Research Topics
Species | Paul LeesonSummaryAffiliation: University of Oxford Country: UK Publications
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Detail Information
Publications
Global and regional left ventricular myocardial deformation measures by magnetic resonance feature tracking in healthy volunteers: comparison with tagging and relevance of genderDaniel Augustine
Oxford Cardiovascular Clinical Research Facility, Department of Cardiovascular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK
J Cardiovasc Magn Reson 15:8. 2013..We used it to record deformation parameters in healthy adults and compared values to those obtained by tagging...
Pediatric prevention of atherosclerosis: targeting early variation in vascular biologyPaul Leeson
Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
Pediatrics 119:1204-6. 2007- Atrial pathology in cardiac amyloidosis: evidence from ECG and cardiovascular magnetic resonanceC Paul Leeson
Department of Cardiology, John Radcliffe Hospital, Headley Way, Oxford, OX3 9DU, UK
Eur Heart J 27:1670. 2006 - MTHFR 677 C>T Polymorphism reveals functional importance for 5-methyltetrahydrofolate, not homocysteine, in regulation of vascular redox state and endothelial function in human atherosclerosisCharalambos Antoniades
Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
Circulation 119:2507-15. 2009..We sought to distinguish the effects of plasma versus vascular tissue 5-MTHF and homocysteine on vascular redox and endothelial nitric oxide bioavailability in human vessels... - Impaired endothelial responses in apparently healthy young people associated with subclinical variation in blood pressure and cardiovascular phenotypeMerzaka Lazdam
Department of Cardiovascular Medicine, University of Oxford, Oxford, UK
Am J Hypertens 25:46-53. 2012..We identified subjects with persistently reduced, or declining, endothelial function during adolescence and early adulthood, without apparent cardiovascular risk, and investigated the clinical relevance of this finding... - Antenatal glucocorticoid exposure and long-term alterations in aortic function and glucose metabolismBrenda A Kelly
Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford, UK
Pediatrics 129:e1282-90. 2012..Animal studies have demonstrated long-term effects of in utero glucocortcoid exposure on vascular development and glucose metabolism. We hypothesized that there would be a similar impact in humans... 
GCH1 haplotype determines vascular and plasma biopterin availability in coronary artery disease effects on vascular superoxide production and endothelial functionCharalambos Antoniades
Department of Cardiovascular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
J Am Coll Cardiol 52:158-65. 2008....- Relation of preoperative radial artery flow-mediated dilatation to nitric oxide bioavailability in radial artery grafts used in off-pump coronary artery bypass graftingCharalambos Antoniades
Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
Am J Cardiol 103:216-20. 2009..These differences are present and can be identified preoperatively by FMD... - Association of plasma asymmetrical dimethylarginine (ADMA) with elevated vascular superoxide production and endothelial nitric oxide synthase uncoupling: implications for endothelial function in human atherosclerosisCharalambos Antoniades
Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK
Eur Heart J 30:1142-50. 2009..However, the mechanisms relating ADMA with vascular function have been evaluated in vitro and in animal models, but its effect in human vasculature is unclear... - Preterm heart in adult life: cardiovascular magnetic resonance reveals distinct differences in left ventricular mass, geometry, and functionAdam J Lewandowski
Oxford Cardiovascular Clinical Research Facility, University of Oxford, Oxford, UK
Circulation 127:197-206. 2013..In animal studies, this results in an adversely remodeled left ventricle. We determined whether preterm birth is associated with a distinct left ventricular structure and function in humans... - Short-term exposure to exogenous lipids in premature infants and long-term changes in aortic and cardiac functionAdam J Lewandowski
Cardiovascular Clinical Research Facility, Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom
Arterioscler Thromb Vasc Biol 31:2125-35. 2011..We investigated whether elevated lipids in humans during the critical period of preterm neonatal life have a long-term impact on aortic and myocardial function relevant to adult disease... - Preoperative sCD40L levels predict risk of atrial fibrillation after off-pump coronary artery bypass graft surgeryCharalambos Antoniades
Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, UK
Circulation 120:S170-6. 2009..Furthermore, we studied the role of inflammation, endothelial function, and redox state in this relation... - Rapid, direct effects of statin treatment on arterial redox state and nitric oxide bioavailability in human atherosclerosis via tetrahydrobiopterin-mediated endothelial nitric oxide synthase couplingCharalambos Antoniades
Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital OX3 9DU, Oxford, UK
Circulation 124:335-45. 2011..We examined the direct effects of atorvastatin on tetrahydrobiopterin-mediated endothelial nitric oxide (NO) synthase coupling in patients with coronary artery disease... - Induction of vascular GTP-cyclohydrolase I and endogenous tetrahydrobiopterin synthesis protect against inflammation-induced endothelial dysfunction in human atherosclerosisCharalambos Antoniades
Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Hedley Way, OX3 9DU, Oxford, UK
Circulation 124:1860-70. 2011..We hypothesized that induction of BH4 synthesis might be an endothelial defense mechanism against inflammation in vascular disease states... - Unique blood pressure characteristics in mother and offspring after early onset preeclampsiaMerzaka Lazdam
Oxford Cardiovascular Clinical Research Facility, Department of Cardiovascular Medicine, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
