Research Topics
Genomes and Genes
| Walter KolchSummaryAffiliation: University of Glasgow Country: UK Publications
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Detail Information
Publications
The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activityChristian Johannes Gloeckner
GSF National Research Center for Environment and Health, Institute of Human Genetics, Munich Neuherberg, Germany
Hum Mol Genet 15:223-32. 2006..This suggests that the pathology of PD caused by the I2020T mutation is associated with an increase rather than a loss in LRRK2 kinase activity...- Mutations of beta-arrestin 2 that limit self-association also interfere with interactions with the beta2-adrenoceptor and the ERK1/2 MAPKs: implications for beta2-adrenoceptor signalling via the ERK1/2 MAPKsTian Rui Xu
Sir Henry Welcome Functional Genomics Facility, Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, UK
Biochem J 413:51-60. 2008..Regulation of beta-arrestin 2 self-association may therefore control beta-arrestin 2-mediated beta2-adrenoceptor-ERK1/2 MAPK signalling... 
Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactionsW Kolch
The Beatson Institute for Cancer Research, CRC Beatson Laboratories, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, U K
Biochem J 351:289-305. 2000....- Erbin: sorting out ErbB2 receptors or giving Ras a break?Walter Kolch
Garscube Estate, Cancer Research UK, Beatson Laboratories, Switchback Road, Glasgow G61 1BD, UK
Sci STKE 2003:pe37. 2003..It also highlights the complexity of cellular signaling networks in which the tasks of individual components are determined by the specific functional context... - Coordinating ERK/MAPK signalling through scaffolds and inhibitorsWalter Kolch
Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow, G61 1BD, UK
Nat Rev Mol Cell Biol 6:827-37. 2005..Computational modelling indicates that, together, these modulators can determine the dynamic biological behaviour of the pathway... - Defining systems biology: through the eyes of a biochemistW Kolch
Beatson Institute for Cancer Research and Institute for Biomedical and Life Sciences, University of Glasgow, Glasgow, UK
IET Syst Biol 2:5-7. 2008 - Ras/Raf signalling and emerging pharmacotherapeutic targetsWalter Kolch
The Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Garscube Estate, Glasgow, UK
Expert Opin Pharmacother 3:709-18. 2002..However, it is not clear which components of this pathway should be targeted and how maximum efficacy can be achieved. This paper reviews the current efforts with an emphasis on new mechanistic and conceptual approaches... - The molecular make-up of a tumour: proteomics in cancer researchWalter Kolch
Sir Henry Wellcome Functional Genomics Facility, Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, UK
Clin Sci (Lond) 108:369-83. 2005..A major challenge will be the integration of proteomics with genomics and metabolomics data and their functional interpretation in conjunction with clinical results and epidemiology... - When kinases meet mathematics: the systems biology of MAPK signallingWalter Kolch
Sir Henry Wellcome Functional Genomics Facility, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
FEBS Lett 579:1891-5. 2005..Systems biology tries to decode this complexity through mathematical modelling and prediction in order to gain a deeper insight into the inner works of signalling networks... - To be or not to be: a question of B-Raf?W Kolch
Institute for Biomedical and Life Sciences, University of Glasgow, Glasgow, UK
Trends Neurosci 24:498-500. 2001..This finding sheds new light on the control of neuronal development and poses new questions with regard to Raf-isozyme-specific functions... - The role of Raf kinases in malignant transformationWalter Kolch
Institute for Biomedical and Life Sciences, University of Glasgow, University Avenue, Glasgow, G12 8QQ, UK
Expert Rev Mol Med 4:1-18. 2002..The molecular mechanisms underlying the role of Raf kinase in tumourigenesis and the opportunities for therapeutic intervention are reviewed in this article... - A Raf-1 mutant that dissociates MEK/extracellular signal-regulated kinase activation from malignant transformation and differentiation but not proliferationAmardeep S Dhillon
