S M Lawrie

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. pmc Medial temporal lobe function during emotional memory in early Alzheimer's disease, mild cognitive impairment and healthy ageing: an fMRI study
    Mario A Parra
    Scottish Dementia Clinical Research Network, Human Cognitive Neuroscience and Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK
    BMC Psychiatry 13:76. 2013
  2. pmc Structural brain changes in First Episode Schizophrenia compared with Fronto-Temporal Lobar Degeneration: a meta-analysis
    Bayanne Olabi
    Division of Psychiatry, School of Molecular and Clinical Medicine, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, EH10 5HF, UK
    BMC Psychiatry 12:104. 2012
  3. pmc Assessment of the impact of the scanner-related factors on brain morphometry analysis with Brainvisa
    Mahsa Shokouhi
    Department of Clinical Physics and Psychological Medicine, College of Medicine, Veterinary and Life Sciences, University of Glasgow, UK
    BMC Med Imaging 11:23. 2011
  4. pmc The prediction of discharge from in-patient psychiatric rehabilitation: a case-control study
    Joanna Bredski
    Rehabilitation Service, Royal Edinburgh Hospital, Edinburgh, UK
    BMC Psychiatry 11:149. 2011
  5. pmc A theory of mind investigation into the appreciation of visual jokes in schizophrenia
    Dominic Marjoram
    Department of Psychiatry, University of Edinburgh, Edinburgh, UK
    BMC Psychiatry 5:12. 2005
  6. pmc Correlations between fMRI activation and individual psychotic symptoms in un-medicated subjects at high genetic risk of schizophrenia
    Heather C Whalley
    Division of Psychiatry, School of Molecular and Clinical Medicine, University of Edinburgh, Edinburgh, Scotland, UK
    BMC Psychiatry 7:61. 2007
  7. pmc Prospective multi-centre Voxel Based Morphometry study employing scanner specific segmentations: procedure development using CaliBrain structural MRI data
    T William J Moorhead
    The Division of Psychiatry, Centre for Clinical Brain Sciences, School of Molecular and Clinical Medicine, University of Edinburgh, Edinburgh, UK
    BMC Med Imaging 9:8. 2009
  8. pmc Low birthweight and preterm birth in young people with special educational needs: a magnetic resonance imaging analysis
    Michael D Spencer
    Division of Psychiatry, University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF, UK
    BMC Med 6:1. 2008
  9. pmc Grey matter changes can improve the prediction of schizophrenia in subjects at high risk
    Dominic E Job
    Division of Psychiatry, School of Molecular and Clinical Medicine, The University of Edinburgh, The Royal Edinburgh Hospital, Morningside Park, Edinburgh, Scotland, EH10 5HF, UK
    BMC Med 4:29. 2006
  10. pmc Brain structure and function changes during the development of schizophrenia: the evidence from studies of subjects at increased genetic risk
    Stephen M Lawrie
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh EH10 5HF, Scotland, UK
    Schizophr Bull 34:330-40. 2008

Collaborators

Detail Information

Publications120 found, 100 shown here

  1. pmc Medial temporal lobe function during emotional memory in early Alzheimer's disease, mild cognitive impairment and healthy ageing: an fMRI study
    Mario A Parra
    Scottish Dementia Clinical Research Network, Human Cognitive Neuroscience and Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK
    BMC Psychiatry 13:76. 2013
    ..We hypothesised that tests of incidental emotional memory may inform on different aspects of cognitive decline in MCI and AD...
  2. pmc Structural brain changes in First Episode Schizophrenia compared with Fronto-Temporal Lobar Degeneration: a meta-analysis
    Bayanne Olabi
    Division of Psychiatry, School of Molecular and Clinical Medicine, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, EH10 5HF, UK
    BMC Psychiatry 12:104. 2012
    ..The authors sought to compare gray matter changes in First Episode Schizophrenia (FES) compared with Fronto-Temporal Lobar Degeneration (FTLD) using meta-analytic methods applied to neuro-imaging studies...
  3. pmc Assessment of the impact of the scanner-related factors on brain morphometry analysis with Brainvisa
    Mahsa Shokouhi
    Department of Clinical Physics and Psychological Medicine, College of Medicine, Veterinary and Life Sciences, University of Glasgow, UK
    BMC Med Imaging 11:23. 2011
    ..It is important therefore to investigate the variability and reliability of morphometric measurements between different scanners and different sessions of the same scanner...
  4. pmc The prediction of discharge from in-patient psychiatric rehabilitation: a case-control study
    Joanna Bredski
    Rehabilitation Service, Royal Edinburgh Hospital, Edinburgh, UK
    BMC Psychiatry 11:149. 2011
    ..None have been carried out for in-patient rehabilitation. We aimed to identify the factors that are associated with achieving discharge from in-patient rehabilitation by carrying out a case-control study...
  5. pmc A theory of mind investigation into the appreciation of visual jokes in schizophrenia
    Dominic Marjoram
    Department of Psychiatry, University of Edinburgh, Edinburgh, UK
    BMC Psychiatry 5:12. 2005
    ..Previous studies have found these to be linked to psychotic symptoms (or psychotic symptom severity) particularly the presence of delusions and hallucinations...
