P F Lalor

Summary

Affiliation: University of Birmingham
Country: UK

Publications

  1. doi request reprint Liver myofibroblasts regulate infiltration and positioning of lymphocytes in human liver
    Andrew P Holt
    Liver Research Group, Institute of Biomedical Research, Division of Medicine, University of Birmingham, Birmingham, United Kingdom
    Gastroenterology 136:705-14. 2009
  2. pmc Vitronectin in human hepatic tumours contributes to the recruitment of lymphocytes in an alpha v beta3-independent manner
    S Edwards
    Liver Research Group, Department of Medicine, 5th Floor, Institute of Biomedical Research, Wolfson Drive, The Medical School, University of Birmingham, Birmingham B15 2TT, UK
    Br J Cancer 95:1545-54. 2006
  3. pmc Hepatic sinusoidal endothelium avidly binds platelets in an integrin-dependent manner, leading to platelet and endothelial activation and leukocyte recruitment
    Patricia F Lalor
    Centre for Liver Research and NIHR Biomedical Research Unit, Institute for Biomedical Research, The Medical School, University of Birmingham, Birmingham, B15 2TT, UK
    Am J Physiol Gastrointest Liver Physiol 304:G469-78. 2013
  4. ncbi request reprint Activation of vascular adhesion protein-1 on liver endothelium results in an NF-kappaB-dependent increase in lymphocyte adhesion
    Patricia F Lalor
    Liver Research Group, Institute of Biomedical Research, University of Birmingham, Birmingham, UK
    Hepatology 45:465-74. 2007
  5. ncbi request reprint Vascular adhesion protein-1 as a potential therapeutic target in liver disease
    Patricia F Lalor
    Liver Research Laboratory, Institute of Biomedical Research, Division of Medicine University of Birmingham, Birmingham B15 2TT UK
    Ann N Y Acad Sci 1110:485-96. 2007
  6. ncbi request reprint The liver: a model of organ-specific lymphocyte recruitment
    Patricia F Lalor
    The Liver Research Laboratories, Clinical Research Block, Department of Medicine, University of Birmingham, Birmingham, B15 2TT, UK
    Expert Rev Mol Med 4:1-16. 2002
  7. ncbi request reprint Recruitment of lymphocytes to the human liver
    Patricia F Lalor
    Liver Research Laboratories, Universityof Birmingham MRC Centre for Immune Regulation, Institute of Clinical Research, Queen Elizabeth Hospital, Edgbaston, Birmingham, United Kingdom
    Immunol Cell Biol 80:52-64. 2002
  8. ncbi request reprint Human hepatic sinusoidal endothelial cells can be distinguished by expression of phenotypic markers related to their specialised functions in vivo
    P F Lalor
    Liver Research Group, Institute of Biomedical Research, Division of Medical Science, University of Birmingham, Birmingham B15 2TT, United Kingdom
    World J Gastroenterol 12:5429-39. 2006
  9. doi request reprint CCL25 and CCL28 promote alpha4 beta7-integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow
    Alice Miles
    Liver Research Group, Medical Research Council Centre for Immune Regulation, Institute of Biomedical Research, University of Birmingham, Birmingham, UK
    Am J Physiol Gastrointest Liver Physiol 294:G1257-67. 2008
  10. ncbi request reprint Vascular adhesion protein-1 mediates adhesion and transmigration of lymphocytes on human hepatic endothelial cells
    Patricia F Lalor
    Liver Research Laboratories, University of Birmingham Institute of Clinical Science, Medical Research Council Center for Immune Regulation, Edgbaston, Birmingham, United Kingdom
    J Immunol 169:983-92. 2002

