Simon C Langley-Evans

Summary

Affiliation: University of Nottingham
Country: UK

Publications

  1. pmc Mitochondrial Respiration Is Decreased in Rat Kidney Following Fetal Exposure to a MaternalLow-ProteinDiet
    Sarah Engeham
    Mitochondrial Research Group, Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK
    J Nutr Metab 2012:989037. 2012
  2. doi request reprint Fetal programming of CVD and renal disease: animal models and mechanistic considerations
    Simon C Langley-Evans
    School of Biosciences, University of Nottingham, Sutton Bonington, Loughborough LE12 5RD, UK
    Proc Nutr Soc 72:317-25. 2013
  3. ncbi request reprint Nutritional programming of blood pressure and renal morphology
    S C Langley-Evans
    Division of Nutritional Biochemistry, University of Nottingham, Sutton Bonington, Loughborough, UK
    Arch Physiol Biochem 111:8-16. 2003
  4. pmc Nutritional programming of disease: unravelling the mechanism
    Simon C Langley-Evans
    Division of Nutritional Sciences, School of Biosciences, University of Nottingham, Sutton Bonington, Loughborough, UK
    J Anat 215:36-51. 2009
  5. ncbi request reprint The association between birthweight and longevity in the rat is complex and modulated by maternal protein intake during fetal life
    Simon C Langley-Evans
    School of Biosciences, University of Nottingham, Sutton Bonington, Loughborough LE12 5RD, UK
    FEBS Lett 580:4150-3. 2006
  6. ncbi request reprint Animal models of programming: early life influences on appetite and feeding behaviour
    Simon C Langley-Evans
    Center for Reproduction and Early Life, University of Nottingham, School of Biosciences, Sutton Bonington, Leicestershire LE12 5RD, UK
    Matern Child Nutr 1:142-8. 2005
  7. ncbi request reprint Maternal protein restriction and fetal growth: lack of evidence of a role for homocysteine in fetal programming
    Simon C Langley-Evans
    School of Biosciences, University of Nottingham, Sutton Bonington, Loughborough LE12 5RD, UK
    Br J Nutr 96:578-86. 2006
  8. ncbi request reprint Diet and the developing immune system
    S C Langley-Evans
    University of Nottingham, Loughborough, UK
    Lupus 15:746-52. 2006
  9. doi request reprint Developmental origins of adult disease
    Simon C Langley-Evans
    School of Biosciences, University of Nottingham, Nottingham, UK
    Med Princ Pract 19:87-98. 2010
  10. ncbi request reprint Programming of hepatic antioxidant capacity and oxidative injury in the ageing rat
    Simon C Langley-Evans
    Centre for Reproduction and Early Life, School of Biosciences, University of Nottingham, Sutton Bonington, Loughborough, UK
    Mech Ageing Dev 126:804-12. 2005

Collaborators

Detail Information

Publications47

  1. pmc Mitochondrial Respiration Is Decreased in Rat Kidney Following Fetal Exposure to a MaternalLow-ProteinDiet
    Sarah Engeham
    Mitochondrial Research Group, Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK
    J Nutr Metab 2012:989037. 2012
    ..In the absence of gross disturbances in respiratory chain protein expression, programming of coupling efficiency may explain the long-term impact of the maternal diet...
  2. doi request reprint Fetal programming of CVD and renal disease: animal models and mechanistic considerations
    Simon C Langley-Evans
    School of Biosciences, University of Nottingham, Sutton Bonington, Loughborough LE12 5RD, UK
    Proc Nutr Soc 72:317-25. 2013
    ..The objective for this review is to provide an overview of the mechanistic basis of fetal programming, demonstrating the critical role of animal models as tools for the investigation of programming phenomena. ..
  3. ncbi request reprint Nutritional programming of blood pressure and renal morphology
    S C Langley-Evans
    Division of Nutritional Biochemistry, University of Nottingham, Sutton Bonington, Loughborough, UK
    Arch Physiol Biochem 111:8-16. 2003
    ..The evidence thus suggests that prenatal undernutrition may programme renal structure in later life, but that renal programming is not one of the primary mechanisms leading to hypertension...
  4. pmc Nutritional programming of disease: unravelling the mechanism
    Simon C Langley-Evans
    Division of Nutritional Sciences, School of Biosciences, University of Nottingham, Sutton Bonington, Loughborough, UK
    J Anat 215:36-51. 2009
    ..Nutrition-related factors may drive these processes by disturbing placental function, including control of materno-fetal endocrine exchanges, or the epigenetic regulation of gene expression...
