Genomes and Genes
Affiliation: University of East Anglia
- Cyclic loading of tendon fascicles using a novel fatigue loading system increases interleukin-6 expression by tenocytesK Legerlotz
School of Biological Sciences, University of East Anglia, Norwich, UK
Scand J Med Sci Sports 23:31-7. 2013..Correlating failure properties with fatigue damage provides a method by which changes in gene expression can be associated with different degrees of fatigue damage...
- Increased expression of IL-6 family members in tendon pathologyKirsten Legerlotz
School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK
Rheumatology (Oxford) 51:1161-5. 2012..The aim of this study was to investigate the expression of IL-6 family members in painful posterior tibialis tendon (PTT) and in painful and ruptured Achilles tendon (AT) compared with normal tendon...
- Cyclical strain modulates metalloprotease and matrix gene expression in human tenocytes via activation of TGFβEleanor R Jones
Soft Tissue Research Group, School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, UK Electronic address
Biochim Biophys Acta 1833:2596-607. 2013..We concluded that TGFβ activation plays an important role in mechanotransduction. Targeting this pathway may have its place in the treatment of tendinopathy. ..
- GAG depletion increases the stress-relaxation response of tendon fascicles, but does not influence recoveryKirsten Legerlotz
School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, UK Institute of Bioengineering, School of Engineering and Materials Science, Queen Mary University of London, UK
Acta Biomater 9:6860-6. 2013..GAGs appear to protect tendon fascicles from fatigue effects, possibly by enabling sample hydration...