Rhoda E Kuc

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint Quantification of endothelin receptor subtypes in peripheral tissues reveals downregulation of ET(A) receptors in ET(B)-deficient mice
    Rhoda E Kuc
    Clinical Pharmacology Unit, University of Cambridge, Level 6, Addenbrooke s Centre for Clinical Investigation, Box 110, Addenbrooke s Hospital, Cambridge CB2 2QQ, United Kingdom
    Exp Biol Med (Maywood) 231:741-5. 2006
  2. ncbi request reprint Novel snake venom ligand dendroaspis natriuretic peptide is selective for natriuretic peptide receptor-A in human heart: downregulation of natriuretic peptide receptor-A in heart failure
    Gurminder Singh
    Clinical Pharmacology Unit, University of Cambridge, Level 6, Centre for Clinical Investigation, Box 110, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Circ Res 99:183-90. 2006
  3. pmc Inotropic action of the puberty hormone kisspeptin in rat, mouse and human: cardiovascular distribution and characteristics of the kisspeptin receptor
    Janet J Maguire
    Clinical Pharmacology Unit, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 6:e27601. 2011
  4. ncbi request reprint Kisspeptins are novel potent vasoconstrictors in humans, with a discrete localization of their receptor, G protein-coupled receptor 54, to atherosclerosis-prone vessels
    Emma J Mead
    Clinical Pharmacology Unit, University of Cambridge, Centre for Clinical Investigation, Addenbrooke s Hospital, Cambridge, CB2 2QQ, UK
    Endocrinology 148:140-7. 2007
  5. doi request reprint Radioligand binding assays and their analysis
    Janet J Maguire
    Clinical Pharmacology Unit, Addenbrooke s Centre for Clinical Investigation, University of Cambridge, Cambridge, UK
    Methods Mol Biol 897:31-77. 2012
  6. ncbi request reprint Immunocytochemical localization of the urotensin-II receptor, UT, to rat and human tissues: relevance to function
    Janet J Maguire
    Clinical Pharmacology Unit, University of Cambridge, Level 6 Centre for Clinical Investigation, Box 110 Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Peptides 29:735-42. 2008
  7. doi request reprint Defining the affinity and receptor sub-type selectivity of four classes of endothelin antagonists in clinically relevant human cardiovascular tissues
    Janet J Maguire
    Clinical Pharmacology Unit, University of Cambridge, Level 6 ACCI, Box 110 Addenbrooke s Hospital, Cambridge, CB2 0QQ, UK Electronic address
    Life Sci 91:681-6. 2012
  8. ncbi request reprint Elevated systemic levels of endothelin-1 and blood pressure correlate with blunted constrictor responses and downregulation of endothelin(A), but not endothelin(B), receptors in an animal model of hypertension
    Sabine Telemaque-Potts
    Clinical Pharmacology Unit, University of Cambridge, Level 6, Centre for Clinical Investigation, Box 110, Addenbrooke s Hospital, Cambridge CB2 2QQ, U K
    Clin Sci (Lond) 103:357S-362S. 2002
  9. doi request reprint Expression and vasoconstrictor function of anorexigenic peptides neuromedin U-25 and S in the human cardiovascular system
    John D Mitchell
    Clinical Pharmacology Unit, Centre for Clinical Investigation, Box 110, Addenbrooke s Hospital, University of Cambridge, Cambridge CB22QQ, UK
    Cardiovasc Res 81:353-61. 2009
  10. doi request reprint Evidence for a novel vasospastic transmitter system, neuromedin U, in the equine digital circulation
    John D Mitchell
    Clinical Pharmacology Unit, University of Cambridge, Level 6 Centre for Clinical Investigation, Box 110 Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Vet J 186:106-9. 2010

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Quantification of endothelin receptor subtypes in peripheral tissues reveals downregulation of ET(A) receptors in ET(B)-deficient mice
    Rhoda E Kuc
    Clinical Pharmacology Unit, University of Cambridge, Level 6, Addenbrooke s Centre for Clinical Investigation, Box 110, Addenbrooke s Hospital, Cambridge CB2 2QQ, United Kingdom
    Exp Biol Med (Maywood) 231:741-5. 2006
    ....
