Meena Kumari

Summary

Affiliation: University College London
Country: UK

Publications

  1. doi request reprint Maternal separation in childhood and diurnal cortisol patterns in mid-life: findings from the Whitehall II study
    M Kumari
    Department of Epidemiology and Public Health, University College London, UK
    Psychol Med 43:633-43. 2013
  2. pmc Effect of Apolipoprotein E epsilon4 on the association between health behaviors and cognitive function in late midlife
    Severine Sabia
    INSERM, U1018 Centre for Research in Epidemiology and Population Health, Hopital Paul Brousse, 16 Avenue Paul Vaillant Couturier, Bâtiment 15 16, F 94807, Villejuif, France
    Mol Neurodegener 5:23. 2010
  3. ncbi request reprint Diabetes and cognitive function in a middle-aged cohort: findings from the Whitehall II study
    Meena Kumari
    Department of Epidemiology and Public Health, International Centre for Health and Society, London, UK
    Neurology 65:1597-603. 2005
  4. pmc Self-reported sleep duration and sleep disturbance are independently associated with cortisol secretion in the Whitehall II study
    Meena Kumari
    Department of Epidemiology and Public Health, University College London, 1 19 Torrington Place, London WC1E 6BT, United Kingdom
    J Clin Endocrinol Metab 94:4801-9. 2009
  5. ncbi request reprint Measures of social position and cortisol secretion in an aging population: findings from the Whitehall II study
    Meena Kumari
    International Institute for Society and Health, University College London, 1 19 Torrington Place, London, WC1E 6BT, UK
    Psychosom Med 72:27-34. 2010
  6. ncbi request reprint Social differences in insulin-like growth factor-1: findings from a British birth cohort
    Meena Kumari
    International Institute for Society and Health, University College London, London, UK
    Ann Epidemiol 18:664-70. 2008
  7. pmc Association of diurnal patterns in salivary cortisol with all-cause and cardiovascular mortality: findings from the Whitehall II study
    Meena Kumari
    Department of Epidemiology and Public Health, University College London, London WC1E 6BT, United Kingdom
    J Clin Endocrinol Metab 96:1478-85. 2011
  8. ncbi request reprint Cortisol secretion and fatigue: associations in a community based cohort
    Meena Kumari
    Department of Epidemiology and Public Health, UCL, 1 19 Torrington Place, London, WC1E 6BT, United Kingdom
    Psychoneuroendocrinology 34:1476-85. 2009
  9. ncbi request reprint Identifying patterns in cortisol secretion in an older population. Findings from the Whitehall II study
    Meena Kumari
    Department of Epidemiology and Public Health, UCL, London, UK
    Psychoneuroendocrinology 35:1091-9. 2010
  10. pmc A nonlinear relationship of generalized and central obesity with diurnal cortisol secretion in the Whitehall II study
    Meena Kumari
    Department of Epidemiology and Public Health, 2 16 Torrington Place, London, WC1E 6BT, United Kingdom
    J Clin Endocrinol Metab 95:4415-23. 2010

Collaborators

Detail Information

Publications74

  1. doi request reprint Maternal separation in childhood and diurnal cortisol patterns in mid-life: findings from the Whitehall II study
    M Kumari
    Department of Epidemiology and Public Health, University College London, UK
    Psychol Med 43:633-43. 2013
    ..Evidence for an association of the diurnal cortisol rhythm with maternal separation in humans is equivocal...
  2. pmc Effect of Apolipoprotein E epsilon4 on the association between health behaviors and cognitive function in late midlife
    Severine Sabia
    INSERM, U1018 Centre for Research in Epidemiology and Population Health, Hopital Paul Brousse, 16 Avenue Paul Vaillant Couturier, Bâtiment 15 16, F 94807, Villejuif, France
    Mol Neurodegener 5:23. 2010
    ....
  3. ncbi request reprint Diabetes and cognitive function in a middle-aged cohort: findings from the Whitehall II study
    Meena Kumari
    Department of Epidemiology and Public Health, International Centre for Health and Society, London, UK
    Neurology 65:1597-603. 2005
    ..To compare cognitive performance in those with diabetes, impaired glucose tolerance, and normoglycemia in a middle-aged cohort...
