P J L Lane

Summary

Affiliation: University of Birmingham
Country: UK

Publications

  1. pmc Lymphoid tissue inducer cells: pivotal cells in the evolution of CD4 immunity and tolerance?
    Peter J L Lane
    MRC Centre for Immune Regulation and College of Medical and Dental Sciences, University of Birmingham Birmingham, UK
    Front Immunol 3:24. 2012
  2. pmc Abrogation of CD30 and OX40 signals prevents autoimmune disease in FoxP3-deficient mice
    Fabrina Gaspal
    MRC Centre for Immune Regulation, Institute for Biomedical Research, Birmingham Medical School, Birmingham B15 2TT, England, UK
    J Exp Med 208:1579-84. 2011
  3. doi request reprint Lymphoid tissue inducer cells: innate cells critical for CD4+ T cell memory responses?
    Peter J L Lane
    MRC Centre for Immune Regulation, College of Medical and Dental Sciences, University of Birmingham, UK
    Ann N Y Acad Sci 1247:1-15. 2012
  4. ncbi request reprint Developmental regulation of dendritic cell function
    P J Lane
    MRC Centre for Immune Regulation, Department of Immunology and Infection, Medical School, University of Birmingham, Birmingham, B15 2TT, UK
    Curr Opin Immunol 11:308-13. 1999
  5. doi request reprint Lymphoid tissue inducer cells in adaptive CD4 T cell dependent responses
    Peter Lane
    MRC Centre for Immune Regulation, Institute for Biomedical Research, Birmingham Medical School, Birmingham, UK
    Semin Immunol 20:159-63. 2008
  6. ncbi request reprint The architects of B and T cell immune responses
    Peter J L Lane
    Medical Research Council Centre for Immune Regulation, Institute for Biomedical Research, Birmingham Medical School, Vincent Drive, Birmingham B15 2TT, UK
    Immunity 29:171-2. 2008
  7. ncbi request reprint Lymphoid tissue inducer cells: bridges between the ancient innate and the modern adaptive immune systems
    P J L Lane
    MRC Centre for Immune Regulation, Institute for Biomedical Research, Birmingham Medical School, Birmingham, UK
    Mucosal Immunol 2:472-7. 2009
  8. ncbi request reprint CD4+CD3- cells regulate the organization of lymphoid tissue and T-cell memory for antibody responses
    Peter J L Lane
    MRC Centre for Immune Regulation, Institute for Biomedical Research, Birmingham Medical School, Birmingham, UK
    Int J Hematol 83:12-6. 2006
  9. pmc Two sides of a cellular coin: CD4(+)CD3- cells regulate memory responses and lymph-node organization
    Peter J L Lane
    Medical Research Council, Centre for Immune Regulation, Birmingham Medical School, Vincent Drive, Birmingham B15 2TT, UK
    Nat Rev Immunol 5:655-60. 2005
  10. ncbi request reprint Dendritic cell subsets and costimulation for effector T-cell responses
    P J Lane
    MRC Centre for Immune Regulation, Department of Immunology and Infection, The Medical School, University of Birmingham, UK
    Curr Opin Pharmacol 1:409-16. 2001