  6. pmc Correlations between fMRI activation and individual psychotic symptoms in un-medicated subjects at high genetic risk of schizophrenia
    Heather C Whalley
    Division of Psychiatry, School of Molecular and Clinical Medicine, University of Edinburgh, Edinburgh, Scotland, UK
    BMC Psychiatry 7:61. 2007
    ....
  7. pmc Prospective multi-centre Voxel Based Morphometry study employing scanner specific segmentations: procedure development using CaliBrain structural MRI data
    T William J Moorhead
    The Division of Psychiatry, Centre for Clinical Brain Sciences, School of Molecular and Clinical Medicine, University of Edinburgh, Edinburgh, UK
    BMC Med Imaging 9:8. 2009
    ..The CaliBrain project was designed to provide for an assessment of scanner differences at three centres in Scotland, and to assess the practicality of pooling scans from multiple-centres...
  8. pmc Low birthweight and preterm birth in young people with special educational needs: a magnetic resonance imaging analysis
    Michael D Spencer
    Division of Psychiatry, University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF, UK
    BMC Med 6:1. 2008
    ..Our aim was to address these issues in a sample of young people receiving additional learning support...
  9. pmc Grey matter changes can improve the prediction of schizophrenia in subjects at high risk
    Dominic E Job
    Division of Psychiatry, School of Molecular and Clinical Medicine, The University of Edinburgh, The Royal Edinburgh Hospital, Morningside Park, Edinburgh, Scotland, EH10 5HF, UK
    BMC Med 4:29. 2006
    ....
  10. pmc Brain structure and function changes during the development of schizophrenia: the evidence from studies of subjects at increased genetic risk
    Stephen M Lawrie
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh EH10 5HF, Scotland, UK
    Schizophr Bull 34:330-40. 2008
    ..Overall, the literature supports the view that there are measurable changes in brain structure and function during the genesis of the disorder, which provide opportunities for early detection and intervention...
  11. pmc Neuroimaging and molecular genetics of schizophrenia: pathophysiological advances and therapeutic potential
    S M Lawrie
    Division of Psychiatry, University of Edinburgh, Edinburgh, UK
    Br J Pharmacol 153:S120-4. 2008
    ..We provide examples of how these advances in our knowledge could lead to the development of new treatments for psychosis...
  12. ncbi request reprint Structural and functional abnormalities of the amygdala in schizophrenia
    Stephen M Lawrie
    Edinburgh University, Department of Psychiatry, Kennedy Tower, Royal Edinburgh Hospital, Edinburgh, Scotland, UK
    Ann N Y Acad Sci 985:445-60. 2003
    ....
  13. ncbi request reprint The 'continuum of psychosis': scientifically unproven and clinically impractical
    Stephen M Lawrie
    Division of Psychiatry, University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, Edinburgh EH10 5HF, UK
    Br J Psychiatry 197:423-5. 2010
    ..Systematic studies are needed to evaluate which of a range of plausible approaches to the classification of psychosis is most useful before change could be justified...
  14. ncbi request reprint Temporal lobe volume changes in people at high risk of schizophrenia with psychotic symptoms
    Stephen M Lawrie
    University Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh, UK
    Br J Psychiatry 181:138-43. 2002
    ..Magnetic resonance imaging (MRI) has demonstrated abnormalities of brain structure, particularly of the temporal lobes, in schizophrenia. These are thought to be neurodevelopmental in origin, but when they become evident is unknown...
  15. ncbi request reprint Neurodevelopmental indices and the development of psychotic symptoms in subjects at high risk of schizophrenia
    S M Lawrie
    Edinburgh University Department of Psychiatry, Edinburgh, UK
    Br J Psychiatry 178:524-30. 2001
    ..Neurological 'soft signs' and minor physical anomalies (MPAs) are reported to be more frequent in patients with schizophrenia than in controls...
  16. ncbi request reprint Qualitative cerebral morphology in schizophrenia: a magnetic resonance imaging study and systematic literature review
    S M Lawrie
    Edinburgh University Department of Psychiatry, Royal Edinburgh Hospital, Scotland, UK
    Schizophr Res 25:155-66. 1997
    ..The degree of atrophy was correlated with the number of HIS foci (r = 0.31, p = 0.014). Taken together with previous studies, these findings demonstrate the value of qualitative examination of MRI images in patients with schizophrenia...
  17. ncbi request reprint Brain abnormality in schizophrenia. A systematic and quantitative review of volumetric magnetic resonance imaging studies
    S M Lawrie
    Department of Psychiatry, Royal Edinburgh Hospital, Scotland
    Br J Psychiatry 172:110-20. 1998
    ..Numerous in vivo brain imaging studies suggest that cerebral structure is abnormal in schizophrenia, but implicate different regions to varying extents...
  18. ncbi request reprint Magnetic resonance imaging of brain in people at high risk of developing schizophrenia
    S M Lawrie
    Department of Psychiatry, Royal Edinburgh Hospital, UK
    Lancet 353:30-3. 1999
    ..Whether these abnormalities of brain structure predate the onset of symptoms is not known...