  4. pmc Self-reported sleep duration and sleep disturbance are independently associated with cortisol secretion in the Whitehall II study
    Meena Kumari
    Department of Epidemiology and Public Health, University College London, 1 19 Torrington Place, London WC1E 6BT, United Kingdom
    J Clin Endocrinol Metab 94:4801-9. 2009
    ..The association of short sleep duration with cortisol secretion has not been thoroughly examined in large community dwelling populations and the relative importance of short sleep duration and sleep disturbance is unclear...
  5. ncbi request reprint Measures of social position and cortisol secretion in an aging population: findings from the Whitehall II study
    Meena Kumari
    International Institute for Society and Health, University College London, 1 19 Torrington Place, London, WC1E 6BT, UK
    Psychosom Med 72:27-34. 2010
    ..To examine whether dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis associated with disadvantaged social position in working populations also occurs in older age groups...
  6. ncbi request reprint Social differences in insulin-like growth factor-1: findings from a British birth cohort
    Meena Kumari
    International Institute for Society and Health, University College London, London, UK
    Ann Epidemiol 18:664-70. 2008
    ..Our aim is to examine whether there are social differences in IGF-1 in a cohort of participants between 44 and 45 years of age...
  7. pmc Association of diurnal patterns in salivary cortisol with all-cause and cardiovascular mortality: findings from the Whitehall II study
    Meena Kumari
    Department of Epidemiology and Public Health, University College London, London WC1E 6BT, United Kingdom
    J Clin Endocrinol Metab 96:1478-85. 2011
    ..Evidence for the association of cortisol with mortality or disease events is mixed, possibly due to a failure to consider diurnal cortisol patterns...
  8. ncbi request reprint Cortisol secretion and fatigue: associations in a community based cohort
    Meena Kumari
    Department of Epidemiology and Public Health, UCL, 1 19 Torrington Place, London, WC1E 6BT, United Kingdom
    Psychoneuroendocrinology 34:1476-85. 2009
    ..Cortisol is also associated with future onset of fatigue suggesting that changes in cortisol secretion are etiologic or occur early in the genesis of fatigue...
  9. ncbi request reprint Identifying patterns in cortisol secretion in an older population. Findings from the Whitehall II study
    Meena Kumari
    Department of Epidemiology and Public Health, UCL, London, UK
    Psychoneuroendocrinology 35:1091-9. 2010
    ..Raised pattern of secretion, which occurs in 27% of our participants is associated with demographic variables, adverse health behaviours, psychosocial environment and impaired physical functioning...
  10. pmc A nonlinear relationship of generalized and central obesity with diurnal cortisol secretion in the Whitehall II study
    Meena Kumari
    Department of Epidemiology and Public Health, 2 16 Torrington Place, London, WC1E 6BT, United Kingdom
    J Clin Endocrinol Metab 95:4415-23. 2010
    ..Evidence for an association of measures of generalized and central obesity with salivary cortisol secretion is equivocal...
  11. ncbi request reprint Chronic stress accelerates atherosclerosis in the apolipoprotein E deficient mouse
    Meena Kumari
    Department of Epidemiology and Public Health, International Centre for Health and Society, London, UK
    Stress 6:297-9. 2003
    ..These data suggest that chronic mild stress can induce or accelerate the development of atherosclerosis...
  12. ncbi request reprint The menopausal transition was associated in a prospective study with decreased health functioning in women who report menopausal symptoms
    Meena Kumari
    International Centre for Health and Society, Department of Epidemiology and Public Health, Royal Free and University College London Medical School, 1 19 Torrington Place, London WC1 6BT, UK
    J Clin Epidemiol 58:719-27. 2005
    ..To examine change in health functioning as women progress through the menopausal transition...
  13. ncbi request reprint Social, behavioral, and metabolic determinants of plasma viscosity in the Whitehall II Study
    Meena Kumari
    International Centre for Health and Society, Department of Epidemiology and Public Health, Royal Free and University College London Medical School, London, UK
    Ann Epidemiol 15:398-404. 2005
    ..To examine the social, biological, and metabolic associations of plasma viscosity in a large epidemiological study...
