Tony Kouzarides

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer
    Luke Hughes-Davies
    Cancer Research UK Wellcome Trust Institute and Department of Pathology, Tennis Court Road, Cambridge CB2 1QR, United Kingdom
    Cell 115:523-35. 2003
  2. pmc Arginine methylation at histone H3R2 controls deposition of H3K4 trimethylation
    Antonis Kirmizis
    Gurdon Institute and Department of Pathology, Tennis Court Road, Cambridge CB2 1QN, UK
    Nature 449:928-32. 2007
  3. pmc Histone H3 tail clipping regulates gene expression
    Helena Santos-Rosa
    Gurdon Institute and Department of Pathology, Tennis Court Road, Cambridge CB2 1QN, UK
    Nat Struct Mol Biol 16:17-22. 2009
  4. ncbi request reprint Chromatin modifications and their function
    Tony Kouzarides
    The Gurdon Institute and Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB21QN, UK
    Cell 128:693-705. 2007
  5. ncbi request reprint Direct binding of INHAT to H3 tails disrupted by modifications
    Robert Schneider
    The Wellcome Trust Cancer Research UK Gurdon Institute and Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QR, United Kingdom
    J Biol Chem 279:23859-62. 2004
  6. pmc Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification
    Peter Tessarz
    1 Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK 2 Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    Nature 505:564-8. 2014
  7. pmc Nucleosome-interacting proteins regulated by DNA and histone methylation
    Till Bartke
    The Gurdon Institute, Department of Pathology, Cambridge, UK
    Cell 143:470-84. 2010
  8. ncbi request reprint Citrullination regulates pluripotency and histone H1 binding to chromatin
    Maria A Christophorou
    1 The Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK 2
    Nature 507:104-8. 2014
  9. ncbi request reprint Histone deimination antagonizes arginine methylation
    Graeme L Cuthbert
    Gurdon Institute and Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, United Kingdom
    Cell 118:545-53. 2004
  10. ncbi request reprint Active genes are tri-methylated at K4 of histone H3
    Helena Santos-Rosa
    Wellcome Trust Cancer Research UK Institute and Department of Pathology, Tennis Court Road, Cambridge, CB2 1QR, UK
    Nature 419:407-11. 2002

Collaborators

Detail Information

Publications68

  1. ncbi request reprint EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer
    Luke Hughes-Davies
    Cancer Research UK Wellcome Trust Institute and Department of Pathology, Tennis Court Road, Cambridge CB2 1QR, United Kingdom
    Cell 115:523-35. 2003
    ..The remarkable clinical overlap between sporadic EMSY amplification and familial BRCA2 deletion implicates a BRCA2 pathway in sporadic breast and ovarian cancer...
  2. pmc Arginine methylation at histone H3R2 controls deposition of H3K4 trimethylation
    Antonis Kirmizis
    Gurdon Institute and Department of Pathology, Tennis Court Road, Cambridge CB2 1QN, UK
    Nature 449:928-32. 2007
    ..Thus, the inability of Spp1 to recognize H3 methylated at R2 prevents Set1 from trimethylating H3K4. These results provide the first mechanistic insight into the function of arginine methylation on chromatin...
  3. pmc Histone H3 tail clipping regulates gene expression
    Helena Santos-Rosa
    Gurdon Institute and Department of Pathology, Tennis Court Road, Cambridge CB2 1QN, UK
    Nat Struct Mol Biol 16:17-22. 2009
    ..These findings identify clipping of H3 tails as a previously uncharacterized modification of promoter-bound nucleosomes, which may result in the localized clearing of repressive signals during the induction of gene expression...
  4. ncbi request reprint Chromatin modifications and their function
    Tony Kouzarides
    The Gurdon Institute and Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB21QN, UK
    Cell 128:693-705. 2007
    ..In this way, histone modifications have the potential to influence many fundamental biological processes, some of which may be epigenetically inherited...
