Paul Leeson

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi request reprint Atrial pathology in cardiac amyloidosis: evidence from ECG and cardiovascular magnetic resonance
    C Paul Leeson
    Department of Cardiology, John Radcliffe Hospital, Headley Way, Oxford, OX3 9DU, UK
    Eur Heart J 27:1670. 2006
  2. ncbi request reprint Pediatric prevention of atherosclerosis: targeting early variation in vascular biology
    Paul Leeson
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
    Pediatrics 119:1204-6. 2007
  3. doi request reprint MTHFR 677 C>T Polymorphism reveals functional importance for 5-methyltetrahydrofolate, not homocysteine, in regulation of vascular redox state and endothelial function in human atherosclerosis
    Charalambos Antoniades
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Circulation 119:2507-15. 2009
  4. doi request reprint Right ventricular systolic dysfunction in young adults born preterm
    Adam J Lewandowski
    Oxford Cardiovascular Clinical Research Facility, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX39DU, UK
    Circulation 128:713-20. 2013
  5. doi request reprint Impaired endothelial responses in apparently healthy young people associated with subclinical variation in blood pressure and cardiovascular phenotype
    Merzaka Lazdam
    Department of Cardiovascular Medicine, University of Oxford, Oxford, UK
    Am J Hypertens 25:46-53. 2012
  6. doi request reprint Antenatal glucocorticoid exposure and long-term alterations in aortic function and glucose metabolism
    Brenda A Kelly
    Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford, UK
    Pediatrics 129:e1282-90. 2012
  7. doi request reprint Association of plasma asymmetrical dimethylarginine (ADMA) with elevated vascular superoxide production and endothelial nitric oxide synthase uncoupling: implications for endothelial function in human atherosclerosis
    Charalambos Antoniades
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK
    Eur Heart J 30:1142-50. 2009
  8. pmc GCH1 haplotype determines vascular and plasma biopterin availability in coronary artery disease effects on vascular superoxide production and endothelial function
    Charalambos Antoniades
    Department of Cardiovascular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
    J Am Coll Cardiol 52:158-65. 2008
  9. pmc Global and regional left ventricular myocardial deformation measures by magnetic resonance feature tracking in healthy volunteers: comparison with tagging and relevance of gender
    Daniel Augustine
    Department of Cardiovascular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK
    J Cardiovasc Magn Reson 15:8. 2013
  10. doi request reprint Relation of preoperative radial artery flow-mediated dilatation to nitric oxide bioavailability in radial artery grafts used in off-pump coronary artery bypass grafting
    Charalambos Antoniades
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    Am J Cardiol 103:216-20. 2009

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Atrial pathology in cardiac amyloidosis: evidence from ECG and cardiovascular magnetic resonance
    C Paul Leeson
    Department of Cardiology, John Radcliffe Hospital, Headley Way, Oxford, OX3 9DU, UK
    Eur Heart J 27:1670. 2006
  2. ncbi request reprint Pediatric prevention of atherosclerosis: targeting early variation in vascular biology
    Paul Leeson
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
    Pediatrics 119:1204-6. 2007
  3. doi request reprint MTHFR 677 C>T Polymorphism reveals functional importance for 5-methyltetrahydrofolate, not homocysteine, in regulation of vascular redox state and endothelial function in human atherosclerosis
    Charalambos Antoniades
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Circulation 119:2507-15. 2009
    ..We sought to distinguish the effects of plasma versus vascular tissue 5-MTHF and homocysteine on vascular redox and endothelial nitric oxide bioavailability in human vessels...
  4. doi request reprint Right ventricular systolic dysfunction in young adults born preterm
    Adam J Lewandowski
    Oxford Cardiovascular Clinical Research Facility, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX39DU, UK
    Circulation 128:713-20. 2013
    ..Animal studies suggest that cardiomyocyte changes are evident in both ventricles after preterm birth; therefore, we investigated whether these young adults also have differences in their right ventricular structure and function...