  19. doi request reprint Prefrontal gyral folding and its cognitive correlates in bipolar disorder and schizophrenia
    A M McIntosh
    Division of Psychiatry, University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, Edinburgh EH105HF, UK
    Acta Psychiatr Scand 119:192-8. 2009
    ..We sought to address whether dorsal or ventral prefrontal gyrification is abnormal in bipolar disorder and to determine its diagnostic specificity and cognitive associations...
  20. doi request reprint Hippocampal function in schizophrenia and bipolar disorder
    J Hall
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK
    Psychol Med 40:761-70. 2010
    ..However, no previous studies have compared hippocampal activation in schizophrenia and bipolar disorder directly...
  21. ncbi request reprint A common neural system mediating two different forms of social judgement
    J Hall
    Division of Psychiatry, University of Edinburgh, Edinburgh EH10 5HF, UK
    Psychol Med 40:1183-92. 2010
    ..We have investigated healthy control participants to see whether there is a common neural system activated during such social decisions, on the basis that deficits in this system may contribute to the impairments seen in these disorders...
  22. doi request reprint Amygdala volume in a population with special educational needs at high risk of schizophrenia
    K A Welch
    Division of Psychiatry, School of Molecular and Clinical Medicine, University of Edinburgh, Edinburgh EH10 5HF, UK
    Psychol Med 40:945-54. 2010
    ..We predicted that people with intellectual impairment and schizotypal features would exhibit amygdala volume reduction as one of the neuroanatomical abnormalities associated with schizophrenia...
  23. doi request reprint fMRI changes over time and reproducibility in unmedicated subjects at high genetic risk of schizophrenia
    H C Whalley
    Division of Psychiatry, School of Molecular and Clinical Medicine, University of Edinburgh, Edinburgh, UK
    Psychol Med 39:1189-99. 2009
    ..e. state effects)...
  24. ncbi request reprint Edinburgh high risk study--findings after four years: demographic, attainment and psychopathological issues
    E C Johnstone
    University Department of Psychiatry, Kennedy Tower, Royal Edinburgh Hospital, Morningside Park, EH10 5HF, Edinburgh, UK
    Schizophr Res 46:1-15. 2000
    ..Clinical schizophrenia has so far developed in 10 high risk subjects and in no controls. Possible confounding effects of drug or alcohol misuse were considered but were found unlikely to be important...
  25. ncbi request reprint Relationship of catechol-O-methyltransferase variants to brain structure and function in a population at high risk of psychosis
    Andrew M McIntosh
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, United Kingdom
    Biol Psychiatry 61:1127-34. 2007
    ....
  26. ncbi request reprint Brain structure, genetic liability, and psychotic symptoms in subjects at high risk of developing schizophrenia
    S M Lawrie
    Edinburgh University Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh, Scotland, United Kingdom
    Biol Psychiatry 49:811-23. 2001
    ..Particular risk factors for schizophrenia may interact at discrete time points of neurodevelopment with different effects on specific brain regions and may represent relatively distinct disease processes...
  27. ncbi request reprint Genetic liability, illicit drug use, life stress and psychotic symptoms: preliminary findings from the Edinburgh study of people at high risk for schizophrenia
    P Miller
    University Department of Psychiatry, Royal Edinburgh Hospital, UK
    Soc Psychiatry Psychiatr Epidemiol 36:338-42. 2001
    ..CONCLUSIONS: Cannabis use, use of other illicit substances and upsetting life events may all lead to psychotic symptoms in vulnerable young people...
  28. ncbi request reprint Methodological issues in volumetric magnetic resonance imaging of the brain in the Edinburgh High Risk Project
    H C Whalley
    Department of Psychiatry, Royal Edinburgh Hospital, UK
    Psychiatry Res 91:31-44. 1999
    ....
  29. doi request reprint A diffusion tensor MRI study of white matter integrity in subjects at high genetic risk of schizophrenia
    S Muñoz Maniega
    Division of Clinical Neurosciences, University of Edinburgh, Edinburgh, UK
    Schizophr Res 106:132-9. 2008
    ..We also found reduced FA in the ALIC of both patients and subjects at high risk of schizophrenia when compared to controls. This may be a possible indicator of the higher vulnerability of relatives to develop the disorder...
  30. ncbi request reprint The effects of a neuregulin 1 variant on white matter density and integrity
    A M McIntosh
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK
    Mol Psychiatry 13:1054-9. 2008
    ..This finding is discussed in the context of NRG1 effects on neuronal migration, axon guidance and myelination...
  31. doi request reprint Tensor-based morphometry of cannabis use on brain structure in individuals at elevated genetic risk of schizophrenia
    K A Welch
    Division of Psychiatry, School of Molecular and Clinical Medicine, University of Edinburgh, Royal Edinburgh Hospital, UK
    Psychol Med 43:2087-96. 2013
    ..We used automated image analysis to compare brain structural changes over time in people at elevated risk of schizophrenia for familial reasons who did and did not use cannabis...