  5. ncbi request reprint Direct binding of INHAT to H3 tails disrupted by modifications
    Robert Schneider
    The Wellcome Trust Cancer Research UK Gurdon Institute and Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QR, United Kingdom
    J Biol Chem 279:23859-62. 2004
    ..We suggest that the charge of the histone tail is a major determinant in allowing INHAT to bind chromatin and coordinate the activity of multiple histone acetyltransferases...
  6. pmc Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification
    Peter Tessarz
    1 Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK 2 Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    Nature 505:564-8. 2014
    ..Together these data identify glutamine methylation of H2A as the first histone epigenetic mark dedicated to a specific RNA polymerase and define its function as a regulator of FACT interaction with nucleosomes. ..
  7. pmc Nucleosome-interacting proteins regulated by DNA and histone methylation
    Till Bartke
    The Gurdon Institute, Department of Pathology, Cambridge, UK
    Cell 143:470-84. 2010
    ....
  8. ncbi request reprint Citrullination regulates pluripotency and histone H1 binding to chromatin
    Maria A Christophorou
    1 The Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK 2
    Nature 507:104-8. 2014
    ..Together, these results uncover a role for citrullination in the regulation of pluripotency and provide new mechanistic insights into how citrullination regulates chromatin compaction. ..
  9. ncbi request reprint Histone deimination antagonizes arginine methylation
    Graeme L Cuthbert
    Gurdon Institute and Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, United Kingdom
    Cell 118:545-53. 2004
    ..The recruitment of PADI4 coincides with deimination of the histone H3 N-terminal tail. These results define deimination as a novel mechanism for antagonizing the transcriptional induction mediated by arginine methylation...
  10. ncbi request reprint Active genes are tri-methylated at K4 of histone H3
    Helena Santos-Rosa
    Wellcome Trust Cancer Research UK Institute and Department of Pathology, Tennis Court Road, Cambridge, CB2 1QR, UK
    Nature 419:407-11. 2002
    ..These findings establish the concept of methyl status as a determinant for gene activity and thus extend considerably the complexity of histone modifications...
  11. pmc JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin
    Mark A Dawson
    Cambridge Institute for Medical Research and Department of Haematology, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK
    Nature 461:819-22. 2009
    ..Tauhese results identify a previously unrecognized nuclear role for JAK2 in the phosphorylation of H3Y41 and reveal a direct mechanistic link between two genes, jak2 and lmo2, involved in normal haematopoiesis and leukaemia...
  12. pmc Distinct transcriptional outputs associated with mono- and dimethylated histone H3 arginine 2
    Antonis Kirmizis
    Gurdon Institute and Department of Pathology, Cambridge CB2 1QN, UK
    Nat Struct Mol Biol 16:449-51. 2009
    ..Collectively, these results indicate that different H3R2 methylation states have defined roles in gene expression...
  13. ncbi request reprint Methylation of H3 lysine 4 at euchromatin promotes Sir3p association with heterochromatin
    Helena Santos-Rosa
    Wellcome Trust Cancer Research United Kingdom Gurdon Institute and Department of Pathology, Tennis Court Road, Cambridge, CB2 1QR, United Kingdom
    J Biol Chem 279:47506-12. 2004
    ..The inability of Sir3p to bind methylated H3 Lys-4 tails suggests a model whereby H3 Lys-4 methylation prevents Sir3p association at euchromatic sites and therefore concentrates Sir3p at unmodified, heterochromatic regions of the genome...
  14. ncbi request reprint Blimp1 associates with Prmt5 and directs histone arginine methylation in mouse germ cells
    Katia Ancelin
    Wellcome Trust Cancer Research UK Gurdon Institute of Cancer and Developmental Biology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    Nat Cell Biol 8:623-30. 2006
    ..Our study demonstrates that Blimp1 is involved in a novel transcriptional regulatory complex in the mouse germ-cell lineage...
  15. pmc The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase
    Francois Fuks
    Wellcome Trust CR UK Institute and Department of Pathology, Cambridge University, Tennis Court Road, Cambridge CB2 1QR, UK
    Nucleic Acids Res 31:2305-12. 2003
    ..These results further substantiate the notion of a self-reinforcing repressive chromatin state through the interplay between these two global epigenetic modifications...
