Jay R Laver

Summary

Affiliation: University of Sheffield
Country: UK

Publications

  1. pmc Bacterial nitric oxide detoxification prevents host cell S-nitrosothiol formation: a novel mechanism of bacterial pathogenesis
    Jay R Laver
    Department of Infection and Immunity, Medical School, The University of Sheffield, Royal Hallamshire Hospital, Beech Hill Rd, Sheffield, South Yorkshire, UK
    FASEB J 24:286-95. 2010
  2. doi Nitrosothiols in bacterial pathogens and pathogenesis
    Jay R Laver
    Department of Infection and Immunity, The University of Sheffield, Sheffield, United Kingdom
    Antioxid Redox Signal 18:309-22. 2013
  3. doi Chemiluminescence quantification of NO and its derivatives in liquid samples
    Jay R Laver
    Academic Unit of Infection and Immunity, School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, United Kingdom
    Methods Enzymol 436:113-27. 2008
  4. ncbi Metabolism of nitric oxide by Neisseria meningitidis modifies release of NO-regulated cytokines and chemokines by human macrophages
    Tania M Stevanin
    Academic Unit of Infection and Immunity, School of Medicine and Biomedical Sciences, University of Sheffield, Royal Hallamshire Hospital, Sheffield, S10 2RX, UK
    Microbes Infect 9:981-7. 2007

Detail Information

Publications4

  1. pmc Bacterial nitric oxide detoxification prevents host cell S-nitrosothiol formation: a novel mechanism of bacterial pathogenesis
    Jay R Laver
    Department of Infection and Immunity, Medical School, The University of Sheffield, Royal Hallamshire Hospital, Beech Hill Rd, Sheffield, South Yorkshire, UK
    FASEB J 24:286-95. 2010
    ..coli. In each case, this effect was shown to be dependent on bacterial NO detoxification genes, which act to prevent SNO formation through the removal of NO. This may represent a novel mechanism of host cell injury by bacteria...
  2. doi Nitrosothiols in bacterial pathogens and pathogenesis
    Jay R Laver
    Department of Infection and Immunity, The University of Sheffield, Sheffield, United Kingdom
    Antioxid Redox Signal 18:309-22. 2013
    ..These processes play well-characterized roles in eukaryotic cells, including a variety of pathologies and in relation to chronic conditions. We know little of the roles of these processes in pathogenic and other bacteria...
  3. doi Chemiluminescence quantification of NO and its derivatives in liquid samples
    Jay R Laver
    Academic Unit of Infection and Immunity, School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, United Kingdom
    Methods Enzymol 436:113-27. 2008
    ..They also allow us to distinguish between the various products that may be generated when NO reacts with molecules in complex biological samples such as cell lysates and supernatants...
  4. ncbi Metabolism of nitric oxide by Neisseria meningitidis modifies release of NO-regulated cytokines and chemokines by human macrophages
    Tania M Stevanin
    Academic Unit of Infection and Immunity, School of Medicine and Biomedical Sciences, University of Sheffield, Royal Hallamshire Hospital, Sheffield, S10 2RX, UK
    Microbes Infect 9:981-7. 2007
    ..Addition of SNAP to cultures infected with wild-type mimicked the effect observed in cultures infected with the norB mutant. In conclusion, NorB-catalysed removal of NO modifies cellular release of NO-regulated cytokines and chemokines...