Andrew J Lees

Summary

Affiliation: University College London
Country: UK

Publications

  1. pmc Salivary cortisol levels in Parkinson's disease and its correlation to risk behaviour
    Atbin Djamshidian
    Reta Lila Weston Institute of Neurological Studies and Queen Square Brain Bank for Neurological Diseases, University College London, London, UK
    J Neurol Neurosurg Psychiatry 82:1107-11. 2011
  2. doi request reprint Perampanel, an AMPA antagonist, found to have no benefit in reducing "off" time in Parkinson's disease
    Andrew Lees
    Reta Lila Weston Institute for Neurological Studies, University College London, London, UK
    Mov Disord 27:284-8. 2012
  3. ncbi request reprint Alternatives to levodopa in the initial treatment of early Parkinson's disease
    Andrew Lees
    Reta Lila Weston Institute of Neurological Sciences, University College London, London, UK
    Drugs Aging 22:731-40. 2005
  4. doi request reprint Evidence-based efficacy comparison of tolcapone and entacapone as adjunctive therapy in Parkinson's disease
    Andrew J Lees
    Reta Lila Weston Institute of Neurological Studies, ION, UCL, London, UK
    CNS Neurosci Ther 14:83-93. 2008
  5. pmc Safety and tolerability of adjunctive tolcapone treatment in patients with early Parkinson's disease
    A J Lees
    Reta Lila Weston Institute for Neurological Studies, University College London, 1 Wakefield St, London WC1N 1PJ, UK
    J Neurol Neurosurg Psychiatry 78:944-8. 2007
  6. doi request reprint The Parkinson chimera
    Andrew J Lees
    Reta Lila Weston Institute for Neurological Studies, Institute of Neurology, UCL and the National Hospital for Neurology and Neurosurgery, Queen Square, London
    Neurology 72:S2-11. 2009
  7. doi request reprint Unresolved issues relating to the shaking palsy on the celebration of James Parkinson's 250th birthday
    Andrew J Lees
    Reta Lila Weston Institute for Neurological Disorders, Institute of Neurology, University College London, London, UK
    Mov Disord 22:S327-34. 2007
  8. doi request reprint Parkinson's disease
    Andrew J Lees
    Department of Molecular Neuroscience and Reta Lila Weston Institute of Neurological Studies, Institute of Neurology, University College London and the National Hospital for Neurology and Neurosurgery, London, UK
    Lancet 373:2055-66. 2009
  9. ncbi request reprint Synphilin-1 and parkin show overlapping expression patterns in human brain and form aggresomes in response to proteasomal inhibition
    Rina Bandopadhyay
    Reta Lila Weston Institute of Neurological Studies, Royal Free and UCL Medical School, The Windeyer Building, 46 Cleveland Street, London W1T 4JF, UK
    Neurobiol Dis 20:401-11. 2005
  10. ncbi request reprint Association of MAPT haplotype-tagging SNPs with sporadic Parkinson's disease
    Jana Vandrovcova
    Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, London, UK
    Neurobiol Aging 30:1477-82. 2009

Detail Information

Publications140 found, 100 shown here

  1. pmc Salivary cortisol levels in Parkinson's disease and its correlation to risk behaviour
    Atbin Djamshidian
    Reta Lila Weston Institute of Neurological Studies and Queen Square Brain Bank for Neurological Diseases, University College London, London, UK
    J Neurol Neurosurg Psychiatry 82:1107-11. 2011
    ..To investigate salivary cortisol samples in patients with Parkinson's disease (PD) with and without impulsive compulsive behaviours (ICB) during a risk task...
  2. doi request reprint Perampanel, an AMPA antagonist, found to have no benefit in reducing "off" time in Parkinson's disease
    Andrew Lees
    Reta Lila Weston Institute for Neurological Studies, University College London, London, UK
    Mov Disord 27:284-8. 2012
    ..Two multicenter randomized, double-blind, placebo-controlled, parallel-group phase III studies assessed the efficacy and safety of adjunctive perampanel in patients with Parkinson's disease and motor fluctuations...
  3. ncbi request reprint Alternatives to levodopa in the initial treatment of early Parkinson's disease
    Andrew Lees
    Reta Lila Weston Institute of Neurological Sciences, University College London, London, UK
    Drugs Aging 22:731-40. 2005
    ..Effective therapy in PD should prevent disease progression and abolish motor and cognitive handicap. Currently, none of the existing drugs meets all these needs...
  4. doi request reprint Evidence-based efficacy comparison of tolcapone and entacapone as adjunctive therapy in Parkinson's disease
    Andrew J Lees
    Reta Lila Weston Institute of Neurological Studies, ION, UCL, London, UK
    CNS Neurosci Ther 14:83-93. 2008
    ..These findings indicate that tolcapone should be considered in all patients with entacapone-refractory motor fluctuations...
  5. pmc Safety and tolerability of adjunctive tolcapone treatment in patients with early Parkinson's disease
    A J Lees
    Reta Lila Weston Institute for Neurological Studies, University College London, 1 Wakefield St, London WC1N 1PJ, UK
    J Neurol Neurosurg Psychiatry 78:944-8. 2007
    ..The safety and tolerability of adjunctive tolcapone initiated simultaneously with levodopa was evaluated with a focus on increases in liver transaminase and hepatotoxicity...
  6. doi request reprint The Parkinson chimera
    Andrew J Lees
    Reta Lila Weston Institute for Neurological Studies, Institute of Neurology, UCL and the National Hospital for Neurology and Neurosurgery, Queen Square, London
    Neurology 72:S2-11. 2009
    ....