  32. pmc The influence of polygenic risk for bipolar disorder on neural activation assessed using fMRI
    H C Whalley
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK
    Transl Psychiatry 2:e130. 2012
    ..The findings suggest that this novel polygenic approach to examine brain-imaging data may be a useful means of identifying genetically mediated traits mechanistically linked to the aetiology of BD...
  33. doi request reprint Anterior cingulate morphology in people at genetic high-risk of schizophrenia
    S M Meredith
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, United Kingdom
    Eur Psychiatry 27:377-85. 2012
    ..We also investigated the association of the cingulate sulcus (CS) and paracingulate sulcus (PCS) variants with intelligence quotient (IQ)...
  34. doi request reprint Orbitofrontal morphology in people at high risk of developing schizophrenia
    G Chakirova
    Imaging lab, Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Kennedy Tower, EH10 5HF, Edinburgh, Scotland, UK
    Eur Psychiatry 25:366-72. 2010
    ..Abnormalities of orbitofrontal cortex (OFC) sulcogyral patterns have been reported in schizophrenia, but it is not known if these predate psychosis...
  35. ncbi request reprint Diffusion tensor imaging (DTI) and proton magnetic resonance spectroscopy (1H MRS) in schizophrenic subjects and normal controls
    R M Steel
    University of Edinburgh, Department of Psychiatry, Kennedy Tower, Royal Edinburgh Hospital, Morningside Park, EH10 5HF, Edinburgh, UK
    Psychiatry Res 106:161-70. 2001
    ....
  36. ncbi request reprint Functional imaging as a predictor of schizophrenia
    Heather C Whalley
    Division of Psychiatry, University of Edinburgh, Edinburgh, Scotland, UK
    Biol Psychiatry 60:454-62. 2006
    ..Prospective studies of young individuals at high risk of schizophrenia allow the investigation of whether neural abnormalities predate development of illness and, if present, have the potential to identify those who may become ill...
  37. doi request reprint Neuroticism, depressive symptoms and white-matter integrity in the Lothian Birth Cohort 1936
    A M McIntosh
    Division of Psychiatry, University of Edinburgh, UK
    Psychol Med 43:1197-206. 2013
    ..We tested whether depressive symptoms were related to reduced white-matter tract fractional anisotropy (FA), a measure of integrity, and then examined whether high neuroticism or low extraversion mediated this relationship...
  38. ncbi request reprint Set shifting and reversal learning in patients with bipolar disorder or schizophrenia
    J McKirdy
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK
    Psychol Med 39:1289-93. 2009
    ..Deficits in reversal learning (RL) have also been shown in schizophrenia but not in bipolar disorder. This study sought to assess the specificity of these findings in a direct comparison of clinically stable patients with each disorder...
  39. ncbi request reprint Connecting the brain and new drug targets for schizophrenia
    H C Whalley
    Division of Psychiatry, University of Edinburgh, Edinburgh, Scotland, UK
    Curr Pharm Des 15:2615-31. 2009
    ..We conclude that substantial work needs to be done on standardising connectivity analyses across laboratories and that disconnectivity studies should be an integral part of drug discovery programmes...
  40. ncbi request reprint Declarative memory in unaffected adult relatives of patients with schizophrenia: a systematic review and meta-analysis
    Marie Claire Whyte
    Division of Psychiatry, University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, Morningside Park, Edinburgh, EH10 5HF, UK
    Schizophr Res 78:13-26. 2005
    ..Investigation of sub-groups within these cohorts (e.g. age groups within or beyond the maximum age of risk) is recommended in order to identify deficits specific to the disease process...
  41. ncbi request reprint Neuropsychological performance over time in people at high risk of developing schizophrenia and controls
    Marie Claire Whyte
    Division of Psychiatry, University of Edinburgh, Morningside Park, Edinburgh, United Kingdom
    Biol Psychiatry 59:730-9. 2006
    ..We sought to: (1) determine baseline neurocognitive predictors of psychosis, and (2) compare performance over time between relatives within the age of maximum risk, and controls...
  42. ncbi request reprint A factor model of the functional psychoses and the relationship of factors to clinical variables and brain morphology
    A M McIntosh
    Department of Psychiatry, University of Edinburgh
    Psychol Med 31:159-71. 2001
    ..We propose that the use of symptom factors may facilitate the investigation of the underlying mechanisms of psychotic illness...
  43. pmc Structural MRI of the brain in presumed carriers of genes for schizophrenia, their affected and unaffected siblings
    R M Steel
    University of Edinburgh, Department of Psychiatry, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF, UK
    J Neurol Neurosurg Psychiatry 72:455-8. 2002
    ..Schizophrenia is a highly heritable disorder associated with structural brain abnormalities. The aim of this study was to establish if the gene(s) for schizophrenia are associated with specific abnormalities of brain structure...
  44. ncbi request reprint Sustained attention in young people at high risk for schizophrenia
    R Cosway
    Department of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Morningside Park
    Psychol Med 32:277-86. 2002
    ..Sustained attention has been found to be impaired in individuals suffering from schizophrenia and their close relatives. This has led to the hypothesis that impaired sustained attention is an indicator of vulnerability to schizophrenia...