  5. ncbi request reprint The association between birthweight and longevity in the rat is complex and modulated by maternal protein intake during fetal life
    Simon C Langley-Evans
    School of Biosciences, University of Nottingham, Sutton Bonington, Loughborough LE12 5RD, UK
    FEBS Lett 580:4150-3. 2006
    ..There was no evidence that undernutrition programmed lifespan through oxidative processes in the major organs. Fetal programming is an important contributor to the ageing process...
  6. ncbi request reprint Animal models of programming: early life influences on appetite and feeding behaviour
    Simon C Langley-Evans
    Center for Reproduction and Early Life, University of Nottingham, School of Biosciences, Sutton Bonington, Leicestershire LE12 5RD, UK
    Matern Child Nutr 1:142-8. 2005
    ..The early life programming of appetite and obesity is a complex phenomenon and our understanding of how maternal nutrition determines later energy balance is at a very early stage...
  7. ncbi request reprint Maternal protein restriction and fetal growth: lack of evidence of a role for homocysteine in fetal programming
    Simon C Langley-Evans
    School of Biosciences, University of Nottingham, Sutton Bonington, Loughborough LE12 5RD, UK
    Br J Nutr 96:578-86. 2006
    ..There was no evidence of increased oxidative injury in fetal tissue that might explain the long-term programming effects of the diet...
  8. ncbi request reprint Diet and the developing immune system
    S C Langley-Evans
    University of Nottingham, Loughborough, UK
    Lupus 15:746-52. 2006
    ..A limited body of evidence implicates fetal programming in the development of autoimmune disorders. This area represents an interesting target for further research and preventive medicine...
  9. doi request reprint Developmental origins of adult disease
    Simon C Langley-Evans
    School of Biosciences, University of Nottingham, Nottingham, UK
    Med Princ Pract 19:87-98. 2010
    ..It is suggested therefore that programming is a product of altered expression of key genes. This drives the tissue remodelling response and future disease risk...
  10. ncbi request reprint Programming of hepatic antioxidant capacity and oxidative injury in the ageing rat
    Simon C Langley-Evans
    Centre for Reproduction and Early Life, School of Biosciences, University of Nottingham, Sutton Bonington, Loughborough, UK
    Mech Ageing Dev 126:804-12. 2005
    ..Mechanisms of ageing appear to be subject to nutritional programming during early development...
  11. ncbi request reprint Fetal programming of cardiovascular function through exposure to maternal undernutrition
    S C Langley-Evans
    Nutritional Biochemistry, University of Nottingham, Sutton Bonington, UK
    Proc Nutr Soc 60:505-13. 2001
    ..Secondary to this activity, the fetal hypothalamic-pituitary-adrenal axis may stimulate renin-angiotensin system activity, resulting in increased vascular resistance and hypertension...
  12. ncbi request reprint Use of folic acid supplements in the first trimester of pregnancy
    Simon C Langley-Evans
    Department of Nutritional Biochemistry, University of Nottingham, Loughborough LE12 5RD, England
    J R Soc Promot Health 122:181-6. 2002
    ....
  13. doi request reprint Obesity induced by cafeteria feeding and pregnancy outcome in the rat
    Asli Akyol
    School of Biosciences, University of Nottingham, Sutton Bonington, Loughborough, UK
    Br J Nutr 102:1601-10. 2009
    ..001). The model will provide a useful vehicle for the investigation of the complex interactions between dietary- and obesity-related factors during pregnancy in their effects on fetal development and postnatal metabolic function...
  14. pmc Prenatal exposure to a low-protein diet programs disordered regulation of lipid metabolism in the aging rat
    Aml Erhuma
    School of Biosciences, University of Nottingham, Queens Medical Centre, Nottingham, UK
    Am J Physiol Endocrinol Metab 292:E1702-14. 2007
    ..The data implicate altered expression of SREBP-1c and ChREBP as key mediators of the programmed phenotype, but the basis of the switch in metabolic status that occurred between 9 and 18 mo of age is, as yet, unidentified...
  15. pmc The effect of feeding a low iron diet prior to and during gestation on fetal and maternal iron homeostasis in two strains of rat
    Ruth Cornock
    School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough LE12 5RD, UK
    Reprod Biol Endocrinol 11:32. 2013
    ..This study examined the impact of iron deficiency on maternal and fetal iron homeostasis in two strains of rat...