  7. doi request reprint Unresolved issues relating to the shaking palsy on the celebration of James Parkinson's 250th birthday
    Andrew J Lees
    Reta Lila Weston Institute for Neurological Disorders, Institute of Neurology, University College London, London, UK
    Mov Disord 22:S327-34. 2007
    ....
  8. doi request reprint Parkinson's disease
    Andrew J Lees
    Department of Molecular Neuroscience and Reta Lila Weston Institute of Neurological Studies, Institute of Neurology, University College London and the National Hospital for Neurology and Neurosurgery, London, UK
    Lancet 373:2055-66. 2009
    ..Embryonic stem cells and gene therapy are promising research therapeutic approaches...
  9. ncbi request reprint Synphilin-1 and parkin show overlapping expression patterns in human brain and form aggresomes in response to proteasomal inhibition
    Rina Bandopadhyay
    Reta Lila Weston Institute of Neurological Studies, Royal Free and UCL Medical School, The Windeyer Building, 46 Cleveland Street, London W1T 4JF, UK
    Neurobiol Dis 20:401-11. 2005
    ..We confirm that synphilin-1 and parkin are components of majority of LBs in Parkinson's disease and that both proteins are susceptible to proteasomal degradation...
  10. ncbi request reprint Association of MAPT haplotype-tagging SNPs with sporadic Parkinson's disease
    Jana Vandrovcova
    Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, London, UK
    Neurobiol Aging 30:1477-82. 2009
    ..However, the effect is not strong, and the H1c haplotype is not involved, suggesting a mechanism that is distinct to that involved in the associated tauopathies and may be explained by the H1/H2 inversion...
  11. doi request reprint Concomitant progressive supranuclear palsy and multiple system atrophy: more than a simple twist of fate?
    Laura Silveira-Moriyama
    Reta Lila Weston Institute for Neurological Studies, UCL Institute of Neurology, London, UK
    Neurosci Lett 467:208-11. 2009
    ..The growing number of collective case reports, including the one reported here, might suggest an increased prevalence of concomitant PSP and MSA than what would be expected by chance...
  12. ncbi request reprint Mutations in the gene LRRK2 encoding dardarin (PARK8) cause familial Parkinson's disease: clinical, pathological, olfactory and functional imaging and genetic data
    Naheed L Khan
    Department of Molecular Neuroscience, Institute of Neurology, London, UK
    Brain 128:2786-96. 2005
    ....
  13. ncbi request reprint Nigral degeneration and striatal dopaminergic dysfunction in idiopathic and Parkin-linked Parkinson's disease
    Michele T M Hu
    MRC Clinical Sciences Centre, Division of Neuroscience, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, United Kingdom
    Mov Disord 21:299-305. 2006
    ....
  14. ncbi request reprint Compulsive drug use linked to sensitized ventral striatal dopamine transmission
    Andrew H Evans
    Reta Lila Weston Institute of Neurological Studies and The National Hospital for Neurology and Neurosurgery, London, United Kingdom
    Ann Neurol 59:852-8. 2006
    ..We aimed to evaluate levodopa-induced dopamine neurotransmission in the striatum of patients with DDS compared with PD control patients...
  15. ncbi request reprint NR4A2 genetic variation in sporadic Parkinson's disease: a genewide approach
    Daniel G Healy
    Department of Molecular Neuroscience, Institute of Neurology, London, United Kingdom
    Mov Disord 21:1960-3. 2006
    ..Here, we use a haplotype-tagging approach in 802 PD patients and 784 controls and demonstrate that common genetic variation, including NR4A2 haplotypes, does not influence the risk of PD in the Caucasian population...
  16. ncbi request reprint Characteristics of two distinct clinical phenotypes in pathologically proven progressive supranuclear palsy: Richardson's syndrome and PSP-parkinsonism
    David R Williams
    The Queen Square Brain Bank for Neurological Disorders, University College London, UK
    Brain 128:1247-58. 2005
    ..The different tau isoform deposition in the basal pons suggests that this may ultimately prove to be a discrete nosological entity...
  17. pmc PREDICT-PD: identifying risk of Parkinson's disease in the community: methods and baseline results
    Alastair J Noyce
    Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, London, UK
    J Neurol Neurosurg Psychiatry 85:31-7. 2014
    ..To present methods and baseline results for an online screening tool to identify increased risk for Parkinson's disease (PD) in the UK population...
  18. doi request reprint Multiple system atrophy-parkinsonism with slow progression and prolonged survival: a diagnostic catch
    Igor N Petrovic
    National Hospital for Neurology and Neurosurgery, Queen Square, and the Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, London, United Kingdom
    Mov Disord 27:1186-90. 2012
    ..Multiple system atrophy (MSA) is a neurodegenerative disease leading to severe physical impairment, with a disease duration from onset to death of 6-9 years...
  19. doi request reprint Dopaminergic modulation of striato-frontal connectivity during motor timing in Parkinson's disease
    Marjan Jahanshahi
    Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London, UK
    Brain 133:727-45. 2010
    ..In contrast, our results establish for the first time that administration of dopaminergic medication increases striatal-frontal connectivity between the caudate nucleus and prefrontal cortex during motor timing...
  20. ncbi request reprint Upregulation of dopamine D2 receptors in dopaminergic drug-naive patients with Parkin gene mutations
    Christoph Scherfler
    MRC Clinical Science Centre and Division of Neuroscience, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, United Kingdom
    Mov Disord 21:783-8. 2006
    ..Parkin-positive patients appear to have a greater susceptibility to the exposure to dopaminergic medication than IPD patients, which in turn might be an indirect effect of their genetic mutation...
