Stanley E Lazic

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. pmc Why we should use simpler models if the data allow this: relevance for ANOVA designs in experimental biology
    Stanley E Lazic
    Department of Physiology, Development and Neuroscience, University of Cambridge, CB2 3DY, UK
    BMC Physiol 8:16. 2008
  2. doi request reprint A retrospective analysis of hand tapping as a longitudinal marker of disease progression in Huntington's disease
    Lucy M Collins
    In Silico Lead Discovery, Novartis Institutes for BioMedical Research, Basel, Switzerland
    BMC Neurol 14:35. 2014
  3. doi request reprint Comment on "Stress in puberty unmasks latent neuropathological consequences of prenatal immune activation in mice"
    Stanley E Lazic
    In Silico Lead Discovery, Novartis Institutes for BioMedical Research, Basel, Switzerland
    Science 340:811. 2013
  4. pmc Improving basic and translational science by accounting for litter-to-litter variation in animal models
    Stanley E Lazic
    In Silico Lead Discovery, Novartis Institutes for BioMedical Research, Switzerland
    BMC Neurosci 14:37. 2013
  5. doi request reprint Modeling hippocampal neurogenesis across the lifespan in seven species
    Stanley E Lazic
    Bioinformatics and Exploratory Data Analysis, F Hoffmann La Roche, Basel, Switzerland
    Neurobiol Aging 33:1664-71. 2012
  6. pmc Using causal models to distinguish between neurogenesis-dependent and -independent effects on behaviour
    Stanley E Lazic
    Bioinformatics and Exploratory Data Analysis, F Hoffmann La Roche, Basel, Switzerland
    J R Soc Interface 9:907-17. 2012
  7. doi request reprint Relating hippocampal neurogenesis to behavior: the dangers of ignoring confounding variables
    Stanley E Lazic
    Bioinformatics and Exploratory Data Analysis, F Hoffmann La Roche, Basel, Switzerland
    Neurobiol Aging 31:2169-71; discussion 2172-5. 2010
  8. pmc The problem of pseudoreplication in neuroscientific studies: is it affecting your analysis?
    Stanley E Lazic
    Department of Applied Mathematics and Theoretical Physics, Cambridge Computational Biology Institute, University of Cambridge, Cambridge CB3 0WA, UK
    BMC Neurosci 11:5. 2010
  9. pmc Visualising disease progression on multiple variables with vector plots and path plots
    Stanley E Lazic
    Cambridge Computational Biology Institute, Department of Applied Mathematics and Theoretical Physics, University of Cambridge, UK
    BMC Med Res Methodol 9:32. 2009
  10. pmc Statistical evaluation of methods for quantifying gene expression by autoradiography in histological sections
    Stanley E Lazic
    Department of Applied Mathematics and Theoretical Physics, Cambridge Computational Biology Institute, University of Cambridge, Cambridge, UK
    BMC Neurosci 10:5. 2009

