Affiliation: University of Manchester
Lilly A, Costa G, Largeot A, Fadlullah M, Lie A Ling M, Lacaud G, et al
. Interplay between SOX7 and RUNX1 regulates hemogenic endothelial fate in the yolk sac. Development. 2016;143:4341-4351 pubmed
..Collectively, these data demonstrate for the first time how direct protein-protein interactions between endothelial and hematopoietic transcription factors regulate contrasting transcriptional programs during HE differentiation and EHT. ..
García Alegría E, Menegatti S, Fadlullah M, Menendez P, Lacaud G, Kouskoff V. Early Human Hemogenic Endothelium Generates Primitive and Definitive Hematopoiesis In Vitro. Stem Cell Reports. 2018;11:1061-1074 pubmed publisher
..Our data establish that hemogenic endothelium populations endowed with primitive and definitive hematopoietic potential are specified simultaneously from the mesoderm in differentiating hESCs. ..
Thambyrajah R, Fadlullah M, Proffitt M, Patel R, Cowley S, Kouskoff V, et al
. HDAC1 and HDAC2 Modulate TGF-? Signaling during Endothelial-to-Hematopoietic Transition. Stem Cell Reports. 2018;10:1369-1383 pubmed publisher
..Altogether, our results establish that HDAC1 and HDAC2 modulate TGF-? signaling and suggest that stimulation of this pathway in HE cells would be beneficial for production of hematopoietic cells for regenerative therapies. ..
Lacaud G, Kouskoff V. Hemangioblast, hemogenic endothelium, and primitive versus definitive hematopoiesis. Exp Hematol. 2017;49:19-24 pubmed publisher
Lilly A, Mazan A, Scott D, Lacaud G, Kouskoff V. SOX7 expression is critically required in FLK1-expressing cells for vasculogenesis and angiogenesis during mouse embryonic development. Mech Dev. 2017;146:31-41 pubmed publisher
..Together, our data reveal the unique role of SOX7 in vasculogenesis and angiogenesis during embryonic development. ..
Stefanska M, Batta K, Patel R, Florkowska M, Kouskoff V, Lacaud G. Primitive erythrocytes are generated from hemogenic endothelial cells. Sci Rep. 2017;7:6401 pubmed publisher
..Taken together, our findings demonstrate that both in vivo and in vitro primitive erythrocytes are generated from hemogenic endothelial cells. ..