
    DNA Repair (Amst) 10:730-3. 2011
  4. ncbi The xeroderma pigmentosum group D (XPD) gene: one gene, two functions, three diseases
    A R Lehmann
    MRC Cell Mutation Unit, University of Sussex, Falmer, Brighton BN1 9RR, UK
    Genes Dev 15:15-23. 2001
  5. ncbi Replication of damaged DNA in mammalian cells: new solutions to an old problem
    Alan R Lehmann
    Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, UK
    Mutat Res 509:23-34. 2002
  6. ncbi DNA repair-deficient diseases, xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy
    Alan R Lehmann
    Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, UK
    Biochimie 85:1101-11. 2003
  7. ncbi XPD structure reveals its secrets
    Alan R Lehmann
    Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton, UK
    DNA Repair (Amst) 7:1912-5. 2008
  8. ncbi Translesion synthesis: Y-family polymerases and the polymerase switch
    Alan R Lehmann
    Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, UK
    DNA Repair (Amst) 6:891-9. 2007
  9. ncbi Gaps and forks in DNA replication: Rediscovering old models
    Alan R Lehmann
    Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, UK
    DNA Repair (Amst) 5:1495-8. 2006
  10. ncbi Translesion synthesis in mammalian cells
    Alan R Lehmann
    Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton, UK
    Exp Cell Res 312:2673-6. 2006

Collaborators

Detail Information

Publications72

  1. pmc ATR-mediated phosphorylation of DNA polymerase η is needed for efficient recovery from UV damage
    Thomas Gohler
    Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, England, UK
    J Cell Biol 192:219-27. 2011
    ..Taken together, our results provide evidence for a link between DNA damage-induced checkpoint activation and translesion synthesis in mammalian cells...
  2. pmc A role for chromatin remodellers in replication of damaged DNA
    Atsuko Niimi
    Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, UK
    Nucleic Acids Res 40:7393-403. 2012
    ....
  3. doi DNA polymerases and repair synthesis in NER in human cells
    Alan R Lehmann
    Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, UK
    DNA Repair (Amst) 10:730-3. 2011
    ..In vitro studies implicated the replicative polymerases in repair synthesis, but recent in vivo data have shown that several DNA polymerases and ligases are involved in these steps in human cells...
  4. ncbi The xeroderma pigmentosum group D (XPD) gene: one gene, two functions, three diseases
    A R Lehmann
    MRC Cell Mutation Unit, University of Sussex, Falmer, Brighton BN1 9RR, UK
    Genes Dev 15:15-23. 2001
  5. ncbi Replication of damaged DNA in mammalian cells: new solutions to an old problem
    Alan R Lehmann
    Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, UK
    Mutat Res 509:23-34. 2002
    ..Many studies have been carried out on the properties of the other polymerases in vitro, but there is as yet very little evidence for their specific roles in vivo...
  6. ncbi DNA repair-deficient diseases, xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy
    Alan R Lehmann
    Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, UK
    Biochimie 85:1101-11. 2003
    ..Skin tumours in XP patients have mutations characteristic of UV-induction in the ras, p53 and ptch genes, showing that sunlight-induced mutations in these genes are important in carcinogenesis in XP patients...
  7. ncbi XPD structure reveals its secrets
    Alan R Lehmann
    Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton, UK
    DNA Repair (Amst) 7:1912-5. 2008
    ..Apart from anticipated helicase domains the structures reveal a 4FeS cluster and novel "Arch" domain. The structures help our understanding of genotype-phenotype relationships in the XPD gene...
  8. ncbi Translesion synthesis: Y-family polymerases and the polymerase switch
    Alan R Lehmann
    Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, UK
    DNA Repair (Amst) 6:891-9. 2007
    ..All the Y-family polymerases have ubiquitin binding sites that increase their binding affinity for ubiquitinated PCNA at the sites of stalled forks...
  9. ncbi Gaps and forks in DNA replication: Rediscovering old models
    Alan R Lehmann
    Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, UK
    DNA Repair (Amst) 5:1495-8. 2006
    ....
