Peter A Lawrence

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint Compartments, wingless and engrailed: patterning the ventral epidermis of Drosophila embryos
    P A Lawrence
    Medical Research Council, Laboratory of Molecular Biology, Cambridge, UK
    Development 122:4095-103. 1996
  2. ncbi request reprint The politics of publication
    Peter A Lawrence
    MRC Laboratory of Molecular Biology, Cambridge CB2 2QH, UK
    Nature 422:259-61. 2003
  3. ncbi request reprint A Wigglesworth classic: how cells make patterns
    Peter Lawrence
    MRC Laboratory of Molecular Biology, Cambridge, UK
    J Exp Biol 207:192-3. 2004
  4. pmc Men, women, and ghosts in science
    Peter A Lawrence
    Laboratory of Molecular Biology, Medical Research Council, Cambridge, United Kingdom
    PLoS Biol 4:e19. 2006
  5. doi request reprint Retiring retirement
    Peter A Lawrence
    Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
    Nature 453:588-90. 2008
  6. pmc Four-jointed modulates growth and planar polarity by reducing the affinity of dachsous for fat
    Amy L Brittle
    Medical Research Council MRC Centre for Developmental and Biomedical Genetics and Department of Biomedical Science, University of Sheffield, Sheffield S10 2TN, UK
    Curr Biol 20:803-10. 2010
  7. pmc Planar cell polarity: A bridge too far?
    Peter A Lawrence
    Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
    Curr Biol 18:R959-61. 2008
  8. ncbi request reprint Cell interactions and planar polarity in the abdominal epidermis of Drosophila
    Peter A Lawrence
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Development 131:4651-64. 2004
  9. pmc Planar cell polarity: one or two pathways?
    Peter A Lawrence
    Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
    Nat Rev Genet 8:555-63. 2007
  10. pmc Do the protocadherins Fat and Dachsous link up to determine both planar cell polarity and the dimensions of organs?
    Peter A Lawrence
    Department of Zoology, Downing Street, University of Cambridge, Cambridge CB2 3EJ, UK
    Nat Cell Biol 10:1379-82. 2008

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Compartments, wingless and engrailed: patterning the ventral epidermis of Drosophila embryos
    P A Lawrence
    Medical Research Council, Laboratory of Molecular Biology, Cambridge, UK
    Development 122:4095-103. 1996
    ..Supporting the hypothesis that Wingless acts as a morphogen, we find that these stripes affect, at a distance, the type of cuticle formed and the planar polarity of the cells...
  2. ncbi request reprint The politics of publication
    Peter A Lawrence
    MRC Laboratory of Molecular Biology, Cambridge CB2 2QH, UK
    Nature 422:259-61. 2003
  3. ncbi request reprint A Wigglesworth classic: how cells make patterns
    Peter Lawrence
    MRC Laboratory of Molecular Biology, Cambridge, UK
    J Exp Biol 207:192-3. 2004
  4. pmc Men, women, and ghosts in science
    Peter A Lawrence
    Laboratory of Molecular Biology, Medical Research Council, Cambridge, United Kingdom
    PLoS Biol 4:e19. 2006
  5. doi request reprint Retiring retirement
    Peter A Lawrence
    Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
    Nature 453:588-90. 2008
  6. pmc Four-jointed modulates growth and planar polarity by reducing the affinity of dachsous for fat
    Amy L Brittle
    Medical Research Council MRC Centre for Developmental and Biomedical Genetics and Department of Biomedical Science, University of Sheffield, Sheffield S10 2TN, UK
    Curr Biol 20:803-10. 2010
    ....
  7. pmc Planar cell polarity: A bridge too far?
    Peter A Lawrence
    Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
    Curr Biol 18:R959-61. 2008
    ..The mechanisms of planar cell polarity are being revealed by genetic analysis. Recent studies have provided new insights into interactions between three proteins involved in planar cell polarity: Flamingo, Frizzled and Van Gogh...
  8. ncbi request reprint Cell interactions and planar polarity in the abdominal epidermis of Drosophila
    Peter A Lawrence
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Development 131:4651-64. 2004
    ..However, some results do not fit with this view--we suggest that these localisations may be more a consequence than a cause of planar polarity...
  9. pmc Planar cell polarity: one or two pathways?
    Peter A Lawrence
    Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
    Nat Rev Genet 8:555-63. 2007
    ..We argue that the prevailing opinion that planar polarity depends on a single genetic pathway is wrong and conclude that there are (at least) two independently acting processes. This conclusion has major consequences for the PCP field...
  10. pmc Do the protocadherins Fat and Dachsous link up to determine both planar cell polarity and the dimensions of organs?
    Peter A Lawrence
    Department of Zoology, Downing Street, University of Cambridge, Cambridge CB2 3EJ, UK
    Nat Cell Biol 10:1379-82. 2008
    ..Here we discuss recent evidence for a 'steepness hypothesis' that links these two apparently disconnected features of animal development...
  11. ncbi request reprint hedgehog and engrailed: pattern formation and polarity in the Drosophila abdomen
    P A Lawrence
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Development 126:2431-9. 1999
    ..Finally, we find that when engrailed is removed from P cells (of, say, segment A5) they transform not into A cells of the same segment, but into A cells of the same parasegment (segment A6)...
  12. ncbi request reprint The hedgehog morphogen and gradients of cell affinity in the abdomen of Drosophila
    P A Lawrence
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Development 126:2441-9. 1999
    ..Within the P compartment we found some evidence for a U-shaped gradient of affinity, but this cannot be due to Hedgehog which does not act in the P compartment...
