Charalambos P Kyriacou

Summary

Affiliation: University of Leicester
Country: UK

Publications

  1. ncbi request reprint The clock gene period in the medfly Ceratitis capitata
    Gabriella M Mazzotta
    Department of Biology, University of Padua, via U Bassi, 58 B, 35131 Padua, Italy
    Genet Res 86:13-30. 2005
  2. doi request reprint Animal behaviour: monarchs catch a cold
    Charalambos P Kyriacou
    Department of Genetics, University of Leicester, LE1 7RH, UK
    Curr Biol 23:R235-6. 2013
  3. pmc Molecular polymorphism, differentiation and introgression in the period gene between Lutzomyia intermedia and Lutzomyia whitmani
    Camila J Mazzoni
    Departamento de Bioquimica e Biologia Molecular, Instituto Oswaldo Cruz FIOCRUZ, Rio de Janeiro, Brazil
    BMC Evol Biol 6:85. 2006
  4. doi request reprint Circadian clocks: genes, sleep, and cognition
    Charalambos P Kyriacou
    Department of Genetics, University of Leicester, Leicester LE1 7RH, UK
    Trends Cogn Sci 14:259-67. 2010
  5. pmc Clocks, cryptochromes and Monarch migrations
    Charalambos P Kyriacou
    Department of Genetics, University of Leicester, Leicester, UK
    J Biol 8:55. 2009
  6. ncbi request reprint Single gene mutations in Drosophila: what can they tell us about the evolution of sexual behaviour?
    Charalambos P Kyriacou
    Department of Genetics, University of Leicester, LE1 7RH, Leicester, UK
    Genetica 116:197-203. 2002
  7. doi request reprint Clines in clock genes: fine-tuning circadian rhythms to the environment
    Charalambos P Kyriacou
    Department of Genetics, University of Leicester, Leicester, UK
    Trends Genet 24:124-32. 2008
  8. ncbi request reprint Neurogenetics: singing in the brain
    Charalambos P Kyriacou
    Department of Genetics, University of Leicester, Leicester LE1 7RH, UK
    Curr Biol 17:R841-3. 2007
  9. pmc Disruption of Cryptochrome partially restores circadian rhythmicity to the arrhythmic period mutant of Drosophila
    Ben H Collins
    Department of Genetics, University of Leicester, Leicester LE1 7RH, United Kingdom
    Proc Natl Acad Sci U S A 102:19021-6. 2005
  10. pmc Circadian rhythm gene regulation in the housefly Musca domestica
    Veryan Codd
    Department of Genetics, University of Leicester, Leicester LE1 7RH, United Kingdom
    Genetics 177:1539-51. 2007