The Beatson Institute for Cancer Research, CR UK Beatson Laboratories, Garscube Estate, Bearsden, Glasgow G61 1BD, Scotland, UK
Mol Cell Biol 23:1983-93. 2003..The results further suggest that RafS259 mutants inhibit signaling pathways required to promote these biological processes... - The mammalian MAPK/ERK pathway exhibits properties of a negative feedback amplifierOliver E Sturm
Department of Computing Science, University of Glasgow, Glasgow G12 8QQ, UK
Sci Signal 3:ra90. 2010..These properties determine biological behavior, including activation kinetics and the response to drugs... - The RKIP (Raf-1 Kinase Inhibitor Protein) conserved pocket binds to the phosphorylated N-region of Raf-1 and inhibits the Raf-1-mediated activated phosphorylation of MEKOliver Rath
The Beatson Institute for Cancer Research, Cancer Research UK Garscube Estate, Bearsden, Glasgow G61 1BD, UK
Cell Signal 20:935-41. 2008..Our results therefore suggest that the RKIP conserved pocket may constitute a novel phosphoamino-acid binding motif and is absolutely required for RKIP function... - Regulation and role of Raf-1/B-Raf heterodimerizationLinda K Rushworth
Signalling and Proteomics Laboratory, Beatson Institute for Cancer Research, Garscube Estate, Glasgow G61 1BD, United Kingdom
Mol Cell Biol 26:2262-72. 2006.... - Inferring signaling pathway topologies from multiple perturbation measurements of specific biochemical speciesTian Rui Xu
Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow G128QQ, UK
Sci Signal 3:ra20. 2010..Thus, our formal methodology rationally infers evidentially supported pathway topologies even when a limited number of biochemical and kinetic measurements are available... - Eukaryotic translation initiation factor 3, subunit a, regulates the extracellular signal-regulated kinase pathwayTian Rui Xu
Institute of Neuroscience and Psychology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
Mol Cell Biol 32:88-95. 2012..Thus, eIF3a is a negative modulator of ERK pathway activation and its biological effects... - The kinase domain of MEKK1 induces apoptosis by dysregulation of MAP kinase pathwaysSimone Boldt
Beatson Institute for Cancer Research, Cancer Research UK, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK
Exp Cell Res 283:80-90. 2003..This suggests that MEKK1 induces apoptosis by causing a general deregulation of MAP kinase signaling rather than by the activation of a single pathway... - MST kinases monitor actin cytoskeletal integrity and signal via c-Jun N-terminal kinase stress-activated kinase to regulate p21Waf1/Cip1 stabilityRuth M Densham
The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow G61 1BD, United Kingdom
Mol Cell Biol 29:6380-90. 2009.... - Regulation of human myoblast differentiation by PEBP4Reynaldo Garcia
Signalling and Proteomics Laboratory, The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK
EMBO Rep 10:278-84. 2009..Thus, PEBP4 participates in the control of muscle cell differentiation by modulating the activity of MEK and ERK... - Regulation of the Raf-MEK-ERK pathway by protein phosphatase 5Alex von Kriegsheim
The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK
Nat Cell Biol 8:1011-6. 2006..Furthermore, depletion of endogenous PP5 increased cellular phospho-Ser 338 levels. Our results suggest that PP5 is a physiological regulator of Raf-1 signalling pathways... - RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor proteinDavid Matallanas
Signaling and Proteomics Laboratory, The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK
Mol Cell 27:962-75. 2007..Our results describe an MST2-dependent effector pathway for RASSF1A proapoptotic signaling and indicate that silencing of RASSF1A in tumors removes a proapoptotic signal emanating from p73... - The Bcr-Abl kinase regulates the actin cytoskeleton via a GADS/Slp-76/Nck1 adaptor protein pathwayChristian Preisinger
Beatson Institute for Cancer Research, Glasgow, UK
Cell Signal 22:848-56. 2010..These findings highlight the importance of protein interaction dependent adaptor protein pathways in oncogenic kinase signaling... - Taming the Hippo: Raf-1 controls apoptosis by suppressing MST2/HippoWalter Kolch
