P Langhorne

Summary

Affiliation: University of Glasgow
Country: UK

Publications

  1. doi request reprint Motor recovery after stroke: a systematic review
    Peter Langhorne
    Stroke Therapy Evaluation Programme, Academic Section of Geriatric Medicine, Cardiovascular and Medical Sciences Division, Royal Infirmary, Glasgow, UK
    Lancet Neurol 8:741-54. 2009
  2. ncbi request reprint Early supported discharge services for stroke patients: a meta-analysis of individual patients' data
    Peter Langhorne
    Academic Section of Geriatric Medicine, Level 3, Centre Block, Royal Infirmary, Glasgow G4 OSF, UK
    Lancet 365:501-6. 2005
  3. ncbi request reprint Stroke units in their natural habitat: systematic review of observational studies
    Pamela Seenan
    Academic Section of Geriatric Medicine, Royal Infirmary, Glasgow, UK
    Stroke 38:1886-92. 2007
  4. doi request reprint WITHDRAWN: Services for helping acute stroke patients avoid hospital admission
    Peter Langhorne
    Academic Section of Geriatric Medicine, University of Glasgow, 3rd Floor, Centre Block, RoyalInfirmary, Glasgow, G4 0SF, UK
    Cochrane Database Syst Rev 1:CD000444. 2012
  5. pmc Developing and evaluating the implementation of a complex intervention: using mixed methods to inform the design of a randomised controlled trial of an oral healthcare intervention after stroke
    Marian C Brady
    Nursing, Midwifery and Allied Health Professions Research Unit, Glasgow Caledonian University, Glasgow, UK
    Trials 12:168. 2011
  6. pmc Risk of acute myocardial infarction with nonselective non-steroidal anti-inflammatory drugs: a meta-analysis
    Gurkirpal Singh
    Division of Gastroenterology and Hepatology, Stanford University School of Medicine, 100 Hamilton Avenue, Suite 225 42, Palo Alto, CA 94301, USA
    Arthritis Res Ther 8:R153. 2006
  7. ncbi request reprint Medical complications after stroke: a multicenter study
    P Langhorne
    Academic Section of Geriatric Medicine, Royal Infirmary, Glasgow, Scotland, UK
    Stroke 31:1223-9. 2000
  8. ncbi request reprint Is stroke unit care portable? A systematic review of the clinical trials
    P Langhorne
    Academic Section of Geriatric Medicine, Level 3, Centre Block, Royal Infirmary, Glasgow G4 0SF, UK
    Age Ageing 34:324-30. 2005
  9. ncbi request reprint Early supported discharge after stroke
    Peter Langhorne
    Academic Section of Geriatric Medicine, University of Glasgow, Glasgow, UK
    J Rehabil Med 39:103-8. 2007
  10. doi request reprint Estimating the impact of stroke unit care in a whole population: an epidemiological study using routine data
    Peter Langhorne
    Cardiovascular and Medical Sciences Division, University of Glasgow, Glasgow, UK
    J Neurol Neurosurg Psychiatry 81:1301-5. 2010

Detail Information

Publications59

  1. doi request reprint Motor recovery after stroke: a systematic review
    Peter Langhorne
    Stroke Therapy Evaluation Programme, Academic Section of Geriatric Medicine, Cardiovascular and Medical Sciences Division, Royal Infirmary, Glasgow, UK
    Lancet Neurol 8:741-54. 2009
    ..Although the existing evidence is limited by poor trial designs, some treatments do show promise for improving motor recovery, particularly those that have focused on high-intensity and repetitive task-specific practice...
  2. ncbi request reprint Early supported discharge services for stroke patients: a meta-analysis of individual patients' data
    Peter Langhorne
    Academic Section of Geriatric Medicine, Level 3, Centre Block, Royal Infirmary, Glasgow G4 OSF, UK
    Lancet 365:501-6. 2005
    ..Services have been developed that offer patients early discharge from hospital with rehabilitation at home (early supported discharge [ESD]). We have assessed the effects and costs of such services...
