Research Topics
Genomes and Genes
Species | Meena KumariSummaryAffiliation: University College London Country: UK Publications
| Collaborators
|
Detail Information
Publications
Maternal separation in childhood and diurnal cortisol patterns in mid-life: findings from the Whitehall II studyM Kumari
Department of Epidemiology and Public Health, University College London, UK
Psychol Med 43:633-43. 2013..Evidence for an association of the diurnal cortisol rhythm with maternal separation in humans is equivocal...
Effect of Apolipoprotein E epsilon4 on the association between health behaviors and cognitive function in late midlifeSeverine Sabia
INSERM, U1018 Centre for Research in Epidemiology and Population Health, Hopital Paul Brousse, 16 Avenue Paul Vaillant Couturier, Bâtiment 15 16, F 94807, Villejuif, France
Mol Neurodegener 5:23. 2010....- Social differences in insulin-like growth factor-1: findings from a British birth cohortMeena Kumari
International Institute for Society and Health, University College London, London, UK
Ann Epidemiol 18:664-70. 2008..Our aim is to examine whether there are social differences in IGF-1 in a cohort of participants between 44 and 45 years of age... - A nonlinear relationship of generalized and central obesity with diurnal cortisol secretion in the Whitehall II studyMeena Kumari
Department of Epidemiology and Public Health, 2 16 Torrington Place, London, WC1E 6BT, United Kingdom
J Clin Endocrinol Metab 95:4415-23. 2010..Evidence for an association of measures of generalized and central obesity with salivary cortisol secretion is equivocal... - Cortisol secretion and fatigue: associations in a community based cohortMeena Kumari
Department of Epidemiology and Public Health, UCL, 1 19 Torrington Place, London, WC1E 6BT, United Kingdom
Psychoneuroendocrinology 34:1476-85. 2009..Cortisol is also associated with future onset of fatigue suggesting that changes in cortisol secretion are etiologic or occur early in the genesis of fatigue... - Self-reported sleep duration and sleep disturbance are independently associated with cortisol secretion in the Whitehall II studyMeena Kumari
Department of Epidemiology and Public Health, University College London, 1 19 Torrington Place, London WC1E 6BT, United Kingdom
J Clin Endocrinol Metab 94:4801-9. 2009..The association of short sleep duration with cortisol secretion has not been thoroughly examined in large community dwelling populations and the relative importance of short sleep duration and sleep disturbance is unclear... - Measures of social position and cortisol secretion in an aging population: findings from the Whitehall II studyMeena Kumari
International Institute for Society and Health, University College London, 1 19 Torrington Place, London, WC1E 6BT, UK
Psychosom Med 72:27-34. 2010..To examine whether dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis associated with disadvantaged social position in working populations also occurs in older age groups... - Identifying patterns in cortisol secretion in an older population. Findings from the Whitehall II studyMeena Kumari
Department of Epidemiology and Public Health, UCL, London, UK
Psychoneuroendocrinology 35:1091-9. 2010..Raised pattern of secretion, which occurs in 27% of our participants is associated with demographic variables, adverse health behaviours, psychosocial environment and impaired physical functioning... 
