S J Leevers

Summary

Affiliation: University College London
Country: UK

Publications

  1. pmc Control of growth and differentiation by Drosophila RasGAP, a homolog of p120 Ras-GTPase-activating protein
    P Feldmann
    Cancer Research Campaign Center for Cell and Molecular Biology, The Institute of Cancer Research, Chester Beatty Laboratories, London SW3 6JB, United Kingdom
    Mol Cell Biol 19:1928-37. 1999
  2. ncbi request reprint Signalling through phosphoinositide 3-kinases: the lipids take centre stage
    S J Leevers
    Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK
    Curr Opin Cell Biol 11:219-25. 1999
  3. ncbi request reprint Growth control: invertebrate insulin surprises!
    S J Leevers
    Ludwig Institute for Cancer Research, 91 Riding House Street, W1W 7BS, London, UK
    Curr Biol 11:R209-12. 2001
  4. ncbi request reprint Perspectives: cell biology. All creatures great and small
    S J Leevers
    Ludwig Institute for Cancer Research, London, UK
    Science 285:2082-3. 1999
  5. ncbi request reprint Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein
    D J Clancy
    Department of Biology, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE, UK
    Science 292:104-6. 2001
  6. ncbi request reprint Regulation of imaginal disc cell size, cell number and organ size by Drosophila class I(A) phosphoinositide 3-kinase and its adaptor
    D Weinkove
    Ludwig Institute for Cancer Research 91 Riding House Street, W1P 8BT, Department of Biochemistry and Molecular Biology Gower Street, London, UK
    Curr Biol 9:1019-29. 1999
  7. ncbi request reprint p60 is an adaptor for the Drosophila phosphoinositide 3-kinase, Dp110
    D Weinkove
    Ludwig Institute for Cancer Research, 91 Riding House Street, London W1P 8BT, United Kingdom
    J Biol Chem 272:14606-10. 1997
  8. ncbi request reprint Do growth and cell division rates determine cell size in multicellular organisms?
    C M Coelho
    Ludwig Institute for Cancer Research, London W1P 8BT, UK
    J Cell Sci 113:2927-34. 2000
  9. ncbi request reprint Phosphoinositide 3-kinases: a conserved family of signal transducers
    B Vanhaesebroeck
    Ludwig Institute for Cancer Research, London, UK
    Trends Biochem Sci 22:267-72. 1997
  10. pmc The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth
    S J Leevers
    Ludwig Institute for Cancer Research, London, UK
    EMBO J 15:6584-94. 1996