The Beatson Institute for Cancer Research, Glasgow, UK
Cell Cycle 4:365-7. 2005..Thus, by linking mitogenic and apoptotic signalling the MST:Raf-1 complex may serve as a safeguard against unlicensed proliferation... - Cyclic AMP-dependent kinase regulates Raf-1 kinase mainly by phosphorylation of serine 259Amardeep S Dhillon
The Beatson Institute for Cancer Research, Bearsden, Glasgow G61 1BD, United Kingdom
Mol Cell Biol 22:3237-46. 2002..Using RafS259 mutants we also demonstrate that Raf-1 is the sole target for PKA inhibition of ERK and ERK-induced gene expression, and that Raf-1 inhibition is mediated mainly through serine 259 phosphorylation... - Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1Eric O'Neill
The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK
Science 306:2267-70. 2004..Conversely, depletion of Raf-1 from Raf-1+/+ mouse or human cells led to MST2 activation and apoptosis. The concomitant depletion of both Raf-1 and MST2 prevented apoptosis... - Raf kinase inhibitor protein regulation of raf and MAPK signalingSuzanne Hagan
The Beatson Institute for Cancer Research, Signalling and Proteomics Laboratory, Glasgow, United Kingdom
Methods Enzymol 407:248-59. 2006..More recently, RKIP has emerged as an important suppressor of metastasis. Here, we review the functions of RKIP and present methods to detect and measure RKIP expression and activity in cells and tissues... - A Hippo in the ointment: MST signalling beyond the flyDavid Matallanas
Signalling and Proteomics Laboratory, The Beatson Institute for Cancer Research, Bearsden, Glasgow, United Kingdom
Cell Cycle 7:879-84. 2008.... - Untying the regulation of the Raf-1 kinaseAmardeep S Dhillon
The Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories Garscube Estate, Glasgow, UK
Arch Biochem Biophys 404:3-9. 2002..KSR is a dynamic scaffold whose function and localization is regulated by phosphorylation... - Raf-1 and B-Raf promote protein kinase C theta interaction with BADAlison Hindley
Signalling and Proteomics Laboratory, The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK
Cell Signal 19:547-55. 2007.... - Engineering the serine/threonine protein kinase Raf-1 to utilise an orthogonal analogue of ATP substituted at the N6 positionAlison D Hindley
Beatson Institute for Cancer Research, G61 1BD, Glasgow, UK
FEBS Lett 556:26-34. 2004..Importantly we show that our approach can be used to tag putative direct substrates of Raf-1 kinase with (32)P-N(6)(2-phenethyl) ATP in cell lysates... - Computational modelling of cancerous mutations in the EGFR/ERK signalling pathwayRichard J Orton
Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Glasgow, UK
BMC Syst Biol 3:100. 2009..In this study, we have used computational modelling techniques to investigate what effects various cancerous alterations have on the signalling flow through the ERK pathway... - Proteomics and phosphoproteomics for the mapping of cellular signalling networksChristian Preisinger
The Beatson Institute for Cancer Research, Glasgow, UK
Proteomics 8:4402-15. 2008.... - Phosphatase and feedback regulation of Raf-1 signalingAmardeep S Dhillon
Signaling and Proteomics Group, Beatson Institute for Cancer Research, Glasgow, UK
Cell Cycle 6:3-7. 2007..Both these events require dynamic changes in Raf-1 phosphorylation. Here, we discuss the critical role of phosphatases and feedback phosphorylation during activation and inactivation of Raf-1 signaling... - Transcriptional repression of telomerase RNA gene expression by c-Jun-NH2-kinase and Sp1/Sp3Alan E Bilsland
Centre for Oncology and Applied Pharmacology, University of Glasgow, Scotland, UK
Cancer Res 66:1363-70. 2006..No corresponding changes in Sp1/Sp3 protein levels were detected. Thus, JNK represses hTR promoter activity and expression, apparently by enhancing repression through Sp3... - Chip-based dynamic real-time quantification of drug-induced cytotoxicity in human tumor cellsDonald Wlodkowic
The Bioelectronics Research Center, Department of Electronics and Electrical Engineering, University of Glasgow, G12 8LT Glasgow, UK