  16. pmc Processes underlying the nutritional programming of embryonic development by iron deficiency in the rat
    Angelina Swali
    School of Biosciences, University of Nottingham, Sutton Bonington, Loughborough, United Kingdom
    PLoS ONE 7:e48133. 2012
    ..Therefore these findings offer an insight into the underlying mechanisms associated with the development of the embryo during conditions of poor iron status, and its health in adult life...
  17. ncbi request reprint Fetal programming of appetite by exposure to a maternal low-protein diet in the rat
    Leanne Bellinger
    School of Biosciences, University of Nottingham, Sutton Bonington, Loughborough LE12 5RD, U K
    Clin Sci (Lond) 109:413-20. 2005
    ..The data suggest that programming of feeding behaviour is likely to be gender-specific and dependent upon the timing of nutrient insult in fetal life. This work may have implications for the development of the metabolic syndrome...
  18. ncbi request reprint Fetal exposure to a maternal low-protein diet is associated with altered left ventricular pressure response to ischaemia-reperfusion injury
    Matthew J Elmes
    Division of Nutritional Sciences, University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire, UK
    Br J Nutr 98:93-100. 2007
    ..Undernutrition during development may increase susceptibility to CHD by impairing recovery from coronary events...
  19. doi request reprint Supplementation of a maternal low-protein diet in rat pregnancy with folic acid ameliorates programming effects upon feeding behaviour in the absence of disturbances to the methionine-homocysteine cycle
    Sarah F Engeham
    School of Biosciences, University of Nottingham, Sutton Bonington, Loughborough LE12 5RD, UK
    Br J Nutr 103:996-1007. 2010
    ..The present findings indicated that any role for DNA methylation in programming of physiology is not related to major perturbations of folate metabolism, and is likely to be gene-specific rather than genome-wide...
  20. doi request reprint Feeding pregnant rats a low-protein diet alters the hepatic expression of SREBP-1c in their offspring via a glucocorticoid-related mechanism
    Aml Erhuma
    School of Biomedical Sciences, University of Nottingham, Queen s Medical Centre, Nottingham, NG7 2UH, UK
    Endocrine 36:333-8. 2009
    ..Together these studies demonstrate that foetal over-exposure to glucocorticoids, through indirect mechanism, play a crucial role in low-protein-diet-induced changes in lipid metabolism regulating genes...
  21. pmc Intergenerational programming of impaired nephrogenesis and hypertension in rats following maternal protein restriction during pregnancy
    Matthew Harrison
    University of Nottingham, School of Biosciences, Sutton Bonington, Loughborough LE12 5RD, UK
    Br J Nutr 101:1020-30. 2009
    ..No effect was noted in the F3 generation. It is concluded that fetal protein restriction may play a critical role in determining blood pressure and overall disease risk in a subsequent generation...
  22. pmc Sex-specific effects of prenatal low-protein and carbenoxolone exposure on renal angiotensin receptor expression in rats
    Sarah McMullen
    Division of Nutritional Sciences, University of Nottingham, Loughborough, LE12 5RD, United Kingdom
    Hypertension 46:1374-80. 2005
    ..Despite being targeted to the postnephrogenic period, inhibition of type 1 angiotensin receptor had an inhibitory effect on renal and somatic growth, additionally indicating its unsuitability during early life...
  23. pmc Prenatal exposure to undernutrition and programming of responses to high-fat feeding in the rat
    Aml Erhuma
    School of Biomedical Sciences, University of Nottingham, Queens Medical Centre, Nottingham NG7 2UH, UK
    Br J Nutr 98:517-24. 2007
    ..This study further establishes a role for prenatal nutrition in programming the genes involved in lipid metabolism and appetite regulation...
  24. pmc Fetal exposure to a maternal low-protein diet during mid-gestation results in muscle-specific effects on fibre type composition in young rats
    Joanne E Mallinson
    Division of Nutritional Sciences, School of Biosciences, University of Nottingham, Sutton Bonington, Loughborough, LE12 5RD, UK
    Br J Nutr 98:292-9. 2007
    ..In conclusion, a maternal low-protein diet mainly during mid-pregnancy reduced muscle fibre number and density in 4-week-old rats, but there were muscle-specific differences in the fibre types affected...