  10. ncbi Translesion synthesis in mammalian cells
    Alan R Lehmann
    Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton, UK
    Exp Cell Res 312:2673-6. 2006
    ..When the fork is blocked PCNA gets ubiquitinated. This increases its affinity for the TLS polymerases, which all have novel ubiquitin-binding motifs, thereby facilitating their engagement at the stalled fork to effect TLS...
  11. pmc Xeroderma pigmentosum
    Alan R Lehmann
    Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, UK
    Orphanet J Rare Dis 6:70. 2011
    ..In the absence of neurological problems and with lifetime protection against sunlight, the prognosis is good. In patients with neurological problems, these are progressive, leading to disabilities and a shortened lifespan...
  12. ncbi Clubbing together on clamps: The key to translesion synthesis
    Alan R Lehmann
    Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, UK
    DNA Repair (Amst) 5:404-7. 2006
    ..The clamps are dimeric in bacteria and trimeric in eukaryotes and archaea, raising the question of whether more than one polymerase can interact with the clamp simultaneously. Recently published data suggest that this is indeed the case...
  13. doi Ubiquitin-family modifications in the replication of DNA damage
    Alan R Lehmann
    Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, UK
    FEBS Lett 585:2772-9. 2011
    ..The Y-family polymerases themselves can be ubiquitinated and, in the case of DNA polymerase η, this results in the polymerase being excluded from chromatin...
  14. ncbi Replication of damaged DNA by translesion synthesis in human cells
    Alan R Lehmann
    Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, UK
    FEBS Lett 579:873-6. 2005
    ..These polymerases are located in replication factories during DNA replication and the polymerase sliding clamp PCNA plays an important role in mediating switching between different polymerases...
  15. ncbi Replication of damaged DNA
    Alan R Lehmann
    Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, UK
    Cell Cycle 2:300-2. 2003
    ..Emerging evidence suggests that the polymerase switch from replicative to translesion polymerases might be mediated by post-translational modifications...
  16. ncbi The role of SMC proteins in the responses to DNA damage
    Alan R Lehmann
    Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, UK
    DNA Repair (Amst) 4:309-14. 2005
    ..The Smc5-6 complex is involved in a variety of DNA repair and damage response pathways by as yet unknown mechanisms, but is also associated with repair by homologous recombination...
  17. pmc Fission yeast rad17: a homologue of budding yeast RAD24 that shares regions of sequence similarity with DNA polymerase accessory proteins
    D J Griffiths
    MRC Cell Mutation Unit, Sussex University, Falmer, UK
    EMBO J 14:5812-23. 1995
    ..These studies have also defined an element of the radiation sensitivity caused by loss of Rad17 function which is not associated with the radiation-induced G2 arrest defect seen in the rad17.d null mutant cells...
  18. pmc Cloning and characterisation of the Schizosaccharomyces pombe rad8 gene, a member of the SNF2 helicase family
    C L Doe
    School of Biological Sciences, University of Sussex, Falmer, Brighton, UK
    Nucleic Acids Res 21:5964-71. 1993
    ..Analysis of radiation sensitivity though the cell cycle indicates that, unlike most other rad mutants, rad8 is most sensitive to irradiation during the G1/S period...
  19. pmc Characterization of a novel human SMC heterodimer homologous to the Schizosaccharomyces pombe Rad18/Spr18 complex
    E M Taylor
    MRC Cell Mutation Unit, University of Sussex, Falmer, Brighton BN1 9RR, United Kingdom
    Mol Biol Cell 12:1583-94. 2001
    ..Both hSMC5 and hSMC6 proteins are expressed at extremely high levels in the testis and associate with the sex chromosomes in the late stages of meiotic prophase, suggesting a possible role for these proteins in meiosis...
  20. ncbi Two individuals with features of both xeroderma pigmentosum and trichothiodystrophy highlight the complexity of the clinical outcomes of mutations in the XPD gene
    B C Broughton
    Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RR, UK
    Hum Mol Genet 10:2539-47. 2001
    ..Our findings highlight the complexities of genotype-phenotype relationships in the XPD gene...
