Tilo Kunath

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. ncbi request reprint Early trophoblast determination and stem cell maintenance in the mouse--a review
    T Kunath
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada M5G 1X5
    Placenta 25:S32-8. 2004
  2. ncbi request reprint FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment
    Tilo Kunath
    Centre Development in Stem Cell Biology, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, UK
    Development 134:2895-902. 2007
  3. ncbi request reprint Primed for pluripotency
    Tilo Kunath
    MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, EH9 3JQ, UK
    Cell Stem Cell 8:241-2. 2011
  4. doi request reprint BMP signaling induces visceral endoderm differentiation of XEN cells and parietal endoderm
    Agnieszka Paca
    MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, University of Edinburgh, Edinburgh, EH9 3JQ, United Kingdom
    Dev Biol 361:90-102. 2012
  5. pmc ERK2 suppresses self-renewal capacity of embryonic stem cells, but is not required for multi-lineage commitment
    William B Hamilton
    MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 8:e60907. 2013
  6. ncbi request reprint Mouse trophoblast stem cells
    Jennifer Quinn
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Ontario, Canada
    Methods Mol Med 121:125-48. 2006
  7. pmc Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus
    Michael J Devine
    MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, University of Edinburgh, Edinburgh EH9 3JQ, UK
    Nat Commun 2:440. 2011
  8. pmc Gene expression profiling of embryo-derived stem cells reveals candidate genes associated with pluripotency and lineage specificity
    Tetsuya S Tanaka
    Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, 21224 6820, USA
    Genome Res 12:1921-8. 2002
  9. ncbi request reprint Phenotypic analyses of mouse embryos with ubiquitous expression of Oct4: effects on mid-hindbrain patterning and gene expression
    Veronica Ramos-Mejia
    Departamento de Fisiologia Molecular y Genetica del Desarrollo, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Cuernavaca, Morelos, Mexico
    Dev Dyn 232:180-90. 2005

Collaborators

Detail Information

Publications9

  1. ncbi request reprint Early trophoblast determination and stem cell maintenance in the mouse--a review
    T Kunath
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada M5G 1X5
    Placenta 25:S32-8. 2004
    ..The first half of this review will focus on determination of the mouse trophoblast lineage and the second half will discuss the maintenance of trophoblast stem cells...
  2. ncbi request reprint FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment
    Tilo Kunath
    Centre Development in Stem Cell Biology, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, UK
    Development 134:2895-902. 2007
    ....
  3. ncbi request reprint Primed for pluripotency
    Tilo Kunath
    MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, EH9 3JQ, UK
    Cell Stem Cell 8:241-2. 2011
    ..In this issue of Cell Stem Cell, Najm et al. (2011) demonstrate that EpiSCs can be routinely derived from preimplantation embryos, showing that both human and mouse blastocysts can produce the same class of primed pluripotent cells...
  4. doi request reprint BMP signaling induces visceral endoderm differentiation of XEN cells and parietal endoderm
    Agnieszka Paca
    MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, University of Edinburgh, Edinburgh, EH9 3JQ, United Kingdom
    Dev Biol 361:90-102. 2012
    ..Generation of visceral endoderm from XEN cells uncovers the true potential of these blastocyst-derived cells and is a significant step towards modelling early developmental events ex vivo...
  5. pmc ERK2 suppresses self-renewal capacity of embryonic stem cells, but is not required for multi-lineage commitment
    William B Hamilton
    MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 8:e60907. 2013
    ..We show that ERK2 contributes to the destabilization of ES cell self-renewal by reducing expression of pluripotency genes, such as Nanog, but is not specifically required for the early stages of germ layer specification...
  6. ncbi request reprint Mouse trophoblast stem cells
    Jennifer Quinn
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Ontario, Canada
    Methods Mol Med 121:125-48. 2006
    ..This chapter will discuss the initial derivation of trophoblast stem cells from the blastocyst stage, maintenance, differentiation, flow cytometry and transfection techniques that can be used with these cells...
  7. pmc Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus
    Michael J Devine
    MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, University of Edinburgh, Edinburgh EH9 3JQ, UK
    Nat Commun 2:440. 2011
    ..This model represents a new experimental system to identify compounds that reduce levels of α-synuclein, and to investigate the mechanistic basis of neurodegeneration caused by α-synuclein dysfunction...
  8. pmc Gene expression profiling of embryo-derived stem cells reveals candidate genes associated with pluripotency and lineage specificity
    Tetsuya S Tanaka
    Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, 21224 6820, USA
    Genome Res 12:1921-8. 2002
    ..We suggest that pluripotency requires a set of genes not expressed in other cell types, whereas lineage-restricted stem cells, like TS cells, express genes predictive of their differentiated lineage...
  9. ncbi request reprint Phenotypic analyses of mouse embryos with ubiquitous expression of Oct4: effects on mid-hindbrain patterning and gene expression
    Veronica Ramos-Mejia
    Departamento de Fisiologia Molecular y Genetica del Desarrollo, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Cuernavaca, Morelos, Mexico
    Dev Dyn 232:180-90. 2005
    ..Our observations support the hypothesis that Oct4, like zebrafish Pou2, has a conserved function during early brain patterning in mouse...