  21. doi request reprint Lewy- and Alzheimer-type pathologies in Parkinson's disease dementia: which is more important?
    Yaroslau Compta
    Queen Square Brain Bank for Neurological Disorders, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Brain 134:1493-505. 2011
    ..Cortical amyloid-β and age at disease onset seem to determine the rate to dementia...
  22. doi request reprint Hyposmia in progressive supranuclear palsy
    Laura Silveira-Moriyama
    Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, London, United Kingdom
    Mov Disord 25:570-7. 2010
    ..Further prospective studies including patients with early PSP and PSP-P with postmortem confirmation might help clarify if smell tests could be useful when the differential diagnosis lies between PD and PSP...
  23. ncbi request reprint L-Dopa-responsive Parkinson's syndrome in association with phenylketonuria: In vivo dopamine transporter and D2 receptor findings
    Andrew H Evans
    Reta Lila Weston Institute of Neurological Studies, University College London, United Kingdom
    Mov Disord 19:1232-6. 2004
    ..This combination of imaging findings indicates a possible upregulation of postsynaptic D2 receptors in the context of intact presynaptic dopamine nerve terminal density...
  24. pmc Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study
    Daniel G Healy
    Department of Clinical Neurosciences, Institute of Neurology, University College London, London, UK
    Lancet Neurol 7:583-90. 2008
    ..LRRK2-associated PD be distinguished from idiopathic PD; which mutations in LRRK2 are pathogenic; and what is the age-specific cumulative risk of PD for individuals who inherit or are at risk of inheriting a deleterious mutation in LRRK2?..
  25. doi request reprint In vivo assessment of brain monoamine systems in parkin gene carriers: a PET study
    Nicola Pavese
    MRC Clinical Science Centre and Division of Neuroscience and Mental Health, Imperial College, London, UK
    Exp Neurol 222:120-4. 2010
    ..These findings suggest that parkin patients and IPD patients with similar striatal dysfunction have different patterns of monoaminergic involvement, with more widespread dysfunction in IPD...
  26. ncbi request reprint UCHL-1 is not a Parkinson's disease susceptibility gene
    Daniel G Healy
    Department of Molecular Neuroscience, Institute of Neurology, University College London, London, United Kingdom
    Ann Neurol 59:627-33. 2006
    ..The strongest evidence comes from a meta-analysis of small studies that reported the S18Y polymorphism as protective against PD, after pooling studies of white and Asian subjects. Here, we present data that challenge this association...
  27. doi request reprint Brain stem pathology in Parkinson's disease: an evaluation of the Braak staging model
    Ann E Kingsbury
    Reta Lila Weston Institute of Neurological Studies, UCL, Institute of Neurology, London, United Kingdom
    Mov Disord 25:2508-15. 2010
    ..These findings broadly support the Braak hypothesis of caudo-rostral development but indicate that the extent of the disease in the cortex and the severity of pathology in the medulla were independent of one another...
  28. ncbi request reprint A comparison of depression, anxiety, and health status in patients with progressive supranuclear palsy and multiple system atrophy
    Anette Schrag
    Institute of Neurology, University College London, London, UK
    Mov Disord 25:1077-81. 2010
    ..Anxiety symptoms affected 37% of patients in both groups and contributed to impaired subjective health status. Pain was more problematic in MSA than PSP...
  29. ncbi request reprint Nonmotor symptoms as presenting complaints in Parkinson's disease: a clinicopathological study
    Sean S O'Sullivan
    Reta Lila Weston Institute of Neurological Studies, Institute of Neurology, University College London, London, United Kingdom
    Mov Disord 23:101-6. 2008
    ..Presenting with NMS does not affect the motor response to medication, but is associated with shorter disease duration (chi(2) P = 0.016)...
  30. ncbi request reprint Neuropathological findings in benign tremulous parkinsonism
    Marianna Selikhova
    Queen Square Brain Bank for Neurological Disorders and Institute of Neurology, University College London, London, United Kingdom
    Mov Disord 28:145-52. 2013
    ....
  31. doi request reprint Parkin disease: a clinicopathologic entity?
    Karen M Doherty
    Reta Lila Weston Institute for Neurological Studies, University College London, London, England
    JAMA Neurol 70:571-9. 2013
    ..The few available detailed neuropathologic reports suggest that homozygous and compound heterozygous parkin mutations are characterized by severe substantia nigra pars compacta neuronal loss...
  32. ncbi request reprint Pathological tau burden and distribution distinguishes progressive supranuclear palsy-parkinsonism from Richardson's syndrome
    David R Williams
    Queen Square Brain Bank for Neurological Disorders, London, UK
    Brain 130:1566-76. 2007
    ..The grading system we have developed provides an easy-to-use and sensitive tool for the morphological assessment of PSP-tau pathology and allows for consideration of the clinical diversity that is known to occur in PSP...
  33. ncbi request reprint The spectrum of pathological involvement of the striatonigral and olivopontocerebellar systems in multiple system atrophy: clinicopathological correlations
    Tetsutaro Ozawa
    Queen Square Brain Bank, Department of Molecular Neuroscience, Institute of Neurology, Queen Square, UCL, London, UK
    Brain 127:2657-71. 2004
    ....
  34. ncbi request reprint UCHL-1 gene in multiple system atrophy: a haplotype tagging approach
    Daniel G Healy
    Department of Molecular Neuroscience, Institute of Neurology, Queen Square, London United Kingdom
    Mov Disord 20:1338-43. 2005
    ..This search included the S18Y variant of UCHL-1, which has been reported to be protective in Parkinson's disease...
