Justin C Konje

Summary

Affiliation: University of Leicester
Country: UK

Publications

  1. pmc Changes in maternal serum transforming growth factor beta-1 during pregnancy: a cross-sectional study
    Mandeep Singh
    Women s Hospital, Kensington Building, Leicester Royal Infirmary, Leicester LE1 5WW, UK
    Biomed Res Int 2013:318464. 2013
  2. pmc Spatio-temporal expression patterns of anandamide-binding receptors in rat implantation sites: evidence for a role of the endocannabinoid system during the period of placental development
    Bruno M Fonseca
    Serviço de Bioquímica, Faculdade de Farmacia, Universidade do Porto, Porto, Portugal
    Reprod Biol Endocrinol 7:121. 2009
  3. ncbi request reprint Normative values of Doppler velocimetry of five major fetal arteries as determined by color power angiography
    Justin C Konje
    Fetal Growth and Development Research Group, Department of Cancer Studies and Molecular Medicine, Leicester Warwick Medical School, University of Leicester, Leicester, UK
    Acta Obstet Gynecol Scand 84:230-7. 2005
  4. ncbi request reprint 3-dimensional colour power angiography for staging human placental development
    Justin C Konje
    Fetal Growth and Development Research Group, Department of Obstetrics and Gynaecology, University of Leicester, Leicester, UK
    Lancet 362:1199-201. 2003
  5. doi request reprint Elevated anandamide and related N-acylethanolamine levels occur in the peripheral blood of women with ectopic pregnancy and are mirrored by changes in peripheral fatty acid amide hydrolase activity
    Alpha K Gebeh
    Endocannabinoid Research Group, Reproductive Sciences Section, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester Royal Infirmary, University of Leicester, Leicester LE2 7LX, United Kingdom
    J Clin Endocrinol Metab 98:1226-34. 2013
  6. doi request reprint The effect of the levonorgestrel-releasing intrauterine system, Mirena® on mast cell numbers in women with endometriosis undergoing symptomatic treatment
    Samuel L Engemise
    Reproductive Science Section, Department of Cancer Studies and Molecular Medicine, University of Leicester, United Kingdom
    Eur J Obstet Gynecol Reprod Biol 159:439-42. 2011
  7. doi request reprint Ectopic pregnancy is associated with high anandamide levels and aberrant expression of FAAH and CB1 in fallopian tubes
    Alpha K Gebeh
    Endocannabinoid Research Group, Reproductive Sciences Section, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester LE2 7LX, United Kingdom
    J Clin Endocrinol Metab 97:2827-35. 2012
  8. doi request reprint Histomorphometric evaluation of cannabinoid receptor and anandamide modulating enzyme expression in the human endometrium through the menstrual cycle
    Anthony H Taylor
    Endocannabinoid Research Group, Reproductive Sciences Section, Department of Cancer Studies and Molecular Medicine, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, P O Box 65, Leicester, Leicestershire, LE2 7LX, UK
    Histochem Cell Biol 133:557-65. 2010
  9. pmc Characterization of anandamide-stimulated cannabinoid receptor signaling in human ULTR myometrial smooth muscle cells
    Paul J Brighton
    Endocannabinoid Research Group, Reproductive Sciences Section, Department of Cancer Studies, University of Leicester, Clinical Sciences Building, Leicester Royal Infirmary, Leicester LE2 7LX, United Kingdom
    Mol Endocrinol 23:1415-27. 2009
  10. pmc Characterization of the endocannabinoid system, CB(1) receptor signalling and desensitization in human myometrium
    Paul J Brighton
    Endocannabinoid Research Group, Reproductive Sciences Section, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester Royal Infirmary, Leicester, UK
    Br J Pharmacol 164:1479-94. 2011

Collaborators

Detail Information

Publications47

  1. pmc Changes in maternal serum transforming growth factor beta-1 during pregnancy: a cross-sectional study
    Mandeep Singh
    Women s Hospital, Kensington Building, Leicester Royal Infirmary, Leicester LE1 5WW, UK
    Biomed Res Int 2013:318464. 2013
    ..04 + 4.3 versus 36.7 + 7.0 ng/mL). This differential change in TGF-β1 levels is probably an important modulating factor in the aetiopathogenesis of abnormal intrauterine fetal growth...