Collaborators

Detail Information

Publications28

  1. doi request reprint Liver myofibroblasts regulate infiltration and positioning of lymphocytes in human liver
    Andrew P Holt
    Liver Research Group, Institute of Biomedical Research, Division of Medicine, University of Birmingham, Birmingham, United Kingdom
    Gastroenterology 136:705-14. 2009
    ..We investigated whether activated human liver myofibroblasts (aLMF) affect the migration and accumulation of lymphocytes within the inflamed liver...
  2. pmc Vitronectin in human hepatic tumours contributes to the recruitment of lymphocytes in an alpha v beta3-independent manner
    S Edwards
    Liver Research Group, Department of Medicine, 5th Floor, Institute of Biomedical Research, Wolfson Drive, The Medical School, University of Birmingham, Birmingham B15 2TT, UK
    Br J Cancer 95:1545-54. 2006
    ..Thus, we provide evidence that vitronectin in liver tumours can support the recruitment and retention of effector lymphocytes by an uPAR-dependent mechanism...
  3. pmc Hepatic sinusoidal endothelium avidly binds platelets in an integrin-dependent manner, leading to platelet and endothelial activation and leukocyte recruitment
    Patricia F Lalor
    Centre for Liver Research and NIHR Biomedical Research Unit, Institute for Biomedical Research, The Medical School, University of Birmingham, Birmingham, B15 2TT, UK
    Am J Physiol Gastrointest Liver Physiol 304:G469-78. 2013
    ..Thus the ability of platelets to activate endothelium and promote leukocyte adhesion may reflect an additional mechanism through which they promote liver injury...
  4. ncbi request reprint Activation of vascular adhesion protein-1 on liver endothelium results in an NF-kappaB-dependent increase in lymphocyte adhesion
    Patricia F Lalor
    Liver Research Group, Institute of Biomedical Research, University of Birmingham, Birmingham, UK
    Hepatology 45:465-74. 2007
    ..This response is likely to be important for the recruitment of leukocytes to the liver and suggests that VAP-1 inhibitors have therapeutic potential for treating chronic inflammatory liver disease...
  5. ncbi request reprint Vascular adhesion protein-1 as a potential therapeutic target in liver disease
    Patricia F Lalor
    Liver Research Laboratory, Institute of Biomedical Research, Division of Medicine University of Birmingham, Birmingham B15 2TT UK
    Ann N Y Acad Sci 1110:485-96. 2007
    ..The restricted expression of VAP-1 and increased production of sVAP-1 in inflammatory liver disease confirm the validity of this molecule as a therapeutic target...
  6. ncbi request reprint The liver: a model of organ-specific lymphocyte recruitment
    Patricia F Lalor
    The Liver Research Laboratories, Clinical Research Block, Department of Medicine, University of Birmingham, Birmingham, B15 2TT, UK
    Expert Rev Mol Med 4:1-16. 2002
    ..This article discusses the expression and function of adhesion molecules within the liver and demonstrates how specific populations of effector lymphocytes can be selectively recruited to the liver...
  7. ncbi request reprint Recruitment of lymphocytes to the human liver
    Patricia F Lalor
    Liver Research Laboratories, Universityof Birmingham MRC Centre for Immune Regulation, Institute of Clinical Research, Queen Elizabeth Hospital, Edgbaston, Birmingham, United Kingdom
    Immunol Cell Biol 80:52-64. 2002
    ..We also discuss the expression and function of a newly defined adhesion protein, (VAP-1), and suggest that the unique functions of this protein may provide therapeutic potential for the treatment of liver disease...
  8. ncbi request reprint Human hepatic sinusoidal endothelial cells can be distinguished by expression of phenotypic markers related to their specialised functions in vivo
    P F Lalor
    Liver Research Group, Institute of Biomedical Research, Division of Medical Science, University of Birmingham, Birmingham B15 2TT, United Kingdom
    World J Gastroenterol 12:5429-39. 2006
    ....
  9. doi request reprint CCL25 and CCL28 promote alpha4 beta7-integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow
    Alice Miles
    Liver Research Group, Medical Research Council Centre for Immune Regulation, Institute of Biomedical Research, University of Birmingham, Birmingham, UK
    Am J Physiol Gastrointest Liver Physiol 294:G1257-67. 2008
    ....
  10. ncbi request reprint Vascular adhesion protein-1 mediates adhesion and transmigration of lymphocytes on human hepatic endothelial cells