Collaborators

Detail Information

Publications37

  1. pmc Lymphoid tissue inducer cells: pivotal cells in the evolution of CD4 immunity and tolerance?
    Peter J L Lane
    MRC Centre for Immune Regulation and College of Medical and Dental Sciences, University of Birmingham Birmingham, UK
    Front Immunol 3:24. 2012
    ..We suggest that like memory CD4 T cells, LTi also play a role in the selection and maintenance of the T(regs) that under normal circumstances are absolutely required to regulate CD4 effector cells...
  2. pmc Abrogation of CD30 and OX40 signals prevents autoimmune disease in FoxP3-deficient mice
    Fabrina Gaspal
    MRC Centre for Immune Regulation, Institute for Biomedical Research, Birmingham Medical School, Birmingham B15 2TT, England, UK
    J Exp Med 208:1579-84. 2011
    ....
  3. doi request reprint Lymphoid tissue inducer cells: innate cells critical for CD4+ T cell memory responses?
    Peter J L Lane
    MRC Centre for Immune Regulation, College of Medical and Dental Sciences, University of Birmingham, UK
    Ann N Y Acad Sci 1247:1-15. 2012
    ....
  4. ncbi request reprint Developmental regulation of dendritic cell function
    P J Lane
    MRC Centre for Immune Regulation, Department of Immunology and Infection, Medical School, University of Birmingham, Birmingham, B15 2TT, UK
    Curr Opin Immunol 11:308-13. 1999
    ..In particular, there have been some key insights into how dendritic cells subsequently direct the evolution of immune responses by differential expression of co-stimulatory molecules...
  5. doi request reprint Lymphoid tissue inducer cells in adaptive CD4 T cell dependent responses
    Peter Lane
    MRC Centre for Immune Regulation, Institute for Biomedical Research, Birmingham Medical School, Birmingham, UK
    Semin Immunol 20:159-63. 2008
    ..We speculate that their human equivalents could be potential targets for HIV infection and their destruction explains the pattern of loss of CD4 T cells...
  6. ncbi request reprint The architects of B and T cell immune responses
    Peter J L Lane
    Medical Research Council Centre for Immune Regulation, Institute for Biomedical Research, Birmingham Medical School, Vincent Drive, Birmingham B15 2TT, UK
    Immunity 29:171-2. 2008
    ..Published work links adult lymphoid tissue-inducer cells (LTi) with T cell-dependent antibody responses. In this issue of Immunity, Tsuji et al. (2008) associate LTi with T cell-independent IgA antibody responses in the gut...
  7. ncbi request reprint Lymphoid tissue inducer cells: bridges between the ancient innate and the modern adaptive immune systems
    P J L Lane
    MRC Centre for Immune Regulation, Institute for Biomedical Research, Birmingham Medical School, Birmingham, UK
    Mucosal Immunol 2:472-7. 2009
    ..In this review, we concentrate on the latter function: the sustenance by LTis of CD4 T-cell responses for protective immunity...
  8. ncbi request reprint CD4+CD3- cells regulate the organization of lymphoid tissue and T-cell memory for antibody responses
    Peter J L Lane
    MRC Centre for Immune Regulation, Institute for Biomedical Research, Birmingham Medical School, Birmingham, UK
    Int J Hematol 83:12-6. 2006
    ....
  9. pmc Two sides of a cellular coin: CD4(+)CD3- cells regulate memory responses and lymph-node organization
    Peter J L Lane
    Medical Research Council, Centre for Immune Regulation, Birmingham Medical School, Vincent Drive, Birmingham B15 2TT, UK
    Nat Rev Immunol 5:655-60. 2005
    ....
  10. ncbi request reprint Dendritic cell subsets and costimulation for effector T-cell responses
    P J Lane
    MRC Centre for Immune Regulation, Department of Immunology and Infection, The Medical School, University of Birmingham, UK
    Curr Opin Pharmacol 1:409-16. 2001
    ..Recent work has revealed the specialization between different dendritic cell subsets and how this relates to their different functions in optimizing T-cell help for antibody responses and inflammatory T-cell responses...
  11. ncbi request reprint OX40 signals during priming on dendritic cells inhibit CD4 T cell proliferation: IL-4 switches off OX40 signals enabling rapid proliferation of Th2 effectors
    Mi Yeon Kim
    Medical Research Council Centre for Immune Regulation, Birmingham Medical School, Birmingham, United Kingdom
    J Immunol 174:1433-7. 2005
    ..This would serve to limit inappropriate T cell responses. In contrast, OX40 signals from CD4(+)CD3(-) cells located in the outer T zone select proliferating Th2 effectors into the memory T cell pool...
  12. ncbi request reprint Role of CD30 in B/T segregation in the spleen
    Vasileios Bekiaris
    Medical Research Council Centre for Immune Regulation, Birmingham Medical School, Birmingham, UK
    J Immunol 179:7535-43. 2007
    ....
  13. pmc Lymphotoxin signals from positively selected thymocytes regulate the terminal differentiation of medullary thymic epithelial cells
    Andrea J White
    Medical Research Council Centre for Immune Regulation, Institute for Biomedical Research, Medical School, University of Birmingham, Edgbaston, Birmingham, UK
    J Immunol 185:4769-76. 2010
    ..Collectively, our results reveal further complexity in the mechanisms regulating thymus medulla development and highlight the role of distinct TNFRs in initial and terminal differentiation stages in mTECs...