  14. ncbi request reprint Prospective study of social and other risk factors for incidence of type 2 diabetes in the Whitehall II study
    Meena Kumari
    International Centre for Health and Society, Department of Epidemiology and Public Health, University College London, London, England
    Arch Intern Med 164:1873-80. 2004
    ..Social inequalities in the incidence of type 2 diabetes and the relation of health behaviors and psychosocial factors to the incidence of type 2 diabetes are not well established...
  15. ncbi request reprint Lifecourse influences on health among British adults: effects of region of residence in childhood and adulthood
    David P Strachan
    Division of Community Health Sciences, St George s University of London, Cranmer Terrace, London, UK
    Int J Epidemiol 36:522-31. 2007
    ..We examined inter-regional migrants in Britain to evaluate the relative importance of early and recent exposures for adult cardiorespiratory risk factors, mental ill-health and sensory function...
  16. doi request reprint Gene-centric analysis identifies variants associated with interleukin-6 levels and shared pathways with other inflammation markers
    Tina Shah
    Genetic Epidemiology Group, Research Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, London WC1E 6BT, United Kingdom
    Circ Cardiovasc Genet 6:163-70. 2013
    ..Genetic variants associated with IL-6 provide important tools for probing the causal relevance of IL-6 signaling in a range of cardiometabolic diseases...
  17. pmc Influence of common genetic variation on blood lipid levels, cardiovascular risk, and coronary events in two British prospective cohort studies
    Sonia Shah
    Department of Genetics, Environment and Evolution, University College London Genetics Institute, Gower St, London WC1E 6BT, UK
    Eur Heart J 34:972-81. 2013
    ....
  18. ncbi request reprint Psychological coping styles and cortisol over the day in healthy older adults
    Katie O'Donnell
    Psychobiology Group, Department of Epidemiology and Public Health, University College London, 1 19 Torrington Place, London WC1E 6BT, UK
    Psychoneuroendocrinology 33:601-11. 2008
    ..The results indicate that adaptive coping styles are related to low levels of cortisol over the day, suggesting that neuroendocrine pathways may partly mediate relationships between psychological coping and health...
  19. ncbi request reprint Sleep and biomarkers in the English Longitudinal Study of Ageing: associations with C-reactive protein, fibrinogen, dehydroepiandrosterone sulfate and hemoglobin
    Marta Jackowska
    Research Department of Epidemiology and Public Health, University College London, 1 19 Torrington Place, London WC1E 6BT, United Kingdom Electronic address
    Psychoneuroendocrinology 38:1484-93. 2013
    ..A better understanding of these relationships using longitudinal cohort studies will broaden our understanding of the mechanisms relating sleep indices and ill health in advancing age. ..
  20. pmc Antidepressant medication use and risk of hyperglycemia and diabetes mellitus: a noncausal association?
    Mika Kivimaki
    Department of Epidemiology and Public Health, University College London, United Kingdom
    Biol Psychiatry 70:978-84. 2011
    ..To examine this, we assessed the associations of antidepressant use with change in glucose levels and incidence of undiagnosed and diagnosed diabetes...
  21. ncbi request reprint Work stress and coronary heart disease: what are the mechanisms?
    Tarani Chandola
    Department of Epidemiology and Public Health, University College London, 1 19 Torrington Place, London WC1E 6BT, UK
    Eur Heart J 29:640-8. 2008
    ..To determine the biological and behavioural factors linking work stress with coronary heart disease (CHD)...
  22. pmc Inflammation, insulin resistance, and diabetes--Mendelian randomization using CRP haplotypes points upstream
    Eric J Brunner
    Department of Epidemiology and Public Health, Royal Free and University College London Medical School, London, United Kingdom
    PLoS Med 5:e155. 2008
    ..Our objective was to examine the nature of the association between CRP phenotype and diabetes development using CRP haplotypes as instrumental variables...
