Research Topics
| Matthew A Lambon RalphSummaryAffiliation: University of Manchester Country: UK Publications
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Publications
Finite case series or infinite single-case studies? Comments on "Case series investigations in cognitive neuropsychology" by Schwartz and Dell (2010)Matthew A Lambon Ralph
Neuroscience and Aphasia Research Unit, School of Psychological Sciences, University of Manchester, Manchester, UK
Cogn Neuropsychol 28:466-74; discussion 515-20. 2011..We conclude by suggesting that, alongside other neuroscience techniques, case-series cognitive neuropsychology provides a crucial contribution to the future of clinical and cognitive neuroscience...- Generalization and differentiation in semantic memory: insights from semantic dementiaMatthew A Lambon Ralph
Neuroscience and Aphasia Research Unit, School of Psychological Sciences, University of Manchester, Manchester, UK
Ann N Y Acad Sci 1124:61-76. 2008..The article describes a comprehensive array of under- and overgeneralization errors by patients with SD when engaged in receptive and expressive verbal and nonverbal tasks and everyday behaviors... - Taking both sides: do unilateral anterior temporal lobe lesions disrupt semantic memory?Matthew A Lambon Ralph
Neuroscience and Aphasia Research Unit, School of Psychological Sciences, University of Manchester, Zochonis Building, Brunswick Street, Manchester, M13 9PL, UK
Brain 133:3243-55. 2010.... - Predicting the outcome of anomia therapy for people with aphasia post CVA: both language and cognitive status are key predictorsMatthew A Lambon Ralph
Neuroscience and Aphasia Research Unit, School of Psychological Sciences, University of Manchester, Oxford Road, Manchester, UK
Neuropsychol Rehabil 20:289-305. 2010..Pre-treatment naming ability also predicted gain after the anomia therapy. When combined, both cognitive and language (naming or phonological) skills were found to be independent predictors of therapy outcome... 
Semantic memory is impaired in patients with unilateral anterior temporal lobe resection for temporal lobe epilepsyMatthew A Lambon Ralph
Neuroscience and Aphasia Research Unit NARU, School of Psychological Sciences, University of Manchester, Manchester M13 9PL, UK
Brain 135:242-58. 2012....- Different impairments of semantic cognition in semantic dementia and semantic aphasia: evidence from the non-verbal domainFaye Corbett
Neuroscience and Aphasia Research Unit NARU, School of Psychological Sciences, University of Manchester, Manchester, UK
Brain 132:2593-608. 2009..This study provides converging evidence for qualitatively different impairments of semantic cognition in SD and SA, and uniquely demonstrates this pattern in a non-verbal expressive domain-object use... 
Neural basis of category-specific semantic deficits for living things: evidence from semantic dementia, HSVE and a neural network modelMatthew A Lambon Ralph
School of Psychological Sciences, University of Manchester, Manchester, UK
Brain 130:1127-37. 2007..Three novel predictions from this model were tested and confirmed, thereby adding weight to the hypothesis that both type and distribution of pathology can be critical in producing neuropsychological phenomena...- Conceptual knowledge is underpinned by the temporal pole bilaterally: convergent evidence from rTMSMatthew A Lambon Ralph
University of Manchester, UK
Cereb Cortex 19:832-8. 2009..The time required to make semantic decisions was slowed considerably, yet specifically, by this procedure. The results confirm that both TPs form a critical substrate within the neural network that supports conceptual knowledge... - Elucidating the nature of deregulated semantic cognition in semantic aphasia: evidence for the roles of prefrontal and temporo-parietal corticesKrist A Noonan
University of Manchester, Manchester, UK
J Cogn Neurosci 22:1597-613. 2010.... - Surface dyslexia in semantic dementia: a comparison of the influence of consistency and regularityElizabeth Jefferies
Department of Psychology, University of Manchester, UK
Neurocase 10:290-9. 2004..2001) and the triangle model (Plaut et al., 1996). It is argued that the triangle model provides a more straightforward account of the relationship between word comprehension and consistency effects in reading... - The natural history of late-stage "pure" semantic dementiaElizabeth Jefferies
School of Psychological Sciences, University of Manchester, Oxford Road, Manchester, M13 9PL, UK
Neurocase 12:1-14. 2006..These findings are discussed in terms of theories that posit strong interactivity between phonology and semantics... - When does less yield more? The impact of severity upon implicit recognition in pure alexiaDaniel J Roberts
Neuroscience and Aphasia Research Unit, School of Psychological Sciences, University of Manchester, Manchester, UK