  35. ncbi request reprint Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress
    Miratul M K Muqit
    Department of Molecular Neuroscience, Institute of Neurology, University College London, London, UK
    J Neurochem 98:156-69. 2006
    ..These observations provide valuable insights into the mechanisms of LB formation in PD that should lead to a better understanding of PD pathogenesis...
  36. ncbi request reprint Development, characterisation and epitope mapping of novel monoclonal antibodies for DJ-1 (PARK7) protein
    Rina Bandopadhyay
    Reta Lila Weston Institute of Neurological Studies, Royal Free and UCL Medical School, The Windeyer Building, 46, Cleveland Street, London W1T 4JF, UK
    Neurosci Lett 383:225-30. 2005
    ..These antibodies could be exploited as important tools in dissecting out DJ-1 expression in different species and examination of the role of DJ-1 in Parkinson's disease...
  37. ncbi request reprint Relationships between age and late progression of Parkinson's disease: a clinico-pathological study
    Peter A Kempster
    Reta Lila Weston Institute of Neurological Studies, University College London, 1 Wakefield Street, London WC1N 1PJ, UK
    Brain 133:1755-62. 2010
    ..The chief effects of age on the rate of progression are seen over the early-middle part of the disease. An exponential curve for clinical progression provides the best explanation for these observations about age and the disease course...
  38. doi request reprint Does corticobasal degeneration exist? A clinicopathological re-evaluation
    Helen Ling
    Reta Lila Weston Institute of Neurological Studies, Institute of Neurology, University College London, 1 Wakefield Street, London WC1N 1PJ, UK
    Brain 133:2045-57. 2010
    ..Despite these diagnostic difficulties we conclude that corticobasal degeneration is a discrete clinicopathological entity but with a broader clinical spectrum than was originally proposed...
  39. doi request reprint Sleep disturbance and impulsive-compulsive behaviours in Parkinson's disease
    Sean S O'Sullivan
    Reta Lila Weston Institute of Neurological Studies, University College London, London, UK
    J Neurol Neurosurg Psychiatry 82:620-2. 2011
    ..Impulsive-compulsive behaviours (ICBs) in Parkinson's disease (PD) have been anecdotally linked with impaired sleep. The authors investigate measures of sleep in PD patients with and without ICBs, and in healthy controls...
  40. ncbi request reprint Differential DJ-1 gene expression in Parkinson's disease
    Ravindran Kumaran
    Reta Lila Weston Institute of Neurological Disease, Institute of Neurology, University College London, 1, Wakefield Street, WC1N 1PJ, UK
    Neurobiol Dis 36:393-400. 2009
    ..Our findings point to a putative role of DJ-1 in the pathogenesis of PD...
  41. ncbi request reprint Disentangling the relationship between lewy bodies and nigral neuronal loss in Parkinson's disease
    Laura Parkkinen
    Queen Square Brain Bank for Neurological Disorders, London, UK
    J Parkinsons Dis 1:277-86. 2011
    ..Our data also provides no support for a primary pathogenic role of LBs as neither their distribution nor density was associated with the severity of nigral cell loss. ..
  42. ncbi request reprint Dopamine agonists rather than deep brain stimulation cause reflection impulsivity in Parkinson's disease
    Atbin Djamshidian
    Department of Molecular Neuroscience and Reta Lila Weston Institute for Neurological Studies, University of London, London, UK
    J Parkinsons Dis 3:139-44. 2013
    ..However, it is unclear whether bilateral deep brain stimulation of the subthalamic nucleus also causes impairment in decision making...
  43. ncbi request reprint The clinical features of pathologically confirmed vascular parkinsonism
    Philip George Glass
    Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, 1 Wakefield St, London, WC1N 1PJ, UK
    J Neurol Neurosurg Psychiatry 83:1027-9. 2012
    ..To evaluate in detail the clinical features in a large series of pathologically confirmed cases of vascular Parkinsonism (VP)...
  44. pmc Widespread Lewy body and tau accumulation in childhood and adult onset dystonia-parkinsonism cases with PLA2G6 mutations
    Coro Paisan-Ruiz
    Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK
    Neurobiol Aging 33:814-23. 2012
    ..Later onset cases tended to have less tau involvement but still severe alpha-synuclein pathology. The clinical and neuropathological features clearly represent a link between PLA2G6 and parkinsonian disorders...
  45. ncbi request reprint Parkin disease in a Brazilian kindred: Manifesting heterozygotes and clinical follow-up over 10 years
    Naheed L Khan
    Department of Molecular Neuroscience, Institute of Neurology, Queen Square, London, United Kingdom
    Mov Disord 20:479-84. 2005
    ..Some acceleration of disability was observed in some of the cases as they entered the third decade of illness, but dementia was absent...
  46. pmc Novelty seeking behaviour in Parkinson's disease
    Atbin Djamshidian
    Department of Molecular Neuroscience and Reta Lila Weston Institute for Neurological Studies, University of London, London, United Kingdom
    Neuropsychologia 49:2483-8. 2011
    ..Our findings suggest that attraction to novelty is a personality trait in all PD patients with ICBs which is independent of medication status...
  47. ncbi request reprint [123I] FP-CIT spect study in vascular parkinsonism and Parkinson's disease
    Jan Zijlmans
    National Hospital for Neurology and Neurosurgery, London, United Kingdom
    Mov Disord 22:1278-85. 2007
    ..The presence of a rather symmetrical FP-CIT uptake in the basal ganglia may help to distinguish VP from PD and could therefore be used as a criterion for the clinical diagnosis of VP...