  2. ncbi request reprint Novel snake venom ligand dendroaspis natriuretic peptide is selective for natriuretic peptide receptor-A in human heart: downregulation of natriuretic peptide receptor-A in heart failure
    Gurminder Singh
    Clinical Pharmacology Unit, University of Cambridge, Level 6, Centre for Clinical Investigation, Box 110, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Circ Res 99:183-90. 2006
    ....
  3. pmc Inotropic action of the puberty hormone kisspeptin in rat, mouse and human: cardiovascular distribution and characteristics of the kisspeptin receptor
    Janet J Maguire
    Clinical Pharmacology Unit, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 6:e27601. 2011
    ....
  4. ncbi request reprint Kisspeptins are novel potent vasoconstrictors in humans, with a discrete localization of their receptor, G protein-coupled receptor 54, to atherosclerosis-prone vessels
    Emma J Mead
    Clinical Pharmacology Unit, University of Cambridge, Centre for Clinical Investigation, Addenbrooke s Hospital, Cambridge, CB2 2QQ, UK
    Endocrinology 148:140-7. 2007
    ....
  5. doi request reprint Radioligand binding assays and their analysis
    Janet J Maguire
    Clinical Pharmacology Unit, Addenbrooke s Centre for Clinical Investigation, University of Cambridge, Cambridge, UK
    Methods Mol Biol 897:31-77. 2012
    ..The measurement of bound radioligand within discrete regions of autoradiographical images using -computer-assisted image analysis is described...
  6. ncbi request reprint Immunocytochemical localization of the urotensin-II receptor, UT, to rat and human tissues: relevance to function
    Janet J Maguire
    Clinical Pharmacology Unit, University of Cambridge, Level 6 Centre for Clinical Investigation, Box 110 Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Peptides 29:735-42. 2008
    ....
  7. doi request reprint Defining the affinity and receptor sub-type selectivity of four classes of endothelin antagonists in clinically relevant human cardiovascular tissues
    Janet J Maguire
    Clinical Pharmacology Unit, University of Cambridge, Level 6 ACCI, Box 110 Addenbrooke s Hospital, Cambridge, CB2 0QQ, UK Electronic address
    Life Sci 91:681-6. 2012
    ..Additionally, affinities (K(B)) for these antagonists, determined in ET-1-mediated vasoconstriction assays in human blood vessels, were used to identify discrepancies between K(B) and K(D) determined in the same tissues...
  8. ncbi request reprint Elevated systemic levels of endothelin-1 and blood pressure correlate with blunted constrictor responses and downregulation of endothelin(A), but not endothelin(B), receptors in an animal model of hypertension
    Sabine Telemaque-Potts
    Clinical Pharmacology Unit, University of Cambridge, Level 6, Centre for Clinical Investigation, Box 110, Addenbrooke s Hospital, Cambridge CB2 2QQ, U K
    Clin Sci (Lond) 103:357S-362S. 2002
    ..The results show that ET(A) (but not ET(B)) receptors are modulated in this experimental model of hypertension and provide further evidence for selective blockade of the ET(A) receptor as a therapeutic strategy...
  9. doi request reprint Expression and vasoconstrictor function of anorexigenic peptides neuromedin U-25 and S in the human cardiovascular system
    John D Mitchell
    Clinical Pharmacology Unit, Centre for Clinical Investigation, Box 110, Addenbrooke s Hospital, University of Cambridge, Cambridge CB22QQ, UK
    Cardiovasc Res 81:353-61. 2009
    ..We examined the hypothesis that NMU fulfils the criteria for controlling vascular reactivity within the human cardiovascular system...
