Genomes and Genes
Amanda J Law
Affiliation: University of Oxford
- Molecular cloning of a brain-specific, developmentally regulated neuregulin 1 (NRG1) isoform and identification of a functional promoter variant associated with schizophreniaWei Tan
SAIC Frederick, NCI, National Institutes of Health, Frederick, Maryland 21702, USA
J Biol Chem 282:24343-51. 2007....
- Expression of NMDA receptor NR1, NR2A and NR2B subunit mRNAs during development of the human hippocampal formationAmanda J Law
Department of Psychiatry, University of Oxford, Neurosciences Building, Warneford Hospital, Oxford OX3 7JX, UK
Eur J Neurosci 18:1197-205. 2003..Changes in subunit composition may thus contribute to maturational differences in human hippocampal N-methyl-d-aspartate receptor function, and to their role in the pathophysiology of schizophrenia and other neurodevelopmental disorders...
- Disease-associated intronic variants in the ErbB4 gene are related to altered ErbB4 splice-variant expression in the brain in schizophreniaAmanda J Law
Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK
Hum Mol Genet 16:129-41. 2007....
- Neuregulin 1 transcripts are differentially expressed in schizophrenia and regulated by 5' SNPs associated with the diseaseAmanda J Law
Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, United Kingdom
Proc Natl Acad Sci U S A 103:6747-52. 2006..These data implicate variation in isoform expression as a molecular mechanism for the genetic association of NRG1 with schizophrenia...
- Reduced spinophilin but not microtubule-associated protein 2 expression in the hippocampal formation in schizophrenia and mood disorders: molecular evidence for a pathology of dendritic spinesAmanda J Law
University Department of Psychiatry, Neurosciences Building, Warneford Hospital, Oxford OX3 7JX, UK
Am J Psychiatry 161:1848-55. 2004..There is reasonable neuropathological evidence for a presynaptic pathology but few studies of the postsynaptic component. This study tested the hypothesis that hippocampal dendritic pathology is also present in schizophrenia...
- Neuregulin-1 (NRG-1) mRNA and protein in the adult human brainA J Law
Neurosciences Building, Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX, UK
Neuroscience 127:125-36. 2004..Using these normative data, future studies can ascertain whether the role of NRG-1 in the disease is mediated, or accompanied, via alterations in its expression...
- Antipsychotics increase microtubule-associated protein 2 mRNA but not spinophilin mRNA in rat hippocampus and cortexAmanda J Law
Department of Psychiatry, University of Oxford, Neurosciences Building, Warneford Hospital, Oxford, United Kingdom
J Neurosci Res 76:376-82. 2004..Such actions may underlie their long-term effects on neural plasticity in areas of the brain implicated in the pathology of schizophrenia...
- Changes in NMDA receptor subunit mRNAs and cyclophilin mRNA during development of the human hippocampusAmanda J Law
Department of Psychiatry, University of Oxford, OX3 7JX, United Kingdom
Ann N Y Acad Sci 1003:426-30. 2003
- The distribution and morphology of prefrontal cortex pyramidal neurons identified using anti-neurofilament antibodies SMI32, N200 and FNP7. Normative data and a comparison in subjects with schizophrenia, bipolar disorder or major depressionAmanda J Law
Department of Psychiatry, University of Oxford, Neurosciences Building, Warneford Hospital, OX3 7JX, Oxford, UK
J Psychiatr Res 37:487-99. 2003..However, we found no clear evidence that the prefrontal neuropathology of schizophrenia or mood disorders preferentially affects SMI32-, N200- or FNP7-immunoreactive pyramidal neurons...
- Early parental deprivation in the marmoset monkey produces long-term changes in hippocampal expression of genes involved in synaptic plasticity and implicated in mood disorderAmanda J Law
Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, Oxfordshire OX3 7JX, UK
Neuropsychopharmacology 34:1381-94. 2009..Equally, the negative results suggest that other features of mood disorder, such as decreased hippocampal volume and BDNF expression, are related to different aspects of the pathophysiological process...
- Transgenic overexpression of the type I isoform of neuregulin 1 affects working memory and hippocampal oscillations but not long-term potentiationInga H Deakin
Department of Psychiatry, University of Oxford, Oxford, UK
Cereb Cortex 22:1520-9. 2012..However, the findings, in concert with those from other genetic and pharmacological manipulations of NRG1, emphasize the complex and pleiotropic nature of the gene, even with regard to a single isoform...
- Neuregulin 1 and schizophrenia: genetics, gene expression, and neurobiologyPaul J Harrison
Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, United Kingdom
Biol Psychiatry 60:132-40. 2006..We review the structure and functions of NRG1, consider the evidence for and against it being a schizophrenia susceptibility gene, and discuss mechanisms that might underlie the contribution of NRG1 to disease pathophysiology...
- Behavioural characterization of neuregulin 1 type I overexpressing transgenic miceInga H Deakin
Department of Psychiatry, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
Neuroreport 20:1523-8. 2009..The pattern of results shows both similarities and differences to those reported in hypomorphic NRG1 mice, and may be relevant for interpreting the increased NRG1 type I expression observed in schizophrenia...
- Glutamate receptors and transporters in the hippocampus in schizophreniaPaul J Harrison
Department of Psychiatry, Neurosciences Building, Warneford Hospital, University of Oxford, Oxford, OX3 7JX, United Kingdom
Ann N Y Acad Sci 1003:94-101. 2003..The recently described susceptibility genes for schizophrenia all act upon glutamatergic synaptic transmission, which may, therefore, be part of the core pathophysiology of the disorder...
- Gene expression in the anterior cingulate cortex and amygdala of adolescent marmoset monkeys following parental separations in infancyAmanda J Law
Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
Int J Neuropsychopharmacol 12:761-72. 2009..The results differ from those reported in the hippocampus of the same animals, indicating the presence of limbic region-specific long-term molecular responses to early life stress...
- Elevated neuregulin-1 and ErbB4 protein in the prefrontal cortex of schizophrenic patientsVictor Z Chong
MiNDS Unit, CBDB, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bldg 10, Bethesda, MD 20892, USA
Schizophr Res 100:270-80. 2008..We hypothesize that ErbB4 proteolytic processing may also be altered in schizophrenia, yielding altered ratios of functionally distinct forms of ErbB4...
- Alpha7 nicotinic acetylcholine receptor mRNA expression and binding in postmortem human brain are associated with genetic variation in neuregulin 1Shiny V Mathew
Intramural Research Program, National Institute of Mental Health, NIH, Bethesda, MD 20892 1385, USA
Hum Mol Genet 16:2921-32. 2007..Together, these results suggest that the molecular mechanism of the association between NRG1 risk alleles and schizophrenia may include down-regulation of nAChR alpha7 expression...