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- Lambert D, Clarke N, Hooper N, Turner A. Calmodulin interacts with angiotensin-converting enzyme-2 (ACE2) and inhibits shedding of its ectodomain. FEBS Lett. 2008;582:385-90 pubmed..We also show that calmodulin associates with ACE2 and that this interaction is decreased by calmodulin inhibitors. ..