  3. ncbi request reprint Stroke units in their natural habitat: systematic review of observational studies
    Pamela Seenan
    Academic Section of Geriatric Medicine, Royal Infirmary, Glasgow, UK
    Stroke 38:1886-92. 2007
    ..However, there are concerns that the benefits seen in clinical trials may not be replicated in routine practice. We carried out a systematic review of observational studies of stroke unit implementation...
  4. doi request reprint WITHDRAWN: Services for helping acute stroke patients avoid hospital admission
    Peter Langhorne
    Academic Section of Geriatric Medicine, University of Glasgow, 3rd Floor, Centre Block, RoyalInfirmary, Glasgow, G4 0SF, UK
    Cochrane Database Syst Rev 1:CD000444. 2012
    ..Stroke patients are usually admitted to hospital for their acute care and rehabilitation. Services to help acute stroke patients avoid admission to hospital ('hospital-at-home') have now been developed...
  5. pmc Developing and evaluating the implementation of a complex intervention: using mixed methods to inform the design of a randomised controlled trial of an oral healthcare intervention after stroke
    Marian C Brady
    Nursing, Midwifery and Allied Health Professions Research Unit, Glasgow Caledonian University, Glasgow, UK
    Trials 12:168. 2011
    ..Our aim was to develop and evaluate the implementation of a complex, multidimensional oral health care (OHC) intervention for people in stroke rehabilitation settings which would inform the development of a randomised controlled trial...
  6. pmc Risk of acute myocardial infarction with nonselective non-steroidal anti-inflammatory drugs: a meta-analysis
    Gurkirpal Singh
    Division of Gastroenterology and Hepatology, Stanford University School of Medicine, 100 Hamilton Avenue, Suite 225 42, Palo Alto, CA 94301, USA
    Arthritis Res Ther 8:R153. 2006
    ..Nonselective NSAIDs are frequently prescribed, and so further investigation into the risk of AMI is warranted because the potential for harm can be substantial...
  7. ncbi request reprint Medical complications after stroke: a multicenter study
    P Langhorne
    Academic Section of Geriatric Medicine, Royal Infirmary, Glasgow, Scotland, UK
    Stroke 31:1223-9. 2000
    ..This prospective, multicenter study was performed to determine the frequency of symptomatic complications up to 30 months after stroke using prespecified definitions of complications...
  8. ncbi request reprint Is stroke unit care portable? A systematic review of the clinical trials
    P Langhorne
    Academic Section of Geriatric Medicine, Level 3, Centre Block, Royal Infirmary, Glasgow G4 0SF, UK
    Age Ageing 34:324-30. 2005
    ..It is not known if mobile stroke teams can achieve the good results seen in trials of geographically discrete stroke wards (stroke units)...
  9. ncbi request reprint Early supported discharge after stroke
    Peter Langhorne
    Academic Section of Geriatric Medicine, University of Glasgow, Glasgow, UK
    J Rehabil Med 39:103-8. 2007
    ..In conclusion, an illustrative case report is set out, indicating a typical patient pathway in an early supported discharge service...
  10. doi request reprint Estimating the impact of stroke unit care in a whole population: an epidemiological study using routine data
    Peter Langhorne
    Cardiovascular and Medical Sciences Division, University of Glasgow, Glasgow, UK
    J Neurol Neurosurg Psychiatry 81:1301-5. 2010
    ..However, it is unclear what impact this complex intervention actually has in routine practice. A comprehensive national dataset was used to study the impact of stroke unit implementation...
  11. ncbi request reprint Evidence-based stroke rehabilitation
    Peter Langhorne
    Stroke Therapy Evaluation Programme STEP, Academic Section of Geriatric Medicine, Third Floor Centre Block, Royal Infirmary, Glasgow G4 0SF, UK
    Age Ageing 31:17-20. 2002
    ..This article describes some steps taken to develop such information based on common questions generated by clinicians...
  12. ncbi request reprint What are the components of effective stroke unit care?