  48. doi request reprint Cue-induced striatal dopamine release in Parkinson's disease-associated impulsive-compulsive behaviours
    Sean S O'Sullivan
    Reta Lila Weston Institute of Neurological Studies, University College London, London WC1N 1PJ, UK
    Brain 134:969-78. 2011
    ....
  49. doi request reprint The effect of drug treatment on neurogenesis in Parkinson's disease
    Sean S O'Sullivan
    Reta Lila Weston Institute of Neurological Studies, University College London, London, United Kingdom
    Mov Disord 26:45-50. 2011
    ..Our findings suggest a positive impact of chronic L-dopa use on the number of NSC in the SVZ of PD patients, which may have relevance for future studies on neuroprotection in neurodegenerative diseases...
  50. ncbi request reprint The glucocerobrosidase E326K variant predisposes to Parkinson's disease, but does not cause Gaucher's disease
    Raquel Duran
    Reta Lila Weston Laboratories and Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK
    Mov Disord 28:232-6. 2013
    ..Our aim was to assess the contribution of GBA1 mutations in a series of early-onset PD...
  51. pmc The midbrain to pons ratio: a simple and specific MRI sign of progressive supranuclear palsy
    Luke A Massey
    Sara Koe PSP Research Centre, Rita Lila Weston Institute for Neurology Studies and Queen Square Brain Bank, Department of Molecular Neurosciences, UCL Institute of Neurology, London, UK
    Neurology 80:1856-61. 2013
    ..We aimed to develop in histologically proven disease a simple measure of the midbrain and pons on sagittal MRI to identify PSP...
  52. doi request reprint Regional differences in the severity of Lewy body pathology across the olfactory cortex
    Laura Silveira-Moriyama
    Reta Lila Weston Institute for Neurological Studies, UCL Institute of Neurology, London, UK
    Neurosci Lett 453:77-80. 2009
    ....
  53. pmc Hypokinesia without decrement distinguishes progressive supranuclear palsy from Parkinson's disease
    Helen Ling
    Sara Koe PSP Research Centre, Institute of Neurology, University College London, UK
    Brain 135:1141-53. 2012
    ..Similarly, 'micrographia' and 'lack of decrement in script size' are also more common in progressive supranuclear palsy than in Parkinson's disease...
  54. ncbi request reprint Adult-onset tic disorder, motor stereotypies, and behavioural disturbance associated with antibasal ganglia antibodies
    Mark J Edwards
    Sobell Department of Movement Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square, London, United Kingdom
    Mov Disord 19:1190-6. 2004
    ..We suggest that there might be a causal relationship between ABGA and the clinical syndrome in these cases and that ABGA should be considered as a possible etiology for adult-onset tics...
  55. doi request reprint Impulsive-compulsive spectrum behaviors in pathologically confirmed progressive supranuclear palsy
    Sean S O'Sullivan
    Reta Lila Weston Institute of Neurological Studies, Institute of Neurology, University College London, London, United Kingdom
    Mov Disord 25:638-42. 2010
    ..Pathological comparisons between these three cases and other case series of progressive supranuclear palsy are made...
  56. pmc Distinguishing SWEDDs patients with asymmetric resting tremor from Parkinson's disease: a clinical and electrophysiological study
    Petra Schwingenschuh
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, UCL, Queen Square, London, United Kingdom
    Mov Disord 25:560-9. 2010
    ..The underlying pathophysiology of SWEDDs differs from PD but has similarities with primary dystonia...
  57. ncbi request reprint The use of a color coded probability scale to interpret smell tests in suspected parkinsonism
    Laura Silveira-Moriyama
    Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, London, United Kingdom
    Mov Disord 24:1144-53. 2009
    ..We suggest smell tests could be used routinely in challenging cases where there is diagnostic uncertainty and help inform decision making relating to the need for neuro imaging...
  58. doi request reprint Testing an aetiological model of visual hallucinations in Parkinson's disease
    David A Gallagher
    Institute of Neurology, University College London, UK
    Brain 134:3299-309. 2011
    ..These clinical data are supported by the pathological study, in which higher overall cortical Lewy body counts, and in particular areas implicated in visuoperception and executive function, were associated with visual hallucinations...
  59. ncbi request reprint MRI derived brain atrophy in PSP and MSA-P. Determining sample size to detect treatment effects
    Dominic C Paviour
    The Sara Koe PSP Research Centre, Institute of Neurology, 1 Wakefield Street, London WC1N, UK
    J Neurol 254:478-81. 2007
    ..Regional rather than whole brain atrophy rates calculated from volumetric serial MRI brain scans in PSP and MSA-P provide a more practical and powerful means of monitoring disease progression in clinical trials...
  60. ncbi request reprint Longitudinal MRI in progressive supranuclear palsy and multiple system atrophy: rates and regions of atrophy
    Dominic C Paviour
    The Sara Koe PSP Research Centre, Institute of Neurology, UCL, London UK
    Brain 129:1040-9. 2006
    ..Clinico-radiological associations suggest these regional atrophy rates have potential as markers of disease progression in trials of novel therapies...
  61. ncbi request reprint A common LRRK2 mutation in idiopathic Parkinson's disease
    William P Gilks
    Department of Molecular Neuroscience, Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Lancet 365:415-6. 2005
    ..We suggest that testing for this mutation will be important in the management and genetic counselling of patients with Parkinson's disease...
  62. pmc α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson's disease and multiple system atrophy?
    Aoife P Kiely
    Queen Square Brain Bank, UCL Institute of Neurology, London, UK
    Acta Neuropathol 125:753-69. 2013
    ..Greater understanding of the disease mechanism underlying the G51D mutation could aid in understanding of α-synuclein biology and its impact on disease phenotype...