  45. ncbi request reprint Self-rated schizotypal cognitions, psychotic symptoms and the onset of schizophrenia in young people at high risk of schizophrenia
    P McC Miller
    Department of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF, UK
    Acta Psychiatr Scand 105:341-5. 2002
    ....
  46. doi request reprint Specific cognitive deficits in a group at genetic high risk of schizophrenia
    M O'CONNOR
    University of Edinburgh, UK
    Psychol Med 39:1649-55. 2009
    ....
  47. ncbi request reprint fMRI correlates of state and trait effects in subjects at genetically enhanced risk of schizophrenia
    H C Whalley
    Division of Psychiatry, University of Edinburgh, Edinburgh EH10 5HF, UK
    Brain 127:478-90. 2004
    ....
  48. ncbi request reprint Childhood behaviour, psychotic symptoms and psychosis onset in young people at high risk of schizophrenia: early findings from the edinburgh high risk study
    P M Miller
    Department of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital
    Psychol Med 32:173-9. 2002
    ..Several studies suggest that many patients with schizophrenia have pre-morbid neurodevelopmental abnormalities. This study examines how behavioural abnormalities are associated with mild psychotic symptoms and later schizophrenic illness...
  49. doi request reprint Functional magnetic resonance imaging of BDNF val66met polymorphism in unmedicated subjects at high genetic risk of schizophrenia performing a verbal memory task
    Benjamin J Baig
    Division of Psychiatry, University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, Morningside Park, Edinburgh, United Kingdom
    Psychiatry Res 183:195-201. 2010
    ....
  50. ncbi request reprint Changes in gyrification over 4 years in bipolar disorder and their association with the brain-derived neurotrophic factor valine(66) methionine variant
    Ajay Mirakhur
    Division of Psychiatry, University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, Edinburgh EH10 5HF, United Kingdom
    Biol Psychiatry 66:293-7. 2009
    ..The present study examined longitudinal trends in prefrontal gyrification index (GI) in bipolar disorder and the effect of BDNF genotype...
  51. doi request reprint Hypofrontality in subjects at high genetic risk of schizophrenia with depressive symptoms
    H C Whalley
    Division of Psychiatry, School of Molecular and Clinical Medicine, University of Edinburgh, Edinburgh, Scotland, UK
    J Affect Disord 109:99-106. 2008
    ..The current study sought to investigate the neural correlates of depression in these subjects. We hypothesised abnormal activation of dorsolateral prefrontal regions in those at high risk with depression...
  52. doi request reprint Genetic risk for white matter abnormalities in bipolar disorder
    Andrew M McIntosh
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK
    Int Rev Psychiatry 21:387-93. 2009
    ..These findings are discussed in the context of the current literature, along with possible future research directions...
  53. ncbi request reprint Progressive gray matter loss in patients with bipolar disorder
    T William J Moorhead
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, United Kingdom
    Biol Psychiatry 62:894-900. 2007
    ..We sought to address these uncertainties in a prospective cohort study of people with bipolar I disorder...
  54. ncbi request reprint The neurobiological underpinnings of risk and conversion in relatives of patients with schizophrenia
    Heather C Whalley
    Division of Psychiatry, University of Edinburgh, Scotland, UK
    Int Rev Psychiatry 19:383-97. 2007
    ..The literature on predictors of conversion in people at genetic high risk is much smaller, but suggests a combination of baseline trait severity and further change in key measures...
  55. ncbi request reprint Reduced frontotemporal functional connectivity in schizophrenia associated with auditory hallucinations
    Stephen M Lawrie
    University Department of Psychiatry, Royal Edinburgh Hospital, Morningside Park, Edinburgh, Scotland, UK
    Biol Psychiatry 51:1008-11. 2002
    ..We used functional magnetic resonance imaging (fMRI) to investigate the frontotemporal disconnection hypothesis of schizophrenia...
  56. ncbi request reprint Gyrification in first-episode schizophrenia: a morphometric study
    Jonathan M Harris
    University Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh, United Kingdom
    Biol Psychiatry 55:141-7. 2004
    ..This study aimed to determine whether there are differences in gyral folding in schizophrenia by conducting a detailed analysis of magnetic resonance images...
  57. ncbi request reprint Maternal recall bias, obstetric history and schizophrenia
    A M McIntosh
    Royal Edinburgh Hospital, UK
    Br J Psychiatry 181:520-5. 2002
    ..This study sought to clarify the role of obstetric complications (OCs) and maternal recall bias for patients with first episodes of schizophrenia and those at increased risk of the disorder...
  58. doi request reprint Deficits in facial, body movement and vocal emotional processing in autism spectrum disorders
    R C M Philip
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK
    Psychol Med 40:1919-29. 2010
    ..To date, however, no studies have examined emotion processing in autism across a broad range of social signals...
  59. ncbi request reprint Structural disconnectivity in schizophrenia: a diffusion tensor magnetic resonance imaging study
    J Burns
    Department of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, UK
    Br J Psychiatry 182:439-43. 2003
    ..Diffusion tensor magnetic resonance imaging (DT-MRI) is a technique that has the potential to demonstrate structural disconnectivity in schizophrenia...