    Peter Langhorne
    Academic Section of Geriatric Medicine, Level 3, Centre Block, Royal Infirmary, Glasgow G4 OSF, UK
    Age Ageing 31:365-71. 2002
    ..The effectiveness of organized inpatient (stroke unit) care has been demonstrated in systematic reviews of clinical trials. However, the key components of stroke unit care are poorly understood...
  13. ncbi request reprint Does the organization of postacute stroke care really matter?
    P Langhorne
    Academic Section of Geriatric Medicine, Royal Infirmary, Glasgow, UK
    Stroke 32:268-74. 2001
    ..We conducted a systematic review to evaluate the effectiveness of such services...
  14. ncbi request reprint Screening for thrombophilia in high-risk situations: systematic review and cost-effectiveness analysis. The Thrombosis: Risk and Economic Assessment of Thrombophilia Screening (TREATS) study
    O Wu
    Division of Developmental Medicine, University of Glasgow, UK
    Health Technol Assess 10:1-110. 2006
    ..To evaluate the relative cost-effectiveness of universal and selective VTE history-based screening for thrombophilia compared with no screening in the three high-risk patient groups...
  15. ncbi request reprint Rehabilitation therapy services for stroke patients living at home: systematic review of randomised trials
    L Legg
    Academic Section of Geriatric Medicine, Level 3, Centre Block, Royal Infirmary, Glasgow G4 OSF, UK
    Lancet 363:352-6. 2004
    ..We aimed to assess the effects of therapy-based rehabilitation services targeted at stroke patients resident in the community within 1 year of stroke onset or discharge from hospital...
  16. pmc Poor outcome in primary intracerebral haemorrhage: results of a matched comparison
    M Barber
    Academic Section of Geriatric Medicine, Royal Infirmary, Glasgow, UK
    Postgrad Med J 80:89-92. 2004
    ..Primary intracerebral haemorrhage (PICH) is associated with a poorer outcome than cerebral infarction. This study aimed to determine whether this is explained by the clinical severity of stroke...
  17. doi request reprint Controlling ecological bias in evidence synthesis of trials reporting on collapsed and overlapping covariate categories
    L Govan
    Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK
    Stat Med 29:1340-56. 2010
    ..Results are compared with a model using only the stratified covariate data available, where each stratum is treated as a separate trial, and a model using fully aggregated data, where no covariate data are used...
  18. doi request reprint Urinary tract infection after stroke
    D J Stott
    Academic Section of Geriatric Medicine, Third Floor, Queen Elizabeth Building, Glasgow Royal Infirmary, Glasgow G31 2ER, UK
    QJM 102:243-9. 2009
    ..Urinary tract infection (UTI) is a recognized complication of stroke. We aimed to determine the incidence of UTI after acute stroke, the risk factors associated with this complication, and its association with outcome...
  19. doi request reprint Is informal caregiving independently associated with poor health? A population-based study
    Lynn Legg
    Academic Section of Geriatric Medicine, University of Glasgow, Royal Infirmary, Glasgow G31 2ER, UK
    J Epidemiol Community Health 67:95-7. 2013
    ..Providing informal care has been linked with poor health but has not previously been studied across a whole population. We aimed to study the association between informal care provision and self-reported poor health...
  20. pmc Developing and validating a predictive model for stroke progression
    L E Craig
    College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK
    Cerebrovasc Dis Extra 1:105-14. 2011
    ..The aim of this study was to identify predictors of early stroke progression using two independent patient cohorts...
  21. ncbi request reprint Barriers to achieving evidence-based stroke rehabilitation
    A S Pollock
    Stroke Therapy Evaluation Programme, Academic Section of Geriatric Medicine, Glasgow Royal Infirmary, Scotland
    Clin Rehabil 14:611-7. 2000
    ..To determine the perceived barriers to evidence-based practice by health professionals working within the field of stroke rehabilitation...
  22. ncbi request reprint Thrombophilia in pregnancy: a systematic review
    L Robertson
    Department of Obstetrics and Gynaecology, University of Glasgow, UK
    Br J Haematol 132:171-96. 2006
    ..There is also a lack of controlled trials of antithrombotic intervention to prevent pregnancy complications. Thus, at present, universal screening for thrombophilia in pregnancy cannot be justified clinically...