  14. doi request reprint Splenic stromal cells mediate IL-7 independent adult lymphoid tissue inducer cell survival
    Tie Zheng Hou
    School of Immunity and Infection, MRC Centre for Immune Regulation, Institute for Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, UK
    Eur J Immunol 40:359-65. 2010
    ..Our findings show that adult LTi-like cells require extrinsic signals from podoplanin(+) splenic stromal cells to survive and suggest that IL-7 is not necessary to mediate their survival in the adult spleen...
  15. ncbi request reprint NK cells protect secondary lymphoid tissue from cytomegalovirus via a CD30-dependent mechanism
    Vasileios Bekiaris
    Medical Research Council Centre for Immune Regulation, School of Medicine, University of Birmingham, Birmingham, UK
    Eur J Immunol 39:2800-8. 2009
    ..Our data define the necessity of NK cells for protection of secondary lymphoid organs and describe a mechanism by which this protection is conferred...
  16. ncbi request reprint Mice deficient in OX40 and CD30 signals lack memory antibody responses because of deficient CD4 T cell memory
    Fabrina M C Gaspal
    Medical Research Council Center for Immune Regulation, Institute for Biomedical Research, Birmingham Medical School, Birmingham, United Kingdom
    J Immunol 174:3891-6. 2005
    ..Finally, we show that OX40/CD30 double-knockout OTII transgenic T cells fail to survive compared with normal T cells when cocultured with CD4(+)CD3(-) cells in vitro...
  17. ncbi request reprint Function of CD4+CD3- cells in relation to B- and T-zone stroma in spleen
    Mi Yeon Kim
    Medical Research Council, Centre for Immune Regulation, Institute for Biomedical Research, Birmingham Medical School, UK
    Blood 109:1602-10. 2007
    ..We propose that the function of CD4+CD3- cells is to form a link between primed CD4 T cells and the underlying stromal elements, creating distinct microenvironments in which they enable effector responses...
  18. pmc Heterogeneity of lymphoid tissue inducer cell populations present in embryonic and adult mouse lymphoid tissues
    Mi Yeon Kim
    MRC Centre for Immune Regulation, Institute for Biomedical Research, Birmingham Medical School, Birmingham, UK
    Immunology 124:166-74. 2008
    ..6% for adult CD4(+) and 87.6% for adult CD4(-); 95.3% for embryonic CD4(+) and 91.5% for embryonic CD4(-). Consistently fewer CCR7 single-positive cells were found in the CD4(+) and CD4(-) fractions in the embryo...
  19. ncbi request reprint The generation of thymus-independent germinal centers depends on CD40 but not on CD154, the T cell-derived CD40-ligand
    Fabrina M C Gaspal
    MRC Centre for Immune Regulation, University of Birmingham, Birmingham, UK
    Eur J Immunol 36:1665-73. 2006
    ....
  20. doi request reprint Synergistic OX40 and CD30 signals sustain CD8+ T cells during antigenic challenge
    Vasileios Bekiaris
    Medical Research Council Centre for Immune Regulation, Birmingham Medical School, University of Birmingham, Birmingham, UK
    Eur J Immunol 39:2120-5. 2009
    ....
  21. pmc Transplantation of embryonic spleen tissue reveals a role for adult non-lymphoid cells in initiating lymphoid tissue organization
    Stephanie H Glanville
    MRC Centre for Immune Regulation, Institute for Biomedical Research, Birmingham Medical School, Birmingham, UK
    Eur J Immunol 39:280-9. 2009
    ..The model described here demonstrates a method of transferring whole splenic microenvironments and dissecting the stromal and hematopoietic signals involved in spleen development and organization...
  22. pmc RANK signals from CD4(+)3(-) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla
    Simona W Rossi
    Medical Research Council Centre for Immune Regulation, Institute for Biomedical Research, University of Birmingham, B15 2TT Birmingham, UK
    J Exp Med 204:1267-72. 2007
    ..Collectively, our data reveal cellular and molecular mechanisms leading to the generation of Aire(+) mTECs and highlight a previously unrecognized role for CD4(+)3(-)RANKL(+) inducer cells in intrathymic self-tolerance...
  23. ncbi request reprint OX40 ligand and CD30 ligand are expressed on adult but not neonatal CD4+CD3- inducer cells: evidence that IL-7 signals regulate CD30 ligand but not OX40 ligand expression
    Mi Yeon Kim
    Medical Research Council Centre for Immune Regulation, Division of Medical Sciences, Birmingham Medical School, UK
    J Immunol 174:6686-91. 2005
    ..Furthermore, glucocorticoids, which potently suppress T effector function, did not influence the expression of OX40L and CD30L in the presence of IL-7...
  24. doi request reprint Sequential phases in the development of Aire-expressing medullary thymic epithelial cells involve distinct cellular input
    Andrea J White
    MRC Centre for Immune Regulation, Institute for Biomedical Research, University of Birmingham Medical School, Birmingham, UK
    Eur J Immunol 38:942-7. 2008
    ....
  25. pmc The survival of memory CD4+ T cells within the gut lamina propria requires OX40 and CD30 signals
    David R Withers