    Patricia F Lalor
    Liver Research Laboratories, University of Birmingham Institute of Clinical Science, Medical Research Council Center for Immune Regulation, Edgbaston, Birmingham, United Kingdom
    J Immunol 169:983-92. 2002
    ..Moreover, since VAP-1 is induced on nonhepatic endothelium in response to inflammation, its ability to support lymphocyte transendothelial migration may be an important systemic function of VAP-1...
  11. ncbi request reprint Lymphocyte traffic through sinusoidal endothelial cells is regulated by hepatocytes
    Sarah Edwards
    Liver Research Group, Institute for Biomedical Science, Edgbaston, Birmingham, United Kingdom
    Hepatology 41:451-9. 2005
    ....
  12. doi request reprint Identifying homing interactions in T-cell traffic in human disease
    Patricia F Lalor
    Liver Research Group, Division of Medicine, Institute of Biomedical Research, MRC Centre for Immune Regulation, University of Birmingham, Birmingham, UK
    Methods Mol Biol 616:231-52. 2010
    ..Although our own experience is with human liver tissue, the general principles apply to analysing any organ of interest...
  13. ncbi request reprint MAdCAM-1 expressed in chronic inflammatory liver disease supports mucosal lymphocyte adhesion to hepatic endothelium (MAdCAM-1 in chronic inflammatory liver disease)
    A J Grant
    MRC Centre for Immune Regulation, Liver Research Laboratories, Queen Elizabeth Hospital, Birmingham, UK
    Hepatology 33:1065-72. 2001
    ..This provides a mechanism to explain the hepatic recruitment of mucosal lymphocytes in inflammatory liver disease complicating inflammatory bowel disease...
  14. doi request reprint Haematopoietic stem cell recruitment to injured murine liver sinusoids depends on (alpha)4(beta)1 integrin/VCAM-1 interactions
    D P J Kavanagh
    Centre for Cardiovascular Sciences, Institute of Biomedical Research, The Medical School, University of Birmingham, Edgbaston, Birmingham, UK
    Gut 59:79-87. 2010
    ..However, mechanisms governing HSC recruitment to injured hepatic microcirculation are poorly understood. These were investigated in vivo following hepatic ischaemia-reperfusion (IR) injury and in vitro using flow-based adhesion assays...
  15. ncbi request reprint Hepatitis C virus receptor expression in normal and diseased liver tissue
    Gary M Reynolds
    Liver Laboratories, Institute for Biomedical Research, University of Birmingham and University Hospital Birmingham NHS Foundation Trust, Birmingham, United Kingdom
    Hepatology 47:418-27. 2008
    ..In contrast, CLDN4 hepatocellular staining was comparable in normal and diseased liver tissue...
  16. pmc Expression of DC-SIGN and DC-SIGNR on human sinusoidal endothelium: a role for capturing hepatitis C virus particles
    Wai K Lai
    Liver Research Laboratories, Institute of Biomedical Research, Birmingham University, Edgbaston, B15 2TH, United Kingdom
    Am J Pathol 169:200-8. 2006
    ....
  17. doi request reprint Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver
    Ye H Oo
    Centre for Liver Research, Institute of Biomedical Research, The University of Birmingham Medical School, Queen Elizabeth Hospital, Edgbaston, Birmingham, United Kingdom
    J Immunol 184:2886-98. 2010
    ..Thus, different chemokine receptors play distinct roles in the recruitment and positioning of T(regs) at sites of hepatitis in chronic liver disease...
  18. pmc Hepatic endothelial CCL25 mediates the recruitment of CCR9+ gut-homing lymphocytes to the liver in primary sclerosing cholangitis
    Bertus Eksteen
    Liver Research Laboratories, Institute for Biomedical Research, University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2TT, England, UK
    J Exp Med 200:1511-7. 2004
    ..This is the first demonstration in humans that T cells activated in the gut can be recruited to an extra-intestinal site of disease and provides a paradigm to explain the pathogenesis of extra-intestinal complications of IBD...
  19. ncbi request reprint CXC chemokine ligand 16 promotes integrin-mediated adhesion of liver-infiltrating lymphocytes to cholangiocytes and hepatocytes within the inflamed human liver
    Mathis Heydtmann
    Birmingham University, Edgbaston, United Kingdom
    J Immunol 174:1055-62. 2005
    ..Thus, CXCL16 can promote lymphocyte adhesion to epithelial cells and may function to attract and retain effector cells that promote biliary and hepatocyte destruction in inflammatory liver disease...
