Panagiotis D Kottaridis

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the United King
    P D Kottaridis
    Department of Haematology, University College London, London, United Kingdom
    Blood 98:1752-9. 2001
  2. ncbi request reprint Studies of FLT3 mutations in paired presentation and relapse samples from patients with acute myeloid leukemia: implications for the role of FLT3 mutations in leukemogenesis, minimal residual disease detection, and possible therapy with FLT3 inhibitors
    Panagiotis D Kottaridis
    Department of Haematology, University College London, London, United Kingdom
    Blood 100:2393-8. 2002
  3. ncbi request reprint Prognostic implications of the presence of FLT3 mutations in patients with acute myeloid leukemia
    Panagiotis D Kottaridis
    Department of Haematology, Royal Free and University College London Medical School, 98 Chenies Mews, London WC1E 6HX, UK
    Leuk Lymphoma 44:905-13. 2003
  4. ncbi request reprint Survival and freedom from progression in autotransplant lymphoma patients is independent of stem cell source: further follow-up from the original randomised study to assess engraftment
    P D Kottaridis
    Department of Haematology, University College London Medical School, UK
    Leuk Lymphoma 43:531-6. 2002
  5. doi request reprint HLA-mismatched unrelated donors are a viable alternate graft source for allogeneic transplantation following alemtuzumab-based reduced-intensity conditioning
    Adam J Mead
    Department of Haematology, University College London UCL Medical School, London, United Kingdom
    Blood 115:5147-53. 2010
  6. ncbi request reprint High incidence of cytomegalovirus infection after nonmyeloablative stem cell transplantation: potential role of Campath-1H in delaying immune reconstitution
    Suparno Chakrabarti
    Department of Haematology, Birmingham Heartlands Hospital, University of Birmingham, Birmingham, United Kingdom
    Blood 99:4357-63. 2002
  7. doi request reprint Prognostic role of PET scanning before and after reduced-intensity allogeneic stem cell transplantation for lymphoma
    Jonathan R Lambert
    Department of Haematology, University College London Cancer Institute, London, UK
    Blood 115:2763-8. 2010
  8. ncbi request reprint Respiratory virus infections in transplant recipients after reduced-intensity conditioning with Campath-1H: high incidence but low mortality
    Suparno Chakrabarti
    Department of Haematology, Birmingham Heartlands Hospital, University College Hospital, London, UK
    Br J Haematol 119:1125-32. 2002
  9. doi request reprint Incidence and dynamics of Epstein-Barr virus reactivation after alemtuzumab-based conditioning for allogeneic hematopoietic stem-cell transplantation
    Ben Carpenter
    Department of Haematology, Royal Free Hampstead NHS Trust, London, United Kingdom
    Transplantation 90:564-70. 2010
  10. ncbi request reprint No evidence that FLT3 status should be considered as an indicator for transplantation in acute myeloid leukemia (AML): an analysis of 1135 patients, excluding acute promyelocytic leukemia, from the UK MRC AML10 and 12 trials
    Rosemary E Gale
    Department of Haematology, Royal Free and University College Medical School, London, UK
    Blood 106:3658-65. 2005