Diabetes and cognitive function in a middle-aged cohort: findings from the Whitehall II studyMeena Kumari
Department of Epidemiology and Public Health, International Centre for Health and Society, London, UK
Neurology 65:1597-603. 2005..To compare cognitive performance in those with diabetes, impaired glucose tolerance, and normoglycemia in a middle-aged cohort...- Association of diurnal patterns in salivary cortisol with all-cause and cardiovascular mortality: findings from the Whitehall II studyMeena Kumari
Department of Epidemiology and Public Health, University College London, London WC1E 6BT, United Kingdom
J Clin Endocrinol Metab 96:1478-85. 2011..Evidence for the association of cortisol with mortality or disease events is mixed, possibly due to a failure to consider diurnal cortisol patterns... - The menopausal transition was associated in a prospective study with decreased health functioning in women who report menopausal symptomsMeena Kumari
International Centre for Health and Society, Department of Epidemiology and Public Health, Royal Free and University College London Medical School, 1 19 Torrington Place, London WC1 6BT, UK
J Clin Epidemiol 58:719-27. 2005..To examine change in health functioning as women progress through the menopausal transition... - Social, behavioral, and metabolic determinants of plasma viscosity in the Whitehall II StudyMeena Kumari
International Centre for Health and Society, Department of Epidemiology and Public Health, Royal Free and University College London Medical School, London, UK
Ann Epidemiol 15:398-404. 2005..To examine the social, biological, and metabolic associations of plasma viscosity in a large epidemiological study... - Prospective study of social and other risk factors for incidence of type 2 diabetes in the Whitehall II studyMeena Kumari
International Centre for Health and Society, Department of Epidemiology and Public Health, University College London, London, England
Arch Intern Med 164:1873-80. 2004..Social inequalities in the incidence of type 2 diabetes and the relation of health behaviors and psychosocial factors to the incidence of type 2 diabetes are not well established... - Chronic stress accelerates atherosclerosis in the apolipoprotein E deficient mouseMeena Kumari
Department of Epidemiology and Public Health, International Centre for Health and Society, London, UK
Stress 6:297-9. 2003..These data suggest that chronic mild stress can induce or accelerate the development of atherosclerosis... - Lifecourse influences on health among British adults: effects of region of residence in childhood and adulthoodDavid P Strachan
Division of Community Health Sciences, St George s University of London, Cranmer Terrace, London, UK
Int J Epidemiol 36:522-31. 2007..We examined inter-regional migrants in Britain to evaluate the relative importance of early and recent exposures for adult cardiorespiratory risk factors, mental ill-health and sensory function... - Antidepressant medication use and risk of hyperglycemia and diabetes mellitus: a noncausal association?Mika Kivimaki
Department of Epidemiology and Public Health, University College London, United Kingdom
Biol Psychiatry 70:978-84. 2011..To examine this, we assessed the associations of antidepressant use with change in glucose levels and incidence of undiagnosed and diagnosed diabetes... - Inflammation, insulin resistance, and diabetes--Mendelian randomization using CRP haplotypes points upstreamEric J Brunner
Department of Epidemiology and Public Health, Royal Free and University College London Medical School, London, United Kingdom
PLoS Med 5:e155. 2008..Our objective was to examine the nature of the association between CRP phenotype and diabetes development using CRP haplotypes as instrumental variables... - Work stress and coronary heart disease: what are the mechanisms?Tarani Chandola
Department of Epidemiology and Public Health, University College London, 1 19 Torrington Place, London WC1E 6BT, UK
Eur Heart J 29:640-8. 2008..To determine the biological and behavioural factors linking work stress with coronary heart disease (CHD)... - Psychological coping styles and cortisol over the day in healthy older adultsKatie O'Donnell
Psychobiology Group, Department of Epidemiology and Public Health, University College London, 1 19 Torrington Place, London WC1E 6BT, UK
Psychoneuroendocrinology 33:601-11. 2008..The results indicate that adaptive coping styles are related to low levels of cortisol over the day, suggesting that neuroendocrine pathways may partly mediate relationships between psychological coping and health... - Positive affect and distressed affect over the day in older peopleAndrew Steptoe