  10. doi request reprint Evidence for a novel vasospastic transmitter system, neuromedin U, in the equine digital circulation
    John D Mitchell
    Clinical Pharmacology Unit, University of Cambridge, Level 6 Centre for Clinical Investigation, Box 110 Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Vet J 186:106-9. 2010
    ..125)I]-NMU-25 binding sites were localised to the smooth muscle layer and NMU-25 potently constricted the digital vein. This provides evidence for NMU as a transmitter in the equine digital circulation...
  11. pmc Modulation of the apelin/APJ system in heart failure and atherosclerosis in man
    Sarah L Pitkin
    Clinical Pharmacology Unit, University of Cambridge, Level 6 Centre for Clinical Investigation, Box 110 Addenbrooke s Hospital, Cambridge, UK
    Br J Pharmacol 160:1785-95. 2010
    ..The aim of this study was to determine whether the apelin/APJ system is altered in human cardiovascular disease by investigating whether the expression of apelin or its receptor is altered at the protein level...
  12. ncbi request reprint Cellular distribution of immunoreactive urotensin-II in human tissues with evidence of increased expression in atherosclerosis and a greater constrictor response of small compared to large coronary arteries
    Janet J Maguire
    Clinical Pharmacology Unit, University of Cambridge, Level 6 Centre for Clinical Investigation, Box 110, Addenbrooke s Hospital, Cambridge CB22QQ, UK
    Peptides 25:1767-74. 2004
    ..We conclude that urotensin-II is a locally released vasoactive mediator that may be an important regulator of blood flow particularly to the myocardium and may have a specific role in human atherosclerosis...
  13. ncbi request reprint Endothelin-mediated vasoconstriction in early atherosclerosis is markedly increased in ApoE-/- mouse but prevented by atorvastatin
    Janet J Maguire
    Clinical Pharmacology Unit, Level 6 Centre for Clinical Investigation, Box 110, Addenbrooke s Hospital, Cambridge, CB2 2QQ, UK
    Exp Biol Med (Maywood) 231:806-12. 2006
    ..Therefore, this protective prevention of enhanced ET-1 vasoconstriction in ApoE-/- mice by atorvastatin was independent of its lipid-lowering properties...
  14. ncbi request reprint Radioligand-binding and molecular-imaging techniques for the quantitative analysis of established and emerging orphan receptor systems
    Anthony P Davenport
    Clinical Pharmacology Unit, University of Cambridge, Centre for Clinical Investigation, Addenbrooke s Hospital, Cambridge, UK
    Methods Mol Biol 306:93-120. 2005
  15. ncbi request reprint Identification and cellular localisation of NPW1 (GPR7) receptors for the novel neuropeptide W-23 by [125I]-NPW radioligand binding and immunocytochemistry
    Gurminder Singh
    Clinical Pharmacology Unit, Addenbrooke s Hospital, University of Cambridge, Level 6, Centre for Clinical Investigation, Box 110, Cambridge CB2 2QQ, UK
    Brain Res 1017:222-6. 2004
    ....
  16. doi request reprint Comparison of endothelin receptors in normal versus cirrhotic human liver and in the liver from endothelial cell-specific ET(B) knockout mice
    Lowell Ling
    Clinical Pharmacology Unit, Box 110 Addenbrooke s Hospital, Cambridge CB2 0QQ, United Kingdom
    Life Sci 91:716-22. 2012
    ..Endothelin (ET) antagonists show promise in animal models of cirrhosis and portal hypertension. The aim was to pharmacologically characterise the expression of endothelin receptors in human liver, hepatic artery and portal vein...
  17. ncbi request reprint G-protein-coupled receptors in human atherosclerosis: comparison of vasoconstrictors (endothelin and thromboxane) with recently de-orphanized (urotensin-II, apelin and ghrelin) receptors
    Sidath D Katugampola
    Clinical Pharmacology Unit, University of Cambridge, Level 6, Centre for Clinical Investigations, Box 110, Addenbrooke s Hospital, Cambridge CB2 2QQ, U K
    Clin Sci (Lond) 103:171S-175S. 2002
    ..Intriguingly, the increase in receptor density for the novel vasodilator ghrelin, identified from post-genomic research, may potentially be beneficial with human atherosclerosis...