Anal Chem 81:6952-9. 2009.... - Cell fate decisions are specified by the dynamic ERK interactomeAlex von Kriegsheim
Signalling and Proteomics Laboratory, The Beatson Institute for Cancer Research, Glasgow G61 1BD, UK
Nat Cell Biol 11:1458-64. 2009..Integrating these data with a mathematical model confirmed that ERK dynamics and differentiation are regulated by distributed control mechanisms rather than by a single master switch... - Mapping of signaling pathways by functional interaction proteomicsAlex von Kriegsheim
Cancer Research Beatson Laboratories, Glasgow, UK
Methods Mol Biol 484:177-92. 2008..The second is the differential analysis of binding partners of the C-terminal SH3 domain of the two small adaptor proteins Grb2 and GRAP... - The role of MAPK pathways in the action of chemotherapeutic drugsSimone Boldt
The Beatson Institute for Cancer Research, Cancer Research UK, Bearsden, Glasgow G61 1BD, UK
Carcinogenesis 23:1831-8. 2002..These results suggest that the modulation of MAPK pathways to enhance the efficacy of chemotherapeutic drugs is of limited value unless it is tailored to the specific combination of drug and cancer... - Regulation of Raf-1 activation and signalling by dephosphorylationAmardeep S Dhillon
The Beatson Institute for Cancer Research, CRC Beatson Laboratories, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK
EMBO J 21:64-71. 2002..They also suggest a new model for Raf-1 activation where the release of repression through Ser259 dephosphorylation is the pivotal step... - Unique reporter-based sensor platforms to monitor signalling in cellsMeesbah Jiwaji
Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom School of Life and Health Science, Aston University, Birmingham, United Kingdom
PLoS ONE 7:e50521. 2012..However, few multiplexed methodologies are available to study cell signalling directly at the transcription factor level... - Oncogenic K-RAS is required to maintain changes in cytoskeletal organization, adhesion, and motility in colon cancer cellsClaire B Pollock
The Beatson Institute for Cancer Research, Garscube Estate, Bearsden, United Kingdom
Cancer Res 65:1244-50. 2005..Our findings suggest that mutated K-RAS oncogenes are essential for maintenance of the transformed and invasive phenotype of human colon cancer cells... - Targeting MAPK signalling: Prometheus' fire or Pandora's box?Simone Boldt
Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden Glasgow G61 1BD, UK
Curr Pharm Des 10:1885-905. 2004..Further, we critically discuss the rationale behind current strategies of using MAPK pathways as drug targets and suggest new approaches that take the complexity of MAPK signalling networks into account... - Oncogenic B-Raf mutations: crystal clear at lastAmardeep S Dhillon
The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, United Kingdom
Cancer Cell 5:303-4. 2004..A recent study in Cell by Wan et al. reports the crystal structure of the B-Raf kinase domain, providing important new insights into these questions... - Reduction of Raf-1 kinase inhibitor protein expression correlates with breast cancer metastasisSuzanne Hagan
Beatson Institute for Cancer Research, Signaling and Proteomics Laboratory, Glasgow, UK
Clin Cancer Res 11:7392-7. 2005..Therefore, we investigated whether RKIP expression is altered in clinical specimens of human primary breast cancers and their lymph node metastases... - Addressing the challenge of defining valid proteomic biomarkers and classifiersMohammed Dakna
Mosaiques Diagnostics and Therapeutics, Hannover, Germany
BMC Bioinformatics 11:594. 2010..The second urine of the morning was collected from apparently healthy male and female volunteers (aged 21-40) in the course of the routine medical check-up before recruitment at the Hannover Medical School... - Lab-on-a-chip technologies for proteomic analysis from isolated cellsH Sedgwick
Department of Electronics and Electrical Engineering, University of Glasgow, Glasgow G12 8QQ, UK