    Medical Research Council Centre for Immune Regulation, Institute for Biomedical Research, Medical School, University of Birmingham, Birmingham, United Kingdom
    J Immunol 183:5079-84. 2009
    ..Collectively, these data demonstrate that signals through CD30 and OX40 are required for the survival of CD4(+) T cells within the small intestine lamina propria...
  26. pmc IL-4 directs both CD4 and CD8 T cells to produce Th2 cytokines in vitro, but only CD4 T cells produce these cytokines in response to alum-precipitated protein in vivo
    Karine Serre
    MRC Centre for Immune Regulation, The IBR, School of Immunity and Infection, University of Birmingham, Birmingham B15 2TT, United Kingdom
    Mol Immunol 47:1914-22. 2010
    ....
  27. ncbi request reprint Salmonella induces a switched antibody response without germinal centers that impedes the extracellular spread of infection
    Adam F Cunningham
    Medical Research Council Centre for Immune Regulation, University of Birmingham, Birmingham, United Kingdom
    J Immunol 178:6200-7. 2007
    ..These results may explain why attenuated Salmonella-induced B cell responses are protective in secondary, but not primary infections...
  28. ncbi request reprint The role of lymphoid tissue inducer cells in splenic white pulp development
    David R Withers
    MRC Centre for Immune Regulation, Institute for Biomedical Research, Birmingham Medical School, Birmingham, UK
    Eur J Immunol 37:3240-5. 2007
    ..Our studies indicate that a combination of LT signals from LTi cells and LT-independent signals from lymphocytes is sufficient for expression of podoplanin and CCL21 on splenic T cell zone stroma and subsequent T cell organisation...
  29. doi request reprint Absence of thymus crosstalk in the fetus does not preclude hematopoietic induction of a functional thymus in the adult
    Natalie A Roberts
    MRC Centre for Immune Regulation, Institute for Biomedical Research, University of Birmingham, UK
    Eur J Immunol 39:2395-402. 2009
    ..Collectively, our data argue against a temporal window of thymocyte crosstalk, and instead demonstrates continued receptiveness of thymic epithelium for the formation of functionally competent thymic microenvironments...
  30. ncbi request reprint Generating intrathymic microenvironments to establish T-cell tolerance
    Graham Anderson
    MRC Centre for Immune Regulation, Institute for Biomedical Research, Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Nat Rev Immunol 7:954-63. 2007
    ..We summarize current knowledge on the formation of thymic epithelial-cell microenvironments, and highlight similarities between the environments that produce T cells and those that select and maintain them during immune responses...
  31. doi request reprint Lymphoid tissue inducer cells and the evolution of CD4 dependent high-affinity antibody responses
    Peter J L Lane
    MRC Centre for Immune Regulation, Institute for Biomedical Research, Birmingha Medical School, Birmingham, UK
    Prog Mol Biol Transl Sci 92:159-74. 2010
    ..In this review, we concentrate on the role of this cell type in the making of a tolerant CD4 T cell repertoire and in the sustenance of CD4 T cell responses for protective immunity...
  32. ncbi request reprint Ly49H+ NK cells migrate to and protect splenic white pulp stroma from murine cytomegalovirus infection
    Vasileios Bekiaris
    Medical Research Council Centre for Immune Regulation, Birmingham Medical School, Birmingham, UK
    J Immunol 180:6768-76. 2008
    ..Our data explain how NK cells protect the lymphoid-rich white pulp areas from CMV, allowing protective adaptive T cell-dependent immune responses to develop, and how this mechanism might break down in immunocompromised patients...
  33. ncbi request reprint Neonatal and adult CD4+ CD3- cells share similar gene expression profile, and neonatal cells up-regulate OX40 ligand in response to TL1A (TNFSF15)
    Mi Yeon Kim
    Medical Research Council Centre for Immune Regulation, Institute for Biomedical Research, Birmingham Medical School, Birmingham, United Kingdom
    J Immunol 177:3074-81. 2006
    ..Finally, we demonstrate that this differentiation occurs in vivo: neonatal CD4+ CD3- cells up-regulate both CD30L and OX40L after adoptive transfer into an adult recipient...
  34. ncbi request reprint Established T cell-driven germinal center B cell proliferation is independent of CD28 signaling but is tightly regulated through CTLA-4
    Lucy S K Walker
    Department of Pathology, University of California, San Francisco, CA 94143, USA
    J Immunol 170:91-8. 2003
    ..By examining germinal center responses in mice where the ability to signal through T cell CTLA-4 was compromised, we provide data that supports a critical role for CTLA-4 in down-regulating T cell help for germinal center B cells...
  35. ncbi request reprint CD4(+)CD3(-) accessory cells costimulate primed CD4 T cells through OX40 and CD30 at sites where T cells collaborate with B cells
    Mi Yeon Kim
    Medical Research Council Centre for Immune Regulation, University of Birmingham Medical School, United Kingdom
    Immunity 18:643-54. 2003
    ..Furthermore, we show that the preferential survival of OX40(+) T cells and support of memory T cell help for B cells are linked to their association with CD4(+)CD3(-) cells in vivo...