Lambert D, Yarski M, Warner F, Thornhill P, Parkin E, Smith A, et al. Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2). J Biol Chem. 2005;280:30113-9 pubmed
..The identification of ADAM17 as the protease responsible for ACE2 shedding may provide new insight into the physiological roles of ACE2. ..
Lambert D, Clarke N, Hooper N, Turner A. Calmodulin interacts with angiotensin-converting enzyme-2 (ACE2) and inhibits shedding of its ectodomain. FEBS Lett. 2008;582:385-90 pubmed
..We also show that calmodulin associates with ACE2 and that this interaction is decreased by calmodulin inhibitors. ..