  2. pmc Spatio-temporal expression patterns of anandamide-binding receptors in rat implantation sites: evidence for a role of the endocannabinoid system during the period of placental development
    Bruno M Fonseca
    Serviço de Bioquímica, Faculdade de Farmacia, Universidade do Porto, Porto, Portugal
    Reprod Biol Endocrinol 7:121. 2009
    ....
  3. ncbi request reprint Normative values of Doppler velocimetry of five major fetal arteries as determined by color power angiography
    Justin C Konje
    Fetal Growth and Development Research Group, Department of Cancer Studies and Molecular Medicine, Leicester Warwick Medical School, University of Leicester, Leicester, UK
    Acta Obstet Gynecol Scand 84:230-7. 2005
    ..To produce normograms of Doppler indices of major fetal arteries and their ratios relative to the ascending aorta in a cohort of appropriately grown for gestational age fetuses...
  4. ncbi request reprint 3-dimensional colour power angiography for staging human placental development
    Justin C Konje
    Fetal Growth and Development Research Group, Department of Obstetrics and Gynaecology, University of Leicester, Leicester, UK
    Lancet 362:1199-201. 2003
    ....
  5. doi request reprint Elevated anandamide and related N-acylethanolamine levels occur in the peripheral blood of women with ectopic pregnancy and are mirrored by changes in peripheral fatty acid amide hydrolase activity
    Alpha K Gebeh
    Endocannabinoid Research Group, Reproductive Sciences Section, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester Royal Infirmary, University of Leicester, Leicester LE2 7LX, United Kingdom
    J Clin Endocrinol Metab 98:1226-34. 2013
    ..These observations led to the hypothesis that ectopic pregnancy is associated with a perturbation in levels of endocannabinoids and FAAH activity and that such changes are associated with impaired tubal function...
  6. doi request reprint The effect of the levonorgestrel-releasing intrauterine system, Mirena® on mast cell numbers in women with endometriosis undergoing symptomatic treatment
    Samuel L Engemise
    Reproductive Science Section, Department of Cancer Studies and Molecular Medicine, University of Leicester, United Kingdom
    Eur J Obstet Gynecol Reprod Biol 159:439-42. 2011
    ..The precise mechanisms for this have not been thoroughly investigated. We investigate here one possible mechanism-alteration in the number of mast cells in the endometriotic tissue...
  7. doi request reprint Ectopic pregnancy is associated with high anandamide levels and aberrant expression of FAAH and CB1 in fallopian tubes
    Alpha K Gebeh
    Endocannabinoid Research Group, Reproductive Sciences Section, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester LE2 7LX, United Kingdom
    J Clin Endocrinol Metab 97:2827-35. 2012
    ..g. N-acyl-phosphatidylethanolamine-specific phospholipase D), forms the endocannabinoid system. High anandamide levels are associated with tubal arrest of embryos in mice and may have a similar role in women...
  8. doi request reprint Histomorphometric evaluation of cannabinoid receptor and anandamide modulating enzyme expression in the human endometrium through the menstrual cycle
    Anthony H Taylor
    Endocannabinoid Research Group, Reproductive Sciences Section, Department of Cancer Studies and Molecular Medicine, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, P O Box 65, Leicester, Leicestershire, LE2 7LX, UK
    Histochem Cell Biol 133:557-65. 2010
    ..These data indicate that elements of the 'endocannabinoid system' coexist in many cell types within the uterus and may provide insight into the sites of action of endogenous and exogenous cannabinoids during endometrial transformation...
  9. pmc Characterization of anandamide-stimulated cannabinoid receptor signaling in human ULTR myometrial smooth muscle cells
    Paul J Brighton
    Endocannabinoid Research Group, Reproductive Sciences Section, Department of Cancer Studies, University of Leicester, Clinical Sciences Building, Leicester Royal Infirmary, Leicester LE2 7LX, United Kingdom
    Mol Endocrinol 23:1415-27. 2009
    ..These findings provide an insight into myometrial AEA signaling, highlighting a potential role for endocannabinoids in the regulation of gene expression in myometrial smooth muscle cells...
  10. pmc Characterization of the endocannabinoid system, CB(1) receptor signalling and desensitization in human myometrium
    Paul J Brighton
    Endocannabinoid Research Group, Reproductive Sciences Section, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester Royal Infirmary, Leicester, UK
    Br J Pharmacol 164:1479-94. 2011
    ..However, little is known regarding the presence or role of the endocannabinoid system in myometrial function. Here the presence of the endocannabinoid system and signalling properties of cannabinoid receptors were characterized...
