T Kobayashi

Summary

Affiliation: University of Dundee
Country: UK

Publications

  1. pmc Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2
    T Kobayashi
    MRC Protein Phosphorylation Unit, Department of Biochemistry, University of Dundee, MSI WTB complex, Dow Street, Dundee DD1 5EH, Scotland, UK
    Biochem J 339:319-28. 1999
  2. pmc Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase
    T Kobayashi
    MRC Protein Phosphorylation Unit, Department of Biochemistry, MSI WTB complex, Dow Street, University of Dundee, Dundee DD1 5EH, Scotland, U K
    Biochem J 344:189-97. 1999
  3. ncbi request reprint Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast
    A Casamayor
    MRC Protein Phosphorylation Unit Department of Biochemistry University of Dundee Dundee DD1 5EH Scotland UK
    Curr Biol 9:186-97. 1999
  4. ncbi request reprint IGF-1 up-regulates K+ channels via PI3-kinase, PDK1 and SGK1
    N Gamper
    Sechenov Institute of Evolutionary Physiology and Biochemistry, St Petersburg, Russia
    Pflugers Arch 443:625-34. 2002
  5. ncbi request reprint K+ channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK
    N Gamper
    Department of Physiology, University of Tuebingen, Germany
    Pflugers Arch 445:60-6. 2002
  6. ncbi request reprint An adult-type metachromatic leukodystrophy caused by substitution of serine for glycine-122 in arylsulfatase A
    K Honke
    Biochemistry Laboratory, Hokkaido University School of Medicine, Sapporo, Japan
    Hum Genet 92:451-6. 1993
  7. ncbi request reprint Molecular cloning of MINK, a novel member of mammalian GCK family kinases, which is up-regulated during postnatal mouse cerebral development
    I Dan
    Kusumi Membrane Organizer Project, ERATO, JST, 5 11 33 Chiyoda, Nagoya, Japan
    FEBS Lett 469:19-23. 2000
  8. ncbi request reprint Amino acid residues conferring ligand binding properties of prostaglandin I and prostaglandin D receptors. Identification by site-directed mutagenesis
    T Kobayashi
    Department of Pharmacology, Faculty of Medicine, Kyoto University, Kyoto 606 8501, Japan
    J Biol Chem 275:24294-303. 2000
  9. ncbi request reprint The phosphoinositide-3 kinase gamma-Akt pathway mediates renal tubular injury in cisplatin nephrotoxicity
    H Kuwana
    Department of Nephrology and Blood Purification, Tokyo Medical and Dental University, Tokyo, Japan
    Kidney Int 73:430-45. 2008
  10. ncbi request reprint In vivo and in vitro analyses of the AmyR binding site of the Aspergillus nidulans agdA promoter; requirement of the CGG direct repeat for induction and high affinity binding of AmyR
    S Tani
    Department of Biological Mechanisms and Functions, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya-shi, Aichi, Japan
    Biosci Biotechnol Biochem 65:1568-74. 2001

Collaborators

Detail Information

Publications62

  1. pmc Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2
    T Kobayashi
    MRC Protein Phosphorylation Unit, Department of Biochemistry, University of Dundee, MSI WTB complex, Dow Street, Dundee DD1 5EH, Scotland, UK
    Biochem J 339:319-28. 1999
    ..These findings raise the possibility that some physiological roles ascribed to PKB on the basis of the overexpression of constitutively active PKB mutants might be mediated by SGK...
  2. pmc Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase
    T Kobayashi
    MRC Protein Phosphorylation Unit, Department of Biochemistry, MSI WTB complex, Dow Street, University of Dundee, Dundee DD1 5EH, Scotland, U K
    Biochem J 344:189-97. 1999
    ..Like PKB and SGK1, SGK2 and SGK3 preferentially phosphorylate Ser and Thr residues that lie in Arg-Xaa-Arg-Xaa-Xaa-Ser/Thr motifs...
  3. ncbi request reprint Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast
    A Casamayor
    MRC Protein Phosphorylation Unit Department of Biochemistry University of Dundee Dundee DD1 5EH Scotland UK
    Curr Biol 9:186-97. 1999
    ....
  4. ncbi request reprint IGF-1 up-regulates K+ channels via PI3-kinase, PDK1 and SGK1
    N Gamper
    Sechenov Institute of Evolutionary Physiology and Biochemistry, St Petersburg, Russia
    Pflugers Arch 443:625-34. 2002
    ..In conclusion, IGF-1 through PI3-kinase, PDK1 and SGK1 up-regulates Kv channels, an effect required for the proliferative action of the growth factor...