  16. ncbi request reprint Spatial distribution of di- and tri-methyl lysine 36 of histone H3 at active genes
    Andrew J Bannister
    Wellcome Trust Cancer Research UK Gurdon Institute and Department of Pathology, Tennis Court Road, Cambridge, CB2 1QN, United Kingdom
    J Biol Chem 280:17732-6. 2005
    ..Our data suggest that the unique spatial distribution of di- and tri-Me K36/H3 plays a role in transcriptional termination and/or early RNA processing...
  17. ncbi request reprint Unsafe SETs: histone lysine methyltransferases and cancer
    Robert Schneider
    Wellcome Cancer Research UK Institute and Department of Pathology, Tennis Court Road, Cambridge, UK CB2 1QR
    Trends Biochem Sci 27:396-402. 2002
    ..This article surveys the evidence for a connection between SET-domain-containing proteins and cancer. It proposes that deregulation of SET-domain function has an important role in carcinogenesis...
  18. pmc Histone arginine methylation regulates pluripotency in the early mouse embryo
    Maria Elena Torres-Padilla
    The Wellcome Trust Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    Nature 445:214-8. 2007
    ..Thus, our results identify specific histone modifications as the earliest known epigenetic marker contributing to development of ICM and show that manipulation of epigenetic information influences cell fate determination...
  19. ncbi request reprint Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development
    Sylvia Erhardt
    Wellcome Trust Cancer Research UK Institute, University of Cambridge, Cambridge CB2 1QR, UK
    Development 130:4235-48. 2003
    ..Thus, Ezh2 has significant and diverse roles during early development, as well as during the establishment of the first differentiated cells, the trophectoderm, and of the pluripotent epiblast cells...
  20. ncbi request reprint Crosstalk between CARM1 methylation and CBP acetylation on histone H3
    Sylvain Daujat
    Wellcome Cancer Research UK Institute and Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, United Kingdom
    Curr Biol 12:2090-7. 2002
    ....
  21. ncbi request reprint Methylation of histone H4 lysine 20 controls recruitment of Crb2 to sites of DNA damage
    Steven L Sanders
    The Wellcome Trust Cancer Research UK Gurdon Institute and Department of Pathology, Tennis Court Road, Cambridge CB2 1QN, United Kingdom
    Cell 119:603-14. 2004
    ..These results argue that H4-K20 methylation functions as a "histone mark" required for the recruitment of the checkpoint protein Crb2...
  22. ncbi request reprint Proline isomerization of histone H3 regulates lysine methylation and gene expression
    Christopher J Nelson
    Gurdon Institute and Department of Pathology, Tennis Court Road, Cambridge, CB2 1QR, UK
    Cell 126:905-16. 2006
    ..These results identify proline isomerization as a novel noncovalent histone modification that regulates transcription and provides evidence for crosstalk between histone lysine methylation and proline isomerization...
  23. pmc Three distinct patterns of histone H3Y41 phosphorylation mark active genes
    Mark A Dawson
    Gurdon Institute and Department of Pathology, Cambridge, UK
    Cell Rep 2:470-7. 2012
    ..Together, these data extend our understanding of this conserved and essential signaling pathway and provide insight into the mechanisms by which extracellular stimuli may lead to the coordinated regulation of transcription...
  24. pmc LIF-independent JAK signalling to chromatin in embryonic stem cells uncovered from an adult stem cell disease
    Dean S Griffiths
    Department of Haematology and Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK
    Nat Cell Biol 13:13-21. 2011
    ..Taken together, these results uncover a previously unrecognized role for direct signalling to chromatin by JAK2 as an important mediator of ES cell self-renewal...
  25. pmc Differential expression of selected histone modifier genes in human solid cancers
    Hilal Ozdag
    Department of Oncology, Hutchison MRC Research Centre, University of Cambridge, Cambridge CB2 2XZ, UK
    BMC Genomics 7:90. 2006
    ..Expression of each gene in 225 samples (135 primary tumours, 47 cancer cell lines, and 43 normal tissues) was analysedby QRT-PCR, normalized with 8 housekeeping genes, and given as a ratio by comparison with a universal reference RNA...