  11. doi request reprint Expression of the endocannabinoid system in human first trimester placenta and its role in trophoblast proliferation
    Osama M H Habayeb
    Endocannabinoid Research Group, Reproductive Sciences Section, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester LE2 7LX, United Kingdom
    Endocrinology 149:5052-60. 2008
    ..This effect was mediated through CB2. Together, these data provide insights into how elevated plasma anandamide levels increase the risk of first trimester miscarriage...
  12. doi request reprint Anandamide levels in human female reproductive tissues: solid-phase extraction and measurement by ultraperformance liquid chromatography tandem mass spectrometry
    Timothy H Marczylo
    Endocannabinoid Research Group, Reproductive Sciences Section, Department of Cancer Studies and Molecular Medicine, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, P O Box 65, Leicester, Leicestershire LE2 7LX, UK
    Anal Biochem 400:155-62. 2010
    ..0015), and in plasma from maternal circulation compared with umbilical artery (P=0.0152). The relevance of these changes in AEA concentrations at the maternal:fetal interface requires further investigation...
  13. pmc Rapid measurement of 8-oxo-7,8-dihydro-2'-deoxyguanosine in human biological matrices using ultra-high-performance liquid chromatography-tandem mass spectrometry
    Patricia M W Lam
    Oxidative Stress Group, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester LE2 7LX, UK
    Free Radic Biol Med 52:2057-63. 2012
    ....
  14. pmc Modulation of the endocannabinoid system in viable and non-viable first trimester pregnancies by pregnancy-related hormones
    Anthony H Taylor
    Endocannabinoid Research Group, Reproductive Sciences Section, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, UK
    Reprod Biol Endocrinol 9:152. 2011
    ..In early pregnancy, increased plasma levels of the endocannabinoid anandamide (AEA) are associated with miscarriage through mechanisms that might affect the developing placenta or maternal decidua...
  15. doi request reprint Simultaneous measurement of three N-acylethanolamides in human bio-matrices using ultra performance liquid chromatography-tandem mass spectrometry
    Patricia M W Lam
    Endocannabinoid Research Group, Reproductive Sciences Section, Department of Cancer Studies and Molecular Medicine, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Infirmary Road, Leicester LE2 7LX, UK
    Anal Bioanal Chem 398:2089-97. 2010
    ....
  16. doi request reprint The relationship between plasma levels of the endocannabinoid, anandamide, sex steroids, and gonadotrophins during the menstrual cycle
    Mona R El-Talatini
    Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, United Kingdom
    Fertil Steril 93:1989-96. 2010
    ..To further investigate the relationship between plasma anandamide (AEA), sex steroids, and gonadotrophins to improve our understanding of how AEA may be involved in human fertility...
  17. doi request reprint Changes in glandular and stromal estrogen and progesterone receptor isoform expression in eutopic and ectopic endometrium following treatment with the levonorgestrel-releasing intrauterine system
    Samuel L Engemise
    Reproductive Science Section, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, United Kingdom
    Eur J Obstet Gynecol Reprod Biol 157:101-6. 2011
    ..The precise mechanism for this is unknown. We hypothesized that this involves alteration in the expression of estrogen receptors (ER) and progesterone receptors (PR)...
  18. doi request reprint Quantitative analysis of anandamide and related acylethanolamides in human seminal plasma by ultra performance liquid chromatography tandem mass spectrometry
    Akwasi A Amoako
    Endocannabinoid Research Group, Reproductive Science Section, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester LE2 7LX, United Kingdom
    J Chromatogr B Analyt Technol Biomed Life Sci 878:3231-7. 2010
    ..Consequently, this UHPLC-ESI-MS/MS method represents a rapid, reliable and reproducible technique for the analysis of these endocannabinoids in fresh seminal plasma...
  19. doi request reprint Immunity and early pregnancy events: are endocannabinoids the missing link?
    Katerina N Bambang
    Reproductive Sciences Section, Department of Cancer Studies and Molecular Medicine, University of Leicester LE2 7LX, United Kingdom
    J Reprod Immunol 96:8-18. 2012
    ..We conclude that there are intricate molecular interactions involved in the success of early pregnancy and that the endocannabinoid system, potentially interacting with the immune system, is a key contributor to these events...