  5. doi request reprint Impaired endothelial responses in apparently healthy young people associated with subclinical variation in blood pressure and cardiovascular phenotype
    Merzaka Lazdam
    Department of Cardiovascular Medicine, University of Oxford, Oxford, UK
    Am J Hypertens 25:46-53. 2012
    ..We identified subjects with persistently reduced, or declining, endothelial function during adolescence and early adulthood, without apparent cardiovascular risk, and investigated the clinical relevance of this finding...
  6. doi request reprint Antenatal glucocorticoid exposure and long-term alterations in aortic function and glucose metabolism
    Brenda A Kelly
    Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford, UK
    Pediatrics 129:e1282-90. 2012
    ..Animal studies have demonstrated long-term effects of in utero glucocortcoid exposure on vascular development and glucose metabolism. We hypothesized that there would be a similar impact in humans...
  7. doi request reprint Association of plasma asymmetrical dimethylarginine (ADMA) with elevated vascular superoxide production and endothelial nitric oxide synthase uncoupling: implications for endothelial function in human atherosclerosis
    Charalambos Antoniades
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK
    Eur Heart J 30:1142-50. 2009
    ..However, the mechanisms relating ADMA with vascular function have been evaluated in vitro and in animal models, but its effect in human vasculature is unclear...
  8. pmc GCH1 haplotype determines vascular and plasma biopterin availability in coronary artery disease effects on vascular superoxide production and endothelial function
    Charalambos Antoniades
    Department of Cardiovascular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
    J Am Coll Cardiol 52:158-65. 2008
    ....
  9. pmc Global and regional left ventricular myocardial deformation measures by magnetic resonance feature tracking in healthy volunteers: comparison with tagging and relevance of gender
    Daniel Augustine
    Department of Cardiovascular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK
    J Cardiovasc Magn Reson 15:8. 2013
    ..We used it to record deformation parameters in healthy adults and compared values to those obtained by tagging...
  10. doi request reprint Relation of preoperative radial artery flow-mediated dilatation to nitric oxide bioavailability in radial artery grafts used in off-pump coronary artery bypass grafting
    Charalambos Antoniades
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    Am J Cardiol 103:216-20. 2009
    ..These differences are present and can be identified preoperatively by FMD...
  11. doi request reprint Preoperative sCD40L levels predict risk of atrial fibrillation after off-pump coronary artery bypass graft surgery
    Charalambos Antoniades
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, UK
    Circulation 120:S170-6. 2009
    ..Furthermore, we studied the role of inflammation, endothelial function, and redox state in this relation...
  12. doi request reprint Rapid, direct effects of statin treatment on arterial redox state and nitric oxide bioavailability in human atherosclerosis via tetrahydrobiopterin-mediated endothelial nitric oxide synthase coupling
    Charalambos Antoniades
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital OX3 9DU, Oxford, UK
    Circulation 124:335-45. 2011
    ..We examined the direct effects of atorvastatin on tetrahydrobiopterin-mediated endothelial nitric oxide (NO) synthase coupling in patients with coronary artery disease...
  13. doi request reprint Preterm heart in adult life: cardiovascular magnetic resonance reveals distinct differences in left ventricular mass, geometry, and function
    Adam J Lewandowski
    Oxford Cardiovascular Clinical Research Facility, University of Oxford, Oxford, UK
    Circulation 127:197-206. 2013
    ..In animal studies, this results in an adversely remodeled left ventricle. We determined whether preterm birth is associated with a distinct left ventricular structure and function in humans...
  14. doi request reprint Induction of vascular GTP-cyclohydrolase I and endogenous tetrahydrobiopterin synthesis protect against inflammation-induced endothelial dysfunction in human atherosclerosis
    Charalambos Antoniades
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Hedley Way, OX3 9DU, Oxford, UK
    Circulation 124:1860-70. 2011
    ..We hypothesized that induction of BH4 synthesis might be an endothelial defense mechanism against inflammation in vascular disease states...