  23. pmc Glycemia, insulin resistance, insulin secretion, and risk of depressive symptoms in middle age
    Tasnime N Akbaraly
    Department of Epidemiology and Public Health, University College London, London, UK
    Diabetes Care 36:928-34. 2013
    ..In this study, we investigated prospective associations of levels of fasting glucose and fasting insulin and indices of insulin resistance and secretion with subsequent new-onset depressive symptoms (DepS)...
  24. doi request reprint Positive affect and distressed affect over the day in older people
    Andrew Steptoe
    Department of Epidemiology and Public Health, University College London, London WC1E 6BT, UK
    Psychol Aging 26:956-65. 2011
    ..The associations with loneliness highlight the everyday distress and reduced happiness and excitement experienced by lonely older men and women, and these may contribute to enhanced risks to physical and mental health...
  25. pmc Does high C-reactive protein concentration increase atherosclerosis? The Whitehall II Study
    Mika Kivimaki
    Department of Epidemiology and Public Health, University College London, London, United Kingdom
    PLoS ONE 3:e3013. 2008
    ....
  26. pmc Association between change in body composition and change in inflammatory markers: an 11-year follow-up in the Whitehall II Study
    Eleonor I Fransson
    Department of Epidemiology and Public Health, University College London, 1 19 Torrington Place, London WC1E 6BT, United Kingdom
    J Clin Endocrinol Metab 95:5370-4. 2010
    ..Obesity is associated with low-grade inflammation, but the long-term effects of weight change on inflammation are unknown...
  27. pmc Use of allele-specific FAIRE to determine functional regulatory polymorphism using large-scale genotyping arrays
    Andrew J P Smith
    Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, Institute of Cardiovascular Sciences, University College London, London, United Kingdom
    PLoS Genet 8:e1002908. 2012
    ..Using increasingly comprehensive genotyping chips and distinct tissues for examination, FAIRE-gen has the potential to aid the identification of many causal SNPs associated with disease from GWAS...
  28. ncbi request reprint Association between IL6 gene variants -174G>C and -572G>C and serum IL-6 levels: interactions with social position in the Whitehall II cohort
    Saskia C Sanderson
    Department of Epidemiology and Public Health Whitehall II, 1 19 Torrington Place, University College London, London WC1E 6BT, UK
    Atherosclerosis 204:459-64. 2009
    ..To examine the impact of -174G>C and -572G>C variants in the promoter region of the IL6 gene, and their interactions with social position, on interleukin-6 (IL-6) levels in the Whitehall II cohort...
  29. pmc Examining overweight and obesity as risk factors for common mental disorders using fat mass and obesity-associated (FTO) genotype-instrumented analysis: The Whitehall II Study, 1985-2004
    Mika Kivimaki
    Department of Epidemiology and Public Health, Faculty of Biomedical Sciences, University College London, United Kingdom
    Am J Epidemiol 173:421-9. 2011
    ..Mendelian randomization analyses supported the status of long-term obesity as a risk factor for CMD in men-a finding that should be interpreted cautiously because the function of the FTO gene is unknown...
  30. ncbi request reprint Effects of socioeconomic position on inflammatory and hemostatic markers: a life-course analysis in the 1958 British birth cohort
    Faiza Tabassum
    Department of Epidemiology and Public Health, University College London, London, United Kingdom
    Am J Epidemiol 167:1332-41. 2008
    ..Risk exposure related to SEP accumulates across the life course and contributes to raised levels of fibrinogen and C-reactive protein, while childhood SEP influences hemostatic markers more than does adult SEP...
  31. pmc Apolipoprotein E genotype, cardiovascular biomarkers and risk of stroke: systematic review and meta-analysis of 14,015 stroke cases and pooled analysis of primary biomarker data from up to 60,883 individuals
    Tauseef A Khan
    Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    Int J Epidemiol 42:475-92. 2013
    ..We evaluated the association of APOE genotype with risk of ischaemic stroke and assessed whether the observed effect was consistent with the effects of APOE genotype on LDL-C or other lipids and biomarkers of cardiovascular risk...
  32. pmc Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration
    Aspasia Angelakopoulou
    Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
    Eur Heart J 33:393-407. 2012
    ....
