Affiliation: University of Manchester
Fleury M, Eliades A, Carlsson P, Lacaud G, Kouskoff V. FOXF1 inhibits hematopoietic lineage commitment during early mesoderm specification. Development. 2015;142:3307-20 pubmed publisher
..Our study further suggests that this transcription factor is implicated in actively restraining the specification of mesodermal progenitors to hematopoiesis. ..
Lie A Ling M, Marinopoulou E, Lilly A, Challinor M, Patel R, Lancrin C, et al
. Regulation of RUNX1 dosage is crucial for efficient blood formation from hemogenic endothelium. Development. 2018;145: pubmed publisher
..Together, our results suggest that RUNX1 dosage plays a pivotal role in hemogenic endothelium maturation and the establishment of the hematopoietic system. ..
Pearson S, Cuvertino S, Fleury M, Lacaud G, Kouskoff V. In vivo repopulating activity emerges at the onset of hematopoietic specification during embryonic stem cell differentiation. Stem Cell Reports. 2015;4:431-44 pubmed publisher
Batta K, Florkowska M, Kouskoff V, Lacaud G. Direct reprogramming of murine fibroblasts to hematopoietic progenitor cells. Cell Rep. 2014;9:1871-84 pubmed publisher
Largeot A, Perez Campo F, Marinopoulou E, Lie A Ling M, Kouskoff V, Lacaud G. Expression of the MOZ-TIF2 oncoprotein in mice represses senescence. Exp Hematol. 2016;44:231-7.e4 pubmed publisher
Eliades A, Wareing S, Marinopoulou E, Fadlullah M, Patel R, Grabarek J, et al
. The Hemogenic Competence of Endothelial Progenitors Is Restricted by Runx1 Silencing during Embryonic Development. Cell Rep. 2016;15:2185-2199 pubmed publisher
..Altogether, our data demonstrate that hemogenic competency in recently specified endothelial progenitors is restrained through the active silencing of Runx1 expression. ..
Cuvertino S, Lacaud G, Kouskoff V. SOX7-enforced expression promotes the expansion of adult blood progenitors and blocks B-cell development. Open Biol. 2016;6: pubmed publisher
..Together, these data demonstrate that the uncontrolled expression of the transcription factor SOX7 in adult haematopoietic cells has dramatic consequences on blood homeostasis. ..
Lilly A, Lacaud G, Kouskoff V. SOXF transcription factors in cardiovascular development. Semin Cell Dev Biol. 2017;63:50-57 pubmed publisher
..Understanding how SOXF factors are regulated, as well as their downstream transcriptional target genes, will be important for unravelling their roles in cardiovascular development and related diseases. ..
Lacaud G, Kouskoff V. Hemangioblast, hemogenic endothelium, and primitive versus definitive hematopoiesis. Exp Hematol. 2017;49:19-24 pubmed publisher