Neuropsychologia 48:2437-46. 2010..These results also go some way towards explaining the individual variation in the presence of this effect observed across previous case-study investigations in the literature... - Semantic memory is key to binding phonology: converging evidence from immediate serial recall in semantic dementia and healthy participantsPaul Hoffman
Neuroscience and Aphasia Research Unit, School of Psychological Sciences, Zochonis Building, University of Manchester, Oxford Road, Manchester M13 9PL, UK
Neuropsychologia 47:747-60. 2009.... - Demonstrating the qualitative differences between semantic aphasia and semantic dementia: a novel exploration of nonverbal semantic processingKrist A Noonan
School of Psychological Sciences, University of Manchester, Manchester, UK
Behav Neurol 26:7-20. 2013..In contrast, SD patients performed poorly because their degraded knowledge did not allow the fine-grained distinctions required to complete the task... - Coherent concepts are computed in the anterior temporal lobesMatthew A Lambon Ralph
Neuroscience and Aphasia Research Unit, School of Psychological Sciences, University of Manchester, Manchester M13 9PL, United Kingdom
Proc Natl Acad Sci U S A 107:2717-22. 2010.... - Category-specific versus category-general semantic impairment induced by transcranial magnetic stimulationGorana Pobric
Neuroscience and Aphasia Research Unit, School of Psychological Sciences, University of Manchester, Manchester M13 9PL, UK
Curr Biol 20:964-8. 2010.... - Semantic impairment in stroke aphasia versus semantic dementia: a case-series comparisonElizabeth Jefferies
School of Psychological Sciences, University of Manchester, Manchester, UK
Brain 129:2132-47. 2006.... - The role of the anterior temporal lobes in the comprehension of concrete and abstract words: rTMS evidenceGorana Pobric
Neuroscience and Aphasia Research Unit, School of Psychological Sciences, University of Manchester, UK
Cortex 45:1104-10. 2009..These results confirm that both TPs make a critical contribution to semantic processing, even for abstract concepts that do not have strong sensory representations... - Ventrolateral prefrontal cortex plays an executive regulation role in comprehension of abstract words: convergent neuropsychological and repetitive TMS evidencePaul Hoffman
Neuroscience and Aphasia Research Unit, University of Manchester, Manchester M13 9PL, UK
J Neurosci 30:15450-6. 2010..Regulation is less important for concrete words because their meanings are constrained by their physical referents and do not tend to vary with context... - The treatment of anomia using errorless learningJoanne K Fillingham
Department of Psychology, The University of Manchester, Oxford Road, Manchester M13 9PL, UK
Neuropsychol Rehabil 16:129-54. 2006..It is probable that these factors are essential cognitive components for providing effective monitoring and feedback systems to a more general learning mechanism... - What underlies the neuropsychological pattern of irregular > regular past-tense verb production?Matthew A Lambon Ralph
School of Psychological Sciences, University of Manchester, Oxford Road, Manchester M13 9PL, United Kingdom
Brain Lang 93:106-19. 2005..The phonological nature of the factors that correlated with verb-inflection performance emphasises the role of a phonological deficit in the observed pattern of irregular > regular... - Both the middle temporal gyrus and the ventral anterior temporal area are crucial for multimodal semantic processing: distortion-corrected fMRI evidence for a double gradient of information convergence in the temporal lobesMaya Visser
University of Manchester, Manchester, UK
J Cogn Neurosci 24:1766-78. 2012..Additional planned, ROI analyses show that this result follows from two principal axes of convergence in the temporal lobe: both lateral (toward MTG) and longitudinal (toward the anterior temporal lobe)... - How intensive does anomia therapy for people with aphasia need to be?Karen Sage
Neuroscience and Aphasia Research Unit NARU, School of Psychological Sciences, University of Manchester, UK
Neuropsychol Rehabil 21:26-41. 2011..For the majority of people with aphasia post-stroke, both intense and non-intense therapy for anomia leads to improved naming performance. Retention at one-month post therapy is relatively superior after non-intensive therapy... - Reverse concreteness effects are not a typical feature of semantic dementia: evidence for the hub-and-spoke model of conceptual representationPaul Hoffman
Neuroscience and Aphasia Research Unit, School of Psychological Sciences, University of Manchester, Manchester M13 9PL, UK
Cereb Cortex 21:2103-12. 2011..These factors account for the variability in previous studies and indicate that reverse concreteness effects are not common in SD... - Lichtheim 2: synthesizing aphasia and the neural basis of language in a neurocomputational model of the dual dorsal-ventral language pathwaysTaiji Ueno