  26. pmc Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia
    Mark A Dawson
    Department of Haematology, Cambridge Institute for Medical Research and Addenbrookes Hospital, University of Cambridge, Cambridge CB2 0XY, UK
    Nature 478:529-33. 2011
    ..These findings establish the displacement of BET proteins from chromatin as a promising epigenetic therapy for these aggressive leukaemias...
  27. pmc Phosphorylation of histone H3 Thr-45 is linked to apoptosis
    Paul J Hurd
    Wellcome Trust and Cancer Research UK, Gurdon Institute and Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, United Kingdom
    J Biol Chem 284:16575-83. 2009
    ..Given the nucleosomal position of H3T45, we postulate that H3T45ph induces structural change within the nucleosome to facilitate DNA nicking and/or fragmentation...
  28. pmc A chromodomain switch mediated by histone H3 Lys 4 acetylation regulates heterochromatin assembly
    Blerta Xhemalce
    Wellcome Trust Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge CB2 1QN, United Kingdom
    Genes Dev 24:647-52. 2010
    ..Consistent with structural data, H3K4ac specifically reduces Chp1/Clr4 affinity to H3K9me. We propose that H3K4ac mediates a chromodomain switch from Chp1/Clr4 to Swi6/Chp2 to allow heterochromatin reassembly...
  29. ncbi request reprint Histone H3 lysine 4 methylation patterns in higher eukaryotic genes
    Robert Schneider
    Wellcome CR UK Institute and Department of Pathology, Tennis Court Road, Cambridge, CB2 1QR, UK
    Nat Cell Biol 6:73-7. 2004
    ..These results indicate that in metazoa, di- and tri-methylation of K4/H3 is linked to active transcription and that significant differences exist in the genome-wide methylation pattern as compared with S. cerevisiae...
  30. pmc The breast cancer oncogene EMSY represses transcription of antimetastatic microRNA miR-31
    Emmanuelle Viré
    Gurdon Institute and Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    Mol Cell 53:806-18. 2014
    ..Altogether, these results suggest a pathway underlying the role of EMSY in breast cancer and uncover potential diagnostic and therapeutic targets in sporadic breast cancer...
  31. pmc Genome-wide studies of histone demethylation catalysed by the fission yeast homologues of mammalian LSD1
    Michael Opel
    Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 2:e386. 2007
    ..Thus, our results highlight complex interactions between histone demethylase, deacetylase and chromatin remodelling activities in the regulation of gene expression...
  32. ncbi request reprint Reversing histone methylation
    Andrew J Bannister
    Gurdon Institute and Department of Pathology, Tennis Court Road, Cambridge CB2 1QN, UK
    Nature 436:1103-6. 2005
    ..The discovery of enzymes that reverse the methylation of lysines and arginines challenges our current thinking on the unique nature of histone methylation, and substantially increases the complexity of histone modification pathways...
  33. ncbi request reprint The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation
    Francois Fuks
    Wellcome Cancer Research UK Institute and Department of Pathology, University of Cambridge, Tennis Court Road, United Kingdom
    J Biol Chem 278:4035-40. 2003
    ..Our data provide evidence that MeCP2 reinforces a repressive chromatin state by acting as a bridge between two global epigenetic modifications, DNA methylation and histone methylation...
  34. pmc The S. pombe histone H2A dioxygenase Ofd2 regulates gene expression during hypoxia
    David Lando
    Gurdon Institute and Department of Pathology, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 7:e29765. 2012
    ..Together, these data uncover a novel histone H2A modifying activity involved in the regulation of gene expression during hypoxia...
  35. pmc Human RNA methyltransferase BCDIN3D regulates microRNA processing
    Blerta Xhemalce
    Wellcome Trust Cancer Research UK Gurdon Institute, The Henry Wellcome Building of Cancer and Developmental Biology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    Cell 151:278-88. 2012
    ..Together, our results uncover a miRNA methylation pathway potentially involved in cancer that antagonizes the Dicer-dependent processing of miR-145 as well as other miRNAs...
