Corne J Kros

Summary

Affiliation: University of Sussex
Country: UK

Publications

  1. pmc Mutations in protocadherin 15 and cadherin 23 affect tip links and mechanotransduction in mammalian sensory hair cells
    Kumar N Alagramam
    Otolaryngology Head and Neck Surgery, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio, United States of America
    PLoS ONE 6:e19183. 2011
  2. ncbi request reprint Reduced climbing and increased slipping adaptation in cochlear hair cells of mice with Myo7a mutations
    C J Kros
    School of Biological Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK
    Nat Neurosci 5:41-7. 2002
  3. ncbi request reprint How to build an inner hair cell: challenges for regeneration
    Corne J Kros
    School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK
    Hear Res 227:3-10. 2007
  4. pmc Tuning in to cochlear hair cells
    Corne J Kros
    School of Life Sciences, University of Sussex, Falmer, Brighton, BN1 9QG, UK
    J Physiol 576:7-9. 2006
  5. pmc Developmental changes in the expression of potassium currents of embryonic, neonatal and mature mouse inner hair cells
    Walter Marcotti
    School of Biological Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK
    J Physiol 548:383-400. 2003
  6. pmc Transduction without tip links in cochlear hair cells is mediated by ion channels with permeation properties distinct from those of the mechano-electrical transducer channel
    Walter Marcotti
    Sussex Neuroscience, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, United Kingdom, Department of Biomedical Science, University of Sheffield, Sheffield, S10 2TN, United Kingdom, and Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands
    J Neurosci 34:5505-14. 2014
  7. pmc Effects of intracellular stores and extracellular Ca(2+) on Ca(2+)-activated K(+) currents in mature mouse inner hair cells
    Walter Marcotti
    School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK
    J Physiol 557:613-33. 2004
  8. pmc TRPML3 mutations cause impaired mechano-electrical transduction and depolarization by an inward-rectifier cation current in auditory hair cells of varitint-waddler mice
    Alexander F J van Aken
    School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK
    J Physiol 586:5403-18. 2008
  9. pmc Increase in efficiency and reduction in Ca2+ dependence of exocytosis during development of mouse inner hair cells
    Stuart L Johnson
    School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK
    J Physiol 563:177-91. 2005
  10. pmc A transiently expressed SK current sustains and modulates action potential activity in immature mouse inner hair cells
    Walter Marcotti
    School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK
    J Physiol 560:691-708. 2004

