Lopa Leach

Summary

Affiliation: University of Nottingham
Country: UK

Publications

  1. ncbi request reprint Molecular organization of tight and adherens junctions in the human placental vascular tree
    L Leach
    School of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Nottingham, UK
    Placenta 21:547-57. 2000
  2. ncbi request reprint Vasculogenesis, angiogenesis and the molecular organisation of endothelial junctions in the early human placenta
    Lopa Leach
    School of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Nottingham, Queens Medical Centre, UK
    J Vasc Res 39:246-59. 2002
  3. doi request reprint Placental vascular dysfunction in diabetic pregnancies: intimations of fetal cardiovascular disease?
    Lopa Leach
    Cardiovascular Research Group, School of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham, UK
    Microcirculation 18:263-9. 2011
  4. pmc The phenotype of the human materno-fetal endothelial barrier: molecular occupancy of paracellular junctions dictate permeability and angiogenic plasticity
    Lopa Leach
    School of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Nottingham, UK
    J Anat 200:599-606. 2002
  5. ncbi request reprint Vascular endothelial cadherin and beta-catenin in human fetoplacental vessels of pregnancies complicated by Type 1 diabetes: associations with angiogenesis and perturbed barrier function
    L Leach
    Centre for Integrated Systems Biology and Medicine, School of Biomedical Sciences, University of Nottingham, UK
    Diabetologia 47:695-709. 2004
  6. ncbi request reprint Endothelium, blood vessels and angiogenesis -- a workshop report
    L Leach
    Centre for Integrated Systems Biology and Medicine, School of Biomedical Sciences, Faculty of Medicine, University of Nottingham, Nottingham NG7 2UH, UK
    Placenta 27:S26-9. 2006
  7. pmc Vascular dysfunction in the diabetic placenta: causes and consequences
    Lopa Leach
    School of Biomedical Sciences, Centre for Integrated Systems Biology and Medicine, Institute of Clinical Research, Faculty of Medicine and Health Sciences, University of Nottingham, UK
    J Anat 215:69-76. 2009
  8. ncbi request reprint Reversible disruption of tight junction complexes in the rat blood-brain barrier, following transitory focal astrocyte loss
    Colin L Willis
    MRC Applied Neuroscience Group, School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, NG7 2UH, Nottingham, United Kingdom
    Glia 48:1-13. 2004
  9. pmc Hookworm (Necator americanus) larval enzymes disrupt human vascular endothelium
    Nahed Souadkia
    Division of Molecular and Cellular Science, Immune Modulation, Boots Science Building, School of Pharmacy, University of Nottingham, Nottingham, UK
    Am J Trop Med Hyg 83:549-58. 2010
  10. doi request reprint Transport in the placenta: homogenizing haemodynamics in a disordered medium
    Igor L Chernyavsky
    School of Mathematical Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, UK
    Philos Transact A Math Phys Eng Sci 369:4162-82. 2011

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Molecular organization of tight and adherens junctions in the human placental vascular tree
    L Leach
    School of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Nottingham, UK
    Placenta 21:547-57. 2000
    ..This may allow the increased plasticity necessary in terminal villi for continual growth, proliferation and solute exchange...
  2. ncbi request reprint Vasculogenesis, angiogenesis and the molecular organisation of endothelial junctions in the early human placenta
    Lopa Leach
    School of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Nottingham, Queens Medical Centre, UK
    J Vasc Res 39:246-59. 2002
    ..e. stable or dynamic, dependent on maturity and plasticity. These distinct phenotypes may be influenced by the angiopoietins/VEGF present in the placenta...
  3. doi request reprint Placental vascular dysfunction in diabetic pregnancies: intimations of fetal cardiovascular disease?
    Lopa Leach
    Cardiovascular Research Group, School of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham, UK
    Microcirculation 18:263-9. 2011
    ....
  4. pmc The phenotype of the human materno-fetal endothelial barrier: molecular occupancy of paracellular junctions dictate permeability and angiogenic plasticity
    Lopa Leach
    School of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Nottingham, UK
    J Anat 200:599-606. 2002
    ..This junctional immaturity appears to be at the expense of barrier function resulting in sites of maximal materno-fetal solute exchange...
  5. ncbi request reprint Vascular endothelial cadherin and beta-catenin in human fetoplacental vessels of pregnancies complicated by Type 1 diabetes: associations with angiogenesis and perturbed barrier function
    L Leach
    Centre for Integrated Systems Biology and Medicine, School of Biomedical Sciences, University of Nottingham, UK
    Diabetologia 47:695-709. 2004
    ....
  6. ncbi request reprint Endothelium, blood vessels and angiogenesis -- a workshop report
    L Leach
    Centre for Integrated Systems Biology and Medicine, School of Biomedical Sciences, Faculty of Medicine, University of Nottingham, Nottingham NG7 2UH, UK
    Placenta 27:S26-9. 2006
  7. pmc Vascular dysfunction in the diabetic placenta: causes and consequences
    Lopa Leach
    School of Biomedical Sciences, Centre for Integrated Systems Biology and Medicine, Institute of Clinical Research, Faculty of Medicine and Health Sciences, University of Nottingham, UK
    J Anat 215:69-76. 2009
    ..The altered molecular mechanisms underlying the vascular changes in the diabetic human placenta may reflect similar consequences of high glucose and hyperinsulinaemia...
  8. ncbi request reprint Reversible disruption of tight junction complexes in the rat blood-brain barrier, following transitory focal astrocyte loss
    Colin L Willis
    MRC Applied Neuroscience Group, School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, NG7 2UH, Nottingham, United Kingdom
    Glia 48:1-13. 2004
    ..However, barrier integrity to dextran (10 kDa) and fibrinogen can be restored in the absence of astrocytes and tight junction proteins (occludin, claudin-5, and zonula occludens-1)...
  9. pmc Hookworm (Necator americanus) larval enzymes disrupt human vascular endothelium
    Nahed Souadkia
    Division of Molecular and Cellular Science, Immune Modulation, Boots Science Building, School of Pharmacy, University of Nottingham, Nottingham, UK
    Am J Trop Med Hyg 83:549-58. 2010
    ..Our data suggest that larval proteases play an important role in negotiating the endothelium...
  10. doi request reprint Transport in the placenta: homogenizing haemodynamics in a disordered medium
    Igor L Chernyavsky
    School of Mathematical Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, UK
    Philos Transact A Math Phys Eng Sci 369:4162-82. 2011
    ..This study highlights the importance of quantifying errors owing to spatial disorder in multi-scale approximations of physiological systems...
  11. doi request reprint Isolation and properties of an in vitro human outer blood-retinal barrier model
    Robin D Hamilton
    School of Biomedical Sciences, University of Nottingham, Nottingham, UK
    Methods Mol Biol 686:401-16. 2011
    ....
  12. pmc The modulation of endothelial cell permeability: winter meeting of the Anatomical Society of Great Britain and Ireland (ASGBI), London, UK, 2-4 January 2002
    Lopa Leach
    School of Biomedical Sciences, University of Nottingham, UK
    J Anat 200:539-40. 2002
  13. ncbi request reprint Behaviour of human endothelial cells on surface modified NiTi alloy
    Stuart D Plant
    Christchurch School of Medicine, Lipid and Diabetes Research Group, Canterbury District Health Board, 1st Floor Hagley Hostel, Christchurch Hospital, New Zealand
    Biomaterials 26:5359-67. 2005
    ..8 at%). This study proposes that the integrity of human endothelial monolayers on NiTi is dependent upon the surface chemistry of the alloy and that this can be manipulated, using simple oxidising heat treatments...