Collaborators

Detail Information

Publications18

  1. pmc Why we should use simpler models if the data allow this: relevance for ANOVA designs in experimental biology
    Stanley E Lazic
    Department of Physiology, Development and Neuroscience, University of Cambridge, CB2 3DY, UK
    BMC Physiol 8:16. 2008
    ....
  2. doi request reprint A retrospective analysis of hand tapping as a longitudinal marker of disease progression in Huntington's disease
    Lucy M Collins
    In Silico Lead Discovery, Novartis Institutes for BioMedical Research, Basel, Switzerland
    BMC Neurol 14:35. 2014
    ..The ability to track disease progression using simple, objective, inexpensive, and robust measures would be beneficial...
  3. doi request reprint Comment on "Stress in puberty unmasks latent neuropathological consequences of prenatal immune activation in mice"
    Stanley E Lazic
    In Silico Lead Discovery, Novartis Institutes for BioMedical Research, Basel, Switzerland
    Science 340:811. 2013
    ..The data, however, were analyzed as a completely randomized design, which is inappropriate given these restrictions on randomization. This will increase both false positives and false negatives...
  4. pmc Improving basic and translational science by accounting for litter-to-litter variation in animal models
    Stanley E Lazic
    In Silico Lead Discovery, Novartis Institutes for BioMedical Research, Switzerland
    BMC Neurosci 14:37. 2013
    ..If such experiments are not appropriately designed and analysed, the results can be severely biased as well as extremely underpowered...
  5. doi request reprint Modeling hippocampal neurogenesis across the lifespan in seven species
    Stanley E Lazic
    Bioinformatics and Exploratory Data Analysis, F Hoffmann La Roche, Basel, Switzerland
    Neurobiol Aging 33:1664-71. 2012
    ..7% (95% CI 0.7% to 9.9%) of the existing cell population turns over from middle age and onward. Thus, relatively few new cells are added for much of an animal's life, and only a proportion of these will mature into functional neurons...
  6. pmc Using causal models to distinguish between neurogenesis-dependent and -independent effects on behaviour
    Stanley E Lazic
    Bioinformatics and Exploratory Data Analysis, F Hoffmann La Roche, Basel, Switzerland
    J R Soc Interface 9:907-17. 2012
    ..Many studies in the neurogenesis literature would benefit from the use of statistical methods that can separate neurogenesis-dependent from neurogenesis-independent effects on behaviour...
  7. doi request reprint Relating hippocampal neurogenesis to behavior: the dangers of ignoring confounding variables
    Stanley E Lazic
    Bioinformatics and Exploratory Data Analysis, F Hoffmann La Roche, Basel, Switzerland
    Neurobiol Aging 31:2169-71; discussion 2172-5. 2010
    ..A reanalysis of recently published data showed that after adjusting for the age of the rats, there was no significant relationship between the number of doublecortin-positive cells and working memory...
  8. pmc The problem of pseudoreplication in neuroscientific studies: is it affecting your analysis?
    Stanley E Lazic
    Department of Applied Mathematics and Theoretical Physics, Cambridge Computational Biology Institute, University of Cambridge, Cambridge CB3 0WA, UK
    BMC Neurosci 11:5. 2010
    ..Analysis of such data without taking these dependencies into account can lead to meaningless results, and examples can easily be found in the neuroscience literature...
  9. pmc Visualising disease progression on multiple variables with vector plots and path plots
    Stanley E Lazic
    Cambridge Computational Biology Institute, Department of Applied Mathematics and Theoretical Physics, University of Cambridge, UK
    BMC Med Res Methodol 9:32. 2009
    ....
  10. pmc Statistical evaluation of methods for quantifying gene expression by autoradiography in histological sections
    Stanley E Lazic
    Department of Applied Mathematics and Theoretical Physics, Cambridge Computational Biology Institute, University of Cambridge, Cambridge, UK
    BMC Neurosci 10:5. 2009
    ....
  11. ncbi request reprint Olfactory abnormalities in Huntington's disease: decreased plasticity in the primary olfactory cortex of R6/1 transgenic mice and reduced olfactory discrimination in patients
    Stanley E Lazic
    Centre for Brain Repair, University of Cambridge, CB2 2PY, UK
    Brain Res 1151:219-26. 2007
    ..These results suggest that olfactory impairments observed in HD patients may be the result of reduced plasticity in the primary olfactory cortex...
  12. ncbi request reprint Lack of efficacy of music to improve sleep: a polysomnographic and quantitative EEG analysis
    Stanley E Lazic
    Department of Psychology, Brock University, St Catharines, Ontario, Canada
    Int J Psychophysiol 63:232-9. 2007
    ....
  13. ncbi request reprint Neurogenesis in the R6/1 transgenic mouse model of Huntington's disease: effects of environmental enrichment
    Stanley E Lazic
    Centre for Brain Repair, University of Cambridge, Cambridge CB2 2PY, UK
    Eur J Neurosci 23:1829-38. 2006
    ....
  14. ncbi request reprint Decreased hippocampal cell proliferation in R6/1 Huntington's mice
    Stanley E Lazic
    Centre for Brain Repair, University of Cambridge, Cambridge CB2 2PY, UK
    Neuroreport 15:811-3. 2004
    ..Such a decrease in cell proliferation may be relevant to some of the deficits seen in these mice, although further work is needed to prove this...
  15. ncbi request reprint Polysomnographic and quantitative EEG analysis of subjects with long-term insomnia complaints associated with mild traumatic brain injury
    Benjamin R Williams
    Department of Psychology, Brock University, St Catharines, Ontario, Canada L2S 3A1
    Clin Neurophysiol 119:429-38. 2008
    ....
  16. ncbi request reprint The future of cell-based transplantation therapies for neurodegenerative disorders
    Stanley E Lazic
    Centre for Brain Repair, University of Cambridge, Cambridge CB2 2PY, UK
    J Hematother Stem Cell Res 12:635-42. 2003
    ..Finally we will discuss the prospect of using stem cells to deliver drugs and neurotrophic factors involved in neuroprotective and neuroreparative strategies in Parkinson's disease and other neurodegenerative conditions...
  17. pmc Transcriptional profiling of human brain endothelial cells reveals key properties crucial for predictive in vitro blood-brain barrier models
    Eduard Urich
    CNS Research, F Hoffmann La Roche Ltd, Basel, Switzerland
    PLoS ONE 7:e38149. 2012
    ..A collection of key genes that seems to be highly regulated by the local surroundings of BEC within the neurovascular unit are presented and discussed...
  18. ncbi request reprint Rapid decline in motor symptoms in HD neural transplant patients prior to surgery
    Stanley E Lazic
    Brain Res Bull 63:83-4. 2004