  23. ncbi request reprint A systematic review of exercise trials post stroke
    C Meek
    Mansionhouse Unit, South Glasgow University Hospital Trust, Scotland, UK
    Clin Rehabil 17:6-13. 2003
    ..To perform a systematic review of exercise trials post stroke...
  24. pmc Evidence behind stroke rehabilitation
    P Langhorne
    Stroke Therapy Evaluation Programme STEP, Section of Clinical Gerontology and Vascular Medicine, University of Glasgow, Glasgow, UK
    J Neurol Neurosurg Psychiatry 74:iv18-iv21. 2003
  25. ncbi request reprint Risk of rapid global functional decline in elderly patients with severe cerebral age-related white matter changes: the LADIS study
    Domenico Inzitari
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    Arch Intern Med 167:81-8. 2007
    ..The LADIS (LeukoAraiosis and DISability) Study primarily aims to assess ARWMCs as a determinant of global functional decline in the elderly population...
  26. ncbi request reprint Improved survival after stroke
    Peter Langhorne
    Cerebrovasc Dis 23:320-1. 2007
  27. ncbi request reprint Facilitating recovery: evidence for organized stroke care
    Lalit Kalra
    Department of Stroke Medicine, King s College London School of Medicine, London, UK
    J Rehabil Med 39:97-102. 2007
    ..Finally, some key challenges have been identified for stroke units in improving rehabilitation outcomes over the next decade and for healthcare planners in investing adequately in organized stroke services...
  28. ncbi request reprint Validity and reliability of estimating the scandinavian stroke scale score from medical records
    Mark Barber
    Academic Section of Geriatric Medicine, Royal Infirmary, Glasgow, UK
    Cerebrovasc Dis 17:224-7. 2004
    ..Obtaining this information prospectively requires significant resources. We wished to assess the reliability of estimating the Scandinavian Stroke Scale (SSS) score retrospectively from routine hospital admission records...
  29. ncbi request reprint Physiotherapy treatment approaches for the recovery of postural control and lower limb function following stroke: a systematic review
    Alex Pollock
    Stroke Therapy Evaluation Programme, Academic Section of Geriatric Medicine, Glasgow Royal Infirmary, Glasgow, UK
    Clin Rehabil 21:395-410. 2007
    ..To determine whether there is a difference in global dependency and functional independence in patients with stroke associated with different approaches to physiotherapy treatment...
  30. ncbi request reprint Risk factors for chest infection in acute stroke: a prospective cohort study
    Cameron Sellars
    Academic Section of Geriatric Medicine, Glasgow Royal Infirmary, Glasgow, UK
    Stroke 38:2284-91. 2007
    ..Pneumonia is a major cause of morbidity and mortality after stroke. We aimed to determine key characteristics that would allow prediction of those patients who are at highest risk for poststroke pneumonia...
  31. pmc Occupational therapy for patients with problems in personal activities of daily living after stroke: systematic review of randomised trials
    Lynn Legg
    Academic Section of Geriatric Medicine, Glasgow Royal Infirmary University NHS Trust, Glasgow G31 2ER
    BMJ 335:922. 2007
    ..To determine whether occupational therapy focused specifically on personal activities of daily living improves recovery for patients after stroke...
  32. doi request reprint Multidisciplinary care for elderly people in the community
    David J Stott
    Academic Section of Geriatric Medicine, University of Glasgow Faculty of Medicine, Glasgow Royal Infirmary, Glasgow G31 2ER, UK
    Lancet 371:699-700. 2008
  33. ncbi request reprint Editorial comment--Early supported discharge: an idea whose time has come?