  5. ncbi request reprint K+ channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK
    N Gamper
    Department of Physiology, University of Tuebingen, Germany
    Pflugers Arch 445:60-6. 2002
    ..The present observations thus reveal a powerful stimulating effect of all three isoforms of SGK on K(+) channels. Those effects may participate in regulation of epithelial transport, cell proliferation, and neuromuscular excitability...
  6. ncbi request reprint An adult-type metachromatic leukodystrophy caused by substitution of serine for glycine-122 in arylsulfatase A
    K Honke
    Biochemistry Laboratory, Hokkaido University School of Medicine, Sapporo, Japan
    Hum Genet 92:451-6. 1993
    ..In a transient expression study, COS cells transfected with the mutant cDNA carrying 122Gly-->Ser did not show an increase of ASA activity and produced little material immunoreactive to an anti-ASA antibody, despite normal mRNA levels...
  7. ncbi request reprint Molecular cloning of MINK, a novel member of mammalian GCK family kinases, which is up-regulated during postnatal mouse cerebral development
    I Dan
    Kusumi Membrane Organizer Project, ERATO, JST, 5 11 33 Chiyoda, Nagoya, Japan
    FEBS Lett 469:19-23. 2000
    ..The expression of MINK is up-regulated during the postnatal development of the mouse brain. MINK activates the cJun N-terminal kinase and the p38 pathways...
  8. ncbi request reprint Amino acid residues conferring ligand binding properties of prostaglandin I and prostaglandin D receptors. Identification by site-directed mutagenesis
    T Kobayashi
    Department of Pharmacology, Faculty of Medicine, Kyoto University, Kyoto 606 8501, Japan
    J Biol Chem 275:24294-303. 2000
    ....
  9. ncbi request reprint The phosphoinositide-3 kinase gamma-Akt pathway mediates renal tubular injury in cisplatin nephrotoxicity
    H Kuwana
    Department of Nephrology and Blood Purification, Tokyo Medical and Dental University, Tokyo, Japan
    Kidney Int 73:430-45. 2008
    ..Our results suggest that the PI3K-gamma-Akt pathway lessens apoptosis and plays a critical role in the maintenance of renal function in cisplatin-induced acute kidney injury...
  10. ncbi request reprint In vivo and in vitro analyses of the AmyR binding site of the Aspergillus nidulans agdA promoter; requirement of the CGG direct repeat for induction and high affinity binding of AmyR
    S Tani
    Department of Biological Mechanisms and Functions, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya-shi, Aichi, Japan
    Biosci Biotechnol Biochem 65:1568-74. 2001
    ....
  11. pmc Dominant localization of prostaglandin D receptors on arachnoid trabecular cells in mouse basal forebrain and their involvement in the regulation of non-rapid eye movement sleep
    A Mizoguchi
    Department of Anatomy and Neurobiology, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Proc Natl Acad Sci U S A 98:11674-9. 2001
    ..These results indicate that DPs in the arachnoid trabecular cells of the basal forebrain mediate an increase in the extracellular adenosine level and sleep induction by PGD(2)...
  12. pmc Ski7p G protein interacts with the exosome and the Ski complex for 3'-to-5' mRNA decay in yeast
    Y Araki
    Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo 113 0033, Japan
    EMBO J 20:4684-93. 2001
    ..Thus, Ski7p G protein appears to function as a signal-coupling factor between the two multi-complexes operating in the 3'-to-5' mRNA-decay pathway...
  13. ncbi request reprint Two subtypes of androgen and progestogen receptors in fish testes
    T Ikeuchi
    Laboratory of Reproductive Biology, National Institute for Basic Biology, 444-8585, Okazaki, Japan
    Comp Biochem Physiol B Biochem Mol Biol 129:449-55. 2001
    ..These results clearly indicate that two functional subtypes of AR and PR exist in eel. These findings will advance our understanding of the mechanisms underlying sex steroid signaling...
  14. ncbi request reprint Effect of glucocorticoid on expression of rat MUC5AC mRNA in rat gastric mucosa in vivo and in vitro
    T Tanaka
    Faculty of Pharmaceutical Sciences, Josai University, Sakado, Saitama, Japan
    Biol Pharm Bull 24:634-7. 2001
    ..However, high dose of hydrocortisone directly suppressed the expression of rMUC5AC mRNA. These results suggested that hydrocortisone might directly cause the suppression and indirectly the enhancement of the mucin biosynthesis...