Neuroscience and Aphasia Research Unit, School of Psychological Sciences, University of Manchester, Manchester M139PL, UK
Neuron 72:385-96. 2011.... - What's in a word? A parametric study of semantic influences on visual word recognitionGemma A L Evans
Neuroscience and Aphasia Research Unit, School of Psychological Sciences, Zochonis Building, University of Manchester, Brunswick Street, Manchester M13 9PL, England, UK
Psychon Bull Rev 19:325-31. 2012..These findings provide a clear illustration of the flexible use of semantic information to support normal visual word recognition... - Overview and ways forward for future researchPaul Conroy
Neuroscience and Aphasia Research Unit NARU, School of Psychological Sciences, University of Manchester, Manchester, UK
Neuropsychol Rehabil 22:319-28. 2012..These studies delineate some of the critical theoretical-clinical issues through which we might optimise learning and rehabilitative efforts more fully... - Staging of the cognitive decline in Alzheimer's disease: insights from a detailed neuropsychological investigation of mild cognitive impairment and mild Alzheimer's diseaseStephen F Carter
Neuroscience and Aphasia Research Unit NARU, School of Psychological Sciences, University of Manchester, UK
Int J Geriatr Psychiatry 27:423-32. 2012..The current investigation attempted to elucidate the appearance of additional cognitive deficits in the non-episodic domains and to understand these deficits with respect to the known pathological staging of AD... - Using phonemic cueing of spontaneous naming to predict item responsiveness to therapy for anomia in aphasiaPaul J Conroy
Neuroscience and Aphasia Research Unit, University of Manchester, Manchester, UK
Arch Phys Med Rehabil 93:S53-60. 2012..The relationship between this form of cueing and the outcome of naming therapy is of particular interest given that cueing is an established research and clinical tool within aphasiology, and is commonly used to probe naming performance... - Using parallel distributed processing models to simulate phonological dyslexia: the key role of plasticity-related recoveryStephen R Welbourne
School of Psychological Sciences, University of Manchester, Oxford Road, Manchester, UK
J Cogn Neurosci 19:1125-39. 2007..This result supports the view that plasticity-related changes should be a significant factor in our understanding of chronic behavioral dissociations... - Lexical and semantic influences on item and order memory in immediate serial recognition: evidence from a novel taskElizabeth Jefferies
University of Manchester, Manchester, UK
Q J Exp Psychol (Hove) 59:949-64. 2006..These results point to strong similarities between immediate serial recall and recognition. Lexical/semantic knowledge may contribute to phonological stability in both tasks... - SD-squared revisited: reply to Coltheart, Tree, and Saunders (2010)Anna M Woollams
Neuroscience and Aphasia Research Unit, School of Psychological Sciences, Zochonis Building, University of Manchester, Brunswick Street, Manchester M139PL, England
Psychol Rev 117:273-81; discussion 282-3. 2010..Moreover, we argue that the connectionist triangle model account has substantially greater explanatory and predictive power than the DRC account... - Solving the paradox of the equipotential and modular brain: a neurocomputational model of stroke vs. slow-growing gliomaJames L Keidel
Neuroscience and Aphasia Research Unit NARU, School of Psychological Sciences Zochonis Building, University of Manchester, Brunswick Street, Manchester M139PL, UK
Neuropsychologia 48:1716-24. 2010..This work provides support for a neo-Lashleyan view of cortical organization... - The anterior temporal lobe semantic hub is a part of the language neural network: selective disruption of irregular past tense verbs by rTMSRachel Holland
Neuroscience and Aphasia Research Unit, School of Psychological Sciences, University of Manchester, Manchester, UK
Cereb Cortex 20:2771-5. 2010..When combined with other evidence, these results confirm that the ATL semantic hub is a key component of the neural network for language... - Mimicking aphasic semantic errors in normal speech production: evidence from a novel experimental paradigmCatherine Hodgson
Neuroscience and Aphasia Research Unit, School of Psychological Sciences, Zochonis Building, University of Manchester, Manchester, UK
Brain Lang 104:89-101. 2008..A. (2006). Semantic impairment in stoke aphasia vs. semantic dementia: A case-series comparison. Brain, 129, 2132-2147]. Further implications for theories of semantic cognition and models of speech processing are discussed... - The role of the temporal lobe semantic system in number knowledge: evidence from late-stage semantic dementiaElizabeth Jefferies