    Peter Langhorne
    Stroke 34:2691-2. 2003
  34. ncbi request reprint Alternatives to hospital care
    Helen Rodgers
    Age Ageing 31:151. 2002
  35. ncbi request reprint Predictors of early neurological deterioration after ischaemic stroke: a case-control study
    Mark Barber
    Academic Section of Geriatric Medicine, Glasgow Royal Infirmary, Glasgow, UK
    Gerontology 50:102-9. 2004
    ..Early neurological deterioration after ischaemic stroke (stroke in progression) is reported to be common and associated with poor outcome or death. The causes of progressing stroke are, however, uncertain...
  36. ncbi request reprint Hemostatic function and progressing ischemic stroke: D-dimer predicts early clinical progression
    Mark Barber
    University Section of Clinical Gerontology and Vascular Medicine, Royal Infirmary, Glasgow, UK
    Stroke 35:1421-5. 2004
    ..We hypothesized that activation of the coagulation system is an important contributor in some cases of deterioration. We aimed to characterize alterations in circulating hemostatic markers in patients with progressing stroke...
  37. ncbi request reprint The impact of stroke nurse specialist input on risk factor modification: a randomised controlled trial
    Graham Ellis
    Academic Section of Geriatric Medicine, 3rd Floor, Centre Block, Glasgow Royal Infirmary, Glasgow G4 0SF, UK
    Age Ageing 34:389-92. 2005
  38. ncbi request reprint Impact and influences on caregiver outcomes at one year post-stroke
    Lorraine N Smith
    Nursing and Midwifery School, University of Glasgow, Glasgow G12 8LW, UK
    Cerebrovasc Dis 18:145-53. 2004
    ..Four outcome measures of carer stress and coping at one year post-stroke were identified: carer general health, anxiety, depression and perception of stress...
  39. ncbi request reprint Comprehensive geriatric assessment for older hospital patients
    Graham Ellis
    Academic Section of Geriatric Medicine, University of Glasgow, Level 3, Centre Block, Royal Infirmary, Glasgow G4 0SF, UK
    Br Med Bull 71:45-59. 2004
    ..However, CGA does not reduce long-term mortality. This evidence should inform future service developments...
  40. ncbi request reprint Informal carers' experience of caring for stroke survivors
    Lorraine N Smith
    Nursing and Midwifery School, University of Glasgow, Glasgow, UK
    J Adv Nurs 46:235-44. 2004
    ..However, the burden of caring for stroke survivors usually rests with family members who have neither chosen nor volunteered for the role of 'carer'...
  41. ncbi request reprint Randomized controlled trial of homocysteine-lowering vitamin treatment in elderly patients with vascular disease
    David J Stott
    Division of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom
    Am J Clin Nutr 82:1320-6. 2005
    ..Homocysteine is an independent risk factor for vascular disease and is associated with dementia in older people. Potential mechanisms include altered endothelial and hemostatic function...
  42. ncbi request reprint D-dimer predicts early clinical progression in ischemic stroke: confirmation using routine clinical assays
    Mark Barber
    University Section of Clinical Gerontology and Vascular Medicine, Royal Infirmary, Glasgow, UK
    Stroke 37:1113-5. 2006
    ..We wished to confirm these findings using commercially available assays and to provide data to allow the design of intervention studies...
  43. ncbi request reprint How should stroke services be organised?
    Peter Langhorne
    University of Glasgow, UK
    Lancet Neurol 1:62-8. 2002
  44. ncbi request reprint Effects of augmented exercise therapy time after stroke: a meta-analysis
    Gert Kwakkel
    Department of Physical Therapy and Research Institute for Fundamental and Clinical Human Movement Sciences, VU University Medical Center, Amsterdam, The Netherlands
    Stroke 35:2529-39. 2004
    ..To present a systematic review of studies that addresses the effects of intensity of augmented exercise therapy time (AETT) on activities of daily living (ADL), walking, and dexterity in patients with stroke...
  45. ncbi request reprint European Stroke Initiative Recommendations for Stroke Management-update 2003
    Tom Skyhoj Olsen
    Cerebrovasc Dis 16:311-37. 2003
    ..The recommendations are endorsed by the 3 European societies which are represented in the European Stroke Initiative: the European Stroke Council, the European Neurological Society and the European Federation of Neurological Societies...