  20. doi request reprint A solid-phase method for the extraction and measurement of anandamide from multiple human biomatrices
    Timothy H Marczylo
    Endocannabinoid Research Group, Reproductive Sciences Section, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, Leicestershire LE27LX, UK
    Anal Biochem 384:106-13. 2009
    ....
  21. pmc Arrestins differentially regulate histamine- and oxytocin-evoked phospholipase C and mitogen-activated protein kinase signalling in myometrial cells
    Paul J Brighton
    Endocannabinoid Research Group, Reproductive Sciences Section, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester Royal Infirmary, Leicester, UK
    Br J Pharmacol 162:1603-17. 2011
    ..Here we investigate potential roles that arrestins play in the regulation of myometrial oxytocin/histamine H(1) receptor signalling...
  22. ncbi request reprint Regulation of oxytocin receptor responsiveness by G protein-coupled receptor kinase 6 in human myometrial smooth muscle
    Jonathon M Willets
    Reproductive Sciences Section, Department of Cancer Studies and Molecular Medicine, University of Leicester, Clinical Sciences Building, Leicester Royal Infirmary, Leicester LE2 7LX, United Kingdom
    Mol Endocrinol 23:1272-80. 2009
    ..These data indicate that GRK6 recruitment is a cardinal effector of OTR responsiveness and provide mechanistic insight into the likely in vivo regulation of OTR signaling in uterine smooth muscle...
  23. pmc Localisation and function of the endocannabinoid system in the human ovary
    Mona R El-Talatini
    Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, United Kingdom
    PLoS ONE 4:e4579. 2009
    ..Although anandamide (AEA) had been measured in human follicular fluid and is suggested to play a role in ovarian follicle and oocyte maturity, its exact source and role in the human ovary remains unclear...
  24. doi request reprint Endocannabinoids and pregnancy
    Anthony H Taylor
    Reproductive Sciences Section, University of Leicester, Leicester, United Kingdom
    Clin Chim Acta 411:921-30. 2010
    ..Additionally, the possibility that plasma and tissue AEA and other cannabinoids may represent reliable diagnostic markers of natural and assisted reproduction and pregnancy outcomes in women will be discussed...
  25. ncbi request reprint The effect of mifepristone (RU486) on the endocannabinoid system in human plasma and first-trimester trophoblast of women undergoing termination of pregnancy
    Tulay Karasu
    Endocannabinoid Research Group T K, T H M, A H T, J C K, Reproductive Sciences, Leicester Royal Infirmary, Leicester, Leicestershire, LE2 7LX, United Kingdom Systems Toxicology E L M, Medical Research Council Toxicology Unit, Hodgkin Building, Lancaster Road, Leicester, LE1 9HN, United Kingdom and Contraception, Sexual, and Reproductive Health Services E O, University Hospitals of Leicester National Health Service NHS Trust, St Peters Health Centre, Leicester, LE2 0TA, United Kingdom
    J Clin Endocrinol Metab 99:871-80. 2014
    ..Here the effect of RU486, a P4 antagonist used to initiate medical termination of pregnancy (MTOP), on plasma AEA concentrations and the endocannabinoid system (ECS) in trophoblasts was examined...
  26. ncbi request reprint Longitudinal quantification of uterine artery blood volume flow changes during gestation in pregnancies complicated by intrauterine growth restriction
    Justin C Konje
    Fetal Growth and Development Research Group, Department of Obstetrics and Gynaecology, University of Leicester, UK
    BJOG 110:301-5. 2003
    ..To quantify and compare longitudinal uterine artery volume flow changes in appropriate for gestational age (AGA) pregnancies and those complicated by intrauterine growth restriction (IUGR)...
  27. ncbi request reprint The endocrinological basis of recurrent miscarriages
    Neelam Potdar
    Reproductive Sciences Section, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester Royal Infirmary, Leicester, UK
    Curr Opin Obstet Gynecol 17:424-8. 2005
    ..This review discusses the endocrinological aspects of recurrent miscarriage based on the literature from January 2004 to January 2005, elaborating on the advances in the field and their impact on diagnosis and management...
  28. doi request reprint Smoking induces differential miRNA expression in human spermatozoa: a potential transgenerational epigenetic concern?
    Emma L Marczylo
    Systems Toxicology Group, MRC Toxicology Unit, Leicester, UK
    Epigenetics 7:432-9. 2012
    ..microRNA-mediated perturbation of such pathways may explain how harmful phenotypes can be induced in the progeny of smokers...