  36. ncbi request reprint Cancer epigenetics: from mechanism to therapy
    Mark A Dawson
    Gurdon Institute and Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    Cell 150:12-27. 2012
    ..This information, along with the promising clinical and preclinical results seen with epigenetic drugs against chromatin regulators, signifies that it is time to embrace the central role of epigenetics in cancer...
  37. ncbi request reprint Crystal structure of the ENT domain of human EMSY
    Gayatri B Chavali
    Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Hills Rd, Cambridge CB2 2XY, UK
    J Mol Biol 350:964-73. 2005
    ..The dimerisation of EMSY mediated by the ENT domain could provide flexibility for it to bind two or more different substrates simultaneously...
  38. pmc The PHD and chromo domains regulate the ATPase activity of the human chromatin remodeler CHD4
    Aleksandra A Watson
    Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK
    J Mol Biol 422:3-17. 2012
    ....
  39. pmc Regulation of chromatin by histone modifications
    Andrew J Bannister
    The Gurdon Institute and Department of Pathology, University of Cambridge, Cambridge CB2 1QN, UK
    Cell Res 21:381-95. 2011
    ..Here, we describe the known histone modifications, define where they are found genomically and discuss some of their functional consequences, concentrating mostly on transcription where the majority of characterisation has taken place...
  40. ncbi request reprint Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9
    Peter R Nielsen
    Cambridge Centre for Molecular Recognition, Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK
    Nature 416:103-7. 2002
    ..These findings predict which other chromodomains will bind methylated proteins and suggest a motif that they recognize...
  41. ncbi request reprint Regulation of histone H3 lysine 56 acetylation in Schizosaccharomyces pombe
    Blerta Xhemalce
    Unite de la Dynamique du Génome, Institut Pasteur, 25 rue du Dr Roux, 75724, Paris Cedex 15, France
    J Biol Chem 282:15040-7. 2007
    ....
  42. ncbi request reprint Histone methylation: dynamic or static?
    Andrew J Bannister
    Wellcome Trust Cancer Research UK Institute, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, United Kingdom
    Cell 109:801-6. 2002
    ..So is the methyl group a permanent mark on histones, or can it be removed by an active process necessary for regulated gene expression?..
  43. ncbi request reprint Histone methylation in transcriptional control
    Tony Kouzarides
    Wellcome CRC Institute and Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
    Curr Opin Genet Dev 12:198-209. 2002
    ..Methylated histones have been implicated in heterochromatic repression, promoter regulation and the propagation of a repressed state via DNA methylation...
  44. pmc Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence
    Emma Langley
    Wellcome Institute Cancer Research UK and Department of Pathology, University of Cambridge, Tennis Court Road, CB2 1QR, UK
    EMBO J 21:2383-96. 2002
    ..Taken together, our data establish the SIRT1 deacetylase as a novel negative regulator of p53 function capable of modulating cellular senescence...
  45. pmc Histone H3 lysine 4 methylation is associated with the transcriptional reprogramming efficiency of somatic nuclei by oocytes
    Kazutaka Murata
    The Wellcome Trust Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    Epigenetics Chromatin 3:4. 2010
    ....
  46. pmc Methylation at arginine 17 of histone H3 is linked to gene activation
    Uta Maria Bauer
    Wellcome CRC Institute and Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
    EMBO Rep 3:39-44. 2002
    ..Together these results demonstrate that CARM1 is recruited to an active promoter and that CARM1-mediated R17 methylation on histone H3 takes place in vivo during this active state...
  47. ncbi request reprint Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor
    Luciano Di Croce
    Department of Experimental Oncology, European Institute of Oncology, Milan, Italy
    Science 295:1079-82. 2002
    ..These results establish a mechanistic link between genetic and epigenetic changes during transformation and suggest that hypermethylation contributes to the early steps of carcinogenesis...