  46. ncbi request reprint Oral contraceptives, hormone replacement therapy, thrombophilias and risk of venous thromboembolism: a systematic review. The Thrombosis: Risk and Economic Assessment of Thrombophilia Screening (TREATS) Study
    Olivia Wu
    Department of Obstetrics and Gynaecology, University of Glasgow, Glasgow Royal Infirmary, 10 Alexandra Parade, Glasgow G31 2ER, UK
    Thromb Haemost 94:17-25. 2005
    ..However, further studies are required to establish with greater confidence the associations of these, and other, thrombophilias with venous thromboembolism among hormone users...
  47. ncbi request reprint Speech and language therapy for dysarthria due to nonprogressive brain damage: a systematic Cochrane review
    Cameron Sellars
    STEP Project and Department of Speech and Language Therapy, Glasgow Royal Infirmary, UK
    Clin Rehabil 16:61-8. 2002
    ..Impairment-based therapy and a wide variety of compensatory management strategies are undertaken by speech and language therapists with this patient population...
  48. ncbi request reprint Therapy-based rehabilitation for stroke patients living at home
    Lynn Legg
    Academic Section of Geriatric Medicine, Glasgow Royal Infirmary, Glasgow University, UK
    Stroke 35:1022. 2004
  49. doi request reprint Progression of white matter hyperintensities and incidence of new lacunes over a 3-year period: the Leukoaraiosis and Disability study
    Alida A Gouw
    Department of Neurology, Alzheimer Center and Image Analysis Center, Vrije Universiteit Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Stroke 39:1414-20. 2008
    ..We studied the natural course of white matter hyperintensities (WMH) and lacunes, the main MRI representatives of small vessel disease, over time and evaluated possible predictors for their development...
  50. doi request reprint Reliability and sensitivity of visual scales versus volumetry for evaluating white matter hyperintensity progression
    A A Gouw
    Alzheimer Center, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Cerebrovasc Dis 25:247-53. 2008
    ..However, the most suitable method for measuring WMH progression has not been established yet. We compared the reliability and sensitivity of cross-sectional and longitudinal visual scales with volumetry for measuring WMH progression...
  51. ncbi request reprint Does the prevention of complications explain the survival benefit of organized inpatient (stroke unit) care?: further analysis of a systematic review
    Lindsay Govan
    Academic Section of Geriatric Medicine, University Block, Glasgow Royal Infirmary, Glasgow, UK
    Stroke 38:2536-40. 2007
    ..However, it is unclear how this is achieved. We tested whether stroke unit care could reduce deaths by preventing complications...
  52. ncbi request reprint Organization of stroke care: education, referral, emergency management and imaging, stroke units and rehabilitation. European Stroke Initiative
    Michael Brainin
    Cerebrovasc Dis 17:1-14. 2004
  53. ncbi request reprint Geriatric wards in acute hospitals
    Graham Ellis
    Age Ageing 34:417-8. 2005
  54. ncbi request reprint Mobilisation 'in bed' is not mobilisation
    Julie Bernhardt
    Cerebrovasc Dis 24:157-8; author reply 159. 2007
  55. ncbi request reprint Screening for thrombophilia in high-risk situations: a meta-analysis and cost-effectiveness analysis
    Olivia Wu
    Division of Developmental Medicine, University of Glasgow, Glasgow, UK
    Br J Haematol 131:80-90. 2005
    ..Selective thrombophilia screening based on previous personal and/or family history of venous thromboembolism was more cost-effective than universal screening in all the patient groups evaluated...
  56. ncbi request reprint Stroke units: the next 10 years
    Peter Langhorne
    Academic Section of Geriatric Medicine, Royal Infirmary, Glasgow G4 OSF, UK
    Lancet 363:834-5. 2004
  57. ncbi request reprint An internationally agreed definition of progressing stroke
    Mark Barber
    Cerebrovasc Dis 18:255-6; author reply 256-7. 2004
  58. ncbi request reprint The main components of stroke unit care: what is the question?
    Peter Langhorne
    Cerebrovasc Dis 23:464; author reply 465. 2007