Peter A Lawrence
Affiliation: University of Cambridge
Lawrence P, Sanson B, Vincent J. Compartments, wingless and engrailed: patterning the ventral epidermis of Drosophila embryos. Development. 1996;122:4095-103 pubmed
..Supporting the hypothesis that Wingless acts as a morphogen, we find that these stripes affect, at a distance, the type of cuticle formed and the planar polarity of the cells. ..
Lawrence P. The politics of publication. Nature. 2003;422:259-61 pubmed
Lawrence P. Morphogens: how big is the big picture?. Nat Cell Biol. 2001;3:E151-4 pubmed
..Morphogens are in the front line just now. Here I trace how the concept of a morphogen has evolved over the past 100 years and step a little beyond what we already know. ..
Lawrence P. Rank injustice. Nature. 2002;415:835-6 pubmed
Lawrence P, Struhl G, Casal J. Planar cell polarity: one or two pathways?. Nat Rev Genet. 2007;8:555-63 pubmed
..We argue that the prevailing opinion that planar polarity depends on a single genetic pathway is wrong and conclude that there are (at least) two independently acting processes. This conclusion has major consequences for the PCP field. ..
Lawrence P, Casal J, Struhl G. hedgehog and engrailed: pattern formation and polarity in the Drosophila abdomen. Development. 1999;126:2431-9 pubmed
..Finally, we find that when engrailed is removed from P cells (of, say, segment A5) they transform not into A cells of the same segment, but into A cells of the same parasegment (segment A6). ..
Lawrence P, Casal J, Struhl G. The hedgehog morphogen and gradients of cell affinity in the abdomen of Drosophila. Development. 1999;126:2441-9 pubmed
..Within the P compartment we found some evidence for a U-shaped gradient of affinity, but this cannot be due to Hedgehog which does not act in the P compartment. ..
Lawrence P, Casal J, Struhl G. Cell interactions and planar polarity in the abdominal epidermis of Drosophila. Development. 2004;131:4651-64 pubmed
..However, some results do not fit with this view--we suggest that these localisations may be more a consequence than a cause of planar polarity. ..