Collaborators

Detail Information

Publications39

  1. ncbi request reprint The clock gene period in the medfly Ceratitis capitata
    Gabriella M Mazzotta
    Department of Biology, University of Padua, via U Bassi, 58 B, 35131 Padua, Italy
    Genet Res 86:13-30. 2005
    ....
  2. doi request reprint Animal behaviour: monarchs catch a cold
    Charalambos P Kyriacou
    Department of Genetics, University of Leicester, LE1 7RH, UK
    Curr Biol 23:R235-6. 2013
    ..The stimulus responsible for compass resetting has been identified as a reduction in temperature...
  3. pmc Molecular polymorphism, differentiation and introgression in the period gene between Lutzomyia intermedia and Lutzomyia whitmani
    Camila J Mazzoni
    Departamento de Bioquimica e Biologia Molecular, Instituto Oswaldo Cruz FIOCRUZ, Rio de Janeiro, Brazil
    BMC Evol Biol 6:85. 2006
    ..There is evidence of mitochondrial introgression between the two species but it is not clear whether gene flow also occurs in nuclear genes...
  4. doi request reprint Circadian clocks: genes, sleep, and cognition
    Charalambos P Kyriacou
    Department of Genetics, University of Leicester, Leicester LE1 7RH, UK
    Trends Cogn Sci 14:259-67. 2010
    ....
  5. pmc Clocks, cryptochromes and Monarch migrations
    Charalambos P Kyriacou
    Department of Genetics, University of Leicester, Leicester, UK
    J Biol 8:55. 2009
    ..Recent studies including one in BMC Biology, have begun to dissect the molecular and neurogenetic basis for this most complex behavior...
  6. ncbi request reprint Single gene mutations in Drosophila: what can they tell us about the evolution of sexual behaviour?
    Charalambos P Kyriacou
    Department of Genetics, University of Leicester, LE1 7RH, Leicester, UK
    Genetica 116:197-203. 2002
    ..melanogaster hosts to investigate whether they carry species-specific mating information of the donor...
  7. doi request reprint Clines in clock genes: fine-tuning circadian rhythms to the environment
    Charalambos P Kyriacou
    Department of Genetics, University of Leicester, Leicester, UK
    Trends Genet 24:124-32. 2008
    ..We discuss how population genetics, together with functional assays, can illuminate these possible cases of natural selection in Drosophila clock genes...
  8. ncbi request reprint Neurogenetics: singing in the brain
    Charalambos P Kyriacou
    Department of Genetics, University of Leicester, Leicester LE1 7RH, UK
    Curr Biol 17:R841-3. 2007
    ..The fruitless gene is well-known to play a key role in determining the sexual identity of the fruitfly's nervous system, but new results show that doublesex is also required in thoracic neurons to generate normal male lovesongs...
  9. pmc Disruption of Cryptochrome partially restores circadian rhythmicity to the arrhythmic period mutant of Drosophila
    Ben H Collins
    Department of Genetics, University of Leicester, Leicester LE1 7RH, United Kingdom
    Proc Natl Acad Sci U S A 102:19021-6. 2005
    ..Although we do not yet have a molecular correlate for these apparently iconoclastic observations, we provide a systems explanation for these results based on differential sensitivities of subsets of circadian pacemaker neurons to light...
  10. pmc Circadian rhythm gene regulation in the housefly Musca domestica
    Veryan Codd
    Department of Genetics, University of Leicester, Leicester LE1 7RH, United Kingdom
    Genetics 177:1539-51. 2007
    ....
  11. doi request reprint Drosophila eye color mutants as therapeutic tools for Huntington disease
    Edward W Green
    Department of Genetics, University of Leicester, Leicestershire, UK
    Fly (Austin) 6:117-20. 2012
    ..Our results provide further support for the possibility of therapeutic KP interventions in HD...
  12. ncbi request reprint A constitutively active cryptochrome in Drosophila melanogaster
    Stephane Dissel
    Department of Biology, University of Leicester, University Road, Leicester, LE1 7RH, UK
    Nat Neurosci 7:834-40. 2004
    ..These effects are similar to those seen in wild-type flies under continuous light and suggest a regulatory role for the C terminus of CRY on the photosensitive, photolyase-like part of the protein...
  13. pmc The period gene Thr-Gly polymorphism in Australian and African Drosophila melanogaster populations: implications for selection
    Lesley A Sawyer
    Department of Genetics, University of Leicester, Leicester LE1 7RH, United Kingdom