  15. ncbi request reprint Thermostabilization by replacement of specific residues with lysine in a Bacillus alkaline cellulase: building a structural model and implications of newly formed double intrahelical salt bridges
    T Ozawa
    Tochigi Research Laboratories, Kao Corporation, 2606 Akabane, Ichikai, Haga, Tochigi 321-3497, Japan
    Protein Eng 14:501-4. 2001
    ..These results confirm that the formation of these double intrahelical ion pairs (salt bridges) is responsible for the thermostabilization by the double mutation...
  16. ncbi request reprint The N-terminal internal region of BLM is required for the formation of dots/rod-like structures which are associated with SUMO-1
    H Suzuki
    Molecular Cell Biology Laboratory, Tohoku University, Sendai, Miyagi, 980 8578, Japan
    Biochem Biophys Res Commun 286:322-7. 2001
    ....
  17. ncbi request reprint Activation of c-Jun amino-terminal kinase is required for retinoic acid-induced neural differentiation of P19 embryonal carcinoma cells
    H Wang
    Department of Biochemistry, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    FEBS Lett 503:91-6. 2001
    ..Studies using protein phosphatase inhibitors and protein kinase inhibitors suggested that both okadaic acid-sensitive protein phosphatase(s) and protein kinase C participate in the RA-induced activation of JNK...
  18. ncbi request reprint A potential role for human cohesin in mitotic spindle aster assembly
    H C Gregson
    Department of Biological Chemistry, College of Medicine, University of California, Irvine, CA 92697 1700, USA
    J Biol Chem 276:47575-82. 2001
    ..Our results raise the intriguing possibility that in addition to its well demonstrated function in sister chromatid cohesion, cohesin may be involved in spindle assembly during mitosis...
  19. ncbi request reprint Heat-inducible TNF-alpha gene therapy combined with hyperthermia using magnetic nanoparticles as a novel tumor-targeted therapy
    A Ito
    Department of Biotechnology, Graduate School of Engineering, Nagoya University, Nagoya 464-8603, Japan
    Cancer Gene Ther 8:649-54. 2001
    ..The combined treatment strongly arrested tumor growth in nude mice over a 30-day period, suggesting potential for cancer treatment...
  20. ncbi request reprint Physical and inflammatory stressors elevate circadian clock gene mPer1 mRNA levels in the paraventricular nucleus of the mouse
    S Takahashi
    Department of Pharmacology and Brain Science, School of Human Sciences, Waseda University, Tokorozawa, Saitama, Japan 359-1192
    Endocrinology 142:4910-7. 2001
    ..The present study suggests that a stress-induced disturbance of circadian corticosterone secretion may be associated with the stress-induced expression of mPer1 mRNA in the PVN...
  21. doi request reprint The G1556S-type tuberin variant suppresses tumor formation in tuberous sclerosis 2 mutant (Eker) rats despite its deficiency in mTOR inhibition
    M Shiono
    Department of Pathology and Oncology, Juntendo University School of Medicine, Tokyo, Japan
    Oncogene 27:6690-7. 2008
    ..Identification of such a novel pathway will provide clear implications for generation of new therapeutic targets in the treatment of these tumors...
  22. doi request reprint Interaction of folliculin (Birt-Hogg-Dubé gene product) with a novel Fnip1-like (FnipL/Fnip2) protein
    Y Takagi
    Department of Pathology and Oncology, Juntendo University School of Medicine, Bunkyo ku, Tokyo, Japan
    Oncogene 27:5339-47. 2008
    ..These results suggest that Flcn-FnipL/Fnip2 and Flcn-Fnip1 complexes positively regulate S6K1 phosphorylation and that FnipL/Fnip2 provides an important clue to elucidating the function of Flcn and the pathogenesis of BHD...
  23. ncbi request reprint Adenovirus-mediated REIC/Dkk-3 gene transfer inhibits tumor growth and metastasis in an orthotopic prostate cancer model
    K Edamura
    Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Cancer Gene Ther 14:765-72. 2007
    ..We thus concluded that in situ Ad-REIC/Dkk-3 gene transfer may be a promising therapeutic intervention modality for the treatment of prostate cancer...
  24. ncbi request reprint Rho-associated kinase inhibitor reduces tumor recurrence after liver transplantation in a rat hepatoma model
    T Ogawa
    Second Department of Surgery, Faculty of Medicine, Hirashima University, Hiroshima, Japan
    Am J Transplant 7:347-55. 2007
    ....