Department of Epidemiology and Public Health, University College London, London WC1E 6BT, UK
Psychol Aging 26:956-65. 2011..The associations with loneliness highlight the everyday distress and reduced happiness and excitement experienced by lonely older men and women, and these may contribute to enhanced risks to physical and mental health... - Does high C-reactive protein concentration increase atherosclerosis? The Whitehall II StudyMika Kivimaki
Department of Epidemiology and Public Health, University College London, London, United Kingdom
PLoS ONE 3:e3013. 2008.... - Association between change in body composition and change in inflammatory markers: an 11-year follow-up in the Whitehall II StudyEleonor I Fransson
Department of Epidemiology and Public Health, University College London, 1 19 Torrington Place, London WC1E 6BT, United Kingdom
J Clin Endocrinol Metab 95:5370-4. 2010..Obesity is associated with low-grade inflammation, but the long-term effects of weight change on inflammation are unknown... - Use of allele-specific FAIRE to determine functional regulatory polymorphism using large-scale genotyping arraysAndrew J P Smith
Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, Institute of Cardiovascular Sciences, University College London, London, United Kingdom
PLoS Genet 8:e1002908. 2012..Using increasingly comprehensive genotyping chips and distinct tissues for examination, FAIRE-gen has the potential to aid the identification of many causal SNPs associated with disease from GWAS... - Effects of socioeconomic position on inflammatory and hemostatic markers: a life-course analysis in the 1958 British birth cohortFaiza Tabassum
Department of Epidemiology and Public Health, University College London, London, United Kingdom
Am J Epidemiol 167:1332-41. 2008..Risk exposure related to SEP accumulates across the life course and contributes to raised levels of fibrinogen and C-reactive protein, while childhood SEP influences hemostatic markers more than does adult SEP... - Examining overweight and obesity as risk factors for common mental disorders using fat mass and obesity-associated (FTO) genotype-instrumented analysis: The Whitehall II Study, 1985-2004Mika Kivimaki
Department of Epidemiology and Public Health, Faculty of Biomedical Sciences, University College London, United Kingdom
Am J Epidemiol 173:421-9. 2011..Mendelian randomization analyses supported the status of long-term obesity as a risk factor for CMD in men-a finding that should be interpreted cautiously because the function of the FTO gene is unknown... - Association between IL6 gene variants -174G>C and -572G>C and serum IL-6 levels: interactions with social position in the Whitehall II cohortSaskia C Sanderson
Department of Epidemiology and Public Health Whitehall II, 1 19 Torrington Place, University College London, London WC1E 6BT, UK
Atherosclerosis 204:459-64. 2009..To examine the impact of -174G>C and -572G>C variants in the promoter region of the IL6 gene, and their interactions with social position, on interleukin-6 (IL-6) levels in the Whitehall II cohort... - Influence of common genetic variation on blood lipid levels, cardiovascular risk, and coronary events in two British prospective cohort studiesSonia Shah
Department of Genetics, Environment and Evolution, University College London Genetics Institute, Gower St, London WC1E 6BT, UK
Eur Heart J 34:972-81. 2013..However, their effects are too small to discriminate future lipid-lowering medication requirements or coronary events... - Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics CollaborationAspasia Angelakopoulou
Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
Eur Heart J 33:393-407. 2012.... - Biological predictors of change in functioning in the Whitehall II studyMeena Kumari
International Centre for Health and Society, Department of Epidemiology and Public Health, University College London, London, UK
Ann Epidemiol 14:250-7. 2004..To examine whether risk factors for CHD are related to change in functioning independent of the presence or development of disease... - Genetic variants associated with Von Willebrand factor levels in healthy men and women identified using the HumanCVD BeadChipDelilah Zabaneh
University College London Genetics Institute, Department of Genetics, Environment and Evolution, London, UK
Ann Hum Genet 75:456-67. 2011..These data demonstrate that multiple common alleles with small effects make, in combination, important contributions to individual differences in vWF levels... - Neuroendocrine and inflammatory factors associated with positive affect in healthy men and women: the Whitehall II studyAndrew Steptoe