    Genetics 174:465-80. 2006
    ..melanogaster subgroup of species. Our results further reinforce the view that thermal selection may have contributed to shaping the continental patterns of Thr-Gly variability...
  14. ncbi request reprint Natural selection favors a newly derived timeless allele in Drosophila melanogaster
    Eran Tauber
    Department of Genetics, University of Leicester, Leicester LE1 7RH, UK
    Science 316:1895-8. 2007
    ..The natural mutant allele alters an important life history trait that may enhance the fly's adaptation to seasonal conditions...
  15. ncbi request reprint Molecular analysis of circadian clocks in Drosophila simulans
    Anthony S Rogers
    Department of Genetics, University of Leicester, Leicester LE1 7RH, UK
    Genetica 120:213-22. 2004
    ..Using chimeric per transgenes which carry the different species Thr-Gly fragments, we have been able to identify components of the behaviour that are modulated by this region of the PER protein...
  16. ncbi request reprint Temporal mating isolation driven by a behavioral gene in Drosophila
    Eran Tauber
    Department of Genetics, University of Leicester, LE1 7RH, Leicester, United Kingdom
    Curr Biol 13:140-5. 2003
    ....
  17. doi request reprint The role of natural selection in circadian behaviour: a molecular-genetic approach
    Ezio Rosato
    Department of Genetics, University of Leicester, U K
    Essays Biochem 49:71-85. 2011
    ..We present some examples of how these types of analyses have not only enlightened the evolutionary study of clocks, but have also contributed to a more pragmatic molecular understanding of the function of clock proteins...
  18. pmc Rab11 rescues synaptic dysfunction and behavioural deficits in a Drosophila model of Huntington's disease
    Joern R Steinert
    MRC Toxicology Unit, University of Leicester, Hodgkin Building, Lancaster Road, Leicester, UK
    Hum Mol Genet 21:2912-22. 2012
    ..This work highlights a potential novel HD therapeutic strategy for early intervention, prior to neuronal loss and clinical manifestation of disease...
  19. ncbi request reprint Molecular genetics of the fruit-fly circadian clock
    Ezio Rosato
    Department of Genetics, University of Leicester, Leicester, UK
    Eur J Hum Genet 14:729-38. 2006
    ..We also focus on the evolutionary tinkering of these clock genes and compare and contrast the neuronal basis for behavioural rhythms between the two phyla...
  20. doi request reprint Glutathione peroxidase activity is neuroprotective in models of Huntington's disease
    Robert P Mason
    Department of Genetics, University of Leicester, Leicester, UK
    Nat Genet 45:1249-54. 2013
    ..Because previous clinical trials have indicated that GPx mimetics are well tolerated in humans, this study may have important implications for treating Huntington's disease. ..
  21. ncbi request reprint Analysis of locomotor activity rhythms in Drosophila
    Ezio Rosato
    Department of Genetics, University of Leicester, University Road, Leicester, LE1 7RH, UK
    Nat Protoc 1:559-68. 2006
    ..We describe the setup for studying locomotor activity rhythms in the fruit fly and we introduce the statistical methods in use in our laboratories for the analysis of periodic data...
  22. doi request reprint Functional neurogenomics of the courtship song of male Drosophila melanogaster
    Colin N Moran
    Department of Genetics, University of Leicester, Leicester, UK
    Cortex 45:18-34. 2009
    ..Other candidate genes that could plausibly affect courtship song were involved in mesothoracic or axonal development...
  23. pmc Dissociation of circadian and circatidal timekeeping in the marine crustacean Eurydice pulchra
    Lin Zhang
    Department of Genetics, University of Leicester, Leicester LE1 7RH, UK
    Curr Biol 23:1863-73. 2013
    ..e., ~12.4 hr apart...
  24. doi request reprint Molecular Evolution of a Pervasive Natural Amino-Acid Substitution in Drosophila cryptochrome
    Mirko Pegoraro
    Department of Genetics, University of Leicester, Leicester, United Kingdom
    PLoS ONE 9:e86483. 2014
    ..At the long term, these phase differences in eclosion may contribute to genetic differentiation among individuals, and shape the evolution of wild populations. ..
  25. ncbi request reprint Circadian cycling of the mouse liver transcriptome, as revealed by cDNA microarray, is driven by the suprachiasmatic nucleus
    Ruth A Akhtar