  21. pmc The rad18 gene of Schizosaccharomyces pombe defines a new subgroup of the SMC superfamily involved in DNA repair
    A R Lehmann
    MRC Cell Mutation Unit, University of Sussex, Falmer, Brighton, United Kingdom
    Mol Cell Biol 15:7067-80. 1995
    ..This second repair pathway involves the products of the rhp51 gene (the homolog of the RAD51 gene of S. cerevisiae) and the rad2 gene...
  22. pmc A novel SMC protein complex in Schizosaccharomyces pombe contains the Rad18 DNA repair protein
    M I Fousteri
    MRC Cell Mutation Unit, University of Sussex, Falmer, Brighton BN1 9RR, UK
    EMBO J 19:1691-702. 2000
    ..We have identified an important mutation (S1045A) near the C-terminus of Rad18 that separates its repair and essential roles. Potential models for the role of the Rad18-Spr18 complex during DNA repair are discussed...
  23. ncbi Splitting the ATM: distinct repair and checkpoint defects in ataxia-telangiectasia
    P A Jeggo
    MRC Cell Mutation Unit, University of Sussex, Brighton, UK
    Trends Genet 14:312-6. 1998
    ..A-T cells therefore appear to harbour dual checkpoint/repair defects. Here, we review the evidence supporting this contention and consider its implications for an analysis of the A-T phenotype...
  24. ncbi Mutations in the xeroderma pigmentosum group D DNA repair/transcription gene in patients with trichothiodystrophy
    B C Broughton
    MRC Cell Mutation Unit, University of Sussex, Falmer, Brighton, UK
    Nat Genet 7:189-94. 1994
    ..The patients are all compound heterozygotes and the locations of the mutations enable us to suggest relationships between different domains in the gene and its roles in excision repair and transcription...
  25. pmc Cloning and characterization of the rad4 gene of Schizosaccharomyces pombe; a gene showing short regions of sequence similarity to the human XRCC1 gene
    M Fenech
    MRC Cell Mutation Unit, School of Biology, University of Sussex, Falmer, Brighton, UK
    Nucleic Acids Res 19:6737-41. 1991
    ..Codon usage suggests that the gene is very poorly expressed, and this was confirmed by RNA studies. Gene disruption showed that the rad4 gene was essential for the mitotic growth of S. pombe...
  26. pmc Evolutionary conservation of excision repair in Schizosaccharomyces pombe: evidence for a family of sequences related to the Saccharomyces cerevisiae RAD2 gene
    A M Carr
    MRC Cell Mutation Unit, Sussex University, Falmer, Brighton, UK
    Nucleic Acids Res 21:1345-9. 1993
    ..These findings define new functional domains involved in excision-repair, as well as identifying a conserved family of genes related to RAD2...
  27. pmc Xeroderma pigmentosum and trichothiodystrophy are associated with different mutations in the XPD (ERCC2) repair/transcription gene
    E M Taylor
    Medical Research Council Cell Mutation Unit, Sussex University, Falmer, Brighton BN1 9RR, United Kingdom
    Proc Natl Acad Sci U S A 94:8658-63. 1997
    ..If we eliminate the null mutations, the remaining mutagenic pattern is consistent with the site of the mutation determining the phenotype...
  28. ncbi Minimal ionizing radiation sensitivity in a large cohort of xeroderma pigmentosum fibroblasts
    C F Arlett
    Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton, BN1 9RQ
    Br J Radiol 81:51-8. 2008
    ..Our results confirm the extreme ionizing radiation hypersensitivity of ataxia-telangiectasia; they are also consistent with a tendency for slight hypersensitivity in CS, but not (necessarily) in combined XP/CS...
  29. pmc Molecular analysis of mutations in the CSB (ERCC6) gene in patients with Cockayne syndrome
    D L Mallery
    MRC Cell Mutation Unit, Sussex University, Falmer, Brighton BN1 9RR, United Kingdom
    Am J Hum Genet 62:77-85. 1998
    ..Neither the site nor the nature of the mutation correlated with the severity of the clinical features. Severe truncations were found in different patients with either classical or early-onset forms of the disease...
