Teresa Lambe

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. pmc Immunity against heterosubtypic influenza virus induced by adenovirus and MVA expressing nucleoprotein and matrix protein-1
    Teresa Lambe
    The Jenner Institute, University of Oxford, Oxford, United Kingdom
    Sci Rep 3:1443. 2013
  2. doi request reprint T-cell responses in children to internal influenza antigens, 1 year after immunization with pandemic H1N1 influenza vaccine, and response to revaccination with seasonal trivalent-inactivated influenza vaccine
    Teresa Lambe
    Jenner Institute, Old Road Campus Research Building, Oxford, UK
    Pediatr Infect Dis J 31:e86-91. 2012
  3. pmc Novel viral vectored vaccines for the prevention of influenza
    Teresa Lambe
    Jenner Institute, University of Oxford, Oxford, United Kingdom
    Mol Med 18:1153-60. 2012
  4. pmc DOCK8 is critical for the survival and function of NKT cells
    Greg Crawford
    Medical Research Council Human Immunology Unit, Weatherall Institute for Molecular Medicine, Oxford University, John Radcliffe Hospital, Oxford, United Kingdom
    Blood 122:2052-61. 2013
  5. pmc Preliminary assessment of the efficacy of a T-cell-based influenza vaccine, MVA-NP+M1, in humans
    Patrick J Lillie
    Jenner Institute, University of Oxford, UK
    Clin Infect Dis 55:19-25. 2012
  6. doi request reprint Improved adjuvanting of seasonal influenza vaccines: preclinical studies of MVA-NP+M1 coadministration with inactivated influenza vaccine
    Caitlin E Mullarkey
    Jenner Institute, Old Road Campus Research Building, Oxford, UK
    Eur J Immunol 43:1940-52. 2013
  7. pmc A T cell-inducing influenza vaccine for the elderly: safety and immunogenicity of MVA-NP+M1 in adults aged over 50 years
    Richard D Antrobus
    The Jenner Institute, University of Oxford, Oxford, United Kingdom
    PLoS ONE 7:e48322. 2012
  8. pmc Potent CD8+ T-cell immunogenicity in humans of a novel heterosubtypic influenza A vaccine, MVA-NP+M1
    Tamara K Berthoud
    The Jenner Institute, Oxford University, Oxford, United Kingdom
    Clin Infect Dis 52:1-7. 2011
  9. doi request reprint Clinical Assessment of a Novel Recombinant Simian Adenovirus ChAdOx1 as a Vectored Vaccine Expressing Conserved Influenza A Antigens
    Richard D Antrobus
    The Jenner Institute, University of Oxford, Oxford, UK
    Mol Ther 22:668-74. 2014
  10. pmc Polyethyleneimine is a potent mucosal adjuvant for viral glycoprotein antigens
    Frank Wegmann
    The Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Nat Biotechnol 30:883-8. 2012

