P Landini

Summary

Affiliation: University of Birmingham
Country: UK

Publications

  1. ncbi Ada protein-RNA polymerase sigma subunit interaction and alpha subunit-promoter DNA interaction are necessary at different steps in transcription initiation at the Escherichia coli Ada and aidB promoters
    P Landini
    School of Biochemistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    J Biol Chem 273:13307-12. 1998
  2. ncbi The Escherichia coli Ada protein can interact with two distinct determinants in the sigma70 subunit of RNA polymerase according to promoter architecture: identification of the target of Ada activation at the alkA promoter
    P Landini
    School of Biochemistry, The University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    J Bacteriol 181:1524-9. 1999
  3. ncbi Activation and repression of transcription initiation in bacteria
    G Lloyd
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT
    Essays Biochem 37:17-31. 2001
  4. ncbi The leucine-responsive regulatory protein (Lrp) acts as a specific repressor for sigma s-dependent transcription of the Escherichia coli aidB gene
    P Landini
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester 01655, USA
    Mol Microbiol 20:947-55. 1996
  5. ncbi The RNA polymerase alpha subunit carboxyl-terminal domain is required for both basal and activated transcription from the alkA promoter
    P Landini
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Biol Chem 272:15914-9. 1997
  6. ncbi Structure and transcriptional regulation of the Escherichia coli adaptive response gene aidB
    P Landini
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester 01655
    J Bacteriol 176:6583-9. 1994
  7. ncbi Transcriptional activation of the Escherichia coli adaptive response gene aidB is mediated by binding of methylated Ada protein. Evidence for a new consensus sequence for Ada-binding sites
    P Landini
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester 01655, USA
    J Biol Chem 270:8285-9. 1995
  8. ncbi Expression of the Escherichia coli ada regulon in stationary phase: evidence for rpoS-dependent negative regulation of alkA transcription
    P Landini
    Swiss Federal Institute for Environmental Science and Technology EAWAG, 8600 Dubendorf, Switzerland
    J Bacteriol 181:6836-9. 1999
  9. ncbi Regulatory responses of the adaptive response to alkylation damage: a simple regulon with complex regulatory features
    P Landini
    Department of Environmental Microbiology and Molecular Ecotoxicology, Swiss Institute for Environmental Technology, 8600 Duebendorf, Switzerland
    J Bacteriol 182:6543-9. 2000
  10. ncbi Transcriptional responses to DNA damage
    M R Volkert
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Curr Opin Microbiol 4:178-85. 2001

Collaborators

Detail Information

Publications12

  1. ncbi Ada protein-RNA polymerase sigma subunit interaction and alpha subunit-promoter DNA interaction are necessary at different steps in transcription initiation at the Escherichia coli Ada and aidB promoters
    P Landini
    School of Biochemistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    J Biol Chem 273:13307-12. 1998
    ..Based on these observations, we propose that the role of the alpha subunit at ada and aidB is to allow initial binding of RNA polymerase to the promoters. However, transcription initiation is dependent on meAda-sigma70 interaction...
  2. ncbi The Escherichia coli Ada protein can interact with two distinct determinants in the sigma70 subunit of RNA polymerase according to promoter architecture: identification of the target of Ada activation at the alkA promoter
    P Landini
    School of Biochemistry, The University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    J Bacteriol 181:1524-9. 1999
    ..We propose that meAda can activate transcription at different promoters by contacting distinct determinants in sigma70 region 4 in a manner dependent on the location of the Ada binding site...
  3. ncbi Activation and repression of transcription initiation in bacteria
    G Lloyd
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT
    Essays Biochem 37:17-31. 2001
    ..Many promoters are regulated by more than one transcription factor. A variety of mechanisms whereby a promoter can be regulated by a repressor and an activator, or by two activators, is known...
  4. ncbi The leucine-responsive regulatory protein (Lrp) acts as a specific repressor for sigma s-dependent transcription of the Escherichia coli aidB gene
    P Landini
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester 01655, USA
    Mol Microbiol 20:947-55. 1996
    ..Leucine counteracts Lrp binding to P aidB, as does binding to P aidB of me Ada, which causes Lrp to dissociate from the promoter. The physiological significance of aidB transcription regulation is discussed...
  5. ncbi The RNA polymerase alpha subunit carboxyl-terminal domain is required for both basal and activated transcription from the alkA promoter
    P Landini
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Biol Chem 272:15914-9. 1997
    ..These observations suggest that both forms of Ada protein activate alkA transcription by enhancing RNA polymerase holoenzyme and alpha subunit binding...
  6. ncbi Structure and transcriptional regulation of the Escherichia coli adaptive response gene aidB
    P Landini
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester 01655
    J Bacteriol 176:6583-9. 1994
    ..Ada protein plays a direct role in aidB regulation: methylated Ada is able to bind to the aidB promoter region and to activate transcription from aidB in an in vitro transcription-translation system using crude E. coli extracts...
  7. ncbi Transcriptional activation of the Escherichia coli adaptive response gene aidB is mediated by binding of methylated Ada protein. Evidence for a new consensus sequence for Ada-binding sites
    P Landini
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester 01655, USA
    J Biol Chem 270:8285-9. 1995
    ..We propose that these elements, in addition to the proposed recognition sequence, are important for binding of the Ada protein...
  8. ncbi Expression of the Escherichia coli ada regulon in stationary phase: evidence for rpoS-dependent negative regulation of alkA transcription
    P Landini
    Swiss Federal Institute for Environmental Science and Technology EAWAG, 8600 Dubendorf, Switzerland
    J Bacteriol 181:6836-9. 1999
    ..Thus, at the alkA promoter, the Ada protein can act as both a positive and negative modulator of the adaptive response to alkylation damage, depending on the cell's physiological state...
  9. ncbi Regulatory responses of the adaptive response to alkylation damage: a simple regulon with complex regulatory features
    P Landini
    Department of Environmental Microbiology and Molecular Ecotoxicology, Swiss Institute for Environmental Technology, 8600 Duebendorf, Switzerland
    J Bacteriol 182:6543-9. 2000
  10. ncbi Transcriptional responses to DNA damage
    M R Volkert
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Curr Opin Microbiol 4:178-85. 2001
    ..Transcription of the responses to DNA damage are induced when the activated regulatory proteins stimulate transcription of the genes they control by a variety of complex and unique molecular mechanisms...
  11. ncbi Complex regulatory network controls initial adhesion and biofilm formation in Escherichia coli via regulation of the csgD gene
    C Prigent-Combaret
    Unité de Microbiologie et Génétique, CNRS UMR 5122, Institut National des Sciences Appliquees de Lyon, 69621 Villeurbanne Cedex, France
    J Bacteriol 183:7213-23. 2001
    ....
  12. ncbi RNA polymerase alpha subunit binding site in positively controlled promoters: a new model for RNA polymerase-promoter interaction and transcriptional activation in the Escherichia coli ada and aidB genes
    P Landini
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester 01655, USA
    EMBO J 14:4329-35. 1995
    ..Instead, Ada stimulates transcription by modifying the nature of the RNA polymerase-promoter interaction, allowing RNA polymerase to recognize the core promoter -35 and -10 elements in addition to the UP-like element...