  33. doi request reprint Genetic variation in complement factor H and risk of coronary heart disease: eight new studies and a meta-analysis of around 48,000 individuals
    Reecha Sofat
    Centre for Clinical Pharmacology, Division of Medicine, University College London, Rayne Building, 5 University Street, London WC1E 6JF, UK
    Atherosclerosis 213:184-90. 2010
    ..To investigate the association of polymorphisms in complement factor H (CFH) and coronary heart disease (CHD) using meta-analysis...
  34. ncbi request reprint Biological predictors of change in functioning in the Whitehall II study
    Meena Kumari
    International Centre for Health and Society, Department of Epidemiology and Public Health, University College London, London, UK
    Ann Epidemiol 14:250-7. 2004
    ..To examine whether risk factors for CHD are related to change in functioning independent of the presence or development of disease...
  35. ncbi request reprint Organizational justice and sleeping problems: The Whitehall II study
    Marko Elovainio
    Department of Epidemiology and Public Health, UCL Medical School, London, England, UK
    Psychosom Med 71:334-40. 2009
    ..To test the hypothesis that organizational injustice contributes to sleeping problems. Poor sleep quality can be a marker of prolonged emotional stress and has been shown to have serious effects on the immune system and metabolism...
  36. pmc The relationship between alcohol consumption and cortisol secretion in an aging cohort
    Ellena Badrick
    Department of Epidemiology and Public Health, 1 19 Torrington Place, University College London, London WC1E 6BT, United Kingdom
    J Clin Endocrinol Metab 93:750-7. 2008
    ..Evidence for an association between alcohol consumption and activity of the hypothalamic-pituitary-adrenal (HPA) axis is inconclusive...
  37. doi request reprint Genetic variants associated with Von Willebrand factor levels in healthy men and women identified using the HumanCVD BeadChip
    Delilah Zabaneh
    University College London Genetics Institute, Department of Genetics, Environment and Evolution, London, UK
    Ann Hum Genet 75:456-67. 2011
    ..These data demonstrate that multiple common alleles with small effects make, in combination, important contributions to individual differences in vWF levels...
  38. ncbi request reprint Neuroendocrine and inflammatory factors associated with positive affect in healthy men and women: the Whitehall II study
    Andrew Steptoe
    Department of Epidemiology and Public Health, University College London, London, United Kingdom
    Am J Epidemiol 167:96-102. 2008
    ..These results confirm findings from smaller studies relating cortisol with positive affect while suggesting that in women, positive affect is associated with reduced levels of inflammatory markers...
  39. doi request reprint Gene-targeted analysis of copy number variants identifies 3 novel associations with coronary heart disease traits
    Sean J Costelloe
    Center for Cardiovascular Genetics, Institute of Cardiovascular Science, The Royal Free London NHS Foundation Trust, Pond St, London, UK
    Circ Cardiovasc Genet 5:555-60. 2012
    ..Copy number variants (CNVs) are a major form of genomic variation, which may be implicated in complex disease phenotypes. However, investigation of the role of CNVs in coronary heart disease (CHD) traits has been limited...
  40. pmc A genetic instrument for Mendelian randomization of fibrinogen
    Gie Ken-Dror
    Centre for Cardiovascular Genetics, BHF Laboratories, The Rayne Building, Department of Medicine, Royal Free and University College Medical School, 5 University St, London, WC1E 6JF, UK
    Eur J Epidemiol 27:267-79. 2012
    ..Thus, a combination of several SNPs will provide a stronger instrument for fibrinogen Mendelian randomization studies...
  41. pmc What explains the American disadvantage in health compared with the English? The case of diabetes
    James Banks
    Department of Economics, University College London, London, UK
    J Epidemiol Community Health 66:259-64. 2012
    ..This differential was not explained by conventional risk factors including age, smoking, social position and body mass index (BMI)...
  42. pmc A prospective study of change in sleep duration: associations with mortality in the Whitehall II cohort
    Jane E Ferrie
    Internationale Centre for Health and Society, Department of Epidemiology and Public Health, University College London Medical School, London, UK
    Sleep 30:1659-66. 2007
    ..We investigated associations of sleep duration and change in sleep duration with all-cause, cardiovascular, and non-cardiovascular mortality...