  30. ncbi Dual functions of DNA repair genes: molecular, cellular, and clinical implications
    A R Lehmann
    MRC Cell Mutation Unit, Sussex University, Falmer, Brighton, United Kingdom
    Bioessays 20:146-55. 1998
    ..The involvement of repair proteins in other processes also poses interesting evolutionary questions...
  31. ncbi Clinical and cellular ionizing radiation sensitivity in a patient with xeroderma pigmentosum
    C F Arlett
    Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ
    Br J Radiol 79:510-7. 2006
    ..It is important to resolve how widespread ionizing radiation sensitivity is amongst XP patients...
  32. ncbi Interaction of human DNA polymerase eta with monoubiquitinated PCNA: a possible mechanism for the polymerase switch in response to DNA damage
    Patricia L Kannouche
    Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, United Kingdom
    Mol Cell 14:491-500. 2004
    ..Our findings provide an attractive mechanism by which monoubiquitination of PCNA might mediate the polymerase switch...
  33. pmc Identification and characterization of new elements involved in checkpoint and feedback controls in fission yeast
    F al-Khodairy
    MRC Cell Mutation Unit, Sussex University, Falmer, United Kingdom
    Mol Biol Cell 5:147-60. 1994
    ....
  34. ncbi A novel mutation in the XPA gene associated with unusually mild clinical features in a patient who developed a spindle cell melanoma
    R U Sidwell
    Department of Dermatology, Charing Cross Hospital, London, and Genome Damage and Stability Centre, University of Sussex, Brighton, UK
    Br J Dermatol 155:81-8. 2006
    ..These complementation groups correspond to different proteins involved in the NER process. XP-A classically includes some of the most severely affected patients...
  35. pmc Nse2, a component of the Smc5-6 complex, is a SUMO ligase required for the response to DNA damage
    Emily A Andrews
    Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9RQ, United Kingdom
    Mol Cell Biol 25:185-96. 2005
    ..SA strain. Since nse2.SA cells are sensitive to DNA-damaging agents and to exposure to hydroxyurea, this implicates the Nse2-dependent sumoylation activity in DNA damage responses but not in the essential function of the Smc5-6 complex...
  36. ncbi Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient
    E Riballo
    MRC Cell Mutation Unit, University of Sussex, Brighton, BN1 9RR, UK
    Curr Biol 9:699-702. 1999
    ..The defect, however, may confer a predisposition to leukaemia...
  37. pmc Composition and architecture of the Schizosaccharomyces pombe Rad18 (Smc5-6) complex
    John Sergeant
    Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, United Kingdom
    Mol Cell Biol 25:172-84. 2005
    ..In initial steps to understand the architecture of the complex, we identified two subcomplexes containing Rad18-Spr18-Nse2 and Nse1-Nse3-Rad62. The subcomplexes are probably bridged by a weaker interaction between Nse2 and Nse3...
  38. pmc Localization of DNA polymerases eta and iota to the replication machinery is tightly co-ordinated in human cells
    Patricia Kannouche
    Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, UK
    EMBO J 22:1223-33. 2003
    ..Our results provide strong evidence that poleta targets poliota to the replication machinery, where it may play a general role in maintaining genome integrity as well as participating in translesion DNA synthesis...
  39. pmc Localization of DNA polymerases eta and iota to the replication machinery is tightly co-ordinated in human cells
    Patricia Kannouche
    Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, Cancer Research UK London Research Institute, 44, Lincoln s Inn Fields, London WC2A 3PX, UK
    EMBO J 21:6246-56. 2002
    ..Our results provide strong evidence that poleta targets poliota to the replication machinery, where it may play a general role in maintaining genome integrity as well as participating in translesion DNA synthesis...
  40. ncbi Ubiquitination and deubiquitination of PCNA in response to stalling of the replication fork
    Stephanie Brown
    Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton, UK
    Cell Cycle 8:689-92. 2009
    ..Prevention of PCNA ubiquitination sensitises the cells to killing by both UV and HU...