  60. ncbi request reprint Neuropsychology, genetic liability, and psychotic symptoms in those at high risk of schizophrenia
    Majella Byrne
    University Department of Psychiatry, University of Edinburgh, Scotland
    J Abnorm Psychol 112:38-48. 2003
    ..These results suggest that what is inherited is not the disorder itself but a state of vulnerability manifested by neuropsychological impairment, occurring in many more individuals than are predicted to develop the disorder...
  61. ncbi request reprint Schizophrenia and complications of pregnancy and labor: an individual patient data meta-analysis
    J R Geddes
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Schizophr Bull 25:413-23. 1999
    ..We conclude that some abnormalities of pregnancy and delivery may be associated with development of schizophrenia. The pathophysiology may involve hypoxia and so future studies should focus on the accurate measurement of this exposure...
  62. ncbi request reprint Voxel-based morphometry of comorbid schizophrenia and learning disability: analyses in normalized and native spaces using parametric and nonparametric statistical methods
    T William J Moorhead
    Image Analysis Laboratory, Division of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh, Edinburgh EH10 5HF, Scotland, UK
    Neuroimage 22:188-202. 2004
    ..VBM has the facility to compare grey matter distributions in this structurally diverse cohort...
  63. ncbi request reprint Voxel-based morphometry of patients with schizophrenia or bipolar disorder and their unaffected relatives
    Andrew M McIntosh
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, United Kingdom
    Biol Psychiatry 56:544-52. 2004
    ..This study sought to examine these issues and clarify the associations of phenotypic expression and genetic liability...
  64. ncbi request reprint Predicting schizophrenia: findings from the Edinburgh High-Risk Study
    Eve C Johnstone
    Division of Psychiatry, University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF, UK
    Br J Psychiatry 186:18-25. 2005
    ..The hypothesis that schizophrenia is neurodevelopmental was investigated in a prospective study of young people with a postulated 10-15% risk for the development of schizophrenia...
  65. doi request reprint Associative learning and the genetics of schizophrenia
    Jeremy Hall
    Division of Psychiatry, University of Edinburgh, Edinburgh, EH10 5HF, UK
    Trends Neurosci 32:359-65. 2009
    ..We illustrate how genetic variation in genes from these classes can contribute to the development of psychosis using data from the Edinburgh High Risk Study of schizophrenia...
  66. ncbi request reprint Structural abnormalities of ventrolateral and orbitofrontal cortex in patients with familial bipolar disorder
    Andrew C Stanfield
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK
    Bipolar Disord 11:135-44. 2009
    ..We examined the presence and location of ventral prefrontal abnormalities in a large sample of individuals with bipolar disorder and their relationship to gender, psychotic symptoms, and age...
  67. ncbi request reprint Grey matter changes over time in high risk subjects developing schizophrenia
    Dominic E Job
    Division of Psychiatry, University of Edinburgh, The Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF, Scotland, UK
    Neuroimage 25:1023-30. 2005
    ..These particular reductions may therefore be able to predict the later onset of schizophrenia...
  68. doi request reprint White matter tractography in bipolar disorder and schizophrenia
    Andrew M McIntosh
    Division of Psychiatry, University of Edinburgh, Edinburgh United Kingdom
    Biol Psychiatry 64:1088-92. 2008
    ....
  69. ncbi request reprint Obstetric complications and mild to moderate intellectual disability
    Jessika E Sussmann
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh EH10 5HF, UK
    Br J Psychiatry 194:224-8. 2009
    ..Mild to moderate intellectual disability affects 2.5% of the general population and is associated with an increased risk of several psychiatric disorders. Most cases are of unknown aetiology although genetic factors have an important role...
  70. ncbi request reprint Voxel-based morphometry of grey matter densities in subjects at high risk of schizophrenia
    Dominic E Job
    Department of Psychiatry, University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF, Scotland, UK
    Schizophr Res 64:1-13. 2003
    ..control subjects. In contrast, first episode schizophrenia subjects had less GM than high-risk subjects in several frontal and temporal regions. These results are compatible with the findings of our previous volumetric ROI analysis...
  71. ncbi request reprint Schizotypal components in people at high risk of developing schizophrenia: early findings from the Edinburgh High-Risk Study
    Patrick Miller
    Department of Psychiatry, University of Edinburgh, UK
    Br J Psychiatry 180:179-84. 2002
    ..The study of high-risk groups and the development of schizophrenia...
  72. doi request reprint Effects of the BDNF Val66Met polymorphism on neural responses to facial emotion
    Prerona Mukherjee
    Division of Psychiatry, University of Edinburg, Edinburg, United Kingdom
    Psychiatry Res 191:182-8. 2011
    ..Together, these effects show significant differences in the neural substrate for fear processing with genetic variation in BDNF...
  73. pmc DISC1 in schizophrenia: genetic mouse models and human genomic imaging
    Mandy Johnstone
    Department of Psychiatry, The Royal Edinburgh Hospital, Morningside Terrace, Edinburgh EH10 5HF, UK
    Schizophr Bull 37:14-20. 2011
    ..Here, we focus on the growing literature relating genetic variation in the DISC1 pathway to functional and structural studies of the brain in humans and in the mouse...
