Sue Kyes

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. pmc Patterns of gene recombination shape var gene repertoires in Plasmodium falciparum: comparisons of geographically diverse isolates
    Susan M Kraemer
    Seattle Biomedical Research Institute, 307 Westlake Avenue North, Suite 500, Seattle, WA 98109 5219, USA
    BMC Genomics 8:45. 2007
  2. ncbi request reprint Antigenic variation at the infected red cell surface in malaria
    S Kyes
    Molecular Parasitology Group, Weatherall Institute of Molecular Medicine, Headington, Oxford OX3 9DS United Kingdom
    Annu Rev Microbiol 55:673-707. 2001
  3. ncbi request reprint Stage-specific merozoite surface protein 2 antisense transcripts in Plasmodium falciparum
    Sue Kyes
    Molecular Parasitology Group, Weatherall Institute of Molecular Medicine, Headington, Oxford OX3 9DS, UK
    Mol Biochem Parasitol 123:79-83. 2002
  4. ncbi request reprint Transcription of subtelomerically located var gene variant in Plasmodium falciparum appears to require the truncation of an adjacent var gene
    Paul Horrocks
    Molecular Parasitology Group, Nuffield Department of Medicine, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK
    Mol Biochem Parasitol 134:193-9. 2004
  5. ncbi request reprint Plasmodium falciparum var gene expression is developmentally controlled at the level of RNA polymerase II-mediated transcription initiation
    Sue Kyes
    Weatherall Institute of Molecular Medicine, Oxford University, John Radcliffe Hospital, Headington, Oxford, UK
    Mol Microbiol 63:1237-47. 2007
  6. ncbi request reprint Effect of var gene disruption on switching in Plasmodium falciparum
    Paul Horrocks
    Molecular Parasitology Group, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Mol Microbiol 45:1131-41. 2002
  7. pmc An approach to classifying sequence tags sampled from Plasmodium falciparum var genes
    Peter C Bull
    Kenya Medical Research Institute Centre for Geographic Medicine Research, Coast, Kilifi, Kenya
    Mol Biochem Parasitol 154:98-102. 2007
  8. pmc Characterization of a Plasmodium falciparum macrophage-migration inhibitory factor homologue
    Damien V Cordery
    Centre for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, UK
    J Infect Dis 195:905-12. 2007
  9. pmc Plasmodium falciparum antigenic variation. Mapping mosaic var gene sequences onto a network of shared, highly polymorphic sequence blocks
    Peter C Bull
    Kenya Medical Research Institute, Centre for Geographic Medicine Research, Coast, Kilifi, Kenya
    Mol Microbiol 68:1519-34. 2008
  10. pmc Plasmodium falciparum variant surface antigen expression patterns during malaria
    Peter C Bull
    Nuffield Department of Clinical Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
    PLoS Pathog 1:e26. 2005