  25. ncbi request reprint Maternal low-protein diet in rat pregnancy programs blood pressure through sex-specific mechanisms
    Sarah McMullen
    Centre for Reproduction and Early Life, Division of Nutritional Biochemistry, University of Nottingham, Sutton Bonington Campus, Loughborough LE12 5RD, UK
    Am J Physiol Regul Integr Comp Physiol 288:R85-90. 2005
    ....
  26. ncbi request reprint Prenatal diet determines susceptibility to cardiac ischaemia-reperfusion injury following treatment with diethylmaleic acid and N-acetylcysteine
    Matthew J Elmes
    Division of Nutritional Sciences, University of Nottingham, Loughborough, Leicestershire, UK
    Life Sci 82:149-55. 2008
    ..A nutritionally-imbalanced developmental environment may increase susceptibility to coronary heart disease through the programming of myocardial glutathione metabolism...
  27. pmc Cell cycle regulation and cytoskeletal remodelling are critical processes in the nutritional programming of embryonic development
    Angelina Swali
    School of Biosciences, University of Nottingham, Sutton Bonington, Loughborough, United Kingdom
    PLoS ONE 6:e23189. 2011
    ..These findings offer novel insight into the primary causes and mechanisms leading to the pathologies which have been identified by previous programming studies...
  28. ncbi request reprint Prenatal exposure to a maternal low-protein diet programmes a preference for high-fat foods in the young adult rat
    Leanne Bellinger
    Centre for Reproduction and Early Life, School of Biosciences, University of Nottingham, Sutton Bonington, Loughborough LE12 5RD, UK
    Br J Nutr 92:513-20. 2004
    ..Maternal nutrition may thus promote changes in systems that are involved in control of appetite or the perception of palatability...
  29. pmc Developmental programming of health and disease
    Simon C Langley-Evans
    School of Bioscience, University of Nottingham, Loughborough, UK
    Proc Nutr Soc 65:97-105. 2006
    ..Epigenetic mechanisms, including DNA methylation, may also be important processes in early-life programming...
  30. pmc Prenatal programming of angiotensin II type 2 receptor expression in the rat
    Sarah McMullen
    School of Biosciences, University of Nottingham, Sutton Bonington, Loughborough, Leics, UK
    Br J Nutr 91:133-40. 2004
    ..This may play a key role in the impairment of renal development and the elevation of blood pressure noted in rats exposed to intra-uterine protein restriction...
  31. doi request reprint The impact of maternal cafeteria diet on anxiety-related behaviour and exploration in the offspring
    Thomas Wright
    School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, Loughborough LE125RD, United Kingdom
    Physiol Behav 103:164-72. 2011
    ..The present study demonstrates that pre-gestational, gestational and lactational maternal CD programme behaviour in the offspring with lactational CD reducing anxiety in the male offspring...
  32. pmc Maternal undernutrition programmes atherosclerosis in the ApoE*3-Leiden mouse
    Zoe Yates
    School of Biosciences, University of Nottingham, Sutton Bonington, Loughborough LE12 5RD, UK
    Br J Nutr 101:1185-94. 2009
    ....
  33. doi request reprint Glucose intolerance associated with early-life exposure to maternal cafeteria feeding is dependent upon post-weaning diet
    Asli Akyol
    School of Biosciences, University of Nottingham, Sutton Bonington, Loughborough LE12 5RD, UK
    Br J Nutr 107:964-78. 2012
    ..Although the effects on glucose homeostasis were independent of offspring adiposity, the programming of a glucose-intolerant phenotype was only observed when offspring were weaned on a diet that induced greater fat deposition...
  34. doi request reprint Exposure to maternal consumption of cafeteria diet during the lactation period programmes feeding behaviour in the rat
    Thomas M Wright
    School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, Loughborough LE12 5RD, United Kingdom
    Int J Dev Neurosci 29:785-93. 2011
    ..01). Hypothalamic DA metabolism (DOPAC+HVA/DA ratio) was overall lower in females than in males (P<0.01). This study indicates a programming effect of lactational CD on feeding behaviour and brain monoaminergic neurons...
  35. doi request reprint Protein restriction in the pregnant mouse modifies fetal growth and pulmonary development: role of fetal exposure to {beta}-hydroxybutyrate
    Simon C Langley-Evans
    University of Nottingham, Nutritional Sciences, Sutton Bonington Campus, Division of Nutritional Sciences, Loughborough, Leicestershire, UK
    Exp Physiol 96:203-15. 2011
    ..In conclusion, we find that disturbance of fetal growth by maternal dietary protein restriction is associated and therefore potentially indicated by changes in maternal and fetal ketone body metabolism...