  43. pmc Psychophysiological biomarkers of workplace stressors
    Tarani Chandola
    UCL International Institute of Health and Society, UCL Department of Epidemiology and Public Health, University College London, London, United Kingdom
    Neurosci Biobehav Rev 35:51-7. 2010
    ..This study builds on recent reviews and examines the literature linking work stress with sympatho-adrenal biomarkers (plasma catecholamines and heart rate variability) and HPA axis biomarkers - the post-morning profile of cortisol...
  44. pmc Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip
    Philippa J Talmud
    Centre for Cardiovascular Genetics, Department of Medicine, University College London, London WC1E 6JF, UK
    Am J Hum Genet 85:628-42. 2009
    ..These genes provide further insights into lipid metabolism and the likely effects of modifying the encoded targets therapeutically...
  45. ncbi request reprint Social and psychosocial influences on inflammatory markers and vascular function in civil servants (the Whitehall II study)
    Harry Hemingway
    International Centre for Health and Society, Department of Epidemiology and Public Health, University College London Medical School, London, United Kingdom
    Am J Cardiol 92:984-7. 2003
    ..In a sample of 283 nonsmokers, we found that social position was inversely associated with interleukin-6 and C-reactive protein and that participants with mild depression had impaired endothelial function...
  46. pmc Secretory phospholipase A(2)-IIA and cardiovascular disease: a mendelian randomization study
    Michael V Holmes
    Faculty of Population Health Sciences, University College London, London, United Kingdom Electronic address
    J Am Coll Cardiol 62:1966-76. 2013
    ..This study sought to investigate the role of secretory phospholipase A2 (sPLA2)-IIA in cardiovascular disease...
  47. doi request reprint Use of low-density lipoprotein cholesterol gene score to distinguish patients with polygenic and monogenic familial hypercholesterolaemia: a case-control study
    Philippa J Talmud
    Centre for Cardiovascular Genetics, Institute of Cardiovascular Science, University College London, London, UK
    Lancet 381:1293-301. 2013
    ..We assessed the hypothesis that familial hypercholesterolaemia can also be caused by an accumulation of common small-effect LDL-C-raising alleles...
  48. pmc The relationship between plasma angiopoietin-like protein 4 levels, angiopoietin-like protein 4 genotype, and coronary heart disease risk
    Melissa C Smart-Halajko
    Centre for Cardiovascular Genetics, University College London, 5 University St, London WC1E 6JF, England
    Arterioscler Thromb Vasc Biol 30:2277-82. 2010
    ..To investigate the relationship between angiopoietin-like protein 4 (Angptl4) levels, coronary heart disease (CHD) biomarkers, and ANGPTL4 variants...
  49. doi request reprint BMI and waist circumference as predictors of well-being in older adults: findings from the English Longitudinal Study of Ageing
    Paola Zaninotto
    Department of Epidemiology and Public Health, University College London, London, UK
    Obesity (Silver Spring) 18:1981-7. 2010
    ..In conclusion among older people, for a given BMI, increased WC was related with higher risk of poor QoL and, for women, of depressive symptoms; whereas for a given WC, increased BMI had a protective effect on QoL for women...
  50. pmc Population genomics of cardiometabolic traits: design of the University College London-London School of Hygiene and Tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium
    Tina Shah
    Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London, London, United Kingdom
    PLoS ONE 8:e71345. 2013
    ....
  51. ncbi request reprint Causal relevance of blood lipid fractions in the development of carotid atherosclerosis: Mendelian randomization analysis
    Sonia Shah
    University College London Genetics Institute, University College London, London, United Kingdom
    Circ Cardiovasc Genet 6:63-72. 2013
    ..We aimed to determine the causal association among the 3 major blood lipid fractions and common CIMT using mendelian randomization analysis...
  52. doi request reprint Four genetic loci influencing electrocardiographic indices of left ventricular hypertrophy
    Sonia Shah
    Department of Genetics, Evolution and Environment, University College London, London, United Kingdom
    Circ Cardiovasc Genet 4:626-35. 2011
    ..There is evidence for significant heritability of ECG-LVH. We conducted a large-scale gene-centric association analysis of 4 commonly measured indices of ECG-LVH...