Department of Psychology, University of Manchester, Oxford Road, Manchester M13 9PL, UK
Neuropsychologia 43:887-905. 2005.... - Explaining semantic short-term memory deficits: evidence for the critical role of semantic controlPaul Hoffman
Neuroscience and Aphasia Research Unit NARU, School of Psychological Sciences, University of Manchester, UK
Neuropsychologia 49:368-81. 2011..Instead, we argue that semantic STM patients occupy the mildest end of spectrum of semantic control disorders... - Remembering 'zeal' but not 'thing': reverse frequency effects as a consequence of deregulated semantic processingPaul Hoffman
Neuroscience and Aphasia Research Unit, School of Psychological Sciences, University of Manchester, UK
Neuropsychologia 49:580-4. 2011..In contrast, LF words are associated with more stable patterns of activation because similar semantic information is activated whenever they are encountered... - Guilt-selective functional disconnection of anterior temporal and subgenual cortices in major depressive disorderSophie Green
Neuroscience and Aphasia Research Unit, School of Psychological Sciences, The University of Manchester and Manchester Academic Health Sciences Centre, Manchester, England
Arch Gen Psychiatry 69:1014-21. 2012..Despite its psychopathological importance, the functional neuroanatomy of guilt in MDD is unknown... - The variation of function across the human insula mirrors its patterns of structural connectivity: evidence from in vivo probabilistic tractographyLauren L Cloutman
Neuroscience and Aphasia Research Unit, School of Psychological Sciences, University of Manchester, Manchester, UK
Neuroimage 59:3514-21. 2012.... - Relearning in semantic dementia reflects contributions from both medial temporal lobe episodic and degraded neocortical semantic systems: evidence in support of the complementary learning systems theoryEmily J Mayberry
Neuroscience and Aphasia Research Unit NARU, School of Psychological Sciences, University of Manchester, Manchester, UK
Neuropsychologia 49:3591-8. 2011..Because of neocortical damage to the anterior temporal lobes, relearning is disordered with a characteristic pattern of under- and over-generalisation... - Be concrete to be comprehended: Consistent imageability effects in semantic dementia for nouns, verbs, synonyms and associatesPaul Hoffman
Neuroscience and Aphasia Research Unit NARU, University of Manchester, Manchester, UK Electronic address
Cortex 49:1206-18. 2013..Concrete words succumb less quickly by virtue of their richer and more detailed semantic representations... - Convergent connectivity and graded specialization in the rostral human temporal lobe as revealed by diffusion-weighted imaging probabilistic tractographyRichard J Binney
University of Manchester, UK
J Cogn Neurosci 24:1998-2014. 2012.... - Wernicke's aphasia reflects a combination of acoustic-phonological and semantic control deficits: a case-series comparison of Wernicke's aphasia, semantic dementia and semantic aphasiaHolly Robson
Neuroscience and Aphasia Research Unit NARU, University of Manchester, Manchester, UK
Neuropsychologia 50:266-75. 2012..These results deviate from traditional accounts which emphasise a single impairment and, instead, implicate two deficits underlying the comprehension disorder in WA... - Revealing and quantifying the impaired phonological analysis underpinning impaired comprehension in Wernicke's aphasiaHolly Robson
Neuroscience and Aphasia Research Unit, School of Psychological Sciences, University of Manchester, Manchester, United Kingdom
Neuropsychologia 50:276-88. 2012.... - The role of plasticity-related functional reorganization in the explanation of central dyslexiasStephen R Welbourne
School of Psychological Sciences, University of Manchester, Manchester, UK
Cogn Neuropsychol 28:65-108. 2011..In all cases, the DOL changed significantly in the recovery period, suggesting that postmorbid functional reorganization is important in understanding behaviour in chronic-stage patients... - Lateralization of ventral and dorsal auditory-language pathways in the human brainGeoffrey J M Parker
Imaging Science and Biomedical Engineering, University of Manchester, Manchester M13 9PT, UK
Neuroimage 24:656-66. 2005..The connections are stronger in the dominant hemisphere, in agreement with previous studies of functional lateralization of auditory-language processing... - Shapes, scents and sounds: quantifying the full multi-sensory basis of conceptual knowledgePaul Hoffman
Neuroscience and Aphasia Research Unit NARU, School of Psychological Sciences, Zochonis Building, University of Manchester, Oxford Road, Manchester M13 9PL, UK
Neuropsychologia 51:14-25. 2013..Multi-modal ratings for 160 objects are provided as supplementary materials... - Connectivity-based structural and functional parcellation of the human cortex using diffusion imaging and tractographyLauren L Cloutman