  41. pmc Molecular analysis of mutations in DNA polymerase eta in xeroderma pigmentosum-variant patients
    Bernard C Broughton
    Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RR, United Kingdom
    Proc Natl Acad Sci U S A 99:815-20. 2002
    ..There is a wide variability in clinical features among patients, which is not obviously related to the site or type of mutation...
  42. pmc Transcription-associated breaks in xeroderma pigmentosum group D cells from patients with combined features of xeroderma pigmentosum and Cockayne syndrome
    Therina Theron
    Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, United Kingdom
    Mol Cell Biol 25:8368-78. 2005
    ....
  43. pmc Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse
    T Blunt
    Medical Research Council Cell Mutation Unit, University of Sussex, Brighton, United Kingdom
    Proc Natl Acad Sci U S A 93:10285-90. 1996
    ..This represents a strong candidate for the inactivating mutation in DNA-PKcs in the scid mouse...
  44. ncbi Ubiquitin-PCNA fusion as a mimic for mono-ubiquitinated PCNA in Schizosaccharomyces pombe
    Sharada Ramasubramanyan
    Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton, UK
    DNA Repair (Amst) 9:777-84. 2010
    ..pombe. Replacement of the pcn1 locus with PCNA N-terminally tagged with different epitopes resulted in lethality, probably because the tagged proteins were expressed at substantially reduced levels...
  45. ncbi New functions for Y family polymerases
    Alan R Lehmann
    Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, United Kingdom
    Mol Cell 24:493-5. 2006
    ..Several recent papers suggest that they might have other roles as well in gene conversion, in nucleotide excision repair (NER), and in DNA replication under stressed conditions...
  46. pmc Postreplication repair and PCNA modification in Schizosaccharomyces pombe
    Jonathan Frampton
    Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, United Kingdom
    Mol Biol Cell 17:2976-85. 2006
    ..We show that PCNA modification and cell cycle checkpoints represent two independent signals in response to DNA damage. Finally, we unexpectedly find that PCNA is ubiquitinated in response to DNA damage when cells are arrested in G2...
  47. ncbi Localisation of human Y-family DNA polymerase kappa: relationship to PCNA foci
    Tomoo Ogi
    Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton, BN1 9RR, UK
    J Cell Sci 118:129-36. 2005
    ..The C-terminal 97 amino acids of pol(kappa)are sufficient for this limited localisation into nuclear foci, and include a C2HC zinc finger, bipartite nuclear localisation signal and putative PCNA binding site...
  48. ncbi The Smc5-Smc6 DNA repair complex. bridging of the Smc5-Smc6 heads by the KLEISIN, Nse4, and non-Kleisin subunits
    Jan Palecek
    Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, United Kingdom
    J Biol Chem 281:36952-9. 2006
    ..We further show that Nse3, as well as Nse5 and Nse6, also bridge the heads of Smc5 and -6. The Nse1-Nse3-Nse4 and Nse5-Nse6 subcomplexes bind to the Smc5-Smc6 heads domain at different sites...
  49. pmc Effect of proliferating cell nuclear antigen ubiquitination and chromatin structure on the dynamic properties of the Y-family DNA polymerases
    Simone Sabbioneda
    Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, United Kingdom
    Mol Biol Cell 19:5193-202. 2008
    ..When DNA is exposed at replication forks, the polymerase residence times increase, and this is further facilitated by the ubiquitination of PCNA...
  50. doi Translesion synthesis and error-prone polymerases
    Catherine M Green
    Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton, UK
    Adv Exp Med Biol 570:199-223. 2005
  51. ncbi Mutant sequences in the rpsL gene of Escherichia coli B/r: mechanistic implications for spontaneous and ultraviolet light mutagenesis
    A R Timms
    MRC Cell Mutation Unit, University of Sussex, Falmer, Brighton, Great Britain
    Mol Gen Genet 232:89-96. 1992
    ..One possibility is that spontaneous mutation may often occur in bursts when an error correction mechanism (eg., proofreading, mismatch correction) is temporarily inactive.(ABSTRACT TRUNCATED AT 250 WORDS)..