  53. pmc Blood pressure loci identified with a gene-centric array
    Toby Johnson
    Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, UK
    Am J Hum Genet 89:688-700. 2011
    ....
  54. ncbi request reprint Life-course influences on health in British adults: effects of socio-economic position in childhood and adulthood
    Chris Power
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, 30 Guilford Street, London, UK
    Int J Epidemiol 36:532-9. 2007
    ..We assess whether childhood SEP influences disease risk in mid-life, separately from the effect of adult position, and establish how associations vary across multiple measures of disease risk...
  55. ncbi request reprint The relationship between smoking status and cortisol secretion
    Ellena Badrick
    Department of Epidemiology and Public Health, University College London, London WC1E 6BT, United Kingdom
    J Clin Endocrinol Metab 92:819-24. 2007
    ..Evidence for an association of smoking status with cortisol secretion is mixed...
  56. doi request reprint SERPINA1 11478G→A variant, serum α1-antitrypsin, exacerbation frequency and FEV1 decline in COPD
    Jennifer K Quint
    Academic Unit of Respiratory Medicine, University College London, London, UK
    Thorax 66:418-24. 2011
    ..It was hypothesised that patients with chronic obstructive pulmonary disease (COPD) and this mutation have accelerated lung function decline...
  57. pmc Separating the mechanism-based and off-target actions of cholesteryl ester transfer protein inhibitors with CETP gene polymorphisms
    Reecha Sofat
    Centre for Clinical Pharmacology, Department of Medicine, University College London, London, United Kingdom
    Circulation 121:52-62. 2010
    ..We hypothesized that common single-nucleotide polymorphisms in the CETP gene could help distinguish mechanism-based from off-target actions of CETP inhibitors to inform on the validity of CETP as a therapeutic target...
  58. pmc Meta analysis of candidate gene variants outside the LPA locus with Lp(a) plasma levels in 14,500 participants of six White European cohorts
    Delilah Zabaneh
    University College London Genetics Institute, Department of Genetics, Environment and Evolution, Gower St, London WC1E 6BT, UK
    Atherosclerosis 217:447-51. 2011
    ..We have used data from the HumanCVD BeadChip to explore the contribution of other candidate genes determining Lp(a) levels...
  59. ncbi request reprint Parental separation in childhood and adult inflammation: the importance of material and psychosocial pathways
    Rebecca E Lacey
    Department of Epidemiology and Public Health, University College London, United Kingdom Electronic address
    Psychoneuroendocrinology 38:2476-84. 2013
    ....
  60. pmc Lifecourse social position and D-dimer; findings from the 1958 British birth cohort
    Faiza Tabassum
    Third Sector Research Centre, Faculty of Human and Social Sciences, University of Southampton, Southampton, United Kingdom Department of Infection and Population Health, University College London UCL, London, United Kingdom
    PLoS ONE 9:e93277. 2014
    ..Risk exposure related to SEP accumulates across life and contributes to raised levels of D-dimer. The association of haemostatic markers and social differences in health may be mediated by inflammatory and other markers. ..
  61. ncbi request reprint Alcohol consumption and cognitive performance: a Mendelian randomization study
    Meena Kumari
    Department of Epidemiology and Public Health, University College London, London, UK ISER, University of Essex, Colchester, UK
    Addiction 109:1462-71. 2014
    ..To use Mendelian randomization to assess whether alcohol intake was causally associated with cognitive function...
  62. pmc A gene-centric study of common carotid artery remodelling
    Seamus C Harrison
    Centre for Cardiovascular Genetics, UCL, UK
    Atherosclerosis 226:440-6. 2013
    ..Expansive remodelling is the process of compensatory arterial enlargement in response to atherosclerotic stimuli. The genetic determinants of this process are poorly characterized...
  63. pmc Job strain as a risk factor for coronary heart disease: a collaborative meta-analysis of individual participant data
    Mika Kivimaki
    Department of Epidemiology and Public Health, University College London, London, UK
    Lancet 380:1491-7. 2012
    ..We analysed the relation between job strain and coronary heart disease with a meta-analysis of published and unpublished studies...