J R Soc Interface 5:S123-30. 2008..Using these same trapping electrodes, on-chip electroporation was performed, resulting in cell lysis. Protein release was monitored by confocal fluorescence microscopy... - The Raf-1 kinase associates with vimentin kinases and regulates the structure of vimentin filamentsP Janosch
The Beatson Institute for Cancer Research, Garscube Estate, Glasgow G61 1BD, U K
FASEB J 14:2008-21. 2000..The rearrangement of the vimentin network occurred independently of the MEK/ERK pathway. These data identify a new branch point in Raf-1 signaling, which links Raf-1 to changes in the cytoskeletal architecture... - Conferring specificity on the ubiquitous Raf/MEK signalling pathwayE O'Neill
Beatson Institute for Cancer Research, Switchback Road, Glasgow G61 1BD, UK
Br J Cancer 90:283-8. 2004..Here we review how Raf isozyme diversity contributes to the specification of functional diversity, in particular regarding the role of Raf isozymes in cancer... - MAP kinase signalling pathways in cancerA S Dhillon
The Beatson Institute for Cancer Research, Bearsden, Glasgow, UK
Oncogene 26:3279-90. 2007..The balance and integration between these signals may widely vary in different tumours, but are important for the outcome and the sensitivity to drug therapy... - Extracellular signal regulated kinase (ERK)/mitogen activated protein kinase (MAPK)-independent functions of Raf kinasesAlison Hindley
The Beatson Institute for Cancer Research, CRC Beatson Laboratories, Glasgow, G61 1BD, UK
J Cell Sci 115:1575-81. 2002..Other studies have suggested that Raf has kinase-independent functions and may act as a scaffold protein... - Microfluidic single cell arrays to interrogate signalling dynamics of individual, patient-derived hematopoietic stem cellsShannon L Faley
Bioelectronics Research Centre, University of Glasgow, Oakfield Avenue, Glasgow, UK G12 8LT
Lab Chip 9:2659-64. 2009..Further studies show that dasatinib does, however, markedly reduce CML stem/progenitor cell migration in situ... - On-chip immunoprecipitation for protein purificationMairi E Sandison
Integrative and Systems Biology, FBLS, University of Glasgow, Glasgow, G12 8QQ, UK
Lab Chip 10:2805-13. 2010..The optimised µIP method was used to obtain purified fractions of affinity-tagged protein from a bacterial lysate... - Computational modelling of the receptor-tyrosine-kinase-activated MAPK pathwayRichard J Orton
Bioinformatics Research Centre, Department of Computing Science, University of Glasgow, Glasgow G12 8QQ, Scotland, UK
Biochem J 392:249-61. 2005..Focusing on the MAPK pathway, we introduce the features and functions of the pathway itself before comparing the available models and describing what new biological insights they have led to... - Mammalian sterile 20-like kinases in tumor suppression: an emerging pathwayDavid Matallanas
Beatson Insitute for Cancer Research, University of Glasgow, Glasgow, United Kingdom
Cancer Res 65:5485-7. 2005.... - ERK2 drives tumour cell migration in three-dimensional microenvironments by suppressing expression of Rab17 and liprin-β2Anne von Thun
Beatson Institute for Cancer Research, Glasgow, G61 1BD, UK
J Cell Sci 125:1465-77. 2012..Importantly, knockdown of either Rab17 or liprin-β2 restores invasiveness of ERK2-depleted cells, indicating that ERK2 drives invasion of MDA-MB-231 cells by suppressing expression of these genes... - Capillary electrophoresis-mass spectrometry as a powerful tool in clinical diagnosis and biomarker discoveryWalter Kolch
The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, United Kingdom
Mass Spectrom Rev 24:959-77. 2005..Finally, the benefits and limitations of CE-MS for the analysis of proteins in clinical samples are discussed against the background of alternative technologies... - Investigating the correspondence between transcriptomic and proteomic expression profiles using coupled cluster modelsSimon Rogers
Department of Computing Science, University of Glasgow, Glasgow G128QQ, UK
Bioinformatics 24:2894-900. 2008..A major open question is whether transcriptome and proteome expression is linked and how it is coordinated... - The Renilla luciferase gene as a reference gene for normalization of gene expression in transiently transfected cellsMeesbah Jiwaji
Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK
BMC Mol Biol 11:103. 2010..We have developed and validated a normalization method for qPCR using a co-transfected plasmid... - Induction of apoptosis by protein kinase C delta is independent of its kinase activityAxel Goerke
Medical School Hanover, Department of Nephrology, Carl Neuberg Str 1, 30625 Hannover, Germany
J Biol Chem 277:32054-62. 2002..Our results indicate that distinct protein kinase C isozymes induce apoptosis in vascular smooth muscle cells. More importantly, they show that some protein kinase C effector functions are independent of the catalytic activity... - Regulation of RKIP binding to the N-region of the Raf-1 kinaseSungdae Park
Medical University of Ohio, Department of Biochemistry and Cancer Biology, 3035 Arlington Avenue, Toledo, OH 43614 5804, USA
FEBS Lett 580:6405-12. 2006.... - LPS resistance in monocytic cells caused by reverse signaling through transmembrane TNF (mTNF) is mediated by the MAPK/ERK pathwaySilvia Kirchner
Department of Hematology, University of Regensburg, Regensburg, Germany
J Leukoc Biol 75:324-31. 2004..Thus, reverse signaling achieves LPS resistance in monocytic cells through interference with key signal-transduction pathways... - Proteomic analysis of phosphorylation, oxidation and nitrosylation in signal transductionCorinne M Spickett
Department of Bioscience, University of Strathclyde, Glasgow G1 1XQ, UK
Biochim Biophys Acta 1764:1823-41. 2006.... - High-precision FLIM-FRET in fixed and living cells reveals heterogeneity in a simple CFP-YFP fusion proteinMichael Millington
Collaborative Optical Spectroscopy, Micromanipulation and Imaging Centre COSMIC, The University of Edinburgh, King s Buildings, Edinburgh EH9 3JZ, UK
Biophys Chem 127:155-64. 2007..Our results for this simple control system indicate that the in vivo FLIM-FRET studies of more complex protein-protein interactions would benefit greatly from such quantitative measurements... - Reduction in Raf kinase inhibitor protein expression is associated with increased Ras-extracellular signal-regulated kinase signaling in melanoma cell linesMarion M Schuierer
Institute of Pathology, Medical School of the University of Regensburg, Franz-Josef-Strauss-Allee 11, D-93053 Regensburg, Germany
Cancer Res 64:5186-92. 2004..Taken together, our results suggest that loss of RKIP in malignant melanoma contributes to enhanced invasiveness of transformed cells and therefore to progression of the disease... - The International Consortium on Systems Biology of Receptor Tyrosine Kinase Regulatory NetworksYoshiyuki Sakaki
Syst Biol (Stevenage) 152:53-4. 2005 - Mutationally activated K-ras 4A and 4B both mediate lung carcinogenesisCharles E Patek
Sir Alastair Currie Cancer Research UK Laboratories, Molecular Medicine Centre, The University of Edinburgh, Western General Hospital, Edinburgh, UK
Exp Cell Res 314:1105-14. 2008.... - Raf kinase inhibitor protein expression in a survival analysis of colorectal cancer patientsFahd Al-Mulla
Kuwait University, Faculty of Medicine, Safat, Kuwait
J Clin Oncol 24:5672-9. 2006..We examined whether RKIP expression in primary colorectal cancers (CRCs) correlates with the risk of metastasis and overall survival... - Modeling and simulation of intracellular dynamics: choosing an appropriate frameworkOlaf Wolkenhauer
Systems Biology and Bioinformatics Group, University of Rostock, Rostock 18051, Germany
IEEE Trans Nanobioscience 3:200-7. 2004.... - Giving space to cell signalingBoris N Kholodenko
Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
Cell 133:566-7. 2008..In this issue, Neves et al. (2008) report how the propagation of spatial information is controlled by the shape of hippocampal neurons and feedback and feed-forward motifs of the beta-adrenergic receptor signaling pathway... - Microarray-formatted clinical biomarker assay development using peptide aptamers to anterior gradient-2Euan Murray
CRUK p53 Signal Transduction Group, Cell Signalling Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, United Kingdom
Biochemistry 46:13742-51. 2007.... - Clinical proteomics: a question of technologyWalter Kolch
Rapid Commun Mass Spectrom 18:2365-6. 2004