Neuroscience and Aphasia Research Unit, School of Psychological Sciences, University of Manchester Manchester, UK
Front Neuroanat 6:34. 2012..As such, it is of vital importance to continue to improve the accuracy of the methodology and to extend its potential applications in the study of cognition in neurological health and disease... - The relationship between phonological and morphological deficits in Broca's aphasia: further evidence from errors in verb inflectionNatalie Braber
University of Manchester, UK
Brain Lang 92:278-87. 2005..These results are consistent with the notion that the patients' relatively greater difficulty with regular past tenses reflects a phonological impairment that is sensitive to the complexity of spoken forms... - When objects lose their meaning: what happens to their use?Sasha Bozeat
MRC Cognition and Brain Sciences Unit, Cambridge, England
Cogn Affect Behav Neurosci 2:236-51. 2002..Finally, despite good performance on tests of mechanical problem solving, the patients showed very little evidence of employing these skills in their interactions with real objects... - Homogeneity and heterogeneity in mild cognitive impairment and Alzheimer's disease: a cross-sectional and longitudinal study of 55 casesMatthew A Lambon Ralph
MRC Cognition and Brain Sciences Unit, Addenbrooke s Hospital, Cambridge, UK
Brain 126:2350-62. 2003..Although such cases may mimic more focal lobar degenerative conditions, patients with atypical Alzheimer's disease have pronounced episodic memory impairments, suggesting amnesia as a critical diagnostic feature... - A category-specific advantage for numbers in verbal short-term memory: evidence from semantic dementiaElizabeth Jefferies
University of Bristol, Bristol, UK
Neuropsychologia 42:639-60. 2004.... - Structure and deterioration of semantic memory: a neuropsychological and computational investigationTimothy T Rogers
Medical Research Council Cognition and Brain Sciences Unit, Cambridge, UK
Psychol Rev 111:205-35. 2004..Data from 4 well-known semantic tasks revealed consistent patterns that find a ready explanation in the model. The relationship between the model and related theories of semantic representation is discussed... - Distinct patterns of olfactory impairment in Alzheimer's disease, semantic dementia, frontotemporal dementia, and corticobasal degenerationSimona Luzzi
Department of Neuroscience, University of Ancona, Italy
Neuropsychologia 45:1823-31. 2007..The findings add further insights into the nature of the semantic deficit in SD by exploring a hitherto neglected modality and may have relevance in explaining the altered eating habits commonly associated with SD... - Dissociating stimulus-driven semantic and phonological effect during reading and namingAndrea Mechelli
Institute of Psychiatry, King s College London, London, United Kingdom
Hum Brain Mapp 28:205-17. 2007..In conclusion, this study dissociates the effects of semantic and phonological relatedness between successive items during reading and naming aloud... - Dissociating reading processes on the basis of neuronal interactionsAndrea Mechelli
Functional Imaging Laboratory, Wellcome Department of Imaging Neuroscience, Institute of Neurology, London, UK
J Cogn Neurosci 17:1753-65. 2005..The present investigation is the first to identify distinct neuronal mechanisms for semantic and phonological contributions to reading... - "Presemantic" cognition in semantic dementia: six deficits in search of an explanationKaralyn Patterson
MRC Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 2EF, UK
J Cogn Neurosci 18:169-83. 2006..We argue that these results cannot be explained as associated but unrelated deficits but instead are a principled consequence of a primary semantic impairment... - Unlocking the nature of the phonological-deep dyslexia continuum: the keys to reading aloud are in phonology and semanticsJenni Crisp
North Tyneside Primary Care Trust, UK
J Cogn Neurosci 18:348-62. 2006..This proposal was supported by eliciting the symptoms of deep-phonological dyslexia in nonreading tasks... - Demonstrating a wordlikeness effect on nonword repetition performance in a conduction aphasic patientAkie Saito
Department of Cognitive Psychology in Education, Graduate School of Education, Kyoto University, Yoshida Honmachi, Sakyo ku, Kyoto 606 8501, Japan
Brain Lang 85:222-30. 2003..We conclude that she had difficulty in maintaining stable phonological representations of verbal materials in the output buffer... - Semantic feature knowledge and picture naming in dementia of Alzheimer's type: a new approachPeter Garrard
Institute of Cognitive Neuroscience, Alexandra House, 17 Queen Square, London WC1N 3AR, UK
Brain Lang 93:79-94. 2005..These findings are discussed in the context of contemporary cognitive and computational models of semantic memory organisation...