    Department of Genetics, University of Leicester, LE1 7RH, Leicester, United Kingdom
    Curr Biol 12:540-50. 2002
    ..We used a custom-made cDNA microarray to identify mouse liver transcripts that show circadian cycles of abundance under constant conditions...
  26. doi request reprint The kynurenine pathway modulates neurodegeneration in a Drosophila model of Huntington's disease
    Susanna Campesan
    Department of Genetics, University of Leicester, Leicester LE1 7RH, UK
    Curr Biol 21:961-6. 2011
    ....
  27. pmc Getting a buzz out of the bee genome
    Michael Ashburner
    Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK
    Genome Biol 7:239. 2006
    ..This, and its utility to humans, makes it a fascinating object of study for biologists. Such studies are now further enabled by the release of the honey-bee genome sequence...
  28. ncbi request reprint Isogenic autosomes to be applied in optimal screening for novel mutants with viable phenotypes in Drosophila melanogaster
    Punita Sharma
    Department of Genetics, University of Cambridge, Cambridge, UK
    J Neurogenet 19:57-85. 2005
    ..The lines generated are now being used as target chromosomes in mutagenesis screens, and the characterization reported here will facilitate their use in screens of these lines for behavioral and other viable phenotypes...
  29. ncbi request reprint Origins of circadian rhythmicity
    Ezio Rosato
    Department of Biology, University of Leicester, Leicester LEI 7RH, UK
    J Biol Rhythms 17:506-11. 2002
  30. ncbi request reprint Circadian changes in Drosophila motor terminals
    Kerstin I Mehnert
    Zoology Department, Stockholm University, Stockholm, Sweden
    Dev Neurobiol 67:415-21. 2007
    ..These unexpected results reveal further circadian as well as nonclock related pleiotropic effects for these classic behavioral mutants...
  31. ncbi request reprint The Drosophila clock protein Timeless is a member of the Arm/HEAT family
    Nicolas Vodovar
    Curr Biol 12:R610-1. 2002
  32. ncbi request reprint A molecular basis for natural selection at the timeless locus in Drosophila melanogaster
    Federica Sandrelli
    Department of Biology, University of Padova, 35131 Padova, Italy
    Science 316:1898-900. 2007
    ..This interaction results in a more stable TIMELESS product. These findings reveal a molecular link between diapause and circadian photoreception...
  33. ncbi request reprint Behavioural genetics: sex in fruitflies is fruitless
    Charalambos P Kyriacou
    Nature 436:334-5. 2005
  34. ncbi request reprint Circadian rhythm entrainment in flies and mammals
    Rachel Ben-Shlomo
    Department of Biology, University of Haifa Oranim, Tivon 36006, Israel
    Cell Biochem Biophys 37:141-56. 2002
    ..This review summarized the evolving knowledge of the different types, modes, and molecular processes of entrainment in flies and mammals...
  35. ncbi request reprint Circadian orchestration of the hepatic proteome
    Akhilesh B Reddy
    Medical Research Council, Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
    Curr Biol 16:1107-15. 2006
    ..These findings provide a new perspective on the extensive contribution of circadian programming to hepatic physiology...
  36. pmc Rhythmic expression of the cycle gene in a hematophagous insect vector
    Antonio C A Meireles-Filho
    Department of Biochemistry and Molecular Biology, Instituto Oswaldo Cruz FIOCRUZ, Rio de Janeiro 21045 900, Brazil
    BMC Mol Biol 7:38. 2006
    ..Unlike Drosophila, the molecular clock of insect vectors is poorly understood, despite the importance of circadian behavior in the dynamic of disease transmission...
  37. ncbi request reprint Behavioural genetics: sex, flies and acetate
    Charalambos P Kyriacou
    Nature 446:502-4. 2007
  38. ncbi request reprint Phenotypic effects induced by knock-down of the period clock gene in Bombyx mori
    Federica Sandrelli
    Dipartimento di Biologia, Universita di Padova, Padua 35131, Italy
    Genet Res 89:73-84. 2007
    ....
  39. ncbi request reprint Glucocorticoid signaling synchronizes the liver circadian transcriptome
    Akhilesh B Reddy
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, Cabridgeshire, UK
    Hepatology 45:1478-88. 2007
    ..We have identified the pivotal liver transcription factor, HNF4alpha, as a mediator of circadian and glucocorticoid-regulated transcription, showing that it is a key conduit for downstream targeting...