Collaborators

Detail Information

Publications20

  1. pmc Control of growth and differentiation by Drosophila RasGAP, a homolog of p120 Ras-GTPase-activating protein
    P Feldmann
    Cancer Research Campaign Center for Cell and Molecular Biology, The Institute of Cancer Research, Chester Beatty Laboratories, London SW3 6JB, United Kingdom
    Mol Cell Biol 19:1928-37. 1999
    ..Genetic interactions, however, suggested a Ras-independent role for RasGAP in the regulation of growth. The system described here should enable genetic screens to be performed to identify regulators and effectors of p120 Ras-GAP...
  2. ncbi request reprint Signalling through phosphoinositide 3-kinases: the lipids take centre stage
    S J Leevers
    Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK
    Curr Opin Cell Biol 11:219-25. 1999
    ..Also in 1998, PTEN - a major tumour suppressor in human cancer - was also shown to antagonise PI3K signalling by removing the 3-phosphate from 3-phosphoinositides...
  3. ncbi request reprint Growth control: invertebrate insulin surprises!
    S J Leevers
    Ludwig Institute for Cancer Research, 91 Riding House Street, W1W 7BS, London, UK
    Curr Biol 11:R209-12. 2001
    ..Invertebrates have been found to possess more insulin-like ligands than predicted, some of which behave as receptor antagonists...
  4. ncbi request reprint Perspectives: cell biology. All creatures great and small
    S J Leevers
    Ludwig Institute for Cancer Research, London, UK
    Science 285:2082-3. 1999
  5. ncbi request reprint Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein
    D J Clancy
    Department of Biology, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE, UK
    Science 292:104-6. 2001
    ..The dwarf phenotype of chico homozygotes was also unnecessary for extension of life-span. The role of insulin/IGF signaling in regulating animal aging is therefore evolutionarily conserved...
  6. ncbi request reprint Regulation of imaginal disc cell size, cell number and organ size by Drosophila class I(A) phosphoinositide 3-kinase and its adaptor
    D Weinkove
    Ludwig Institute for Cancer Research 91 Riding House Street, W1P 8BT, Department of Biochemistry and Molecular Biology Gower Street, London, UK
    Curr Biol 9:1019-29. 1999
    ..These observations have led us to investigate the role of Dp100 and its adaptor, p60, in the control of imaginal disc cell size, cell number and organ size...
  7. ncbi request reprint p60 is an adaptor for the Drosophila phosphoinositide 3-kinase, Dp110
    D Weinkove
    Ludwig Institute for Cancer Research, 91 Riding House Street, London W1P 8BT, United Kingdom
    J Biol Chem 272:14606-10. 1997
    ..The complex was found in larvae, pupae, and adults, consistent with p60 functioning as the adaptor for Dp110 throughout the Drosophila life cycle...
  8. ncbi request reprint Do growth and cell division rates determine cell size in multicellular organisms?
    C M Coelho
    Ludwig Institute for Cancer Research, London W1P 8BT, UK
    J Cell Sci 113:2927-34. 2000
    ..These interactions may provide a means of coordinating growth and cell division, such that cells divide only when they are above a minimum size...
  9. ncbi request reprint Phosphoinositide 3-kinases: a conserved family of signal transducers
    B Vanhaesebroeck
    Ludwig Institute for Cancer Research, London, UK
    Trends Biochem Sci 22:267-72. 1997
    ..Potential signalling pathways downstream of PI3Ks have been elucidated and PI3K function is now being characterised in several model organisms...
  10. pmc The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth
    S J Leevers
    Ludwig Institute for Cancer Research, London, UK
    EMBO J 15:6584-94. 1996
    ..These data imply a role for Dp110 in growth control during Drosophila development and have implications for the function of class I PI3Ks in other organisms...
  11. ncbi request reprint Which way is up?
    S J Leevers
    Ludwig Institute for Cancer Research, London, UK
    Trends Genet 16:434-5. 2000
  12. ncbi request reprint Alternative splicing of the Drosophila PTEN gene
    A Smith
    Section of Gene Function and Regulation, Chester Beatty Laboratories, Institute of Cancer Research, 237 Fulham Road, London, UK
    Biochim Biophys Acta 1447:313-7. 1999
    ..Here we show that the PTEN gene is conserved in the invertebrate Drosophila melanogaster and demonstrate that the gene undergoes alternative splicing...
  13. ncbi request reprint Synthesis and function of 3-phosphorylated inositol lipids
    B Vanhaesebroeck
    Ludwig Institute for Cancer Research, Riding House Street, London W1W 7BS
    Annu Rev Biochem 70:535-602. 2001
    ..This field is now moving toward a genetic dissection of 3-phosphoinositide action in a variety of model organisms. Such approaches will reveal the true role of the 3-phosphoinositides at the organismal level in health and disease...
  14. ncbi request reprint Regulation of c-fgr proto-oncogene expression in Epstein-Barr virus infected B-cell lines
    M Patel
    Department of Biochemistry, University College and Middlesex School of Medicine, London, UK
    Int J Cancer 45:342-6. 1990
    ..All 6 cell lines expressed c-fgr mRNA at elevated levels compared to EBV-negative BL cell lines...
  15. ncbi request reprint Structure of the complete human c-fgr proto-oncogene and identification of multiple transcriptional start sites
    M Patel
    Department of Biochemistry, University College of Middlesex School of Medicine, London, UK
    Oncogene 5:201-6. 1990
    ..We have also mapped multiple transcriptional start sites within the 5' flanking region of the c-fgr gene and present an analysis of the nucleotide sequences within this region which may be responsible for regulating c-fgr expression...
  16. ncbi request reprint The genetic control of organ growth: insights from Drosophila
    D Weinkove
    Department of Molecular Biology, The Netherlands Cancer Institute, Amsterdam, 1066 CX, The Netherlands
    Curr Opin Genet Dev 10:75-80. 2000
    ..Furthermore, the role of Drosophila homologues to human tumour suppressor genes and oncogenes in imaginal disc growth has been investigated...
  17. pmc The Drosophila caspase DRONC is regulated by DIAP1
    P Meier
    Biochemistry of the Cell Nucleus Laboratory, Imperial Cancer Research Fund, 44 Lincoln s Inn Fields, London WC2A 3PX
    EMBO J 19:598-611. 2000
    ....
  18. ncbi request reprint Trachealess--a new transcription factor target for PKB/Akt
    J Downward
    Signal Transduction Laboratory, Imperial Cancer Research Fund, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    Dev Cell 1:726-8. 2001
    ..Applying a combined genetic and biochemical approach has led to the identification of a new protein kinase B/Akt target, the transcription factor Trachealess...
  19. ncbi request reprint What goes up must come down
    S J Leevers
    Nat Cell Biol 1:E10-1. 1999
  20. pmc MAPKAP kinase-2; a novel protein kinase activated by mitogen-activated protein kinase
    D Stokoe
    Department of Biochemistry, University of Dundee, UK
    EMBO J 11:3985-94. 1992
    ..These results indicate that MAP kinase activates at least two distinct protein kinases, suggesting that it represents a point at which the growth factor-stimulated protein kinase cascade bifurcates...