Department of Epidemiology and Public Health, University College London, London, United Kingdom
Am J Epidemiol 167:96-102. 2008..These results confirm findings from smaller studies relating cortisol with positive affect while suggesting that in women, positive affect is associated with reduced levels of inflammatory markers... - The relationship between alcohol consumption and cortisol secretion in an aging cohortEllena Badrick
Department of Epidemiology and Public Health, 1 19 Torrington Place, University College London, London WC1E 6BT, United Kingdom
J Clin Endocrinol Metab 93:750-7. 2008..Evidence for an association between alcohol consumption and activity of the hypothalamic-pituitary-adrenal (HPA) axis is inconclusive... - Genetic variation in complement factor H and risk of coronary heart disease: eight new studies and a meta-analysis of around 48,000 individualsReecha Sofat
Centre for Clinical Pharmacology, Division of Medicine, University College London, Rayne Building, 5 University Street, London WC1E 6JF, UK
Atherosclerosis 213:184-90. 2010..To investigate the association of polymorphisms in complement factor H (CFH) and coronary heart disease (CHD) using meta-analysis... - Organizational justice and sleeping problems: The Whitehall II studyMarko Elovainio
Department of Epidemiology and Public Health, UCL Medical School, London, England, UK
Psychosom Med 71:334-40. 2009..To test the hypothesis that organizational injustice contributes to sleeping problems. Poor sleep quality can be a marker of prolonged emotional stress and has been shown to have serious effects on the immune system and metabolism... - Gene-targeted analysis of copy number variants identifies 3 novel associations with coronary heart disease traitsSean J Costelloe
Center for Cardiovascular Genetics, Institute of Cardiovascular Science, The Royal Free London NHS Foundation Trust, Pond St, London, UK
Circ Cardiovasc Genet 5:555-60. 2012..Copy number variants (CNVs) are a major form of genomic variation, which may be implicated in complex disease phenotypes. However, investigation of the role of CNVs in coronary heart disease (CHD) traits has been limited... - A genetic instrument for Mendelian randomization of fibrinogenGie Ken-Dror
Centre for Cardiovascular Genetics, BHF Laboratories, The Rayne Building, Department of Medicine, Royal Free and University College Medical School, 5 University St, London, WC1E 6JF, UK
Eur J Epidemiol 27:267-79. 2012..Thus, a combination of several SNPs will provide a stronger instrument for fibrinogen Mendelian randomization studies... - What explains the American disadvantage in health compared with the English? The case of diabetesJames Banks
Department of Economics, University College London, London, UK
J Epidemiol Community Health 66:259-64. 2012..This differential was not explained by conventional risk factors including age, smoking, social position and body mass index (BMI)... - Psychophysiological biomarkers of workplace stressorsTarani Chandola
UCL International Institute of Health and Society, UCL Department of Epidemiology and Public Health, University College London, London, United Kingdom
Neurosci Biobehav Rev 35:51-7. 2010..This study builds on recent reviews and examines the literature linking work stress with sympatho-adrenal biomarkers (plasma catecholamines and heart rate variability) and HPA axis biomarkers - the post-morning profile of cortisol... - Social and psychosocial influences on inflammatory markers and vascular function in civil servants (the Whitehall II study)Harry Hemingway
International Centre for Health and Society, Department of Epidemiology and Public Health, University College London Medical School, London, United Kingdom
Am J Cardiol 92:984-7. 2003..In a sample of 283 nonsmokers, we found that social position was inversely associated with interleukin-6 and C-reactive protein and that participants with mild depression had impaired endothelial function... - A prospective study of change in sleep duration: associations with mortality in the Whitehall II cohortJane E Ferrie
Internationale Centre for Health and Society, Department of Epidemiology and Public Health, University College London Medical School, London, UK
Sleep 30:1659-66. 2007..We investigated associations of sleep duration and change in sleep duration with all-cause, cardiovascular, and non-cardiovascular mortality... - Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChipPhilippa J Talmud
Centre for Cardiovascular Genetics, Department of Medicine, University College London, London WC1E 6JF, UK