Detail Information

Publications19

  1. pmc Mutations in protocadherin 15 and cadherin 23 affect tip links and mechanotransduction in mammalian sensory hair cells
    Kumar N Alagramam
    Otolaryngology Head and Neck Surgery, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio, United States of America
    PLoS ONE 6:e19183. 2011
    ..These results therefore provide genetic evidence consistent with PCDH15 and CDH23 being part of the tip-link complex and necessary for normal mechanotransduction...
  2. ncbi request reprint Reduced climbing and increased slipping adaptation in cochlear hair cells of mice with Myo7a mutations
    C J Kros
    School of Biological Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK
    Nat Neurosci 5:41-7. 2002
    ..We conclude that myosin VIIA participates in anchoring and holding membrane-bound elements to the actin core of the stereocilium. Myosin VIIA is therefore required for the normal gating of transducer channels...
  3. ncbi request reprint How to build an inner hair cell: challenges for regeneration
    Corne J Kros
    School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK
    Hear Res 227:3-10. 2007
    ..Some implications of this complex developmental programme for the ideal of hair-cell regeneration in the mature mammalian cochlea are discussed...
  4. pmc Tuning in to cochlear hair cells
    Corne J Kros
    School of Life Sciences, University of Sussex, Falmer, Brighton, BN1 9QG, UK
    J Physiol 576:7-9. 2006
  5. pmc Developmental changes in the expression of potassium currents of embryonic, neonatal and mature mouse inner hair cells
    Walter Marcotti
    School of Biological Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK
    J Physiol 548:383-400. 2003
    ..The 4-AP-sensitive current continues to increase after the onset of hearing to form the major part of the mature delayed rectifier, IK,s. By P20 IHCs appear mature in terms of their complement of K+ conductances...
  6. pmc Transduction without tip links in cochlear hair cells is mediated by ion channels with permeation properties distinct from those of the mechano-electrical transducer channel
    Walter Marcotti
    Sussex Neuroscience, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, United Kingdom, Department of Biomedical Science, University of Sheffield, Sheffield, S10 2TN, United Kingdom, and Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands
    J Neurosci 34:5505-14. 2014
    ..These channels are not gated by hair-bundle links and can be activated under a variety of conditions in which normal tip-link-mediated transduction is not operational. ..
  7. pmc Effects of intracellular stores and extracellular Ca(2+) on Ca(2+)-activated K(+) currents in mature mouse inner hair cells
    Walter Marcotti
    School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK
    J Physiol 557:613-33. 2004
    ..Current clamp experiments at body temperature show that I(K,f), but not I(K(Ca)), is essential for fast voltage responses of mature IHCs...
  8. pmc TRPML3 mutations cause impaired mechano-electrical transduction and depolarization by an inward-rectifier cation current in auditory hair cells of varitint-waddler mice
    Alexander F J van Aken
    School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK
    J Physiol 586:5403-18. 2008
    ..Our findings argue against TRPML3 being a component of the hair-cell transducer channel...
  9. pmc Increase in efficiency and reduction in Ca2+ dependence of exocytosis during development of mouse inner hair cells
    Stuart L Johnson
    School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK
    J Physiol 563:177-91. 2005
    ..These properties make the mature cell ideally suited for fine intensity discrimination over a wide dynamic range...
  10. pmc A transiently expressed SK current sustains and modulates action potential activity in immature mouse inner hair cells
    Walter Marcotti
    School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK
    J Physiol 560:691-708. 2004
    ..3 Ca(2+) channels and alpha9alpha10 nAChRs. Current clamp experiments showed that in IHCs the SK current is required for sustaining a train of action potentials and also modulates their frequency when activated by ACh...
  11. ncbi request reprint Development and properties of stereociliary link types in hair cells of the mouse cochlea
    Richard J Goodyear
    School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, United Kingdom
    J Comp Neurol 485:75-85. 2005
    ..These results indicate there is a rich, rapidly changing array of different links covering the developing hair bundle that becomes progressively refined to generate the mature complement by P19...
  12. ncbi request reprint Membrane capacitance measurement using patch clamp with integrated self-balancing lock-in amplifier
    Stuart L Johnson
    School of Biological Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK
    Pflugers Arch 443:653-63. 2002
    ..The track-in approach has considerable advantages over software implementations in terms of economy and convenience, since the resistance and capacitance signals can be recorded directly on any general-purpose data-acquisition system...
  13. pmc Tmc1 is necessary for normal functional maturation and survival of inner and outer hair cells in the mouse cochlea
    Walter Marcotti
    School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK
    J Physiol 574:677-98. 2006
    ..We propose that Tmc1 is involved in trafficking of molecules to the plasma membrane or serves as an intracellular regulatory signal for differentiation of immature hair cells into fully functional auditory receptors...
  14. pmc The aminoglycoside antibiotic dihydrostreptomycin rapidly enters mouse outer hair cells through the mechano-electrical transducer channels
    Walter Marcotti
    School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK
    J Physiol 567:505-21. 2005
    ....
  15. pmc Sodium and calcium currents shape action potentials in immature mouse inner hair cells
    Walter Marcotti
    School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK
    J Physiol 552:743-61. 2003
    ..The size of both currents was positively correlated with the developmental change in action-potential frequency...
  16. ncbi request reprint FM1-43 dye behaves as a permeant blocker of the hair-cell mechanotransducer channel
    J E Gale
    School of Biological Sciences, University of Sussex, Falmer, Brighton, BN1 9QG, United Kingdom
    J Neurosci 21:7013-25. 2001
    ..Calcium chelation and FM1-43 both reduce the ototoxic effects of the aminoglycoside antibiotic neomycin sulfate, suggesting that FM1-43 and aminoglycosides enter hair cells via the same pathway...
  17. pmc Aminoglycoside-induced phosphatidylserine externalization in sensory hair cells is regionally restricted, rapid, and reversible
    Richard J Goodyear
    School of Life Sciences, University of Sussex, Brighton BN1 9QG, United Kingdom
    J Neurosci 28:9939-52. 2008
    ..Internalized annexin V, however, remains below the apical surface, thereby pinpointing a critical role for myosin VI in the transport of endocytosed material away from the periphery of the hair cell...
  18. ncbi request reprint A missense mutation in myosin VIIA prevents aminoglycoside accumulation in early postnatal cochlear hair cells
    G P Richardson
    School of Biological Sciences, University of Sussex, Falmer, Brighton, UK
    Ann N Y Acad Sci 884:110-24. 1999
    ..Possible roles for myosin VIIA in the process of aminoglycoside accumulation are discussed...
  19. ncbi request reprint A receptor-like inositol lipid phosphatase is required for the maturation of developing cochlear hair bundles
    R J Goodyear
    School of Biological Sciences, University of Sussex, Falmer, Brighton, BN1 9QG, United Kingdom
    J Neurosci 23:9208-19. 2003
    ..These results reveal that Ptprq is required for formation of the shaft connectors of the hair bundle, the normal maturation of cochlear hair bundles, and the long-term survival of high-frequency auditory hair cells...