  63. pmc Meta-analysis of early nonmotor features and risk factors for Parkinson disease
    Alastair J Noyce
    Institute of Neurology, University College London, London, United Kingdom
    Ann Neurol 72:893-901. 2012
    ..To evaluate the association between diagnosis of Parkinson disease (PD) and risk factors or early symptoms amenable to population-based screening...
  64. doi request reprint Conventional magnetic resonance imaging in confirmed progressive supranuclear palsy and multiple system atrophy
    Luke A Massey
    Sara Koe PSP Research Centre, UCL Institute of Neurology, University College London, London, United Kingdom
    Mov Disord 27:1754-62. 2012
    ..However, the low sensitivity of these and macroscopic findings at autopsy suggest a need for imaging techniques sensitive to microstructural abnormalities without regional atrophy...
  65. doi request reprint Globular glial tauopathies (GGT) presenting with motor neuron disease or frontotemporal dementia: an emerging group of 4-repeat tauopathies
    Zeshan Ahmed
    Queen Square Brain Bank for Neurological Disorders, Department of Molecular Neuroscience, UCL Institute of Neurology, 1 Wakefield Street, London, WC1N 1PJ, UK
    Acta Neuropathol 122:415-28. 2011
    ..We, therefore, propose the term globular glial tauopathy as an encompassing term to classify this emerging class of 4R tauopathy...
  66. ncbi request reprint A functional polymorphism regulating dopamine beta-hydroxylase influences against Parkinson's disease
    Daniel G Healy
    Department of Molecular Neuroscience, Institute of Neurology, Queen Square, London WC1N 3BG, United Kingdom
    Ann Neurol 55:443-6. 2004
    ..46 (CI = 0.27-0.8). Rather than identifying a haplotype, or a marker in linkage disequilibrium with the risk variant, this to our knowledge is the first report directly linking PD susceptibility with a proven functional variant...
  67. ncbi request reprint Continuous subcutaneous apomorphine therapy improves dyskinesias in Parkinson's disease: a prospective study using single-dose challenges
    Regina Katzenschlager
    Reta Lila Weston Institute of Neurological Studies, University College London, United Kingdom
    Mov Disord 20:151-7. 2005
    ....
  68. doi request reprint Glucocerebrosidase mutations do not cause increased Lewy body pathology in Parkinson's disease
    Laura Parkkinen
    Queen Square Brain Bank for Neurological Disorders, Institute of Neurology, University College London, UK
    Mol Genet Metab 103:410-2. 2011
    ..Our results do not support GBA carriers to have a more advanced neuropathologic disease i.e. increased density of protein aggregates...
  69. ncbi request reprint Natural history and syndromic associations of orthostatic tremor: a review of 41 patients
    Willibald Gerschlager
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, United Kingdom
    Mov Disord 19:788-95. 2004
    ..OT may not be a discrete disorder as commonly believed and associated features like parkinsonism present in nearly 25% of cases. Dopaminergic dysfunction may have a role in the pathophysiology of this disorder...
  70. ncbi request reprint Pathological gambling in Parkinson's disease: risk factors and differences from dopamine dysregulation. An analysis of published case series
    David A Gallagher
    Department of Clinical Neurosciences, Royal Free and University College Medical School, London, United Kingdom
    Mov Disord 22:1757-63. 2007
    ..PG is predominantly associated with oral DA. It often occurs in isolation and may not be associated with DDS, which typically occurs on treatment with levodopa or subcutaneous apomorphine...
  71. ncbi request reprint Punding in Parkinson's disease: its relation to the dopamine dysregulation syndrome
    Andrew H Evans
    Reta Lila Weston Institute of Neurological Studies, London, United Kingdom
    Mov Disord 19:397-405. 2004
    ..We believe that this is an underreported, socially disabling phenomenon that is commonly associated with the syndrome of dopamine dysregulation and is phenomenologically distinct from both obsessive-compulsive disorder and mania...
  72. ncbi request reprint Kufor Rakeb disease: autosomal recessive, levodopa-responsive parkinsonism with pyramidal degeneration, supranuclear gaze palsy, and dementia
    David R Williams
    The Queen Square Brain Bank for Neurological Disorders Reta Lila Weston Institute for Neurological Studies, University College London, London, United Kingdom
    Mov Disord 20:1264-71. 2005
    ..Several new features were identified, including facial-faucial-finger mini-myoclonus, visual hallucinations, and oculogyric dystonic spasms...
  73. ncbi request reprint Neuronal intranuclear inclusion disease: report on a case originally diagnosed as dopa-responsive dystonia with Lewy bodies
    Dominic C Paviour
    The Sara Koe Progressive Supranuclear Palsy Research Centre, Institute of Neurology, University College London, London, United Kingdom
    Mov Disord 20:1345-9. 2005
    ..This rare condition, which may be diagnosed in life with a full thickness rectal biopsy, needs to be considered in the differential diagnosis of any case presenting as progressive juvenile parkinsonism (JP) or dystonia...
  74. ncbi request reprint The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease
    Rina Bandopadhyay
    Reta Lila Weston Institute of Neurological Studies, Royal Free and UCL Medical School, 46 Cleveland Street, London W1T 4JF, UK
    Brain 127:420-30. 2004
    ..These results are consistent with the hypothesis that neuronal-glial interactions are important in the pathophysiology of Parkinson's disease...