  29. ncbi request reprint Prevention of tamoxifen induced endometrial polyps using a levonorgestrel releasing intrauterine system long-term follow-up of a randomised control trial
    Francis J E Gardner
    Department of Obstetrics and Gynaecology, University Hospitals of Leicester, Leicester, LE1 5WW, UK
    Gynecol Oncol 114:452-6. 2009
    ..We here report on the long-term follow-up of this group of women, to test the hypothesis that a LNG-IUS could prevent the pro-proliferative uterine responses of tamoxifen for up to 4.5 years...
  30. ncbi request reprint Plasma anandamide and related n-acylethanolamide levels are not elevated in pregnancies complicated by hyperemesis gravidarum
    Alpha K Gebeh
    Endocannabinoid Research Group, Reproductive Science Section, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, UK and
    J Matern Fetal Neonatal Med 27:954-9. 2014
    ..We tested the hypothesis that plasma endocannabinoid levels are similarly perturbed in women with hyperemesis gravidarum (HG), a condition where the aetiopathogenesis is still unknown, compared to normal pregnant controls...
  31. doi request reprint Fluctuation in anandamide levels from ovulation to early pregnancy in in-vitro fertilization-embryo transfer women, and its hormonal regulation
    Mona R El-Talatini
    Endocannabinoid Research Group, Reproductive Sciences Section, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester Royal Infirmary, PO Box 65, Leicester, Leicestershire LE2 7LX, UK
    Hum Reprod 24:1989-98. 2009
    ..The objective of this study was to investigate plasma AEA concentrations from the time of ovulation to implantation in pregnant and non-pregnant women, and whether AEA is hormonally regulated...
  32. doi request reprint Ultra performance liquid chromatography tandem mass spectrometry method for the measurement of anandamide in human plasma
    Patricia M W Lam
    Department of Cancer Studies and Molecular Medicine, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Infirmary Road, Leicester LE27LX, UK
    Anal Biochem 380:195-201. 2008
    ....
  33. ncbi request reprint Variation in Doppler indices along the length of the cord from the intraabdominal to the placental insertion
    Manjiri Khare
    Fetal Growth and Development Research Group, Reproductive Sciences Section, Department of Cancer Studies and Molecular Medicine, Leicester, UK
    Acta Obstet Gynecol Scand 85:922-8. 2006
    ....
  34. ncbi request reprint Adjunct low-molecular-weight heparin to improve live birth rate after recurrent implantation failure: a systematic review and meta-analysis
    Neelam Potdar
    Leicester Fertility Centre, University Hospitals of Leicester, Leicester LE1 5WW, UK
    Hum Reprod Update 19:674-84. 2013
    ..Further evidence from adequately powered multi-centered RCTs is required prior to recommending LMWH for routine clinical use. This review highlights the need for future basic science and clinical research in this important field...
  35. ncbi request reprint Distribution and function of the endocannabinoid system in the rat and human bladder
    Evangelia Bakali
    Prolapse and Incontinence Research Group, University of Leicester, Leicester, UK
    Int Urogynecol J 24:855-63. 2013
    ..We also evaluated effects of cannabinoid agonists (ACEA, agonist of CB1; GP1A, agonist of CB2) on contractile responses of rat bladder strips...
  36. ncbi request reprint Plasma levels of the endocannabinoid anandamide in women--a potential role in pregnancy maintenance and labor?
    Osama M H Habayeb
    Reproductive Sciences Section, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester Royal Infirmary, Leicester LE2 7LX, United Kingdom
    J Clin Endocrinol Metab 89:5482-7. 2004
    ..At term, AEA levels dramatically increase during labor and are affected by the duration of labor, suggesting a role for AEA in normal labor...
  37. pmc Variation in stability of endogenous reference genes in fallopian tubes and endometrium from healthy and ectopic pregnant women
    Alpha K Gebeh
    Endocannabinoid Research Group, Reproductive Science Section, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, LE2 7LX, UK E Mails A K G A A A J M W
    Int J Mol Sci 13:2810-26. 2012
    ..This study demonstrates that arbitrary selection of reference genes for normalisation in RT-qPCR studies in ectopic pregnancy without validation, risk producing inaccurate data and should therefore be discouraged...