  15. doi request reprint Short-term exposure to exogenous lipids in premature infants and long-term changes in aortic and cardiac function
    Adam J Lewandowski
    Cardiovascular Clinical Research Facility, Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom
    Arterioscler Thromb Vasc Biol 31:2125-35. 2011
    ..We investigated whether elevated lipids in humans during the critical period of preterm neonatal life have a long-term impact on aortic and myocardial function relevant to adult disease...
  16. doi request reprint Concentric left ventricular remodeling and aortic stiffness: a comparison of obesity and hypertension
    Oliver J Rider
    Department of Cardiovascular Medicine, University of Oxford, UK
    Int J Cardiol 167:2989-94. 2013
    ..However, obesity is characterized predominantly by increased abdominal aortic stiffness and with eccentric left ventricular hypertrophy...
  17. pmc Gender-specific differences in left ventricular remodelling in obesity: insights from cardiovascular magnetic resonance imaging
    Oliver J Rider
    Department of Cardiovascular Medicine, University of Oxford, UK
    Eur Heart J 34:292-9. 2013
    ....
  18. doi request reprint Unique blood pressure characteristics in mother and offspring after early onset preeclampsia
    Merzaka Lazdam
    Oxford Cardiovascular Clinical Research Facility, Department of Cardiovascular Medicine, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
    Hypertension 60:1338-45. 2012
    ..These are not evident in mothers and offspring after late-onset preeclampsia or normotensive pregnancy...
  19. ncbi request reprint Altered plasma versus vascular biopterins in human atherosclerosis reveal relationships between endothelial nitric oxide synthase coupling, endothelial function, and inflammation
    Charalambos Antoniades
    Department of Cardiovascular Medicine, University of Oxford, Oxford, UK
    Circulation 116:2851-9. 2007
    ..We sought to define the relationships between plasma and vascular biopterin levels in patients with coronary artery disease and to determine how BH4 levels affect endothelial function, eNOS coupling, and vascular superoxide production...
  20. pmc Pre-eclampsia and offspring cardiovascular health: mechanistic insights from experimental studies
    Esther F Davis
    Oxford Cardiovascular Clinical Research Facility, Department of Cardiovascular Medicine, University of Oxford, Oxford, UK
    Clin Sci (Lond) 123:53-72. 2012
    ....
  21. doi request reprint Dynamic release and clearance of circulating microparticles during cardiac stress
    Daniel Augustine
    From the Oxford Cardiovascular Clinical Research Facility, University of Oxford, Oxford, United Kingdom D A, E L, L N, A J L, E F D, P L and Department of Clinical Immunology, Oxford University Hospitals NHS Trust, Oxford, United Kingdom L V A, B F
    Circ Res 114:109-13. 2014
    ..Microparticles are cell-derived membrane vesicles, relevant to a range of biological responses and known to be elevated in cardiovascular disease...
  22. ncbi request reprint From gene to epigene-based therapies targeting the vascular endothelium
    Adam J Lewandowski
    Department of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, UK
    Curr Vasc Pharmacol 10:125-37. 2012
    ....
  23. ncbi request reprint Images in cardiovascular medicine. Visualization of the ruptured plaque by magnetic resonance imaging
    Frank Wiesmann
    Department of Cardiovascular Medicine, John Radcliffe Hospital, Headley Way, Oxford OX 3 9 DU, UK
    Circulation 108:2542. 2003
  24. doi request reprint Elevated blood pressure in offspring born premature to hypertensive pregnancy: is endothelial dysfunction the underlying vascular mechanism?
    Merzaka Lazdam
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Hypertension 56:159-65. 2010
    ..However, predominant underlying vascular phenotype depends on maternal pathology. Targeting endothelial function may be particularly important for primary prevention after hypertension in pregnancy...