Am J Hum Genet 85:628-42. 2009..These genes provide further insights into lipid metabolism and the likely effects of modifying the encoded targets therapeutically... - Gene-centric analysis identifies variants associated with interleukin-6 levels and shared pathways with other inflammation markersTina Shah
Genetic Epidemiology Group, Research Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, London, United Kingdom
Circ Cardiovasc Genet 6:163-70. 2013..Genetic variants associated with IL-6 provide important tools for probing the causal relevance of IL-6 signaling in a range of cardiometabolic diseases... - The relationship between plasma angiopoietin-like protein 4 levels, angiopoietin-like protein 4 genotype, and coronary heart disease riskMelissa C Smart-Halajko
Centre for Cardiovascular Genetics, University College London, 5 University St, London WC1E 6JF, England
Arterioscler Thromb Vasc Biol 30:2277-82. 2010..To investigate the relationship between angiopoietin-like protein 4 (Angptl4) levels, coronary heart disease (CHD) biomarkers, and ANGPTL4 variants... - BMI and waist circumference as predictors of well-being in older adults: findings from the English Longitudinal Study of AgeingPaola Zaninotto
Department of Epidemiology and Public Health, University College London, London, UK
Obesity (Silver Spring) 18:1981-7. 2010..In conclusion among older people, for a given BMI, increased WC was related with higher risk of poor QoL and, for women, of depressive symptoms; whereas for a given WC, increased BMI had a protective effect on QoL for women... - Use of low-density lipoprotein cholesterol gene score to distinguish patients with polygenic and monogenic familial hypercholesterolaemia: a case-control studyPhilippa J Talmud
Centre for Cardiovascular Genetics, Institute of Cardiovascular Science, University College London, London, UK
Lancet 381:1293-301. 2013..We assessed the hypothesis that familial hypercholesterolaemia can also be caused by an accumulation of common small-effect LDL-C-raising alleles... - Four genetic loci influencing electrocardiographic indices of left ventricular hypertrophySonia Shah
Department of Genetics, Evolution and Environment, University College London, London, United Kingdom
Circ Cardiovasc Genet 4:626-35. 2011..There is evidence for significant heritability of ECG-LVH. We conducted a large-scale gene-centric association analysis of 4 commonly measured indices of ECG-LVH... - Blood pressure loci identified with a gene-centric arrayToby Johnson
Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, UK
Am J Hum Genet 89:688-700. 2011.... - Separating the mechanism-based and off-target actions of cholesteryl ester transfer protein inhibitors with CETP gene polymorphismsReecha Sofat
Centre for Clinical Pharmacology, Department of Medicine, University College London, London, United Kingdom
Circulation 121:52-62. 2010..We hypothesized that common single-nucleotide polymorphisms in the CETP gene could help distinguish mechanism-based from off-target actions of CETP inhibitors to inform on the validity of CETP as a therapeutic target... - Life-course influences on health in British adults: effects of socio-economic position in childhood and adulthoodChris Power
Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, 30 Guilford Street, London, UK
Int J Epidemiol 36:532-9. 2007..We assess whether childhood SEP influences disease risk in mid-life, separately from the effect of adult position, and establish how associations vary across multiple measures of disease risk... - The relationship between smoking status and cortisol secretionEllena Badrick
Department of Epidemiology and Public Health, University College London, London WC1E 6BT, United Kingdom
J Clin Endocrinol Metab 92:819-24. 2007..Evidence for an association of smoking status with cortisol secretion is mixed... - SERPINA1 11478G→A variant, serum α1-antitrypsin, exacerbation frequency and FEV1 decline in COPDJennifer K Quint
Academic Unit of Respiratory Medicine, University College London, London, UK
Thorax 66:418-24. 2011..It was hypothesised that patients with chronic obstructive pulmonary disease (COPD) and this mutation have accelerated lung function decline... - Meta analysis of candidate gene variants outside the LPA locus with Lp(a) plasma levels in 14,500 participants of six White European cohortsDelilah Zabaneh
University College London Genetics Institute, Department of Genetics, Environment and Evolution, Gower St, London WC1E 6BT, UK
Atherosclerosis 217:447-51. 2011..We have used data from the HumanCVD BeadChip to explore the contribution of other candidate genes determining Lp(a) levels... - Causal relevance of blood lipid fractions in the development of carotid atherosclerosis: Mendelian randomization analysisSonia Shah