  64. ncbi request reprint Effects of moderate and vigorous physical activity on heart rate variability in a British study of civil servants
    Kirsten L Rennie
    Department of Epidemiology and Public Health, University College London, London, United Kingdom
    Am J Epidemiol 158:135-43. 2003
    ..Vigorous activity was associated with higher HRV, representing a possible mechanism by which physical activity reduces coronary heart disease risk...
  65. ncbi request reprint ANGPTL4 E40K and T266M: effects on plasma triglyceride and HDL levels, postprandial responses, and CHD risk
    Philippa J Talmud
    Division of Cardiovascular Genetics, Department of Medicine, University College London Medical School, 5 University St, London WC1E 6JF, United Kingdom
    Arterioscler Thromb Vasc Biol 28:2319-25. 2008
    ..We examined the association of common ANGPTL4 variants with CHD traits and risk in 5 studies (13,527 individuals)...
  66. pmc Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study
    Philippa J Talmud
    Centre of Cardiovascular Genetics, Department of Medicine, University College London, London WC1E 6JF
    BMJ 340:b4838. 2010
    ....
  67. pmc SLC2A9 is a high-capacity urate transporter in humans
    Mark J Caulfield
    Clinical Pharmacology and The Genome Centre, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, London, United Kingdom
    PLoS Med 5:e197. 2008
    ..We investigated whether SLC2A9 is a functional urate transporter that contributes to the longstanding association between urate and blood pressure in man...
  68. pmc Polymorphisms in the WNK1 gene are associated with blood pressure variation and urinary potassium excretion
    Stephen Newhouse
    Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, United Kingdom
    PLoS ONE 4:e5003. 2009
    ....
  69. pmc Is there an association between work stress and diurnal cortisol patterns? Findings from the Whitehall II study
    Jing Liao
    Department of Epidemiology and Public Health, University College London, London, United Kingdom
    PLoS ONE 8:e81020. 2013
    ..This study assessed the relation between work stress and diurnal cortisol rhythm in a large-scale occupational cohort, the Whitehall II study...
  70. ncbi request reprint Association of sleep quality and free time leisure activities in Japanese and British civil servants
    Ali Nasermoaddeli
    Department of Welfare Promotion and Epidemiology, Toyama Medical and Pharmaceutical University, Sugitani, Toyama, Japan
    J Occup Health 47:384-90. 2005
    ..46-0.80) and 0.71 (95%CI; 0.56-0.90) for Japanese and British subjects, respectively). Our findings suggest that engagement in social leisure activities is associated with better sleep quality and consequently better general well-being...
  71. pmc Gender-specific associations of short sleep duration with prevalent and incident hypertension: the Whitehall II Study
    Francesco P Cappuccio
    Clinical Sciences Research Institute, Warwick Medical School, Coventry, United Kingdom
    Hypertension 50:693-700. 2007
    ..42 [95% CI: 0.94 to 2.16]; odds ratio: 1.31 [95% CI: 0.65 to 2.63], respectively). Sleep deprivation may produce detrimental cardiovascular effects among women...
  72. pmc Cross-sectional versus prospective associations of sleep duration with changes in relative weight and body fat distribution: the Whitehall II Study
    Saverio Stranges
    Cardiovascular Medicine and Epidemiology Group, Clinical Sciences Research Institute, University of Warwick Medical School, Coventry, England
    Am J Epidemiol 167:321-9. 2008
    ..23, 1.12), nor with the incidence of obesity (odds ratio(adjusted) = 1.05, 95% CI: 0.60, 1.82). There is no temporal relation between short duration of sleep and future changes in measures of body weight and central adiposity...
  73. ncbi request reprint Effect of ethanol on lipid-mediated transfection of primary cortical neurons
    Antje Anji
    Department of Anatomy and Physiology, CVM, Kansas State University, Manhattan 66506, USA
    Ann N Y Acad Sci 993:95-102; discussion 123-4. 2003
    ..These data suggest that perhaps ethanol treatment of fetal cortical neurons improved the DNA uptake and/or increased the expression of the reporter genes...
  74. pmc Vitamin D status in United States war veterans
    Meena Kumari
    Endocr Pract 14:127-8. 2008