Mark Larance

Summary

Affiliation: University of Dundee
Country: UK

Publications

  1. ncbi Global phosphoproteomics identifies a major role for AKT and 14-3-3 in regulating EDC3
    Mark Larance
    Diabetes and Obesity Program, Garvan Institute of Medical Research, Sydney, Australia
    Mol Cell Proteomics 9:682-94. 2010
  2. ncbi A role for 14-3-3 in insulin-stimulated GLUT4 translocation through its interaction with the RabGAP AS160
    Georg Ramm
    Diabetes and Obesity Program, Garvan Institute of Medical Research, Sydney, NSW, Australia
    J Biol Chem 281:29174-80. 2006
  3. ncbi CaMKII-mediated phosphorylation of the myosin motor Myo1c is required for insulin-stimulated GLUT4 translocation in adipocytes
    Ming Fai Yip
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia
    Cell Metab 8:384-98. 2008
  4. ncbi Identification of RhoGAP22 as an Akt-dependent regulator of cell motility in response to insulin
    Alexander F Rowland
    Diabetes and Obesity Program, Garvan Institute of Medical Research, Sydney, New South Wales 2010, Australia
    Mol Cell Biol 31:4789-800. 2011
  5. ncbi The GLUT4 code
    Mark Larance
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Sydney 2010, Australia
    Mol Endocrinol 22:226-33. 2008
  6. ncbi Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein
    Tilman Brummer
    Cancer Research Program, Garvan Institute of Medical Research, Sydney, New South Wales, Australia
    EMBO J 27:2305-16. 2008
  7. ncbi Quantitative proteomic analysis of the adipocyte plasma membrane
    Matthew J Prior
    Diabetes and Obesity Program, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia
    J Proteome Res 10:4970-82. 2011
  8. ncbi Characterization of the role of the Rab GTPase-activating protein AS160 in insulin-regulated GLUT4 trafficking
    Mark Larance
    Diabetes and Obesity Program, Garvan Institute of Medical Research, Sydney, Australia
    J Biol Chem 280:37803-13. 2005
  9. ncbi Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity
    Kyle L Hoehn
    Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
    Cell Metab 11:70-6. 2010

Collaborators

Detail Information

Publications9

  1. ncbi Global phosphoproteomics identifies a major role for AKT and 14-3-3 in regulating EDC3
    Mark Larance
    Diabetes and Obesity Program, Garvan Institute of Medical Research, Sydney, Australia
    Mol Cell Proteomics 9:682-94. 2010
    ..These data highlight an important new arm of the insulin signaling cascade in the regulation of mRNA utilization...
  2. ncbi A role for 14-3-3 in insulin-stimulated GLUT4 translocation through its interaction with the RabGAP AS160
    Georg Ramm
    Diabetes and Obesity Program, Garvan Institute of Medical Research, Sydney, NSW, Australia
    J Biol Chem 281:29174-80. 2006
    ..These data show that the insulin-dependent association of 14-3-3 with AS160 plays an important role in GLUT4 trafficking in adipocytes...
  3. ncbi CaMKII-mediated phosphorylation of the myosin motor Myo1c is required for insulin-stimulated GLUT4 translocation in adipocytes
    Ming Fai Yip
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia
    Cell Metab 8:384-98. 2008
    ..These data suggest that insulin regulates Myo1c function via CaMKII-dependent phosphorylation, and these events play a role in insulin-regulated GLUT4 trafficking in adipocytes likely involving Myo1c motor activity...
  4. ncbi Identification of RhoGAP22 as an Akt-dependent regulator of cell motility in response to insulin
    Alexander F Rowland
    Diabetes and Obesity Program, Garvan Institute of Medical Research, Sydney, New South Wales 2010, Australia
    Mol Cell Biol 31:4789-800. 2011
    ....
  5. ncbi The GLUT4 code
    Mark Larance
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Sydney 2010, Australia
    Mol Endocrinol 22:226-33. 2008
    ..Many are now taking on this challenge...
  6. ncbi Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein
    Tilman Brummer
    Cancer Research Program, Garvan Institute of Medical Research, Sydney, New South Wales, Australia
    EMBO J 27:2305-16. 2008
    ..This represents a novel regulatory mechanism with implications for diverse tyrosine kinase signalling systems...
  7. ncbi Quantitative proteomic analysis of the adipocyte plasma membrane
    Matthew J Prior
    Diabetes and Obesity Program, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia
    J Proteome Res 10:4970-82. 2011
    ..Together these studies provide a wealth of potential therapeutic targets for the manipulation of adipocyte function and a valuable resource for metabolic research and PM biology...
  8. ncbi Characterization of the role of the Rab GTPase-activating protein AS160 in insulin-regulated GLUT4 trafficking
    Mark Larance
    Diabetes and Obesity Program, Garvan Institute of Medical Research, Sydney, Australia
    J Biol Chem 280:37803-13. 2005
    ..These findings support an important role for AS160 in the insulin regulated trafficking of GLUT4...
  9. ncbi Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity
    Kyle L Hoehn
    Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
    Cell Metab 11:70-6. 2010
    ..We conclude that negative energy balance is a prerequisite for weight reduction, and increased fatty acid oxidation per se has little, if any, effect to reduce adiposity...