Collaborators

Detail Information

Publications12

  1. pmc Immunity against heterosubtypic influenza virus induced by adenovirus and MVA expressing nucleoprotein and matrix protein-1
    Teresa Lambe
    The Jenner Institute, University of Oxford, Oxford, United Kingdom
    Sci Rep 3:1443. 2013
    ..These data may be of relevance for the design of optimal immunization regimens for human influenza vaccines, especially for influenza-naïve infants...
  2. doi request reprint T-cell responses in children to internal influenza antigens, 1 year after immunization with pandemic H1N1 influenza vaccine, and response to revaccination with seasonal trivalent-inactivated influenza vaccine
    Teresa Lambe
    Jenner Institute, Old Road Campus Research Building, Oxford, UK
    Pediatr Infect Dis J 31:e86-91. 2012
    ..We investigate here the influenza-specific T-cell response, in children, 1 year after pandemic H1N1 vaccination and the ability to boost the T-cell response with trivalent-inactivated influenza immunization...
  3. pmc Novel viral vectored vaccines for the prevention of influenza
    Teresa Lambe
    Jenner Institute, University of Oxford, Oxford, United Kingdom
    Mol Med 18:1153-60. 2012
    ..These alternate influenza vaccines offer real promise to deliver viable alternatives to currently deployed vaccines and more importantly may confer long-lasting and universal protection against influenza viral infection...
  4. pmc DOCK8 is critical for the survival and function of NKT cells
    Greg Crawford
    Medical Research Council Human Immunology Unit, Weatherall Institute for Molecular Medicine, Oxford University, John Radcliffe Hospital, Oxford, United Kingdom
    Blood 122:2052-61. 2013
    ..Accordingly, impaired NKT cell numbers and function are likely to contribute to the susceptibility of DOCK8-deficient patients to recurrent infections and malignant disease...
  5. pmc Preliminary assessment of the efficacy of a T-cell-based influenza vaccine, MVA-NP+M1, in humans
    Patrick J Lillie
    Jenner Institute, University of Oxford, UK
    Clin Infect Dis 55:19-25. 2012
    ..Following a phase 1 clinical study that demonstrated vaccine safety and immunogenicity, a phase 2a vaccination and influenza challenge study has been conducted in healthy adult volunteers...
  6. doi request reprint Improved adjuvanting of seasonal influenza vaccines: preclinical studies of MVA-NP+M1 coadministration with inactivated influenza vaccine
    Caitlin E Mullarkey
    Jenner Institute, Old Road Campus Research Building, Oxford, UK
    Eur J Immunol 43:1940-52. 2013
    ..The simultaneous induction of T cells and Ab responses has the potential to improve seasonal vaccine performance and could be employed in pandemic situations. ..
  7. pmc A T cell-inducing influenza vaccine for the elderly: safety and immunogenicity of MVA-NP+M1 in adults aged over 50 years
    Richard D Antrobus
    The Jenner Institute, University of Oxford, Oxford, United Kingdom
    PLoS ONE 7:e48322. 2012
    ..We assessed the safety and immunogenicity of MVA-NP+M1, a viral-vectored influenza vaccine designed to boost memory T cell responses, in a group of older adults...
  8. pmc Potent CD8+ T-cell immunogenicity in humans of a novel heterosubtypic influenza A vaccine, MVA-NP+M1
    Tamara K Berthoud
    The Jenner Institute, Oxford University, Oxford, United Kingdom
    Clin Infect Dis 52:1-7. 2011
    ..A vaccine providing protective immunity to the highly conserved internal antigens could provide longer-lasting protection against multiple influenza subtypes...
  9. doi request reprint Clinical Assessment of a Novel Recombinant Simian Adenovirus ChAdOx1 as a Vectored Vaccine Expressing Conserved Influenza A Antigens
    Richard D Antrobus
    The Jenner Institute, University of Oxford, Oxford, UK
    Mol Ther 22:668-74. 2014
    ..We demonstrate ChAdOx1 NP+M1 to be safe and immunogenic. ChAdOx1 is a promising vaccine vector that could be used to deliver vaccine antigens where strong cellular immune responses are required for protection. ..
  10. pmc Polyethyleneimine is a potent mucosal adjuvant for viral glycoprotein antigens
    Frank Wegmann
    The Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Nat Biotechnol 30:883-8. 2012
    ..PEI adjuvanticity required release of host double-stranded DNA that triggered Irf3-dependent signaling. PEI therefore merits further investigation as a mucosal adjuvant for human use...
  11. pmc DOCK8 is essential for T-cell survival and the maintenance of CD8+ T-cell memory
    Teresa Lambe
    Nuffield Department of Medicine, Henry Wellcome Building of Molecular Physiology, Oxford University, Oxford, UK
    Eur J Immunol 41:3423-35. 2011
    ..These findings help to explain why DOCK8-deficient patients are susceptible to recurrent infections and provide new insights into how T-cell memory is sustained...
  12. pmc Expression and cellular immunogenicity of a transgenic antigen driven by endogenous poxviral early promoters at their authentic loci in MVA
    Toritse Orubu
    The Jenner Institute, University of Oxford, Oxford, United Kingdom
    PLoS ONE 7:e40167. 2012
    ....