Hypertension 60:1338-45. 2012..These are not evident in mothers and offspring after late-onset preeclampsia or normotensive pregnancy... - Altered plasma versus vascular biopterins in human atherosclerosis reveal relationships between endothelial nitric oxide synthase coupling, endothelial function, and inflammationCharalambos Antoniades
Department of Cardiovascular Medicine, University of Oxford, Oxford, UK
Circulation 116:2851-9. 2007..We sought to define the relationships between plasma and vascular biopterin levels in patients with coronary artery disease and to determine how BH4 levels affect endothelial function, eNOS coupling, and vascular superoxide production... - Early changes in arterial structure and function following statin initiation: quantification by magnetic resonance imagingJustin M S Lee
Department of Cardiovascular Medicine, University of Oxford, United Kingdom
Atherosclerosis 197:951-8. 2008..50, P<0.001; R(2)=0.22, P<0.05, respectively). Improvements in aortic distensibility and brachial endothelial function that were apparent after 3 months treatment were sustained at the 12-month time point... - Pre-eclampsia and offspring cardiovascular health: mechanistic insights from experimental studiesEsther F Davis
Oxford Cardiovascular Clinical Research Facility, Department of Cardiovascular Medicine, University of Oxford, Oxford, UK
Clin Sci (Lond) 123:53-72. 2012.... - Elevated blood pressure in offspring born premature to hypertensive pregnancy: is endothelial dysfunction the underlying vascular mechanism?Merzaka Lazdam
Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
Hypertension 56:159-65. 2010..However, predominant underlying vascular phenotype depends on maternal pathology. Targeting endothelial function may be particularly important for primary prevention after hypertension in pregnancy... - From gene to epigene-based therapies targeting the vascular endotheliumAdam J Lewandowski
Department of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, UK
Curr Vasc Pharmacol 10:125-37. 2012.... - Images in cardiovascular medicine. Visualization of the ruptured plaque by magnetic resonance imagingFrank Wiesmann
Department of Cardiovascular Medicine, John Radcliffe Hospital, Headley Way, Oxford OX 3 9 DU, UK
Circulation 108:2542. 2003 - Gender-specific differences in left ventricular remodelling in obesity: insights from cardiovascular magnetic resonance imagingOliver J Rider
Department of Cardiovascular Medicine, University of Oxford, UK
Eur Heart J 34:292-9. 2013.... - Prevention of vascular dysfunction after preeclampsia: a potential long-term outcome measure and an emerging goal for treatmentMerzaka Lazdam
Department of Cardiovascular Medicine, Oxford Cardiovascular Clinical Research Facility, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
J Pregnancy 2012:704146. 2012..This paper considers the links between cardiovascular disease and preeclampsia and the implication of these findings for refinement of the management of patients whose care is complicated by preeclampsia... - Patent foramen ovale closure before orthopedic trauma surgery to reduce risk of recurrent systemic fat embolismPaul Leeson
Department of Cardiology, John Radcliffe Hospital, Oxford
J Trauma 65:467-9. 2008 - Cardiovascular risk factors in children and young adults born to preeclamptic pregnancies: a systematic reviewEsther Frances Davis
Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom
Pediatrics 129:e1552-61. 2012..Our objective was to examine evidence for increased cardiovascular risk factors in children exposed to preeclampsia in utero... - Uncomplicated obesity is associated with abnormal aortic function assessed by cardiovascular magnetic resonanceMonique R Robinson
Oxford Centre for Clinical Magnetic Resonance Research OCMR, Department of Cardiovascular Medicine, University of Oxford, Oxford, UK
J Cardiovasc Magn Reson 10:10. 2008..We hypothesised that obesity, uncomplicated by other cardiovascular risk factors, is independently associated with aortic function... - A transesophageal echocardiography study: traumatic left atrial appendage and left upper pulmonary vein dissectionPaul Leeson
Department of Cardiology, John Radcliffe Hospital, Oxford, United Kingdom
J Am Soc Echocardiogr 20:537.e3-5. 2007..The report summarizes the literature on traumatic injury to the left upper pulmonary vein and left atrial appendage and demonstrates the importance of comprehensive echocardiographic studies to identify unexpected pathology... - Atrial septal endocarditisAndrew R J Mitchell
Department of Echocardiography, John Radcliffe Hospital, Headington, Oxford OX3 9DU, United Kingdom
Eur J Echocardiogr 8:48-9. 2007..We present the echocardiography findings from a young man presenting with endocarditis of an abnormal mitral valve in whom endocarditis was demonstrated associated with an atrial septal defect... - Suppurative bacterial myocarditis: echocardiographic and pathological findingsTania Elias
Department of Cardiology, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK
Eur Heart J 29:489. 2008 - Normal variation of magnetic resonance T1 relaxation times in the human population at 1.5 T using ShMOLLIStefan K Piechnik
Department of Cardiovascular Medicine, Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, UK
J Cardiovasc Magn Reson 15:13. 2013..We aimed to assess the variability of myocardial T1 relaxation times in the normal human population estimated with recently proposed Shortened Modified Look-Locker Inversion recovery (ShMOLLI) T1 mapping technique... - 5-methyltetrahydrofolate rapidly improves endothelial function and decreases superoxide production in human vessels: effects on vascular tetrahydrobiopterin availability and endothelial nitric oxide synthase couplingCharalambos Antoniades
Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK
Circulation 114:1193-201. 2006..CONCLUSIONS: 5-MTHF has beneficial effects on endothelial function and vascular superoxide production in human atherosclerosis, by preventing peroxynitrite-mediated BH4 oxidation and improving eNOS coupling...