  48. pmc Mechanisms of P/CAF auto-acetylation
    Helena Santos-Rosa
    Instituto de Biologia Molecular de Barcelona, CID, Consejo Superior de Investigaciones Cientificas CSIC, Jordi Girona 18 26, E 08034 Barcelona, Spain
    Nucleic Acids Res 31:4285-92. 2003
    ..Finally, we show that acetylation of P/CAF leads to an increment of its histone acetyltransferase (HAT) activity. These findings identify a new post-translation modification on P/CAF which may regulate its function...
  49. ncbi request reprint The Tudor domain 'Royal Family': Tudor, plant Agenet, Chromo, PWWP and MBT domains
    Sebastian Maurer-Stroh
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Trends Biochem Sci 28:69-74. 2003
    ..In addition, we have revealed pairs of tandem repeats in the fragile X mental retardation protein (FMRP) family that are also members of this Tudor domain 'Royal Family'...
  50. pmc Binding of EMSY to HP1beta: implications for recruitment of HP1beta and BS69
    Caroline M S Ekblad
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge CB2 2XZ, UK
    EMBO Rep 6:675-80. 2005
    ..The HP1beta-binding motif is necessary and sufficient for EMSY to bind to the chromoshadow domain of HP1beta...
  51. ncbi request reprint cis-acting DNA from fission yeast centromeres mediates histone H3 methylation and recruitment of silencing factors and cohesin to an ectopic site
    Janet F Partridge
    MRC Human Genetics Unit, Crewe Road, EH4 2XU, Edinburgh, United Kingdom
    Curr Biol 12:1652-60. 2002
    ..Defective heterochromatin causes premature sister chromatid separation and chromosome missegregation. The role of cis-acting DNA sequences in the formation of centromeric heterochromatin has not been established...
  52. pmc Methylation of histone H3 Lys 4 in coding regions of active genes
    Bradley E Bernstein
    Department of Chemistry and Chemical Biology and The Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 99:8695-700. 2002
    ..In the context of recent studies showing that Lys 4 methylation precludes histone deacetylase recruitment, we conclude that Set1 facilitates transcription, in part, by protecting active coding regions from deacetylation...
  53. pmc The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase
    Olivier Kirsh
    Unite de Recombinaison et Expression Genetique, INSERM U 163, Institut Pasteur, 28 rue du Dr Roux, F 75724 Paris Cedex 15, France
    EMBO J 21:2682-91. 2002
    ....
  54. ncbi request reprint Histone H3 lysine 4 methylation disrupts binding of nucleosome remodeling and deacetylase (NuRD) repressor complex
    Philip Zegerman
    Wellcome Cancer Research UK Institute, Tennis Court Rd, Cambridge, United Kingdom
    J Biol Chem 277:11621-4. 2002
    ..Given that lysine 4 methylation is found at sites of active transcription, these results suggest that a function of lysine 4 methylation is to disrupt the association of histones with a repressor complex...
  55. pmc A novel human Ada2 homologue functions with Gcn5 or Brg1 to coactivate transcription
    Nickolai A Barlev
    Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennsylvania, USA
    Mol Cell Biol 23:6944-57. 2003
    ....
  56. ncbi request reprint Methylation of histone H3 K4 mediates association of the Isw1p ATPase with chromatin
    Helena Santos-Rosa
    Wellcome Trust Cancer Research UK Institute and Department of Pathology, Tennis Court Road, Cambridge CB2 1QR, United Kingdom
    Mol Cell 12:1325-32. 2003
    ..These results indicate that K4 H3 methylation and Isw1p ATPase activity are intimately linked in regulating transcription of certain genes in yeast...
  57. ncbi request reprint Amplification of the BRCA2 pathway gene EMSY in sporadic breast cancer is related to negative outcome
    Carmen Rodriguez
    Génotype et Phénotypes Tumoraux E 229 INSERM, Centre Val d Aurelle, Montpellier, France
    Clin Cancer Res 10:5785-91. 2004
    ..In a subset of 296 patients, EMSY amplification was found by both uni- and multivariate analyses to correlate with shortened disease-free survival. These data indicate that EMSY is a strong candidate oncogene for the 11q13.5 amplicon...