Collaborators

Detail Information

Publications14

  1. pmc Patterns of gene recombination shape var gene repertoires in Plasmodium falciparum: comparisons of geographically diverse isolates
    Susan M Kraemer
    Seattle Biomedical Research Institute, 307 Westlake Avenue North, Suite 500, Seattle, WA 98109 5219, USA
    BMC Genomics 8:45. 2007
    ....
  2. ncbi request reprint Antigenic variation at the infected red cell surface in malaria
    S Kyes
    Molecular Parasitology Group, Weatherall Institute of Molecular Medicine, Headington, Oxford OX3 9DS United Kingdom
    Annu Rev Microbiol 55:673-707. 2001
    ..In this review, we cover the history of antigenic variation in malaria and then summarize the more recent data with particular emphasis on Plasmodium falciparum, the etiological agent of the most severe form of human malaria...
  3. ncbi request reprint Stage-specific merozoite surface protein 2 antisense transcripts in Plasmodium falciparum
    Sue Kyes
    Molecular Parasitology Group, Weatherall Institute of Molecular Medicine, Headington, Oxford OX3 9DS, UK
    Mol Biochem Parasitol 123:79-83. 2002
  4. ncbi request reprint Transcription of subtelomerically located var gene variant in Plasmodium falciparum appears to require the truncation of an adjacent var gene
    Paul Horrocks
    Molecular Parasitology Group, Nuffield Department of Medicine, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK
    Mol Biochem Parasitol 134:193-9. 2004
    ..These data have implications in our understanding of how spontaneous deletion events within subtelomeric var loci may affect transcription of these var gene variants...
  5. ncbi request reprint Plasmodium falciparum var gene expression is developmentally controlled at the level of RNA polymerase II-mediated transcription initiation
    Sue Kyes
    Weatherall Institute of Molecular Medicine, Oxford University, John Radcliffe Hospital, Headington, Oxford, UK
    Mol Microbiol 63:1237-47. 2007
    ..This represents another example where P. falciparum differs from the paradigm for antigenic variation, Trypanosoma brucei...
  6. ncbi request reprint Effect of var gene disruption on switching in Plasmodium falciparum
    Paul Horrocks
    Molecular Parasitology Group, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Mol Microbiol 45:1131-41. 2002
    ..These data, and the implications for epigenetic transcriptional control of var genes, are discussed...
  7. pmc An approach to classifying sequence tags sampled from Plasmodium falciparum var genes
    Peter C Bull
    Kenya Medical Research Institute Centre for Geographic Medicine Research, Coast, Kilifi, Kenya
    Mol Biochem Parasitol 154:98-102. 2007
  8. pmc Characterization of a Plasmodium falciparum macrophage-migration inhibitory factor homologue
    Damien V Cordery
    Centre for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, UK
    J Infect Dis 195:905-12. 2007
    ..The identification of a parasite homologue of MIF raised the question of whether it affects monocyte function in a manner similar to its human counterpart...
  9. pmc Plasmodium falciparum antigenic variation. Mapping mosaic var gene sequences onto a network of shared, highly polymorphic sequence blocks
    Peter C Bull
    Kenya Medical Research Institute, Centre for Geographic Medicine Research, Coast, Kilifi, Kenya
    Mol Microbiol 68:1519-34. 2008
    ....
  10. pmc Plasmodium falciparum variant surface antigen expression patterns during malaria
    Peter C Bull
    Nuffield Department of Clinical Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
    PLoS Pathog 1:e26. 2005
    ....
  11. ncbi request reprint Genome sequence of the human malaria parasite Plasmodium falciparum
    Malcolm J Gardner
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
    Nature 419:498-511. 2002
    ..The genome sequence provides the foundation for future studies of this organism, and is being exploited in the search for new drugs and vaccines to fight malaria...
  12. pmc Febrile temperatures induce cytoadherence of ring-stage Plasmodium falciparum-infected erythrocytes
    Rachanee Udomsangpetch
    Department of Pathobiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand
    Proc Natl Acad Sci U S A 99:11825-9. 2002
    ..Fever induced cytoadherence is likely to have important pathological consequences and may explain both clinical deterioration with fever in severe malaria and the effects of antipyretics on parasite clearance...
  13. pmc Genome-wide discovery and verification of novel structured RNAs in Plasmodium falciparum
    Tobias Mourier
    Ancient DNA and Evolution Group, Department of Biology, University of Copenhagen, Copenhagen DK 2100, Denmark
    Genome Res 18:281-92. 2008
    ..reichenowi. The high confirmation rate within a single parasite life cycle stage suggests that many more of the predictions may be expressed in other stages of the organism's life cycle...
  14. pmc Genome variation and evolution of the malaria parasite Plasmodium falciparum
    Daniel C Jeffares
    Informatics Division, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA Hinxton, UK
    Nat Genet 39:120-5. 2007
    ..This analysis uncovers the primary evolutionary changes that have occurred since the P. falciparum-P. reichenowi speciation and changes that are occurring within P. falciparum...