  52. pmc Regulation of proliferating cell nuclear antigen ubiquitination in mammalian cells
    Atsuko Niimi
    Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, United Kingdom
    Proc Natl Acad Sci U S A 105:16125-30. 2008
    ..We present a model of translesion synthesis behind the replication fork to explain the persistence of ubiquitinated PCNA...
  53. ncbi The Y-family DNA polymerase kappa (pol kappa) functions in mammalian nucleotide-excision repair
    Tomoo Ogi
    Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton, BN1 9RQ, UK
    Nat Cell Biol 8:640-2. 2006
    ..Our results provide evidence for an unexpected role for pol kappa in mammalian NER...
  54. ncbi Nomenclature of human DNA repair genes
    A R Lehmann
    MRC Cell Mutation Unit, University of Sussex, Falmer, Brighton, UK
    Mutat Res 315:41-2. 1994
  55. pmc Cloning and characterisation of the S. pombe rad15 gene, a homologue to the S. cerevisiae RAD3 and human ERCC2 genes
    J M Murray
    School of Biological Sciences, University of Sussex, Falmer, Brighton, UK
    Nucleic Acids Res 20:2673-8. 1992
    ..Gene deletion experiments indicate that, like the S. cerevisiae RAD3 gene, the S. pombe rad15 gene is essential for viability, suggesting that the protein product has a role in cell proliferation and not solely in DNA repair...
  56. pmc Identification of the proteins, including MAGEG1, that make up the human SMC5-6 protein complex
    Elaine M Taylor
    Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, United Kingdom
    Mol Cell Biol 28:1197-206. 2008
    ..Depletion also confers sensitivity to methyl methanesulfonate. Several of the components are modified by sumoylation and ubiquitination...
  57. ncbi Role of DNA polymerase eta in the UV mutation spectrum in human cells
    Anne Stary
    Laboratory of Genetic Instability and Cancer, UPR 2169 CNRS, Institut Gustave Roussy, 94805 Villejuif, France
    J Biol Chem 278:18767-75. 2003
    ..These results clearly show the protective role of pol eta against UV-induced lesions and the activation by UV of pol eta-independent mutagenic processes...
  58. ncbi A role for polymerase eta in the cellular tolerance to cisplatin-induced damage
    Mark R Albertella
    KuDOS Pharmaceuticals Ltd, Cambridge Science Park, Cambridge, UK
    Cancer Res 65:9799-806. 2005
    ..Together, these data show that pol eta represents an important determinant of cellular responses to cisplatin, which could have implications for acquired or intrinsic resistance to this key chemotherapeutic agent...
  59. ncbi Reduced level of the repair/transcription factor TFIIH in trichothiodystrophy
    Elena Botta
    Istituto di Genetica Molecolare CNR, Via Abbiategrasso, 207, 27100 Pavia, Italy
    Hum Mol Genet 11:2919-28. 2002
    ....
  60. ncbi Ubiquitination of PCNA and the polymerase switch in human cells
    Patricia L Kannouche
    Laboratory of Genetic Instability and Cancer, CNRS, Institut Gustave Roussy, Villejuif, France
    Cell Cycle 3:1011-3. 2004
    ..We point out some apparent differences between mechanisms in Saccharomyces cerevisiae and human cells...
  61. ncbi Neurological symptoms and natural course of xeroderma pigmentosum
    Anu Anttinen
    Department of Neurology, Turku University Central Hospital, PB 52, 20521 Turku, Finland
    Brain 131:1979-89. 2008
    ....
  62. ncbi Proliferating cell nuclear antigen-dependent coordination of the biological functions of human DNA polymerase iota
    Antonio E Vidal
    Laboratory of Genomic Integrity, NICHD, National Institutes of Health, Bethesda, Maryland 20892 2725, USA
    J Biol Chem 279:48360-8. 2004
    ..Thus, PCNA, acting as both a scaffold and a modulator of the different activities involved in replication, appears to recruit and coordinate replicative and translesion DNA synthesis polymerases to ensure genome integrity...