  75. ncbi request reprint Punding and dyskinesias
    Laura Silveira-Moriyama
    Reta Lila Weston Institute of Neurological Studies, University College London, London, United Kingdom
    Mov Disord 21:2214-7. 2006
    ..We suggest the neural systems mediating the expression of dyskinesias and punding might overlap and that punding should be looked for systematically in PD patients presenting with disabling severe dyskinesias...
  76. ncbi request reprint The gene responsible for PARK6 Parkinson's disease, PINK1, does not influence common forms of parkinsonism
    Daniel G Healy
    Department of Molecular Neuroscience, Institute of Neurology, University College London, London, United Kingdom
    Ann Neurol 56:329-35. 2004
    ....
  77. doi request reprint The use of smell identification tests in the diagnosis of Parkinson's disease in Brazil
    Laura Silveira-Moriyama
    Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, London, United Kingdom
    Mov Disord 23:2328-34. 2008
    ..Our data provide support for the use of the UPSIT-40 and SS-16 to help distinguish early PD from controls...
  78. doi request reprint Cortical alpha-synuclein load is associated with amyloid-beta plaque burden in a subset of Parkinson's disease patients
    Tammaryn Lashley
    Queen Square Brain Bank for Neurological Disorders, Department of Molecular Neuroscience, UCL Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Acta Neuropathol 115:417-25. 2008
    ....
  79. doi request reprint Development and assessment of sensitive immuno-PCR assays for the quantification of cerebrospinal fluid three- and four-repeat tau isoforms in tauopathies
    Connie Luk
    Reta Lila Weston Institute, UCL Institute of Neurology, London, UK
    J Neurochem 123:396-405. 2012
    ....
  80. doi request reprint Validation of the MDS-UPDRS Part I for nonmotor symptoms in Parkinson's disease
    David A Gallagher
    Institute of Neurology, University College London, London, UK
    Mov Disord 27:79-83. 2012
    ..0001; other nonmotor features factor score: r = 0.87, P < 0.0001). Our data demonstrate that the MDS-UPDRS Part I total score has a strong relationship with a composite score of validated scales for the nonmotor aspects of PD...
  81. ncbi request reprint The corticotrophin-releasing factor-like peptide urocortin reverses key deficits in two rodent models of Parkinson's disease
    Amjad Abuirmeileh
    Department of Pharmacology, The School of Pharmacy, 29 39 Brunswick Square, London, UK
    Eur J Neurosci 26:417-23. 2007
    ..The apparent ability of UCN to arrest the progression of or even reverse nigral lesions once established suggests that pharmacological manipulation of this system could have substantial therapeutic utility...
  82. doi request reprint Transportin1: a marker of FTLD-FUS
    Jack Brelstaff
    Queen Square Brain Bank for Neurological Disorders, Department of Molecular Neuroscience, UCL Institute of Neurology, University College London, UK
    Acta Neuropathol 122:591-600. 2011
    ..Our biochemical investigations demonstrate that urea-soluble TRN1 is present in aFTLD-U and NIFID, but not in normal control brains. These findings implicate abnormalities of FUS transport in the pathogenesis of FTLD-FUS...
  83. ncbi request reprint Pathophysiological differences between musician's dystonia and writer's cramp
    Karin Rosenkranz
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, UK
    Brain 128:918-31. 2005
    ..The fact that sensory input had no effect on motor output in patients with WC suggests that sensory information from the hand may play a smaller role in provoking pathological changes in WC than in MD...
  84. doi request reprint Dopamine dysregulation syndrome: an overview of its epidemiology, mechanisms and management
    Sean S O'Sullivan
    Reta Lila Weston Institute of Neurological Studies, Institute of Neurology, University College London, London, England
    CNS Drugs 23:157-70. 2009
    ..Further studies are also required to identify factors that can predict those patients with DDS or ICDs who will derive benefit from surgical interventions such as deep brain stimulation...
  85. ncbi request reprint Parkinsonism and nigrostriatal dysfunction are associated with spinocerebellar ataxia type 6 (SCA6)
    Naheed L Khan
    Department of Molecular Neurosciences, Institute of Neurology, London, United Kingdom
    Mov Disord 20:1115-9. 2005
    ..We suggest that SCA6, in common with SCA2 and SCA3, may be associated with Parkinsonism attributable to nigral loss and dopaminergic dysfunction. Moreover, isolated cases may be confused with multiple system atrophy...
  86. pmc A comparative clinical, pathological, biochemical and genetic study of fused in sarcoma proteinopathies
    Tammaryn Lashley
    Queen Square Brain Bank, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Brain 134:2548-64. 2011
    ..The co-existence of fused in sarcoma-positive inclusions in both motor neurons and extramotor cerebral structures is a characteristic finding in sporadic fused in sarcoma proteinopathies, indicating a multisystem disorder...
  87. doi request reprint An intragenic duplication in guanosine triphosphate cyclohydrolase-1 gene in a dopa-responsive dystonia family
    Helen Ling
    Reta Lila Weston Institute of Neurological Studies, Institute of Neurology, University College London, London, United Kingdom
    Mov Disord 26:905-9. 2011
    ..Autosomal dominant dopa-responsive dystonia is commonly caused by mutations in the guanosine triphosphate cyclohydrolase-1 gene...
  88. ncbi request reprint Unclassifiable parkinsonism in two European tertiary referral centres for movement disorders
    Regina Katzenschlager
    National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom
    Mov Disord 18:1123-31. 2003
    ..Prolonged follow-up and neuropathological diagnosis will be needed to determine whether all these cases represent atypical presentations of established clinico-pathological entities or whether some represent unrecognised new disorders...