Collaborators

Detail Information

Publications28

  1. ncbi request reprint The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the United King
    P D Kottaridis
    Department of Haematology, University College London, London, United Kingdom
    Blood 98:1752-9. 2001
    ..The suggestion is made that detection of a FLT3/ITD should be included as a routine test at diagnosis and evaluated for therapeutic management...
  2. ncbi request reprint Studies of FLT3 mutations in paired presentation and relapse samples from patients with acute myeloid leukemia: implications for the role of FLT3 mutations in leukemogenesis, minimal residual disease detection, and possible therapy with FLT3 inhibitors
    Panagiotis D Kottaridis
    Department of Haematology, University College London, London, United Kingdom
    Blood 100:2393-8. 2002
    ..These results indicate that FLT3 mutations are secondary events in leukemogenesis, are unstable, and thus should be used cautiously for the detection of minimal residual disease...
  3. ncbi request reprint Prognostic implications of the presence of FLT3 mutations in patients with acute myeloid leukemia
    Panagiotis D Kottaridis
    Department of Haematology, Royal Free and University College London Medical School, 98 Chenies Mews, London WC1E 6HX, UK
    Leuk Lymphoma 44:905-13. 2003
    ....
  4. ncbi request reprint Survival and freedom from progression in autotransplant lymphoma patients is independent of stem cell source: further follow-up from the original randomised study to assess engraftment
    P D Kottaridis
    Department of Haematology, University College London Medical School, UK
    Leuk Lymphoma 43:531-6. 2002
    ..38). Further prospective studies with larger number of patients need to be done to assess which source of stem cells may translate into a long-term clinical benefit for the patient...
  5. doi request reprint HLA-mismatched unrelated donors are a viable alternate graft source for allogeneic transplantation following alemtuzumab-based reduced-intensity conditioning
    Adam J Mead
    Department of Haematology, University College London UCL Medical School, London, United Kingdom
    Blood 115:5147-53. 2010
    ..44). Mismatch occurred at the antigenic level in 40 cases. The outcome in these cases did not differ significantly from the rest of the cohort. We conclude that RIT using HLA-mismatched grafts is a viable option using FMC conditioning...
  6. ncbi request reprint High incidence of cytomegalovirus infection after nonmyeloablative stem cell transplantation: potential role of Campath-1H in delaying immune reconstitution
    Suparno Chakrabarti
    Department of Haematology, Birmingham Heartlands Hospital, University of Birmingham, Birmingham, United Kingdom
    Blood 99:4357-63. 2002
    ..The use of Campath-1H appeared to be associated with a low incidence of GVHD but a high incidence of CMV infections and prolonged immune paresis...
  7. doi request reprint Prognostic role of PET scanning before and after reduced-intensity allogeneic stem cell transplantation for lymphoma
    Jonathan R Lambert
    Department of Haematology, University College London Cancer Institute, London, UK
    Blood 115:2763-8. 2010
    ....
  8. ncbi request reprint Respiratory virus infections in transplant recipients after reduced-intensity conditioning with Campath-1H: high incidence but low mortality
    Suparno Chakrabarti
    Department of Haematology, Birmingham Heartlands Hospital, University College Hospital, London, UK
    Br J Haematol 119:1125-32. 2002
    ....
  9. doi request reprint Incidence and dynamics of Epstein-Barr virus reactivation after alemtuzumab-based conditioning for allogeneic hematopoietic stem-cell transplantation
    Ben Carpenter
    Department of Haematology, Royal Free Hampstead NHS Trust, London, United Kingdom
    Transplantation 90:564-70. 2010
    ..The pattern of EBV reactivation in patients receiving allogeneic HSCT, incorporating in vivo or in vitro alemtuzumab as the method of TCD, is not known...
  10. ncbi request reprint No evidence that FLT3 status should be considered as an indicator for transplantation in acute myeloid leukemia (AML): an analysis of 1135 patients, excluding acute promyelocytic leukemia, from the UK MRC AML10 and 12 trials
    Rosemary E Gale
    Department of Haematology, Royal Free and University College Medical School, London, UK
    Blood 106:3658-65. 2005
    ..70, CIs = 0.53-0.92; FLT3/ITD(+) OR = 0.59, CIs = 0.40-0.87; test for interaction, P = .5). These results suggest that at present there is no strong evidence that FLT3 status should influence the decision to proceed to transplantation...
  11. ncbi request reprint Reduced intensity transplantation: where are we now?
    Stephen Mackinnon
    Royal Free and University College London, London, UK
    Hematol J 5:S34-8. 2004
  12. ncbi request reprint Flt3 mutations and leukaemia
    Panagiotis D Kottaridis
    Department of Haematology, Royal Free and University College London Medical School, 98 Chenies Mews, London WC1E 6HX, UK
    Br J Haematol 122:523-38. 2003
  13. ncbi request reprint Relationship between FLT3 mutation status, biologic characteristics, and response to targeted therapy in acute promyelocytic leukemia
    Rosemary E Gale
    Department of Haematology, University College London Hospitals, United Kingdom
    Blood 106:3768-76. 2005
    ..Furthermore, in the presence of CEP-701, ATRA-induced differentiation was reduced in FLT3/ITD+ cells. These data carry implications for the use of FLT3 inhibitors as frontline therapy for APL...
  14. doi request reprint Acute myeloid leukaemia blast cells with a tyrosine kinase domain mutation of FLT3 are less sensitive to lestaurtinib than those with a FLT3 internal tandem duplication
