Yoon Kong Loke
Affiliation: University of Oxford
- Aspirin for the prevention of cardiovascular disease: calculating benefit and harm in the individual patientYoon Kong Loke
Department of Clinical Pharmacology, University of Oxford, Radcliffe Infirmary, Oxford OX2 6HE
Br J Clin Pharmacol 55:282-7. 2003..To estimate the absolute reduction in the risk of cardiovascular events and absolute increase in gastrointestinal haemorrhage associated with aspirin for individuals with different baseline risks...
- Incomplete evidence: the inadequacy of databases in tracing published adverse drug reactions in clinical trialsS Derry
Department of Clinical Pharmacology, University of Oxford, Radcliffe Infirmary, Oxford, OX2 6HE, United Kingdom
BMC Med Res Methodol 1:7. 2001..We have determined how often automated search methods, using indexing terms and/or textwords in the title or abstract, would fail to retrieve trials with adverse effects data...
- A comparison of three different sources of data in assessing the frequencies of adverse reactions to amiodaroneYoon K Loke
Department of Clinical Pharmacology, University of Oxford, Radcliffe Infirmary, Oxford OX2 6HE, UK
Br J Clin Pharmacol 57:616-21. 2004....
- Does anybody read "evidence-based" articles?Yoon K Loke
Department of Clinical Pharmacology, University of Oxford, Radcliffe Infirmary, Oxford OX2 6HE, United Kingdom
BMC Med Res Methodol 3:14. 2003..Editorials (average of 2537 hits per article) were viewed much more frequently than Papers, even where the editorial was written as an accompanying piece with a direct link to the paper...
- Air travel and venous thrombosis: how much help might aspirin be?Yoon K Loke
University of Oxford, Oxford, United Kingdom
MedGenMed 4:4. 2002..If the rate of travel-related DVT is 20 per 100,000 travelers, then we will have to treat 17,000 people with aspirin to prevent 1 additional DVT...
- Appetite suppressants and valvular heart disease - a systematic reviewYoon K Loke
Department of Clinical Pharmacology, University of Oxford, Radcliffe Infirmary, OX2 6HE, United Kingdom
BMC Clin Pharmacol 2:6. 2002..Our objective was to systematically assess the risk of valvular heart disease with appetite suppressants...
- Reporting of adverse drug reactions in randomised controlled trials - a systematic surveyY K Loke
Department of Clinical Pharmacology, University of Oxford, Radcliffe Infirmary, OX2 6HE, England
BMC Clin Pharmacol 1:3. 2001..However, some researchers have found numerous deficiencies in trial reports of adverse effects. We sought to confirm these findings by evaluating trials of drug therapy published in seven eminent medical journals in 1997...
- Adverse drug reactions: keeping up to dateJeffrey K Aronson
University Department of Clinical Pharmacology, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, UK
Fundam Clin Pharmacol 16:49-56. 2002..Systematic reviews are too few in number (only 1.25% of publications on adverse drug reactions cited in Side Effects of Drugs Annual); more are needed...
- Determining the reporting quality of RCTs in clinical pharmacologyEdward Mills
University of Oxford, Oxford, UK
Br J Clin Pharmacol 58:61-5. 2004..The Consolidated Standards for Reporting Trials (CONSORT) are recommendations for improving the quality of reports of randomized controlled trials (RCTs)...
- Assessing the benefit-harm balance at the bedsideYoon Kong Loke
School of Medicine, Health Policy and Practice University of East Anglia, Norwich NR4 7TJ
BMJ 329:7-8. 2004