Amanda J Law

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi Molecular cloning of a brain-specific, developmentally regulated neuregulin 1 (NRG1) isoform and identification of a functional promoter variant associated with schizophrenia
    Wei Tan
    SAIC Frederick, NCI, National Institutes of Health, Frederick, Maryland 21702, USA
    J Biol Chem 282:24343-51. 2007
  2. ncbi Expression of NMDA receptor NR1, NR2A and NR2B subunit mRNAs during development of the human hippocampal formation
    Amanda J Law
    Department of Psychiatry, University of Oxford, Neurosciences Building, Warneford Hospital, Oxford OX3 7JX, UK
    Eur J Neurosci 18:1197-205. 2003
  3. ncbi Disease-associated intronic variants in the ErbB4 gene are related to altered ErbB4 splice-variant expression in the brain in schizophrenia
    Amanda J Law
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK
    Hum Mol Genet 16:129-41. 2007
  4. pmc Neuregulin 1 transcripts are differentially expressed in schizophrenia and regulated by 5' SNPs associated with the disease
    Amanda J Law
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, United Kingdom
    Proc Natl Acad Sci U S A 103:6747-52. 2006
  5. ncbi Reduced spinophilin but not microtubule-associated protein 2 expression in the hippocampal formation in schizophrenia and mood disorders: molecular evidence for a pathology of dendritic spines
    Amanda J Law
    University Department of Psychiatry, Neurosciences Building, Warneford Hospital, Oxford OX3 7JX, UK
    Am J Psychiatry 161:1848-55. 2004
  6. ncbi Neuregulin-1 (NRG-1) mRNA and protein in the adult human brain
    A J Law
    Neurosciences Building, Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX, UK
    Neuroscience 127:125-36. 2004
  7. ncbi Antipsychotics increase microtubule-associated protein 2 mRNA but not spinophilin mRNA in rat hippocampus and cortex
    Amanda J Law
    Department of Psychiatry, University of Oxford, Neurosciences Building, Warneford Hospital, Oxford, United Kingdom
    J Neurosci Res 76:376-82. 2004
  8. ncbi Changes in NMDA receptor subunit mRNAs and cyclophilin mRNA during development of the human hippocampus
    Amanda J Law
    Department of Psychiatry, University of Oxford, OX3 7JX, United Kingdom
    Ann N Y Acad Sci 1003:426-30. 2003
  9. ncbi The distribution and morphology of prefrontal cortex pyramidal neurons identified using anti-neurofilament antibodies SMI32, N200 and FNP7. Normative data and a comparison in subjects with schizophrenia, bipolar disorder or major depression
    Amanda J Law
    Department of Psychiatry, University of Oxford, Neurosciences Building, Warneford Hospital, OX3 7JX, Oxford, UK
    J Psychiatr Res 37:487-99. 2003
  10. pmc Early parental deprivation in the marmoset monkey produces long-term changes in hippocampal expression of genes involved in synaptic plasticity and implicated in mood disorder
    Amanda J Law
    Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, Oxfordshire OX3 7JX, UK
    Neuropsychopharmacology 34:1381-94. 2009