    Adam J Mead
    Department of Haematology, Royal Free and University College Medical School, London, UK
    Br J Haematol 141:454-60. 2008
    ..These results suggest that FLT3/TKD+ and FLT3/WT cases should not be differentiated when considering patients for treatment with FLT3 inhibitors...
  15. ncbi request reprint Limiting transplantation-related mortality following unrelated donor stem cell transplantation by using a nonmyeloablative conditioning regimen
    Ronjon Chakraverty
    Department of Haematology, University College Hospital, 98 Chenies Mews, London WC1E 6HX, United Kingdom
    Blood 99:1071-8. 2002
    ..In summary, a nonmyeloablative regimen incorporating in vivo CAMPATH-1H is effective in promoting durable engraftment in most patients and in reducing the risk of severe GVHD following matched unrelated donor transplantation...
  16. doi request reprint p53-mediated apoptosis of CLL cells: evidence for a transcription-independent mechanism
    Andrew J Steele
    Department of Hematology, Royal Free and University College Medical School, London, United Kingdom
    Blood 112:3827-34. 2008
    ..Therefore, strategies that block up-regulation of p53-mediated transcription may be of value in enhancing apoptosis induction of CLL cells by p53-elevating drugs...
  17. ncbi request reprint Diffuse bowel fluorodeoxyglucose uptake on positron emission tomography scan following allogeneic stem cell transplant
    Wendy A Stewart
    Department of Haematology, Ealing Hospital, Middlesex, London, UK
    Br J Haematol 133:219. 2006
  18. doi request reprint Does BCR/ABL1 positive acute myeloid leukaemia exist?
    Ellie P Nacheva
    UCL Med School, Royal Free Campus, London, UK
    Br J Haematol 161:541-50. 2013
    ....
  19. ncbi request reprint In vivo CAMPATH-1H prevents GvHD following nonmyeloablative stem-cell transplantation
    P D Kottaridis
    Department of Haematology, University College London Hospital, UK
    Cytotherapy 3:197-201. 2001
    ....
  20. ncbi request reprint Germ cell damage and Leydig cell insufficiency in recipients of nonmyeloablative transplantation for haematological malignancies
    C Kyriacou
    Department of Hematology, University College London Hospitals, London, UK
    Bone Marrow Transplant 31:45-50. 2003
    ..09). Our data suggest that this type of regimen is potentially gonadotoxic and consideration should be given to fertility counselling and testosterone replacement therapy post-transplant...
  21. ncbi request reprint Treatment of gonadal damage in recipients of allogeneic or autologous transplantation for haematological malignancies
    R Chatterjee
    Department of Obstetrics, University College London Medical School, London, UK
    Bone Marrow Transplant 30:629-35. 2002
    ..Although generally reassuring, continued monitoring of the offspring of SCT survivors and follow-up of all recipients of SCT is important for return of spontaneous or induced fertility...
  22. ncbi request reprint Excessive T cell depletion of peripheral blood stem cells has an adverse effect upon outcome following allogeneic stem cell transplantation
    R Chakraverty
    Department of Haematology, University College London, London, UK
    Bone Marrow Transplant 28:827-34. 2001
    ....
  23. ncbi request reprint Role of nonmyeloablative allogeneic stem-cell transplantation after failure of autologous transplantation in patients with lymphoproliferative malignancies
    Katharine Branson
    CR UK Department of Medical Oncology, Christie Hospital, Manchester, United Kingdom
    J Clin Oncol 20:4022-31. 2002
    ..The aim of the current study was to evaluate the safety and efficacy of sibling, HLA-matched, nonmyeloablative allogeneic SCT with donor lymphocyte infusion (DLI) in patients with lymphoid malignancy after failure of autologous SCT...
  24. ncbi request reprint RAS mutation in acute myeloid leukemia is associated with distinct cytogenetic subgroups but does not influence outcome in patients younger than 60 years
    David T Bowen
    Division of Pathology and Neuroscience, Ninewells Hospital, Dundee DD1 9SY, United Kingdom
    Blood 106:2113-9. 2005
    ..RAS mutation did not influence clinical outcome (overall/disease-free survival, complete remission, relapse rate) either for the entire cohort or within cytogenetic risk groups...
  25. ncbi request reprint Nonmyeloablative transplantation with or without alemtuzumab: comparison between 2 prospective studies in patients with lymphoproliferative disorders
    Jose A Perez-Simon
    Department of Hematology, Hospital Universitairo de Salamanca, Paseo de San Vicente s n, 37007 Salamanca, Spain
    Blood 100:3121-7. 2002
    ..Patients receiving alemtuzumab often required DLIs to achieve similar tumor control but the incidence of GVHD was not significantly increased after DLI...
  26. ncbi request reprint Development of squamous cell carcinoma of the skin during induction chemotherapy for acute myeloid leukemia
    Panagiotis D Kottaridis
    Leuk Lymphoma 43:459-60. 2002
  27. ncbi request reprint The allogeneic effect in non-Hodgkin's lymphoma
    Anthony H Goldstone
    North London Cancer Network, 6th Floor, Rosenheim Wing, 25 Grafton Way, London WC1E 6DB, UK
    Leuk Lymphoma 44:S91-7. 2003
    ..However, treatment will be improved by optimizating conditioning regimens and a better understanding of patient selection criteria and the immune processes involved in graft-vs.-host disease and GVT...
  28. ncbi request reprint Cavernosal arterial insufficiency and metabolic syndrome probably represent a common pathology of endothelial dysfunction in recipients of high-dose therapy and stem-cell transplantation
    Ratna Chatterjee
    J Clin Oncol 22:2253-4. 2004