  18. ncbi request reprint Down-regulation of ETA receptors in ETB receptor-deficient mice
    Anthony P Davenport
    Clinical Pharmacology Unit, Centre for Clinical Investigation, Addenbrookes Hospital, Cambridge, UK
    J Cardiovasc Pharmacol 44:S276-8. 2004
    ..These results reveal deletion of the ETB subtype is associated with a reduction in both central and peripheral ETA number, and may reflect an unsuspected role for ETB receptors in regulating development or expression of the ETA subtype...
  19. ncbi request reprint Arteriojugular endothelin-1 gradients in aneurysmal subarachnoid haemorrhage
    David K Menon
    Department of Anaesthesia and Wolfson Brain Imaging Centre, Addenbrooke s Hospital, University of Cambridge CB2 2QQ, U K
    Clin Sci (Lond) 103:399S-403S. 2002
    ..Larger AJ differences may predict vasospasm, but further work is needed to confirm this observation. AJ gradient measurement may provide a useful technique for investigating the role of other peptides in acute brain injury...
  20. doi request reprint Comparison of human ETA and ETB receptor signalling via G-protein and β-arrestin pathways
    Janet J Maguire
    Clinical Pharmacology Unit, University of Cambridge, Level 6 ACCI, Box 110 Addenbrooke s Hospital, Cambridge, CB2 0QQ, UK
    Life Sci 91:544-9. 2012
    ....
  21. ncbi request reprint Immunocytochemical localization of receptors using light and confocal microscopy with application to the phenotypic characterization of knock-out mice
    Anthony P Davenport
    Clinical Pharmacology Unit, University of Cambridge, Centre for Clinical Investigation, Addenbrooke s Hospital, Cambridge, UK
    Methods Mol Biol 306:155-72. 2005
  22. doi request reprint Cellular localization of receptors using antibodies visualized by light and dual labeling confocal microscopy
    Anthony P Davenport
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Centre for Clinical Investigation, Cambridge, UK
    Methods Mol Biol 897:239-60. 2012
    ..Receptor immunocytochemistry can be used to analyze the resulting phenotype in whole body sections of mice without preselection of the tissue to be studied...
  23. ncbi request reprint Radioligand binding assays and quantitative autoradiography of endothelin receptors
    Anthony P Davenport
    Clinical Pharmacology Unit, University of Cambridge, Cambridge, UK
    Methods Mol Biol 206:45-70. 2002
  24. doi request reprint Microarray, qPCR, and KCNJ5 sequencing of aldosterone-producing adenomas reveal differences in genotype and phenotype between zona glomerulosa- and zona fasciculata-like tumors
    Elena A B Azizan
    Department of Clinical Pharmacology, University of Cambridge, Box 110, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, United Kingdom
    J Clin Endocrinol Metab 97:E819-29. 2012
    ..Aldosterone-producing adenomas (APA) are heterogeneous. The recent finding of somatic KCNJ5 mutations suggests a genetic explanation...
  25. ncbi request reprint Immunocytochemical localization of endothelin peptides, precursors, and endothelin-converting enzymes
    Rhoda E Kuc
    Clinical Pharmacology Unit, University of Cambridge, Cambridge, UK
    Methods Mol Biol 206:3-19. 2002
  26. ncbi request reprint Analysis of endothelins by enzyme-linked immunosorbent assay and radioimmunoassay
    Anthony P Davenport
    Clinical Pharmacology Unit, University of Cambridge, Cambridge, UK
    Methods Mol Biol 206:21-36. 2002
  27. pmc Regional heterogeneity in the haemodynamic responses to urotensin II infusion in relation to UT receptor localisation
    Sheila M Gardiner
    Centre for Integrated Systems Biology and Medicine, School of Biomedical Sciences, University of Nottingham, Nottingham NG7 2UH
    Br J Pharmacol 147:612-21. 2006
    ..UT receptor-like immunoreactivity present in skeletal muscle is consistent with the haemodynamic pattern...