Research Topics
Species | Charles Henderson LawrieSummaryAffiliation: University of Oxford Country: UK Publications
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Publications
Ixodid and argasid tick species and west nile virusCharles Henderson Lawrie
Centre for Ecology and Hydrology, Oxford, United Kingdom
Emerg Infect Dis 10:653-7. 2004..moubata ticks co-fed upon uninfected hosts. Although ticks are unlikely to play a major role in WNV transmission, our findings suggest that some species have the potential to act as reservoirs for the virus...
MicroRNA expression distinguishes between germinal center B cell-like and activated B cell-like subtypes of diffuse large B cell lymphomaCharles H Lawrie
Nuffield Department of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
Int J Cancer 121:1156-61. 2007..001), we suggest that microRNAs could be clinically useful molecular markers for DLBCL as well as other cancers...
MicroRNA expression in lymphoid malignancies: new hope for diagnosis and therapy?Charles Henderson Lawrie
Nuffield Department of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UK
J Cell Mol Med 12:1432-44. 2008....- MicroRNAs in hematological malignanciesCharles H Lawrie
Biodonostia Research Institute, San Sebastian, Spain IKERBASQUE, Basque Foundation for Science, Bilbao, Spain Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Oxford, UK Electronic address
Blood Rev 27:143-54. 2013..Although still in its infancy, the miRNA field has already added much to our understanding of hematological processes, and provides us with novel tools as both biomarkers and therapeutic agents for hematological malignancies... - Inter- and intra-observational variability in immunohistochemistry: a multicentre analysis of diffuse large B-cell lymphoma stainingCharles H Lawrie
Biodonostia Research Institute, San Sebastian, and IKERBASQUE, Basque Foundation for Science, Bilbao, Spain
Histopathology 61:18-25. 2012..However, despite the obvious need to address such variability, very few studies have done so... - MicroRNA expression in multiple myeloma is associated with genetic subtype, isotype and survivalJianxiang Chi
Nuffield Department of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, UK
Biol Direct 6:23. 2011..0) of purified tumor (CD138+) cells from 33 patients with MM, 5 patients with monoclonal gammopathy of undetermined significance (MGUS) and 9 controls... - microRNA expression in erythropoiesis and erythroid disordersCharles H Lawrie
Lymphoid Malignancy Research Group, Nuffield Department of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UK
Br J Haematol 150:144-51. 2010..In this review the rapidly accumulating evidence that points to the major role microRNAs play in both erythropoiesis and erythroid disorders is discussed... - Expression of microRNAs in diffuse large B cell lymphoma is associated with immunophenotype, survival and transformation from follicular lymphomaCharles H Lawrie
Nuffield Department of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UK
J Cell Mol Med 13:1248-60. 2009..05). These data suggest that microRNAs have potential as diagnostic and prognostic markers in these lymphomas and may be used to identify FCL patients at risk of high-grade transformation... - Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphomaCharles H Lawrie
Nuffield Department of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UK
Br J Haematol 141:672-5. 2008..05). This is the first description of circulating microRNAs and suggests that microRNAs have potential as non-invasive diagnostic markers for DLBCL and possibly other cancers... - MicroRNA expression in lymphomaCharles H Lawrie
University of Oxford, Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Oxford, OX3 9DU, UK
Expert Opin Biol Ther 7:1363-74. 2007..In this review the authors discuss the rapidly accumulating evidence for the central role that microRNAs play in both haematopoiesis and haematological malignancy, in particular focusing on their role in lymphoma... - Susceptibility of mosquito and tick cell lines to infection with various flavivirusesC H Lawrie
Nuffield Department of Clinical Laboratory Sciences, University of Oxford, UK
Med Vet Entomol 18:268-74. 2004.... - MicroRNAs and haematology: small molecules, big functionCharles H Lawrie
Nuffield Department of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UK
Br J Haematol 137:503-12. 2007..g. MIRN155 (miR-155) and MIRN17-92 (miR-17-miR-92) cluster] in lymphomas. This review discusses the rapidly accumulating research that points to the major role microRNAs play in both haematopoiesis and haematological malignancy... - Cancer-associated carbohydrate identification in Hodgkin's lymphoma by carbohydrate array profilingCharles H Lawrie
Nuffield Department of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, UK
Int J Cancer 118:3161-6. 2006..271). We suggest that this technique could provide a powerful tool for identifying novel carbohydrates in other cancers... - Investigation of the mechanisms of anti-complement activity in Ixodes ricinus ticksCharles H Lawrie
LRF Immunodiagnostics Unit, Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Level 5, Academic Block, University of Oxford, Oxford OX3 9DU, UK
Mol Immunol 42:31-8. 2005..The activity was specific for the alpha-chain of C3 but not of C3(H2O) nor the alpha'-chain of C3b. It is proposed that SGE-modified C3 does not participate in convertase formation, probably having a reduced affinity for factor B... - MicroRNA expression in Sezary syndrome: identification, function, and diagnostic potentialErica Ballabio
Nuffield Department of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
Blood 116:1105-13. 2010..We also provide the first in vivo evidence for down-regulation of the miR-17-92 cluster in malignancy and demonstrate that ectopic miR-17-5p expression increases apoptosis and decreases cell proliferation in SzS cells... - CD4-positive T-helper cell responses to the PASD1 protein in patients with diffuse large B-cell lymphomaKamel Ait-Tahar
Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Oxford, UK
Haematologica 96:78-86. 2011.... - Gene expression profiling of CD34+ cells in patients with the 5q- syndromeJacqueline Boultwood
LRF Molecular Haematology Unit, NDCLS, John Radcliffe Hospital, Oxford, UK
Br J Haematol 139:578-89. 2007..This study suggests that several of the genes mapping to the CDR of the 5q- syndrome play a role in the pathogenesis of this disorder... - MORC4, a novel member of the MORC family, is highly expressed in a subset of diffuse large B-cell lymphomasAmanda P Liggins
LRF Lymphoma Antigens Group, John Radcliffe Hospital, Oxford, Oxfordshire, UK
Br J Haematol 138:479-86. 2007..0031). The differential expression of MORC4 identifies this molecule as a potential lymphoma biomarker, whose overexpression may contribute to the immunological recognition of MORC4 by a subgroup of DLBCL patients... - Aberrant expression of the neuronal transcription factor FOXP2 in neoplastic plasma cellsAndrew J Campbell
Nuffield Department of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UK
Br J Haematol 149:221-30. 2010..FOXP2 represents the first transcription factor whose expression consistently differentiates normal and abnormal plasma cells and FOXP2 target genes are implicated in MM pathogenesis...