  89. ncbi request reprint Failure in heat-shock protein expression in response to UBB+1 protein in progressive supranuclear palsy in humans
    Andrew D Hope
    Reta Lila Weston Institute of Neurological Studies, University College London, 46 Cleveland Street, London, W1T 4JF, UK
    Neurosci Lett 359:94-8. 2004
    ..As HSPs are involved in both normal tau and proteasome function, these findings may be relevant to the aetiology of PSP and other tauopathies...
  90. ncbi request reprint Genome-wide analysis of the parkinsonism-dementia complex of Guam
    Huw R Morris
    Department of Molecular Pathogenesis and Sara Koe PSP Research Centre, Queen Square Brain Bank for Neurological Disorders, Insatitute of Neurology, University College London, London, England, UK
    Arch Neurol 61:1889-97. 2004
    ..It occurs in focal geographic isolates, including Guam and the Kii peninsula of Japan. The familial clustering of the disease has suggested that a genetic factor could be important in its etiology...
  91. ncbi request reprint Visual hallucinations in the diagnosis of idiopathic Parkinson's disease: a retrospective autopsy study
    David R Williams
    Queen Square Brain Bank for Neurological Disorders and Institute of Neurology, University College London, London, UK
    Lancet Neurol 4:605-10. 2005
    ..The cause of VH is now thought to be nerve-cell loss and Lewy-body pathology in the ventral-temporal regions of the brain. However, the use of VH as a clinical sign of PD has not been investigated...
  92. ncbi request reprint Punding in Parkinson's disease
    Sean S O'Sullivan
    Reta Lila Weston Institute of Neurological Studies, Institute of Neurology, University College London, London, UK
    Pract Neurol 7:397-9. 2007
  93. ncbi request reprint Parkin disease: a phenotypic study of a large case series
    Naheed L Khan
    Department of Molecular Pathogenesis, Royal Free Hospital and University College Medical School, London, UK
    Brain 126:1279-92. 2003
    ..Some relatives carrying a single parkin mutation without extrapyramidal symptoms or signs also had psychiatric symptoms that might be related to their carrier status...
  94. ncbi request reprint Dopamine dysregulation syndrome in Parkinson's disease
    Andrew H Evans
    Reta Lila Weston Institute of Neurological Studies, University College London, The National Hospital for Neurology and Neurosurgery, London, UK
    Curr Opin Neurol 17:393-8. 2004
    ..This review examines the phenomenology of dopamine dysregulation syndrome in relation to the current understanding of basal ganglia function and its impact on long-term management...
  95. ncbi request reprint Excessive hoarding in Parkinson's disease
    Sean S O'Sullivan
    Reta Lila Weston Institute of Neurological Studies, University College London, United Kingdom
    Mov Disord 25:1026-33. 2010
    ..The association of hoarding with other ICBs and low trait impulse control suggests that excessive hoarding is related to the spectrum of impulsive behaviors in PD...
  96. ncbi request reprint Alteration in alpha-synuclein mRNA expression in Parkinson's disease
    Ann E Kingsbury
    Queen Square Brain Bank for Neurological Disorders, Institute of Neurology, London, United Kingdom
    Mov Disord 19:162-70. 2004
    ..These findings are in broad agreement with other studies of the expression of alpha-synuclein mRNA in human brain and suggest that Lewy body formation is unlikely to be the result of overexpression of alpha-synuclein...
  97. ncbi request reprint Genetic variation at the tau locus and clinical syndromes associated with progressive supranuclear palsy
    David R Williams
    The Queen Square Brain Bank for Neurological Disorders, Institute of Neurology, Queen Square, London, United Kingdom
    Mov Disord 22:895-7. 2007
    ..No mutations were found in 75 patients (21 PSP-P), and H1c was associated with both Richardson's syndrome and PSP-P compared with controls. Routine screening for MAPT mutations in atypical PSP is not recommended...
  98. ncbi request reprint Diffusion-weighted magnetic resonance imaging differentiates Parkinsonian variant of multiple-system atrophy from progressive supranuclear palsy
    Dominic C Paviour
    Sara Koe PSP Research Centre, Institute of Neurology, University College London, London, United Kingdom
    Mov Disord 22:68-74. 2007
    ..Increased rADCs in the pons and MCP were associated with smaller pontine and cerebellar volumes in MSA-P. rADCs distinguish MSA-P from PSP. These have a clinical correlate and are associated with reduced brainstem and cerebellar volumes...
  99. ncbi request reprint A genetic cluster of early onset Parkinson's disease in a Colombian population
    Nicolas Pineda-Trujillo
    Galton Laboratory, University College London, London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 141:885-9. 2006
    ..Haplotype data exclude a recent common ancestry between the Spanish and Antioquian patients studied here and is consistent with the introduction of the G736A mutation in Antioquia during early colonial times (about 16 generations ago)...
  100. ncbi request reprint Holmes tremor: Application of modern neuroimaging techniques
    Dominic C Paviour
    The Sara Koe PSP Research Centre, The Institute of Neurology, UCL, London, United Kingdom
    Mov Disord 21:2260-2. 2006
    ..Modern neuroimaging techniques in this case confirm that a combination of damage to the cerebello-rubrothalamic pathway and the nigrostriatal pathway is required for the full Holmes tremor syndrome to occur...
  101. ncbi request reprint Regional brain volumes distinguish PSP, MSA-P, and PD: MRI-based clinico-radiological correlations
    Dominic C Paviour
    The Sara Koe PSP Research Centre, Institute of Neurology UCL, London United Kingdom
    Mov Disord 21:989-96. 2006
    ..These distinct patterns of cortical and subcortical atrophy, when considered together rather than independently, better differentiate PSP and MSA-P from each other and also from healthy controls...