Toru Kondo

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. pmc Persistence of a small subpopulation of cancer stem-like cells in the C6 glioma cell line
    Toru Kondo
    Department of Cell Fate Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    Proc Natl Acad Sci U S A 101:781-6. 2004
  2. ncbi request reprint A role for Noggin in the development of oligodendrocyte precursor cells
    Toru Kondo
    Medical Research Council Laboratory for Molecular Cell Biology and Cell Biology Unit and the Biology Department, University College London, London WC1E 6BT, UK
    Dev Biol 267:242-51. 2004
  3. pmc Nuclear export of OLIG2 in neural stem cells is essential for ciliary neurotrophic factor-induced astrocyte differentiation
    Takao Setoguchi
    Centre for Brain Repair, University of Cambridge, E D Adrian Building, Forvie Site, Robinson Way, Cambridge CB2 2PY, UK
    J Cell Biol 166:963-8. 2004
  4. pmc Chromatin remodeling and histone modification in the conversion of oligodendrocyte precursors to neural stem cells
    Toru Kondo
    Medical Research Council Laboratory for Molecular Cell Biology, Cell Biology Unit, University College London, London WC1E 6BT, United Kingdom
    Genes Dev 18:2963-72. 2004
  5. ncbi request reprint Cancer stem cells persist in many cancer cell lines
    Takao Setoguchi
    University of Cambridge Center for Brain Repair, The E D Adrian Building, Forvie Site, Robinson Way, Cambridge, UK
    Cell Cycle 3:414-5. 2004
  6. ncbi request reprint A potential role for bone morphogenetic protein signalling in glial cell fate determination following adult central nervous system injury in vivo
    David W Hampton
    ICORD, University of British Columbia, Vancouver, BC, Canada
    Eur J Neurosci 26:3024-35. 2007
  7. ncbi request reprint Brain cancer stem-like cells
    Toru Kondo
    Centre for Brain Repair, University of Cambridge, Cambridge CB2 2PY, UK
    Eur J Cancer 42:1237-42. 2006
  8. ncbi request reprint Id4 is required for the correct timing of neural differentiation
    Lynn Bedford
    Institute of Genetics, Queen s Medical Centre, School of Biology, The University of Nottingham, UK
    Dev Biol 280:386-95. 2005
  9. ncbi request reprint Epigenetic alchemy for cell fate conversion
    Toru Kondo
    Laboratory for Cell Lineage Modulation, RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe 650 0047, Japan
    Curr Opin Genet Dev 16:502-7. 2006
  10. ncbi request reprint Multiple roles of Id4 in developmental myelination: predicted outcomes and unexpected findings
    Mireya Marin-Husstege
    Department of Neuroscience and Cell Biology, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Glia 54:285-96. 2006