  25. ncbi request reprint QTL analysis of Fusarium head blight resistance using a high-density linkage map in barley
    K Hori
    Research Institute for Bioresources, Okayama University, Chuo, Kurashiki 710 0046, Japan
    Theor Appl Genet 111:1661-72. 2005
    ..In contrast, RI lines with three susceptible alleles showed reactions close to H.E.S. 4. Therefore, the markers closely linked to the QTL can be efficiently used for the selection of resistance...
  26. ncbi request reprint A novel polymorphism of FcalphaRI (CD89) associated with aggressive periodontitis
    S Kaneko
    Division of Periodontology, Department of Oral Biological Science, Niigata University, Graduate School of Medical and Dental Sciences, Niigata, Japan
    Tissue Antigens 63:572-7. 2004
    ..These results document a genetic polymorphism at the FcalphaRI ligand-binding site to be associated with susceptibility to AGP...
  27. ncbi request reprint FcgammaRIIB gene polymorphisms in Japanese periodontitis patients
    K Yasuda
    Division of Periodontology, Department of Oral Biological Science, Niigata University, Graduate School of Medical and Dental Sciences, Gakkocho dori, Niigata, Japan
    Genes Immun 4:541-6. 2003
    ..011). These results document the association of FcgammaRIIB gene polymorphisms with susceptibility to periodontitis in the Japanese...
  28. ncbi request reprint Molecular analyses of Machado-Joseph disease
    T Kobayashi
    Graduate School of Biostudies, Kyoto University, Kyoto, and CREST, Japan Science and Technology Corporation, Japan
    Cytogenet Genome Res 100:261-75. 2003
  29. ncbi request reprint Seven single nucleotide substitutions in human Fc(gamma) receptor IIB gene
    K Yasuda
    Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Tissue Antigens 58:339-42. 2001
    ..These substitutions were found to be located in the ligand-binding domain and the intron, which might alter the function of Fc(gamma)RIIb...
  30. ncbi request reprint Molecular cloning and sequencing of the gene encoding an exopolygalacturonase of a Bacillus isolate and properties of its recombinant enzyme
    K Sawada
    Tochigi Research Laboratories, Kao Corporation, 2606 Akabane, Ichikai, Haga, 321-3497 Tochigi, Japan
    Biochim Biophys Acta 1568:162-70. 2001
    ..30% identity for both. High homology was observed in a suitably aligned internal region of the three enzymes (65% identity), and some of the conserved aa residues appeared to form the catalytic core of the enzymes...
  31. ncbi request reprint Cloning and characterization of the T-box gene Tbx6 in Xenopus laevis
    H Uchiyama
    Graduate School of Integrated Science, Yokohama City University, 22 2 Seto, Kanazawa Ku, Yokohama 236 0027, Japan
    Dev Growth Differ 43:657-69. 2001
    ..These results suggest that Tbx6 is implicated in ventral mesoderm specification but is involved in muscle differentiation when acting together with the dorsalizing factor noggin...
  32. ncbi request reprint CD9 amino acids critical for upregulation of diphtheria toxin binding
    H Hasuwa
    Division of Cell Biology, Kurume University, Kurume, Fukuoka, 839 0861, Japan
    Biochem Biophys Res Commun 289:782-90. 2001
    ....
  33. pmc hADA3 is required for p53 activity
    T Wang
    Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    EMBO J 20:6404-13. 2001
    ..This interaction is enhanced dramatically after DNA damage due to phosphorylation event(s) in the p53 N-terminus. Proper hADA3 function is essential for full transcriptional activity of p53 and p53-mediated apoptosis...
  34. ncbi request reprint Calcium- and magnesium-dependent interactions between the C-terminus of troponin I and the N-terminal, regulatory domain of troponin C
    J Digel
    Medical Biotechnology Center, University of Maryland Biotechnology Institute, Baltimore 21201, USA
    Arch Biochem Biophys 387:243-9. 2001
    ..Our results provide the first indica- tion that the C-terminus of TnI may play an important role in the regulation of vertebrate striated muscle through Ca2+-dependent interactions with the regula- tory domain of TnC...
  35. ncbi request reprint Enzymatic properties of the highly thermophilic and alkaline pectate lyase Pel-4B from alkaliphilic Bacillus sp. strain P-4-N and the entire nucleotide and amino acid sequences
    Y Hatada
    Tochigi Research Laboratories of Kao Corporation, Haga, Japan
    Extremophiles 5:127-33. 2001
    ..strains KSM-P7 and KSM-P103 and the fungi Aspergillus nidulans and Colletotrichum gloeosporioides f. sp. malvae...