  74. doi request reprint Midbrain activation during Pavlovian conditioning and delusional symptoms in schizophrenia
    Liana Romaniuk
    University of Edinburgh, Royal Edinburgh Hospital, Scotland
    Arch Gen Psychiatry 67:1246-54. 2010
    ..Recent theories have suggested that the inappropriate activation of limbic motivational systems in response to neutral stimuli may underlie the development of delusions in schizophrenia...
  75. doi request reprint Effects of the BDNF val66met polymorphism on prefrontal brain function in a population at high genetic risk of schizophrenia
    Heather C Whalley
    Division of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh, Edinburgh, UK
    Am J Med Genet B Neuropsychiatr Genet 153:1474-82. 2010
    ..BDNF may therefore be one of the heritable factors involved in the development of abnormal prefrontal function in schizophrenia. © 2010 Wiley-Liss, Inc...
  76. ncbi request reprint A neuregulin 1 variant associated with abnormal cortical function and psychotic symptoms
    Jeremy Hall
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Morningside Park, Edinburgh, EH10 5HF, UK
    Nat Neurosci 9:1477-8. 2006
    ..We show that this variant is associated with (i) decreased activation of frontal and temporal lobe regions, (ii) increased development of psychotic symptoms and (iii) decreased premorbid IQ...
  77. doi request reprint White matter abnormalities in bipolar disorder and schizophrenia detected using diffusion tensor magnetic resonance imaging
    Jessika E Sussmann
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK
    Bipolar Disord 11:11-8. 2009
    ..Diffusion tensor imaging (DTI) studies suggest altered connectivity in both disorders. We aim to address the diagnostic specificity of white matter abnormalities in these disorders...
  78. doi request reprint Functional imaging of emotional memory in bipolar disorder and schizophrenia
    Heather C Whalley
    Division of Psychiatry, School of Molecular and Clinical Medicine, University of Edinburgh, Edinburgh, Scotland, UK
    Bipolar Disord 11:840-56. 2009
    ..We also investigate associations between activation levels and symptom severity across the disorders...
  79. doi request reprint Genetic variation in the DAOA (G72) gene modulates hippocampal function in subjects at high risk of schizophrenia
    Jeremy Hall
    Division of Psychiatry, University of Edinburgh, United Kingdom
    Biol Psychiatry 64:428-33. 2008
    ..Preliminary evidence in healthy control subjects has implicated genetic variation in the DAOA gene in the modulation of hippocampal complex and prefrontal cortex activation...
  80. ncbi request reprint Overactivation of fear systems to neutral faces in schizophrenia
    Jeremy Hall
    Division of Psychiatry, University of Edinburgh, United Kingdom
    Biol Psychiatry 64:70-3. 2008
    ..We investigated whether the apparent decrease in amygdala activation in schizophrenia could actually derive from increased amygdala activation to the neutral comparator stimuli...
  81. ncbi request reprint Grey matter correlates of early psychotic symptoms in adolescents at enhanced risk of psychosis: a voxel-based study
    Michael D Spencer
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, EH10 5HF, UK
    Neuroimage 35:1181-91. 2007
    ....
  82. ncbi request reprint Emotional memory in schizophrenia
    Jeremy Hall
    Division of Psychiatry, University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, Edinburgh EH10 5HF, UK
    Neuropsychologia 45:1152-9. 2007
    ..These findings are consistent with the view that medial temporal lobe and in particular amygdala function is abnormal in schizophrenia...
  83. ncbi request reprint Increased right prefrontal cortical folding in adolescents at risk of schizophrenia for cognitive reasons
    Andrew C Stanfield
    Division of Psychiatry, School of Molecular and Clinical Medicine, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, United Kingdom
    Biol Psychiatry 63:80-5. 2008
    ..We examined the association between these measures in adolescents at enhanced risk of developing schizophrenia due to cognitive impairment...
  84. ncbi request reprint Empirical comparison of maximal voxel and non-isotropic adjusted cluster extent results in a voxel-based morphometry study of comorbid learning disability with schizophrenia
    T William J Moorhead
    Division of Psychiatry, Image Analysis Laboratory, University of Edinburgh, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF, Scotland UK
    Neuroimage 28:544-52. 2005
    ....
  85. ncbi request reprint What does the Edinburgh high-risk study tell us about schizophrenia?
    Eve C Johnstone
    University Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh, Scotland, UK
    Am J Med Genet 114:906-12. 2002
    ..It is suggested that in high-risk subjects, the change from vulnerability to psychosis may be preceded by reduction in size and deteriorating function of the temporal lobe...
  86. ncbi request reprint Towards a neuroanatomy of autism: a systematic review and meta-analysis of structural magnetic resonance imaging studies
    Andrew C Stanfield
    Division of Psychiatry, School of Molecular and Clinical Medicine, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK
    Eur Psychiatry 23:289-99. 2008
    ..Structural brain abnormalities have been described in autism but studies are often small and contradictory. We aimed to identify which brain regions can reliably be regarded as different in autism compared to healthy controls...