  63. ncbi Co-localization in replication foci and interaction of human Y-family members, DNA polymerase pol eta and REVl protein
    Agnès Tissier
    UPR9OO3 CNRS, Cancerogenese et Mutagenese Moleculaire et Structurale, ESBS, Pole API Bd Sébastien Brant BP 10413, F 67412 Illkirch, France
    DNA Repair (Amst) 3:1503-14. 2004
    ..This hREV1 nuclear localization occurs independently of the presence of hpol eta. Taken together, our data suggest a central role for hREV1 as a scaffold that recruits DNA polymerases involved in TLS...
  64. ncbi Maintaining integrity
    Yosef Shiloh
    The David and Inez Myers Laboratory for Genetic Research, Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Nat Cell Biol 6:923-8. 2004
    ..Current progress in this rapidly expanding field was the subject of an EMBO workshop, Maintenance of Genomic Integrity, that took place in June 2004 in Galway, Ireland. Top..
  65. ncbi Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis
    Marzena Bienko
    Institute for Biochemistry II, Goethe University Medical School, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Science 310:1821-4. 2005
    ..Our results indicate that Ub-binding domains of Y-family polymerases play crucial regulatory roles in TLS...
  66. ncbi Two new XPD patients compound heterozygous for the same mutation demonstrate diverse clinical features
    Mitsuo Fujimoto
    Department of Dermatology, Jichi Medical School, Japan
    J Invest Dermatol 125:86-92. 2005
    ..Despite these similarities between our two patients, their clinical features are quite different and the clinical severity correlates with other cellular responses to ultraviolet irradiation...
  67. ncbi An Xpd mouse model for the combined xeroderma pigmentosum/Cockayne syndrome exhibiting both cancer predisposition and segmental progeria
    Jaan Olle Andressoo
    Medical Genetics Center, Department of Cell Biology and Genetics, Center of Biomedical Genetics, Cancer Genomics Center, Erasmus Medical Center, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands
    Cancer Cell 10:121-32. 2006
    ..Like CS fibroblasts, XPCS and TTD fibroblasts from human and mouse showed evidence of defective repair of oxidative DNA lesions that may underlie these segmental progeroid symptoms...
  68. ncbi Trading places: how do DNA polymerases switch during translesion DNA synthesis?
    Errol C Friedberg
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Mol Cell 18:499-505. 2005
    ..This review addresses recent advances in our understanding of DNA polymerase switching during TLS in bacteria such as E. coli and in lower and higher eukaryotes...
  69. ncbi Incidence of DNA repair deficiency disorders in western Europe: Xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy
    Wim J Kleijer
    Department of Clinical Genetics, Erasmus Medical Centre, Rotterdam, The Netherlands
    DNA Repair (Amst) 7:744-50. 2008
    ..1 per million for TTD. Perhaps contrary to general conceptions, compared to XP the incidence of CS appears to be somewhat higher and the incidence of TTD to be quite similar in the native West-European population...
  70. ncbi DNA repair: from molecular mechanism to human disease
    Errol C Friedberg
    Department of Pathology, University of Texas Southwestern, Medical Center at Dallas, 75390, USA
    DNA Repair (Amst) 5:986-96. 2006
  71. ncbi DNA polymerases eta and iota
    Alexandra Vaisman
    Laboratory of Genomic Integrity, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 2725, USA
    Adv Protein Chem 69:205-28. 2004
  72. ncbi Mutations in the C7orf11 (TTDN1) gene in six nonphotosensitive trichothiodystrophy patients: no obvious genotype-phenotype relationships
    Elena Botta
    Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche CNR, Pavia, Italy
    Hum Mutat 28:92-6. 2007
    ..Mutations in TTDN1 do not affect the response to ultraviolet (UV) light or the steady state level of the repair/transcription factor IIH (TFIIH), which is central to the onset of the photosensitive form of TTD...