  13. ncbi request reprint Science or alchemy?
    P A Lawrence
    Division of Cell Biology, MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Nat Rev Genet 2:139-42. 2001
    ..We sell our results, we hide our ignorance and we use stock terms that gain spurious weight through repeated use. I illustrate from the field of developmental genetics...
  14. ncbi request reprint Morphogens: how big is the big picture?
    P A Lawrence
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
    Nat Cell Biol 3:E151-4. 2001
    ..Morphogens are in the front line just now. Here I trace how the concept of a morphogen has evolved over the past 100 years and step a little beyond what we already know...
  15. ncbi request reprint Rank injustice
    Peter A Lawrence
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Nature 415:835-6. 2002
  16. ncbi request reprint Towards a model of the organisation of planar polarity and pattern in the Drosophila abdomen
    Peter A Lawrence
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Development 129:2749-60. 2002
    ..A simple model that accommodates our results is that X forms a monotonic gradient extending from the back of the A compartment to the front of the P compartment in the next segment, a unit constituting a parasegment...
  17. ncbi request reprint Q & A
    Peter Lawrence
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Curr Biol 13:R82. 2003
  18. pmc Two separate molecular systems, Dachsous/Fat and Starry night/Frizzled, act independently to confer planar cell polarity
    José Casal
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Development 133:4561-72. 2006
    ..We consider how polarity may be propagated by Ds-Ft heterodimers acting as bridges between cells...
  19. pmc Mechanosensilla in the adult abdomen of Drosophila: engrailed and slit help to corral the peripheral sensory axons into segmental bundles
    Caroline C G Fabre
    Department of Zoology, University of Cambridge, Cambridge, UK
    Development 137:2885-94. 2010
    ..We conclude that, during normal development, gradients of Slit protein repel axons away from compartment boundaries - in consequence, the bristles from each segment send their nerves to the CNS in separated sets...
  20. pmc The abdomen of Drosophila: does planar cell polarity orient the neurons of mechanosensory bristles?
    Caroline C G Fabre
    Department of Zoology, Downing St, Cambridge CB2 3EJ, UK, MRC Laboratory of Molecular Biology, Hills Rd, Cambridge CB2 OQH, UK
    Neural Dev 3:12. 2008
    ..The neurons include a single dendrite and an axon; it is not known whether the orientation of these processes is influenced by PCP...
  21. pmc The muscle pattern of the Drosophila abdomen depends on a subdivision of the anterior compartment of each segment
    Joanna Krzemien
    Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 2EJ, UK
    Development 139:75-83. 2012
    ..The dorsal adult muscles are polarised in the anteroposterior axis: we disprove the hypothesis that muscle orientation depends on genes that define planar cell polarity in the epidermis...
  22. pmc Planar cell polarity: the orientation of larval denticles in Drosophila appears to depend on gradients of Dachsous and Fat
    Ada Repiso
    Department of Zoology, Downing Street, Cambridge, UK
    Development 137:3411-5. 2010
    ..We show, by altering the concentration gradients of Dachsous during development, that we can change the polarity of the denticles made by larval cells as they progress between the first and third larval instars without mitosis...
  23. ncbi request reprint Developmental compartments and planar polarity in Drosophila
    José Casal
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
    Curr Biol 12:1189-98. 2002
    ....
  24. pmc The mechanisms of planar cell polarity, growth and the Hippo pathway: some known unknowns
    Peter A Lawrence
    Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3 EJ, United Kingdom
    Dev Biol 377:1-8. 2013
    ..We offer some new ways of making sense of published results, particularly those relating to the Frizzled/Starry night and Dachsous/Fat systems of PCP...
  25. pmc Planar cell polarity: fashioning solutions
    Peter A Lawrence
    Department of Zoology, University of Cambridge, Cambridge, UK
    Fly (Austin) 5:126-8. 2011
    ..In this "extra view" I reflect on fashion, illustrating by a small discovery of ours, and discussing why it was not made before...
  26. ncbi request reprint Last hideout of the unknown?
    Peter A Lawrence
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH
    Nature 429:247. 2004
  27. ncbi request reprint Francis Crick 1916-2004
    Mark Bretscher
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Curr Biol 14:R642-5. 2004
  28. pmc Substrate-borne vibratory communication during courtship in Drosophila melanogaster
    Caroline C G Fabre
    Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 2EJ, UK
    Curr Biol 22:2180-5. 2012
    ..Our findings in Drosophila open a door to study the neuromuscular circuitry responsible for these signals and the sensory systems needed for their reception...
  29. ncbi request reprint Mosaic and regulative development: two faces of one coin
    Peter A Lawrence
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Curr Biol 16:R236-9. 2006
  30. ncbi request reprint The mismeasurement of science
    Peter A Lawrence
    Department of Zoology, University of Cambridge, Downing Street, Cambridge, UK
    Curr Biol 17:R583-5. 2007
  31. ncbi request reprint Obituary: Edward B. Lewis (1918-2004)
    Matthew P Scott
    Matthew P Scott is in the Departments of Developmental Biology, Genetics and Bioengineering, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305 5439, USA E mail
    Nature 431:143. 2004
  32. ncbi request reprint Let's encourage gentler, more reflective scientists
    Peter A Lawrence
    Nature 442:510. 2006