  20. doi request reprint Adhesion of human haematopoietic (CD34+) stem cells to human liver compartments is integrin and CD44 dependent and modulated by CXCR3 and CXCR4
    Heather A Crosby
    Centre for Liver Research and NIHR Biomedical Research Unit for Liver Disease, University of Birmingham and Queen Elizabeth Hospital Birmingham, Birmingham B15 2TT, UK
    J Hepatol 51:734-49. 2009
    ..Our aim therefore was to determine which factors where involved in adhesion of circulating HSC to liver endothelium and sequestration around epithelial cells within the liver...
  21. pmc Lymphocyte recruitment to the liver: molecular insights into the pathogenesis of liver injury and hepatitis
    Shishir Shetty
    Liver Research Group, MRC Centre for Immune Regulation, 5th Floor, Institute of Biomedical Research, University of Birmingham, Birmingham B15 2TT, UK
    Toxicology 254:136-46. 2008
    ....
  22. ncbi request reprint Lymphocyte recruitment to the liver in alcoholic liver disease
    Geoffrey Haydon
    The Liver Research Laboratories, The University of Birmingham Institute of Clinical Science, MRC Centre for Immune Regulation, The Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TT, UK
    Alcohol 27:29-36. 2002
    ..Potentially the most exciting potential is to modulate the nature of the lymphocyte subsets recruited to the liver, so that harmful cells are excluded and beneficial subsets are preferentially recruited...
  23. ncbi request reprint Homing of mucosal lymphocytes to the liver in the pathogenesis of hepatic complications of inflammatory bowel disease
    Allister J Grant
    Liver Research Laboratories, University of Birmingham Institute of Clinical Science, MRC Centre for Immune Regulation, Queen Elizabeth Hospital, Edgbaston, B15 2TT, Birmingham, UK
    Lancet 359:150-7. 2002
    ..Recent reports that some lymphocyte homing-receptors are shared by the liver and gut provide a molecular basis for this hypothesis and explain the distribution of extraintestinal disease in inflammatory bowel disease...
  24. ncbi request reprint The role of cytokines and chemokines in the development of steatohepatitis
    Patricia F Lalor
    Liver Research Group, MRC Centre for Immune Regulation, Institute of Biomedical Research, University of Birmingham Medical School, Birmingham, United Kingdom
    Semin Liver Dis 27:173-93. 2007
    ..A better understanding of this process might allow therapeutic intervention to switch off the inflammatory response before irreversible damage occurs in both ALD and NAFLD...
  25. ncbi request reprint Expression of tissue factor pathway inhibitor-2 in murine and human liver regulation during inflammation
    Toru Hisaka
    GREF, INSERM E 362 and IFR 66, Universite Victor Segalen Bordeaux 2, Bordeaux, France
    Thromb Haemost 91:569-75. 2004
    ..The large difference in the level of liver expression of human and murine TFPI-2 suggests that despite significant sequence similarities, these proteins presumably have different functions in the two species...
  26. ncbi request reprint Interactions of LSECtin and DC-SIGN/DC-SIGNR with viral ligands: Differential pH dependence, internalization and virion binding
    Thomas Gramberg
    Institute of Virology, University Hospital Erlangen, 91054 Erlangen, Germany
    Virology 373:189-201. 2008
    ..Our results reveal important differences between pathogen capture by DC-SIGN/R and LSECtin and hint towards different biological functions of these lectins...
  27. ncbi request reprint LSECtin interacts with filovirus glycoproteins and the spike protein of SARS coronavirus
    Thomas Gramberg
    Institute for Clinical and Molecular Virology, University Erlangen Nurnberg, Germany
    Virology 340:224-36. 2005
    ..In summary, we identified LSECtin as an attachment factor that in conjunction with DC-SIGNR might concentrate viral pathogens in liver and lymph nodes...
  28. pmc An inflammation-induced mechanism for leukocyte transmigration across lymphatic vessel endothelium
    Louise A Johnson
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, and Institute of Biomedical Research, MRC Centre for Immune Regulation, University of Birmingham Medical School, UK
    J Exp Med 203:2763-77. 2006
    ..These results reveal a CAM-mediated mechanism for recruiting leukocytes to the lymph nodes in inflammation and highlight the process of lymphatic transmigration as a potential new target for antiinflammatory therapy...