Affiliation: University of Oxford
- Patterns of gene recombination shape var gene repertoires in Plasmodium falciparum: comparisons of geographically diverse isolatesSusan M Kraemer
Seattle Biomedical Research Institute, 307 Westlake Avenue North, Suite 500, Seattle, WA 98109 5219, USA
BMC Genomics 8:45. 2007....
- Antigenic variation at the infected red cell surface in malariaS Kyes
Molecular Parasitology Group, Weatherall Institute of Molecular Medicine, Headington, Oxford OX3 9DS United Kingdom
Annu Rev Microbiol 55:673-707. 2001..In this review, we cover the history of antigenic variation in malaria and then summarize the more recent data with particular emphasis on Plasmodium falciparum, the etiological agent of the most severe form of human malaria...
- Stage-specific merozoite surface protein 2 antisense transcripts in Plasmodium falciparumSue Kyes
Molecular Parasitology Group, Weatherall Institute of Molecular Medicine, Headington, Oxford OX3 9DS, UK
Mol Biochem Parasitol 123:79-83. 2002
- Transcription of subtelomerically located var gene variant in Plasmodium falciparum appears to require the truncation of an adjacent var genePaul Horrocks
Molecular Parasitology Group, Nuffield Department of Medicine, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK
Mol Biochem Parasitol 134:193-9. 2004..These data have implications in our understanding of how spontaneous deletion events within subtelomeric var loci may affect transcription of these var gene variants...
- Plasmodium falciparum var gene expression is developmentally controlled at the level of RNA polymerase II-mediated transcription initiationSue Kyes
Weatherall Institute of Molecular Medicine, Oxford University, John Radcliffe Hospital, Headington, Oxford, UK
Mol Microbiol 63:1237-47. 2007..This represents another example where P. falciparum differs from the paradigm for antigenic variation, Trypanosoma brucei...
- Effect of var gene disruption on switching in Plasmodium falciparumPaul Horrocks
Molecular Parasitology Group, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
Mol Microbiol 45:1131-41. 2002..These data, and the implications for epigenetic transcriptional control of var genes, are discussed...
- An approach to classifying sequence tags sampled from Plasmodium falciparum var genesPeter C Bull
Kenya Medical Research Institute Centre for Geographic Medicine Research, Coast, Kilifi, Kenya
Mol Biochem Parasitol 154:98-102. 2007
- Characterization of a Plasmodium falciparum macrophage-migration inhibitory factor homologueDamien V Cordery
Centre for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, UK
J Infect Dis 195:905-12. 2007..The identification of a parasite homologue of MIF raised the question of whether it affects monocyte function in a manner similar to its human counterpart...
- Plasmodium falciparum antigenic variation. Mapping mosaic var gene sequences onto a network of shared, highly polymorphic sequence blocksPeter C Bull
Kenya Medical Research Institute, Centre for Geographic Medicine Research, Coast, Kilifi, Kenya
Mol Microbiol 68:1519-34. 2008....
- Plasmodium falciparum variant surface antigen expression patterns during malariaPeter C Bull
Nuffield Department of Clinical Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
PLoS Pathog 1:e26. 2005....
- Genome sequence of the human malaria parasite Plasmodium falciparumMalcolm J Gardner
The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
Nature 419:498-511. 2002..The genome sequence provides the foundation for future studies of this organism, and is being exploited in the search for new drugs and vaccines to fight malaria...
- Febrile temperatures induce cytoadherence of ring-stage Plasmodium falciparum-infected erythrocytesRachanee Udomsangpetch
Department of Pathobiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand
Proc Natl Acad Sci U S A 99:11825-9. 2002..Fever induced cytoadherence is likely to have important pathological consequences and may explain both clinical deterioration with fever in severe malaria and the effects of antipyretics on parasite clearance...
- Genome-wide discovery and verification of novel structured RNAs in Plasmodium falciparumTobias Mourier
Ancient DNA and Evolution Group, Department of Biology, University of Copenhagen, Copenhagen DK 2100, Denmark
Genome Res 18:281-92. 2008..reichenowi. The high confirmation rate within a single parasite life cycle stage suggests that many more of the predictions may be expressed in other stages of the organism's life cycle...
- Genome variation and evolution of the malaria parasite Plasmodium falciparumDaniel C Jeffares
Informatics Division, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA Hinxton, UK
Nat Genet 39:120-5. 2007..This analysis uncovers the primary evolutionary changes that have occurred since the P. falciparum-P. reichenowi speciation and changes that are occurring within P. falciparum...