University College London Genetics Institute, University College London, London, United Kingdom
Circ Cardiovasc Genet 6:63-72. 2013..We aimed to determine the causal association among the 3 major blood lipid fractions and common CIMT using mendelian randomization analysis... - Job strain as a risk factor for coronary heart disease: a collaborative meta-analysis of individual participant dataMika Kivimaki
Department of Epidemiology and Public Health, University College London, London, UK
Lancet 380:1491-7. 2012..We analysed the relation between job strain and coronary heart disease with a meta-analysis of published and unpublished studies... - Effects of moderate and vigorous physical activity on heart rate variability in a British study of civil servantsKirsten L Rennie
Department of Epidemiology and Public Health, University College London, London, United Kingdom
Am J Epidemiol 158:135-43. 2003..Vigorous activity was associated with higher HRV, representing a possible mechanism by which physical activity reduces coronary heart disease risk... - Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort studyPhilippa J Talmud
Centre of Cardiovascular Genetics, Department of Medicine, University College London, London WC1E 6JF
BMJ 340:b4838. 2010.... - ANGPTL4 E40K and T266M: effects on plasma triglyceride and HDL levels, postprandial responses, and CHD riskPhilippa J Talmud
Division of Cardiovascular Genetics, Department of Medicine, University College London Medical School, 5 University St, London WC1E 6JF, United Kingdom
Arterioscler Thromb Vasc Biol 28:2319-25. 2008..We examined the association of common ANGPTL4 variants with CHD traits and risk in 5 studies (13,527 individuals)... - A gene-centric study of common carotid artery remodellingSeamus C Harrison
Centre for Cardiovascular Genetics, UCL, UK Electronic address
Atherosclerosis 226:440-6. 2013..Expansive remodelling is the process of compensatory arterial enlargement in response to atherosclerotic stimuli. The genetic determinants of this process are poorly characterized... - Polymorphisms in the WNK1 gene are associated with blood pressure variation and urinary potassium excretionStephen Newhouse
Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, United Kingdom
PLoS ONE 4:e5003. 2009.... - SLC2A9 is a high-capacity urate transporter in humansMark J Caulfield
Clinical Pharmacology and The Genome Centre, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, London, United Kingdom
PLoS Med 5:e197. 2008..We investigated whether SLC2A9 is a functional urate transporter that contributes to the longstanding association between urate and blood pressure in man... - Cross-sectional versus prospective associations of sleep duration with changes in relative weight and body fat distribution: the Whitehall II StudySaverio Stranges
Cardiovascular Medicine and Epidemiology Group, Clinical Sciences Research Institute, University of Warwick Medical School, Coventry, England
Am J Epidemiol 167:321-9. 2008..23, 1.12), nor with the incidence of obesity (odds ratio(adjusted) = 1.05, 95% CI: 0.60, 1.82). There is no temporal relation between short duration of sleep and future changes in measures of body weight and central adiposity... - Gender-specific associations of short sleep duration with prevalent and incident hypertension: the Whitehall II StudyFrancesco P Cappuccio
Clinical Sciences Research Institute, Warwick Medical School, Coventry, United Kingdom
Hypertension 50:693-700. 2007..42 [95% CI: 0.94 to 2.16]; odds ratio: 1.31 [95% CI: 0.65 to 2.63], respectively). Sleep deprivation may produce detrimental cardiovascular effects among women... - Association of sleep quality and free time leisure activities in Japanese and British civil servantsAli Nasermoaddeli
Department of Welfare Promotion and Epidemiology, Toyama Medical and Pharmaceutical University, Sugitani, Toyama, Japan
J Occup Health 47:384-90. 2005..46-0.80) and 0.71 (95%CI; 0.56-0.90) for Japanese and British subjects, respectively). Our findings suggest that engagement in social leisure activities is associated with better sleep quality and consequently better general well-being... - Effect of ethanol on lipid-mediated transfection of primary cortical neuronsAntje Anji
Department of Anatomy and Physiology, CVM, Kansas State University, Manhattan 66506, USA
Ann N Y Acad Sci 993:95-102; discussion 123-4. 2003..These data suggest that perhaps ethanol treatment of fetal cortical neurons improved the DNA uptake and/or increased the expression of the reporter genes... - Vitamin D status in United States war veteransMeena Kumari
Endocr Pract 14:127-8. 2008