  38. doi request reprint Selective regulation of H1 histamine receptor signaling by G protein-coupled receptor kinase 2 in uterine smooth muscle cells
    Jonathon M Willets
    Reproductive Sciences Section, Department of Cancer Studies and Molecular Medicine, University of Leicester, Clinical Sciences Building, Leicester Royal Infirmary, Leicester LE2 7LX, United Kingdom
    Mol Endocrinol 22:1893-907. 2008
    ..These data provide insights into the in situ regulation of this receptor subtype and may inform pathophysiological functioning in preterm labor and other conditions involving uterine smooth muscle dysregulation...
  39. ncbi request reprint Endogenous cannabinoids: metabolism and their role in reproduction
    Osama M H Habayeb
    Department of Obstetrics and Gynaecology, Leicester Medical School, University of Leicester, Robert Kilpatrick Clinical, Leicester Royal Infirmary, UK
    Life Sci 70:1963-77. 2002
    ..The bulk of the literature concerning endocannabinoids is based upon anandamide related studies; therefore, in this review we focus on the metabolism of anandamide and its role in reproduction...
  40. doi request reprint Successful treatment of refractory endometriosis-related chronic pelvic pain with aromatase inhibitors in premenopausal patients
    Alka Verma
    Women s Hospital, Leicester Royal Infirmary, Leicester LE1 5WW, UK
    Eur J Obstet Gynecol Reprod Biol 143:112-5. 2009
    ..The objective of this study was to determine the efficacy and side effects of aromatase inhibitors in the treatment of premenopausal patients with endometriosis associated with chronic pelvic pain refractory to conventional treatment...
  41. ncbi request reprint Population-based study of the outcome following the prenatal diagnosis of cystic hygroma
    Edmund S Howarth
    University Hospitals of Leicester, Leicester Royal Infirmary, Leicester LE1 5WW, UK
    Prenat Diagn 25:286-91. 2005
    ..To identify the population prevalence, pregnancy outcome, and the pattern of associated anomalies with a prenatal diagnosis of cystic hygroma...
  42. ncbi request reprint Delta9-tetrahydrocannabinol inhibits cytotrophoblast cell proliferation and modulates gene transcription
    Manjiri Khare
    Clinical Division of Obstetrics and Gynaecology, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, University of Leicester, Leicester, UK
    Mol Hum Reprod 12:321-33. 2006
    ..This study may provide insight into the mechanisms underlying the effects of Delta9-THC and cannabis use upon placental development during pregnancy...
  43. ncbi request reprint Of mice and (wo)men: factors influencing successful implantation including endocannabinoids
    Sarah E Melford
    The Endocannabinoid Research Group, Reproductive Sciences Section, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester Royal Infirmary, PO Box 65, Leicester, Leicestershire LE2 7LX, UK
    Hum Reprod Update 20:415-28. 2014
    ..We highlight numerous differences between the mice and women and conclude it is becoming clear that all of the data from mouse studies cannot be confidently extrapolated to human reproduction. ..
  44. doi request reprint Interlaboratory comparison of methodologies for the measurement of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine
    Marcus S Cooke
    Department of Cancer Studies and Molecular Medicine, Radiation and Oxidative Stress Section, University of Leicester, Leicester, UK
    Biomarkers 14:103-10. 2009
    ..0001). While it is reassuring to note good agreement between chromatographic assays, this study reveals significant short-comings in the ELISA, which brings into question its continued use in its present form...
  45. ncbi request reprint The one-stop recurrent miscarriage clinic: an evaluation of its effectiveness and outcome
    Osama M H Habayeb
    Reproductive Sciences Section, Department of Cancer Studies and Molecular Medicine, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester, UK
    Hum Reprod 19:2952-8. 2004
    ..The objectives of this study were to examine the effect of a 'one-stop' clinic on 'the interval', throughput and the outcome from this clinic...
  46. ncbi request reprint A comparison of prenatal versus postnatal karyotyping for the investigation of intrauterine fetal death after the first trimester of pregnancy
    Manjiri Khare
    Women s Perinatal and Sexual Health Services Directorate, University Hospitals of Leicester NHS Trust, UK
    Prenat Diagn 25:1192-5. 2005
    ..Results from such techniques are disappointing. The aim of this audit was to compare the results of karyotyping IUFD by invasive testing (amniocentesis or chorionic villus sampling) and solid tissues (skin biopsy)...