  25. doi request reprint Cardiovascular risk factors in children and young adults born to preeclamptic pregnancies: a systematic review
    Esther Frances Davis
    Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom
    Pediatrics 129:e1552-61. 2012
    ..Our objective was to examine evidence for increased cardiovascular risk factors in children exposed to preeclampsia in utero...
  26. pmc Early changes in arterial structure and function following statin initiation: quantification by magnetic resonance imaging
    Justin M S Lee
    Department of Cardiovascular Medicine, University of Oxford, United Kingdom
    Atherosclerosis 197:951-8. 2008
    ..50, P<0.001; R(2)=0.22, P<0.05, respectively). Improvements in aortic distensibility and brachial endothelial function that were apparent after 3 months treatment were sustained at the 12-month time point...
  27. pmc Prevention of vascular dysfunction after preeclampsia: a potential long-term outcome measure and an emerging goal for treatment
    Merzaka Lazdam
    Department of Cardiovascular Medicine, Oxford Cardiovascular Clinical Research Facility, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    J Pregnancy 2012:704146. 2012
    ..This paper considers the links between cardiovascular disease and preeclampsia and the implication of these findings for refinement of the management of patients whose care is complicated by preeclampsia...
  28. ncbi request reprint Patent foramen ovale closure before orthopedic trauma surgery to reduce risk of recurrent systemic fat embolism
    Paul Leeson
    Department of Cardiology, John Radcliffe Hospital, Oxford
    J Trauma 65:467-9. 2008
  29. pmc Uncomplicated obesity is associated with abnormal aortic function assessed by cardiovascular magnetic resonance
    Monique R Robinson
    Oxford Centre for Clinical Magnetic Resonance Research OCMR, Department of Cardiovascular Medicine, University of Oxford, Oxford, UK
    J Cardiovasc Magn Reson 10:10. 2008
    ..We hypothesised that obesity, uncomplicated by other cardiovascular risk factors, is independently associated with aortic function...
  30. pmc Normal variation of magnetic resonance T1 relaxation times in the human population at 1.5 T using ShMOLLI
    Stefan K Piechnik
    Department of Cardiovascular Medicine, Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, UK
    J Cardiovasc Magn Reson 15:13. 2013
    ..We aimed to assess the variability of myocardial T1 relaxation times in the normal human population estimated with recently proposed Shortened Modified Look-Locker Inversion recovery (ShMOLLI) T1 mapping technique...
  31. ncbi request reprint Atrial septal endocarditis
    Andrew R J Mitchell
    Department of Echocardiography, John Radcliffe Hospital, Headington, Oxford OX3 9DU, United Kingdom
    Eur J Echocardiogr 8:48-9. 2007
    ..We present the echocardiography findings from a young man presenting with endocarditis of an abnormal mitral valve in whom endocarditis was demonstrated associated with an atrial septal defect...
  32. ncbi request reprint A transesophageal echocardiography study: traumatic left atrial appendage and left upper pulmonary vein dissection
    Paul Leeson
    Department of Cardiology, John Radcliffe Hospital, Oxford, United Kingdom
    J Am Soc Echocardiogr 20:537.e3-5. 2007
    ..The report summarizes the literature on traumatic injury to the left upper pulmonary vein and left atrial appendage and demonstrates the importance of comprehensive echocardiographic studies to identify unexpected pathology...
  33. ncbi request reprint Suppurative bacterial myocarditis: echocardiographic and pathological findings
    Tania Elias
    Department of Cardiology, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK
    Eur Heart J 29:489. 2008
  34. ncbi request reprint 5-methyltetrahydrofolate rapidly improves endothelial function and decreases superoxide production in human vessels: effects on vascular tetrahydrobiopterin availability and endothelial nitric oxide synthase coupling
    Charalambos Antoniades
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK
    Circulation 114:1193-201. 2006
    ..We hypothesized that 5-MTHF would improve endothelial function by decreasing superoxide and peroxynitrite production and by improving eNOS coupling, mediated by BH4 availability...