Collaborators

Detail Information

Publications17

  1. ncbi Molecular cloning of a brain-specific, developmentally regulated neuregulin 1 (NRG1) isoform and identification of a functional promoter variant associated with schizophrenia
    Wei Tan
    SAIC Frederick, NCI, National Institutes of Health, Frederick, Maryland 21702, USA
    J Biol Chem 282:24343-51. 2007
    ....
  2. ncbi Expression of NMDA receptor NR1, NR2A and NR2B subunit mRNAs during development of the human hippocampal formation
    Amanda J Law
    Department of Psychiatry, University of Oxford, Neurosciences Building, Warneford Hospital, Oxford OX3 7JX, UK
    Eur J Neurosci 18:1197-205. 2003
    ..Changes in subunit composition may thus contribute to maturational differences in human hippocampal N-methyl-d-aspartate receptor function, and to their role in the pathophysiology of schizophrenia and other neurodevelopmental disorders...
  3. ncbi Disease-associated intronic variants in the ErbB4 gene are related to altered ErbB4 splice-variant expression in the brain in schizophrenia
    Amanda J Law
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK
    Hum Mol Genet 16:129-41. 2007
    ....
  4. pmc Neuregulin 1 transcripts are differentially expressed in schizophrenia and regulated by 5' SNPs associated with the disease
    Amanda J Law
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, United Kingdom
    Proc Natl Acad Sci U S A 103:6747-52. 2006
    ..These data implicate variation in isoform expression as a molecular mechanism for the genetic association of NRG1 with schizophrenia...
  5. ncbi Reduced spinophilin but not microtubule-associated protein 2 expression in the hippocampal formation in schizophrenia and mood disorders: molecular evidence for a pathology of dendritic spines
    Amanda J Law
    University Department of Psychiatry, Neurosciences Building, Warneford Hospital, Oxford OX3 7JX, UK
    Am J Psychiatry 161:1848-55. 2004
    ..There is reasonable neuropathological evidence for a presynaptic pathology but few studies of the postsynaptic component. This study tested the hypothesis that hippocampal dendritic pathology is also present in schizophrenia...
  6. ncbi Neuregulin-1 (NRG-1) mRNA and protein in the adult human brain
    A J Law
    Neurosciences Building, Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX, UK
    Neuroscience 127:125-36. 2004
    ..Using these normative data, future studies can ascertain whether the role of NRG-1 in the disease is mediated, or accompanied, via alterations in its expression...
  7. ncbi Antipsychotics increase microtubule-associated protein 2 mRNA but not spinophilin mRNA in rat hippocampus and cortex
    Amanda J Law
    Department of Psychiatry, University of Oxford, Neurosciences Building, Warneford Hospital, Oxford, United Kingdom
    J Neurosci Res 76:376-82. 2004
    ..Such actions may underlie their long-term effects on neural plasticity in areas of the brain implicated in the pathology of schizophrenia...
  8. ncbi Changes in NMDA receptor subunit mRNAs and cyclophilin mRNA during development of the human hippocampus
    Amanda J Law
    Department of Psychiatry, University of Oxford, OX3 7JX, United Kingdom
    Ann N Y Acad Sci 1003:426-30. 2003
  9. ncbi The distribution and morphology of prefrontal cortex pyramidal neurons identified using anti-neurofilament antibodies SMI32, N200 and FNP7. Normative data and a comparison in subjects with schizophrenia, bipolar disorder or major depression
    Amanda J Law
    Department of Psychiatry, University of Oxford, Neurosciences Building, Warneford Hospital, OX3 7JX, Oxford, UK
    J Psychiatr Res 37:487-99. 2003
    ..However, we found no clear evidence that the prefrontal neuropathology of schizophrenia or mood disorders preferentially affects SMI32-, N200- or FNP7-immunoreactive pyramidal neurons...
  10. pmc Early parental deprivation in the marmoset monkey produces long-term changes in hippocampal expression of genes involved in synaptic plasticity and implicated in mood disorder
    Amanda J Law
    Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, Oxfordshire OX3 7JX, UK
    Neuropsychopharmacology 34:1381-94. 2009
    ..Equally, the negative results suggest that other features of mood disorder, such as decreased hippocampal volume and BDNF expression, are related to different aspects of the pathophysiological process...
  11. pmc Transgenic overexpression of the type I isoform of neuregulin 1 affects working memory and hippocampal oscillations but not long-term potentiation
    Inga H Deakin
    Department of Psychiatry, University of Oxford, Oxford, UK
    Cereb Cortex 22:1520-9. 2012
    ..However, the findings, in concert with those from other genetic and pharmacological manipulations of NRG1, emphasize the complex and pleiotropic nature of the gene, even with regard to a single isoform...
  12. ncbi Neuregulin 1 and schizophrenia: genetics, gene expression, and neurobiology
    Paul J Harrison
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, United Kingdom
    Biol Psychiatry 60:132-40. 2006
    ..We review the structure and functions of NRG1, consider the evidence for and against it being a schizophrenia susceptibility gene, and discuss mechanisms that might underlie the contribution of NRG1 to disease pathophysiology...
  13. pmc Behavioural characterization of neuregulin 1 type I overexpressing transgenic mice
    Inga H Deakin
    Department of Psychiatry, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
    Neuroreport 20:1523-8. 2009
    ..The pattern of results shows both similarities and differences to those reported in hypomorphic NRG1 mice, and may be relevant for interpreting the increased NRG1 type I expression observed in schizophrenia...
  14. ncbi Glutamate receptors and transporters in the hippocampus in schizophrenia
    Paul J Harrison
    Department of Psychiatry, Neurosciences Building, Warneford Hospital, University of Oxford, Oxford, OX3 7JX, United Kingdom
    Ann N Y Acad Sci 1003:94-101. 2003
    ..The recently described susceptibility genes for schizophrenia all act upon glutamatergic synaptic transmission, which may, therefore, be part of the core pathophysiology of the disorder...
  15. pmc Gene expression in the anterior cingulate cortex and amygdala of adolescent marmoset monkeys following parental separations in infancy
    Amanda J Law
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
    Int J Neuropsychopharmacol 12:761-72. 2009
    ..The results differ from those reported in the hippocampus of the same animals, indicating the presence of limbic region-specific long-term molecular responses to early life stress...
  16. pmc Elevated neuregulin-1 and ErbB4 protein in the prefrontal cortex of schizophrenic patients
    Victor Z Chong
    MiNDS Unit, CBDB, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bldg 10, Bethesda, MD 20892, USA
    Schizophr Res 100:270-80. 2008
    ..We hypothesize that ErbB4 proteolytic processing may also be altered in schizophrenia, yielding altered ratios of functionally distinct forms of ErbB4...
  17. ncbi Alpha7 nicotinic acetylcholine receptor mRNA expression and binding in postmortem human brain are associated with genetic variation in neuregulin 1
    Shiny V Mathew
    Intramural Research Program, National Institute of Mental Health, NIH, Bethesda, MD 20892 1385, USA
    Hum Mol Genet 16:2921-32. 2007
    ..Together, these results suggest that the molecular mechanism of the association between NRG1 risk alleles and schizophrenia may include down-regulation of nAChR alpha7 expression...