  58. ncbi request reprint Isothiazolones as inhibitors of PCAF and p300 histone acetyltransferase activity
    Lindsay Stimson
    Cancer Research UK Centre for Cancer Therapeutics at The Institute of Cancer Research, Haddow Laboratories, 15 Cotswold Road, Sutton, Surrey SM2 5NG, United Kingdom
    Mol Cancer Ther 4:1521-32. 2005
    ..As one of the first series of small-molecule inhibitors of HAT activity, further analogue synthesis is being pursued to examine the potential scope for reducing chemical reactivity while maintaining HAT inhibition...
  59. pmc Human but not yeast CHD1 binds directly and selectively to histone H3 methylated at lysine 4 via its tandem chromodomains
    Robert J Sims
    Howard Hughes Medical Institute and Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Biol Chem 280:41789-92. 2005
    ....
  60. ncbi request reprint Dynamic distribution of the replacement histone variant H3.3 in the mouse oocyte and preimplantation embryos
    Maria Elena Torres-Padilla
    The Wellcome Trust Cancer Research UK Gurdon Institute, University of Cambridge, U K
    Int J Dev Biol 50:455-61. 2006
    ....
  61. ncbi request reprint Acetylation of beta-catenin by CREB-binding protein (CBP)
    Daniel Wolf
    Wellcome CRC Cancer Research Campaign Institute and Department of Pathology, University of Cambridge, United Kingdom
    J Biol Chem 277:25562-7. 2002
    ..This suggests that acetylation of beta-catenin is involved in regulating Wnt signaling in a promoter-specific fashion...
  62. ncbi request reprint New nomenclature for chromatin-modifying enzymes
    C David Allis
    Cell 131:633-6. 2007
  63. ncbi request reprint Histone methylation defines epigenetic asymmetry in the mouse zygote
    Katharine L Arney
    The Wellcome Trust Cancer Research UK Institute of Cancer and Developmental Biology, University of Cambridge
    Int J Dev Biol 46:317-20. 2002
    ..The early recruitment of heterochromatic factors specifically to the maternal genome could explain the preferential DNA demethylation of the paternal genome in the zygote...
  64. pmc Dnmt3L is a transcriptional repressor that recruits histone deacetylase
    Rachel Deplus
    Free University of Brussels, Faculty of Medicine, Laboratory of Molecular Virology, 808 Route de Lennik, 1070 Brussels, Belgium
    Nucleic Acids Res 30:3831-8. 2002
    ..The fact that, despite the absence of a methyltransferase domain, Dnmt3L retains the capacity to contact deacetylase further substantiates the notion that the Dnmts can repress transcription independently of their methylating activities...
  65. doi request reprint Heritable gene repression through the action of a directed DNA methyltransferase at a chromosomal locus
    Alexander E Smith
    Department of Haematological Medicine, The Rayne Institute, King s College London, Guy s, King s, and St Thomas School of Medicine, 123 Coldharbour Lane, London, United Kingdom
    J Biol Chem 283:9878-85. 2008
    ....
  66. ncbi request reprint DNA methyltransferases get connected to chromatin
    Wendy A Burgers
    Trends Genet 18:275-7. 2002
    ..A picture is emerging whereby the Dnmts are intimately connected to the chromatin environment in which they are working...
  67. pmc Myc represses transcription through recruitment of DNA methyltransferase corepressor
    Carmen Brenner
    Free University of Brussels, Faculty of Medicine, Laboratory of Molecular Virology, Brussels, Belgium
    EMBO J 24:336-46. 2005
    ..Furthermore, these findings suggest that targeting of DNA methyltransferases by transcription factors is a wide and general mechanism for the generation of specific DNA methylation patterns within a cell...
  68. ncbi request reprint Histone methylation: recognizing the methyl mark
    Andrew J Bannister
    Wellcome Trust Cancer Research, United Kingdom Institute, Department of Pathology, University of Cambridge, United Kingdom
    Methods Enzymol 376:269-88. 2004