Nick Lane

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint An Origin-of-Life Reactor to Simulate Alkaline Hydrothermal Vents
    Barry Herschy
    Department of Genetics, Evolution and Environment, University College London, London, UK
    J Mol Evol 79:213-27. 2014
  2. pmc Energy, genes and evolution: introduction to an evolutionary synthesis
    Nick Lane
    Department of Genetics, Evolution and Environment, University College London, London, UK
    Philos Trans R Soc Lond B Biol Sci 368:20120253. 2013
  3. ncbi request reprint The origin of membrane bioenergetics
    Nick Lane
    Research Department of Genetics, Evolution and Environment, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK
    Cell 151:1406-16. 2012
  4. doi request reprint The problem with mixing mitochondria
    Nick Lane
    Department of Genetics, Evolution and Environment, University College London, Gower Street, London WC1E 6BT, UK Electronic address
    Cell 151:246-8. 2012
  5. ncbi request reprint The energetics of genome complexity
    Nick Lane
    Department of Genetics, Evolution and Environment, University College London, Gower Street, London W1E 6BT, UK
    Nature 467:929-34. 2010
  6. pmc Energetics and genetics across the prokaryote-eukaryote divide
    Nick Lane
    Department of Genetics, Evolution and Environment, University College London, London, UK
    Biol Direct 6:35. 2011
  7. ncbi request reprint Mitonuclear match: optimizing fitness and fertility over generations drives ageing within generations
    Nick Lane
    Department of Genetics, Evolution and Environment, University College London, London, UK
    Bioessays 33:860-9. 2011
  8. pmc Dynamics of mitochondrial inheritance in the evolution of binary mating types and two sexes
    Zena Hadjivasiliou
    CoMPLEX, University College London, Gower Street, London W1E 6BT, UK
    Proc Biol Sci 280:20131920. 2013
  9. ncbi request reprint A unifying view of ageing and disease: the double-agent theory
    Nick Lane
    Department of Surgery, Royal Free and University College Medical School, Pond Street, NW3 2QG London, UK
    J Theor Biol 225:531-40. 2003
  10. ncbi request reprint How did LUCA make a living? Chemiosmosis in the origin of life
    Nick Lane
    Department of Genetics, Evolution and Environment, University College London, London, UK
    Bioessays 32:271-80. 2010

Collaborators

Detail Information

Publications13

  1. ncbi request reprint An Origin-of-Life Reactor to Simulate Alkaline Hydrothermal Vents
    Barry Herschy
    Department of Genetics, Evolution and Environment, University College London, London, UK
    J Mol Evol 79:213-27. 2014
    ..These simulated vent structures appear to generate low yields of simple organics. Synthetic microporous matrices can concentrate organics by thermophoresis over several orders of magnitude under continuous open-flow vent conditions. ..
  2. pmc Energy, genes and evolution: introduction to an evolutionary synthesis
    Nick Lane
    Department of Genetics, Evolution and Environment, University College London, London, UK
    Philos Trans R Soc Lond B Biol Sci 368:20120253. 2013
    ..We hope that these papers will contribute to a new evolutionary synthesis of energetics and genetics...
  3. ncbi request reprint The origin of membrane bioenergetics
    Nick Lane
    Research Department of Genetics, Evolution and Environment, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK
    Cell 151:1406-16. 2012
    ..Our hypothesis accounts for the Na(+)/H(+) promiscuity of bioenergetic proteins, as well as the deep divergence between bacteria and archaea...
  4. doi request reprint The problem with mixing mitochondria
    Nick Lane
    Department of Genetics, Evolution and Environment, University College London, Gower Street, London WC1E 6BT, UK Electronic address
    Cell 151:246-8. 2012
    ..show that heteroplasmy has surprising genetic and behavioral effects in mice, even when each haplotype alone produces a normal phenotype. This interference is bioenergetic and may have contributed to the evolution of sexes...
  5. ncbi request reprint The energetics of genome complexity
    Nick Lane
    Department of Genetics, Evolution and Environment, University College London, Gower Street, London W1E 6BT, UK
    Nature 467:929-34. 2010
    ..This vast leap in genomic capacity was strictly dependent on mitochondrial power, and prerequisite to eukaryote complexity: the key innovation en route to multicellular life...
  6. pmc Energetics and genetics across the prokaryote-eukaryote divide
    Nick Lane
    Department of Genetics, Evolution and Environment, University College London, London, UK
    Biol Direct 6:35. 2011
    ..Here I argue that the eukaryotic cell originated in a unique prokaryotic endosymbiosis, a singular event that transformed the selection pressures acting on both host and endosymbiont...
  7. ncbi request reprint Mitonuclear match: optimizing fitness and fertility over generations drives ageing within generations
    Nick Lane
    Department of Genetics, Evolution and Environment, University College London, London, UK
    Bioessays 33:860-9. 2011
    ..This coherent view of eukaryotic energetics offers striking insights into infertility and age-related diseases...
  8. pmc Dynamics of mitochondrial inheritance in the evolution of binary mating types and two sexes
    Zena Hadjivasiliou
    CoMPLEX, University College London, Gower Street, London W1E 6BT, UK
    Proc Biol Sci 280:20131920. 2013
    ..We conclude that UPI of mitochondria alone is unlikely to have driven the evolution of two mating types in unicellular eukaryotes. ..
  9. ncbi request reprint A unifying view of ageing and disease: the double-agent theory
    Nick Lane
    Department of Surgery, Royal Free and University College Medical School, Pond Street, NW3 2QG London, UK
    J Theor Biol 225:531-40. 2003
    ..Gene therapies for age-related diseases are unlikely to succeed unless oxidative stress can be controlled physiologically, thereby altering the activity and function of potentially hundreds of genes...
  10. ncbi request reprint How did LUCA make a living? Chemiosmosis in the origin of life
    Nick Lane
    Department of Genetics, Evolution and Environment, University College London, London, UK
    Bioessays 32:271-80. 2010
    ..Synthesis of ATP by chemiosmosis today involves generation of an ion gradient by means of vectorial electron transfer from a donor to an acceptor. We argue that the first donor was hydrogen and the first acceptor CO2...
  11. pmc Selection for mitonuclear co-adaptation could favour the evolution of two sexes
    Zena Hadjivasiliou
    CoMPLEX, University College London, Gower Street, London W1E 6BT, UK
    Proc Biol Sci 279:1865-72. 2012
    ..We conclude that, under a wide range of conditions, selection for mitonuclear co-adaptation favours the evolution of two distinct mating types or sexes in sexual species...
  12. pmc A bioenergetic basis for membrane divergence in archaea and bacteria
    Víctor Sojo
    Department of Genetics, Evolution and Environment, University College London, London, United Kingdom CoMPLEX, University College London, London, United Kingdom
    PLoS Biol 12:e1001926. 2014
    ..Our findings elucidate the paradox that archaea and bacteria share DNA transcription, ribosomal translation, and ATP synthase, yet differ in equally fundamental traits that depend on the membrane, including DNA replication. ..