  87. ncbi request reprint Structural correlates of intellectual impairment and autistic features in adolescents
    Michael D Spencer
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, EH10 5HF, UK
    Neuroimage 33:1136-44. 2006
    ....
  88. ncbi request reprint Functional disconnectivity in subjects at high genetic risk of schizophrenia
    Heather C Whalley
    Division of Psychiatry, School of Informatics, University of Edinburgh, Edinburgh, Scotland
    Brain 128:2097-108. 2005
    ..These connectivity abnormalities may underlie the diverse deficits seen in the established condition and the more subtle deficits seen in close relatives of those with the disorder...
  89. ncbi request reprint Neural correlates of enhanced genetic risk for schizophrenia
    Heather C Whalley
    Division of Psychiatry, University of Edinburgh, Edinburgh, Scotland
    Neuroscientist 11:238-49. 2005
    ..In this article, studies on such individuals are discussed. It is concluded that deficits are apparent in relatives that are similar to but less marked than those seen in patients with schizophrenia...
  90. ncbi request reprint Brain-behaviour relationships in people at high genetic risk of schizophrenia
    G Katherine S Lymer
    Division of Psychiatry, School of Molecular and Clinical Medicine, The University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF, UK
    Neuroimage 33:275-85. 2006
    ..These results suggest complex and changing patterns of structural-functional relationships in those subjects at high-risk of schizophrenia...
  91. ncbi request reprint Automated computation of the Gyrification Index in prefrontal lobes: methods and comparison with manual implementation
    T William J Moorhead
    Division of Psychiatry, University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF, Scotland, UK
    Neuroimage 31:1560-6. 2006
    ..A-GI is therefore a reliable measure of cortical folding that could be usefully applied to a number of MRI data sets of the brain in health and disease...
  92. ncbi request reprint Schizotypal cognitions as a predictor of psychopathology in adolescents with mild intellectual impairment
    Eve C Johnstone
    Division of Psychiatry, Kennedy Tower, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF, UK
    Br J Psychiatry 191:484-92. 2007
    ..It is suggested that they may be detectable by simple means...
  93. ncbi request reprint White matter density in patients with schizophrenia, bipolar disorder and their unaffected relatives
    Andrew M McIntosh
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh EH10 5HF, Scotland, UK
    Biol Psychiatry 58:254-7. 2005
    ..This study sought to assess white matter density in patients and relatives with histories of bipolar disorder and/or schizophrenia...
  94. ncbi request reprint Genetic liability to schizophrenia or bipolar disorder and its relationship to brain structure
    Andrew M McIntosh
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh EH 10 5HF, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 141:76-83. 2006
    ..Genes for bipolar illness might have subtle effects on brain structure, which may need particularly large samples to detect...
  95. doi request reprint Prefrontal function and activation in bipolar disorder and schizophrenia
    Andrew M McIntosh
    Division of Psychiatry, University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, Edinburgh, UK
    Am J Psychiatry 165:378-84. 2008
    ..The authors sought to determine whether there are differences in language-associated prefrontal activation that discriminate bipolar disorder and schizophrenia...
  96. ncbi request reprint Pathogenesis of schizophrenia: a psychopathological perspective
    D G Cunningham Owens
    University of Edinburgh, Division of Psychiatry, Kennedy Tower, Royal Edinburgh Hospital, Morningside Terrace, Edinburgh EH10 5HF, UK
    Br J Psychiatry 186:386-93. 2005
    ..Despite interest in early treatment of schizophrenia, premorbid and prodromal symptomatology remain poorly delineated...
  97. ncbi request reprint Neuropsychological impairments in people with schizophrenia or bipolar disorder and their unaffected relatives
    Andrew M McIntosh
    Division of Psychiatry, Royal Edinburgh Hospital, Edinburgh EH10 5HF, UK
    Br J Psychiatry 186:378-85. 2005
    ..Neuropsychological abnormalities in schizophrenia are well replicated and are present in unaffected relatives. Cognitive findings in bipolar disorder are less clearly established...
  98. ncbi request reprint Increased prefrontal gyrification in a large high-risk cohort characterizes those who develop schizophrenia and reflects abnormal prefrontal development
    Jonathan M Harris
    Division of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom
    Biol Psychiatry 62:722-9. 2007
    ....
  99. doi request reprint The effects of DISC1 risk variants on brain activation in controls, patients with bipolar disorder and patients with schizophrenia
    Goultchira Chakirova
    The University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, Scotland, UK
    Psychiatry Res 192:20-8. 2011
    ..These findings may provide a better understanding of the neural effects of DISC1 variants and on the pathophysiology of schizophrenia and bipolar disorder...
  100. ncbi request reprint Compliance therapy for schizophrenia
    A M McIntosh
    University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK EH10 5HF
    Cochrane Database Syst Rev 3:CD003442. 2006
    ..Schizophrenia is a severe mental illness characterised by delusions and hallucinations. Antipsychotic drugs does reduce these symptoms, but at least half of people given these drugs do not comply with the treatment regimen prescribed...