  36. pmc The impact of maternal protein restriction during rat pregnancy upon renal expression of angiotensin receptors and vasopressin-related aquaporins
    Ruth Cornock
    School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough LE12 5RD, UK
    Reprod Biol Endocrinol 8:105. 2010
    ....
  37. ncbi request reprint Periodontal disease is associated with lower antioxidant capacity in whole saliva and evidence of increased protein oxidation
    Dean V Sculley
    Division of Nutritional Biochemistry, School of Biosciences, University of Nottingham, Sutton Bonington, Loughborough, Leicestershire LE12 5RD, UK
    Clin Sci (Lond) 105:167-72. 2003
    ..Women had significantly lower total antioxidant status than men, regardless of periodontal health. Periodontal disease is associated with reduced salivary antioxidant status and increased oxidative damage within the oral cavity...
  38. ncbi request reprint Sex differences in sensitivity to beta-adrenergic agonist isoproterenol in the isolated adult rat heart following prenatal protein restriction
    Matthew J Elmes
    Division of Nutritional Sciences, University of Nottingham, Loughborough, Leicestershire, UK
    Br J Nutr 101:725-34. 2009
    ..049). In conclusion, maternal protein restriction programmes cardiac sympathetic activity in a sex-specific manner, and may explain increased susceptibility to ischaemia-reperfusion injury in males subject to fetal undernutrition...
  39. pmc Prenatal protein restriction leads to a disparity between aortic and peripheral blood pressure in Wistar male offspring
    Angelina Swali
    School of Biosciences, University of Nottingham, Sutton Bonington, Loughborough LE12 5RD, UK
    J Physiol 588:3809-18. 2010
    ..Such a disparity between central and peripheral blood pressure measurements could have important clinical implications regarding cardiovascular risk assessment and treatment...
  40. doi request reprint Communication skills for behaviour change in dietetic consultations
    K Whitehead
    School of Biosciences, University of Nottingham, Sutton Bonington, Loughborough, UK
    J Hum Nutr Diet 22:493-500; quiz 501-3. 2009
    ..This study investigated the views of UK dietitians about their training needs and experience in relation to communication skills in dietetic practice...
  41. pmc The Effects of Prenatal Protein Restriction on β-Adrenergic Signalling of the Adult Rat Heart during Ischaemia Reperfusion
    Kevin J P Ryan
    Division of Nutritional Sciences, University of Nottingham, Loughborough, Leicestershire LE12 5RD, UK
    J Nutr Metab 2012:397389. 2012
    ..In contrast, females exhibiting both decreased membrane expression of β(2)-AR and catecholamine levels were protected from IR injury...
  42. ncbi request reprint Wheezing and eczema in relation to infant anthropometry: evidence of developmental programming of disease in childhood
    Lynda J Carrington
    Centre for Reproduction and Early Life, University of Nottingham, School of Biosciences, Sutton Bonington, Loughborough, UK
    Matern Child Nutr 2:51-61. 2006
    ..Brain sparing does not appear to play a role in this early life programming...
  43. doi request reprint Childhood obesity and adult cardiovascular disease risk: a systematic review
    L J Lloyd
    Division of Nutritional Sciences, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, UK
    Int J Obes (Lond) 34:18-28. 2010
    ..Given the evidence of tracking of body mass index (BMI) from childhood to adulthood, this systematic review investigated the independent relationship between childhood BMI and adult CVD risk...
  44. ncbi request reprint Increased systolic blood pressure in rats induced by a maternal low-protein diet is reversed by dietary supplementation with glycine
    Alan A Jackson
    Institute of Human Nutrition, Fetal Origins of Adult Disease Research Division, University of Southampton, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Clin Sci (Lond) 103:633-9. 2002
    ..The availability of glycine appears to be of critical importance for normal cardiovascular development...
  45. ncbi request reprint Salivary antioxidants and periodontal disease status
    Dean V Sculley
    Centre for Healthcare Education, University College Northampton, UK
    Proc Nutr Soc 61:137-43. 2002
    ..An improved understanding of the role antioxidants play in periodontitis, and the influence of nutrition on antioxidant status, may lead to a possible nutritional strategy for the treatment of periodontal disease...
  46. ncbi request reprint Essential hypertension: defending the contribution of a congenital nephron deficit
    Sarah McMullen
    Hypertension 46:e4; author reply e4-5. 2005