Jay R Laver
Affiliation: University of Sheffield
- Bacterial nitric oxide detoxification prevents host cell S-nitrosothiol formation: a novel mechanism of bacterial pathogenesisJay R Laver
Department of Infection and Immunity, Medical School, The University of Sheffield, Royal Hallamshire Hospital, Beech Hill Rd, Sheffield, South Yorkshire, UK
FASEB J 24:286-95. 2010..coli. In each case, this effect was shown to be dependent on bacterial NO detoxification genes, which act to prevent SNO formation through the removal of NO. This may represent a novel mechanism of host cell injury by bacteria...
- Nitrosothiols in bacterial pathogens and pathogenesisJay R Laver
Department of Infection and Immunity, The University of Sheffield, Sheffield, United Kingdom
Antioxid Redox Signal 18:309-22. 2013..These processes play well-characterized roles in eukaryotic cells, including a variety of pathologies and in relation to chronic conditions. We know little of the roles of these processes in pathogenic and other bacteria...
- Chemiluminescence quantification of NO and its derivatives in liquid samplesJay R Laver
Academic Unit of Infection and Immunity, School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, United Kingdom
Methods Enzymol 436:113-27. 2008..They also allow us to distinguish between the various products that may be generated when NO reacts with molecules in complex biological samples such as cell lysates and supernatants...
- Metabolism of nitric oxide by Neisseria meningitidis modifies release of NO-regulated cytokines and chemokines by human macrophagesTania M Stevanin
Academic Unit of Infection and Immunity, School of Medicine and Biomedical Sciences, University of Sheffield, Royal Hallamshire Hospital, Sheffield, S10 2RX, UK
Microbes Infect 9:981-7. 2007..Addition of SNAP to cultures infected with wild-type mimicked the effect observed in cultures infected with the norB mutant. In conclusion, NorB-catalysed removal of NO modifies cellular release of NO-regulated cytokines and chemokines...