Collaborators

Detail Information

Publications13

  1. pmc Persistence of a small subpopulation of cancer stem-like cells in the C6 glioma cell line
    Toru Kondo
    Department of Cell Fate Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    Proc Natl Acad Sci U S A 101:781-6. 2004
    ..We propose that many cancer cell lines contain a minor subpopulation of stem cells that is enriched in an SP, can be maintained indefinitely in culture, and is crucial for their malignancy...
  2. ncbi request reprint A role for Noggin in the development of oligodendrocyte precursor cells
    Toru Kondo
    Medical Research Council Laboratory for Molecular Cell Biology and Cell Biology Unit and the Biology Department, University College London, London WC1E 6BT, UK
    Dev Biol 267:242-51. 2004
    ..These findings suggest that BMPs in FCS are largely responsible for the 2A-inducing activity of FCS and that Noggin may normally inhibit the formation of 2As in the developing CNS...
  3. pmc Nuclear export of OLIG2 in neural stem cells is essential for ciliary neurotrophic factor-induced astrocyte differentiation
    Takao Setoguchi
    Centre for Brain Repair, University of Cambridge, E D Adrian Building, Forvie Site, Robinson Way, Cambridge CB2 2PY, UK
    J Cell Biol 166:963-8. 2004
    ..We propose that the AKT-stimulated export of OLIG2 from the nucleus of NSCs is essential for the astrocyte differentiation...
  4. pmc Chromatin remodeling and histone modification in the conversion of oligodendrocyte precursors to neural stem cells
    Toru Kondo
    Medical Research Council Laboratory for Molecular Cell Biology, Cell Biology Unit, University College London, London WC1E 6BT, United Kingdom
    Genes Dev 18:2963-72. 2004
    ..Our findings suggest that the conversion of OPCs to NSLCs depends on progressive chromatin remodeling, mediated in part by Brca1 and Brm...
  5. ncbi request reprint Cancer stem cells persist in many cancer cell lines
    Takao Setoguchi
    University of Cambridge Center for Brain Repair, The E D Adrian Building, Forvie Site, Robinson Way, Cambridge, UK
    Cell Cycle 3:414-5. 2004
    ..We propose that many cancer cell lines contain a minor subpopulation of stem cells that is enriched in a SP, can be maintained indefinitely in culture, and is crucial for their malignancy...
  6. ncbi request reprint A potential role for bone morphogenetic protein signalling in glial cell fate determination following adult central nervous system injury in vivo
    David W Hampton
    ICORD, University of British Columbia, Vancouver, BC, Canada
    Eur J Neurosci 26:3024-35. 2007
    ..This potential conversion of inhibitory OPCs to type 2 astrocyte-like cells in vivo suggests that endogenous BMPs, unmasked by noggin antagonism, might be exploited to manipulate cell fate following CNS trauma...
  7. ncbi request reprint Brain cancer stem-like cells
    Toru Kondo
    Centre for Brain Repair, University of Cambridge, Cambridge CB2 2PY, UK
    Eur J Cancer 42:1237-42. 2006
    ..The purified cancer stem-like cells, but not the other cancer cells, self-renew and form tumours when transplanted in vivo. Thus, cancer stem-like cells in brain tumours might be a crucial target for anti-brain tumour therapy...
  8. ncbi request reprint Id4 is required for the correct timing of neural differentiation
    Lynn Bedford
    Institute of Genetics, Queen s Medical Centre, School of Biology, The University of Nottingham, UK
    Dev Biol 280:386-95. 2005
    ..Together, these in vivo and in vitro data suggest a crucial role for Id4 in regulating NPC proliferation and differentiation...
  9. ncbi request reprint Epigenetic alchemy for cell fate conversion
    Toru Kondo
    Laboratory for Cell Lineage Modulation, RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe 650 0047, Japan
    Curr Opin Genet Dev 16:502-7. 2006
    ..Thus, epigenetic research might generate the alchemy required to convert any non-neural stem cells into functional neural stem cells, which are few and difficult to extract from the adult central nervous system...
  10. ncbi request reprint Multiple roles of Id4 in developmental myelination: predicted outcomes and unexpected findings
    Mireya Marin-Husstege
    Department of Neuroscience and Cell Biology, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Glia 54:285-96. 2006
    ..These data support the role of Id4 as oligodendrocyte differentiation inhibitor with the ability to differentially regulate the expression and subcellular distribution of myelin gene products...
  11. pmc Inhibition of histone deacetylase activity induces developmental plasticity in oligodendrocyte precursor cells
    Costas A Lyssiotis
    The Skaggs Institute of Chemical Biology and Department of Chemistry, The Scripps Research Institute, 10550 North Torry Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 104:14982-7. 2007
    ..This series of experiments demonstrates that global histone acetylation, induced by HDAC inhibition, can partially reverse the lineage restriction of OPCs, thereby inducing developmental plasticity...
  12. ncbi request reprint [Cancer stem cells in cancer cell lines]
    Takao Setoguchi
    University of Cambridge Center for Brain Repair
    Tanpakushitsu Kakusan Koso 50:1995-2000. 2005
  13. ncbi request reprint Stem cell-like cancer cells in cancer cell lines
    Toru Kondo
    Laboratory for Cell Lineage Modulation, Center for Developmental Biology, RIKEN, Kobe 650 0047, Japan
    Cancer Biomark 3:245-50. 2007
    ..In this review I summarize the recent progress in CSC research using cancer cell lines...