Daniel W Lambert

Summary

Affiliation: University of Leeds
Country: UK

Publications

  1. ncbi Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2)
    Daniel W Lambert
    Proteolysis Research Group, School of Biochemistry and Microbiology, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Biol Chem 280:30113-9. 2005
  2. ncbi Calmodulin interacts with angiotensin-converting enzyme-2 (ACE2) and inhibits shedding of its ectodomain
    Daniel W Lambert
    Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK
    FEBS Lett 582:385-90. 2008
  3. doi Angiotensin-converting enzyme 2 is subject to post-transcriptional regulation by miR-421
    Daniel W Lambert
    School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, U K
    Clin Sci (Lond) 127:243-9. 2014
  4. ncbi Angiotensin-converting enzyme 2 (ACE2), but not ACE, is preferentially localized to the apical surface of polarized kidney cells
    Fiona J Warner
    Proteolysis Research Group, School of Biochemistry and Microbiology, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Biol Chem 280:39353-62. 2005
  5. pmc Angiotensin converting enzyme (ACE) and ACE2 bind integrins and ACE2 regulates integrin signalling
    Nicola E Clarke
    Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom
    PLoS ONE 7:e34747. 2012
  6. doi Functional angiotensin-converting enzyme 2 is expressed in human cardiac myofibroblasts
    Jodie L Guy
    Institute of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK
    Exp Physiol 93:579-88. 2008
  7. doi Epigenetic regulation of angiotensin-converting enzyme 2 (ACE2) by SIRT1 under conditions of cell energy stress
    Nicola E Clarke
    School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, U K
    Clin Sci (Lond) 126:507-16. 2014
  8. ncbi Angiotensin-converting enzyme 2 and new insights into the renin-angiotensin system
    Daniel W Lambert
    Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK
    Biochem Pharmacol 75:781-6. 2008
  9. pmc Endothelin-converting enzyme-1 (ECE-1) is post-transcriptionally regulated by alternative polyadenylation
    Alison R Whyteside
    Institute of Molecular and Cellular Biology, University of Leeds, Leeds, United Kindom
    PLoS ONE 9:e83260. 2014

Detail Information

Publications9

  1. ncbi Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2)
    Daniel W Lambert
    Proteolysis Research Group, School of Biochemistry and Microbiology, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Biol Chem 280:30113-9. 2005
    ..The identification of ADAM17 as the protease responsible for ACE2 shedding may provide new insight into the physiological roles of ACE2...
  2. ncbi Calmodulin interacts with angiotensin-converting enzyme-2 (ACE2) and inhibits shedding of its ectodomain
    Daniel W Lambert
    Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK
    FEBS Lett 582:385-90. 2008
    ..We also show that calmodulin associates with ACE2 and that this interaction is decreased by calmodulin inhibitors...
  3. doi Angiotensin-converting enzyme 2 is subject to post-transcriptional regulation by miR-421
    Daniel W Lambert
    School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, U K
    Clin Sci (Lond) 127:243-9. 2014
    ....
  4. ncbi Angiotensin-converting enzyme 2 (ACE2), but not ACE, is preferentially localized to the apical surface of polarized kidney cells
    Fiona J Warner
    Proteolysis Research Group, School of Biochemistry and Microbiology, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Biol Chem 280:39353-62. 2005
    ..These studies suggest that both ACE2 and ACE are ectoenzymes that have distinct localization and secretion patterns that determine their role on the cell surface in kidney epithelium and in urine...
  5. pmc Angiotensin converting enzyme (ACE) and ACE2 bind integrins and ACE2 regulates integrin signalling
    Nicola E Clarke
    Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom
    PLoS ONE 7:e34747. 2012
    ..As such, ectodomain shedding of ACE2 may play a role in the process of pathological cardiac remodelling...
  6. doi Functional angiotensin-converting enzyme 2 is expressed in human cardiac myofibroblasts
    Jodie L Guy
    Institute of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK
    Exp Physiol 93:579-88. 2008
    ....
  7. doi Epigenetic regulation of angiotensin-converting enzyme 2 (ACE2) by SIRT1 under conditions of cell energy stress
    Nicola E Clarke
    School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, U K
    Clin Sci (Lond) 126:507-16. 2014
    ..Inhibition of SIRT1 activity ablated the AICAR-induced increase in ACE2. In conclusion, we have established that the expression of the ACE2 transcript is controlled by the activity of SIRT1 under conditions of energy stress. ..
  8. ncbi Angiotensin-converting enzyme 2 and new insights into the renin-angiotensin system
    Daniel W Lambert
    Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK
    Biochem Pharmacol 75:781-6. 2008
    ..We also discuss parallel developments in the study of collectrin, a catalytically inactive homologue of ACE2 with critical functions in the pancreas and kidney...
  9. pmc Endothelin-converting enzyme-1 (ECE-1) is post-transcriptionally regulated by alternative polyadenylation
    Alison R Whyteside
    Institute of Molecular and Cellular Biology, University of Leeds, Leeds, United Kindom
    PLoS ONE 9:e83260. 2014
    ..This is the first study to identify ECE-1 as a target for APA, a regulatory mechanism aberrantly activated in cancer cells, and provides novel information about the mechanisms leading to ECE-1 overexpression in malignant cells. ..