  36. ncbi request reprint Two novel mutations (C53S, S26L) in the connexin32 of Charcot-Marie-Tooth disease type X families
    T Yoshimura
    Department of Neurology, Neurological Institute, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Hum Mutat 8:270-2. 1996
  37. ncbi request reprint Purification and characterization of 3'-phosphoadenosine-5'-phosphosulfate:GalCer sulfotransferase from human renal cancer cells
    K Honke
    Biochemistry Laboratory, Hokkaido University School of Medicine, Sapporo
    J Biochem 119:421-7. 1996
    ..Neither galactose nor lactose served as an acceptor. These observations suggest that the sulfotransferase prefers beta-glycoside, especially beta-galactoside, at the nonreducing termini of sugar chains attached to a lipid moiety...
  38. ncbi request reprint Structural dimorphism in the mitochondrial targeting sequence in the human manganese superoxide dismutase gene. A predictive evidence for conformational change to influence mitochondrial transport and a study of allelic association in Parkinson's disease
    S Shimoda-Matsubayashi
    Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
    Biochem Biophys Res Commun 226:561-5. 1996
    ..An association study using this polymorphism showed significant allelic deviation for -9Ala allele (12.1% vs. 19.3%) in Parkinson's disease...
  39. ncbi request reprint A novel emerin mutation in a Japanese patient with Emery-Dreifuss muscular dystrophy
    T Yamada
    Department of Neurology, Neurological Institute, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Hum Genet 97:693-4. 1996
    ..This deletion causes a frameshift, changing the amino acid sequence (amino acids 206-235) and generating an early stop codon...
  40. ncbi request reprint Characterization of a mouse recA-like gene specifically expressed in testis
    S Sato
    Kazusa DNA Research Institute, Chiba, Japan
    DNA Res 2:147-50. 1995
    ..Reverse transcription-PCR using poly(A)+ RNAs from various tissues as templates indicated that transcription of MmLim15 occurred specifically in the testis, suggesting that the MmLim15 product participates in meiotic recombination...
  41. ncbi request reprint Functional analysis of the slaty gene product (TRP2) as dopachrome tautomerase and the effect of a point mutation on its catalytic function
    G Kroumpouzos
    Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
    Biochem Biophys Res Commun 202:1060-8. 1994
    ..We further demonstrate that the slaty mutation dramatically decreases the catalytic function of the protein...
  42. ncbi request reprint Purification and characterization of lysophospholipase L2 of Escherichia coli K-12
    K Karasawa
    J Biochem 98:1117-25. 1985
    ..coli K-12 homogenates [Doi, O. & Nojima, S. (1975) J. Biol. Chem. 250, 5208-5214]...
  43. pmc Tyrosinase related protein 1 (TRP1) functions as a DHICA oxidase in melanin biosynthesis
    T Kobayashi
    Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
    EMBO J 13:5818-25. 1994
    ..This enzyme activity appears to be essential to the further metabolism of DHICA to a high molecular weight pigmented biopolymer...
  44. ncbi request reprint Molecular cloning and expression of mouse mg(2+)-dependent protein phosphatase beta-4 (type 2C beta-4)
    S Kato
    Department of Biochemistry, Tohoku University, Sendai, Japan
    Arch Biochem Biophys 318:387-93. 1995
    ..These results suggest that the complex structure of MPP beta isoforms and their tissue- and developmental stage-specific expression reflect the variety of their physiological functions...
  45. ncbi request reprint Isolation of a cDNA for a growth factor of vascular endothelial cells from human lung cancer cells: its identity with insulin-like growth factor II
    K Hagiwara
    Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo
    Jpn J Cancer Res 86:202-7. 1995
    ..The nucleotide sequence encoded by the cDNA proved to be identical with that of insulin-like growth factor II...
  46. ncbi request reprint A germline insertion in the tuberous sclerosis (Tsc2) gene gives rise to the Eker rat model of dominantly inherited cancer
    T Kobayashi
    Department of Experimental Pathology, Cancer Institute, Tokyo, Japan
    Nat Genet 9:70-4. 1995
    ..The Eker rat may therefore provide insights into species-specific differences in tumourigenesis and/or phenotype-specific mutations...
  47. ncbi request reprint Molecular cloning of a mouse G-protein-activated K+ channel (mGIRK1) and distinct distributions of three GIRK (GIRK1, 2 and 3) mRNAs in mouse brain
    T Kobayashi
    Department of Neuropathology, Niigata University, Japan
    Biochem Biophys Res Commun 208:1166-73. 1995
    ....
  48. ncbi request reprint Differentiation-dependent enhanced expression of protein phosphatase 2Cbeta in germ cells of mouse seminiferous tubules
    S Kato
    Department of Biochemistry, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    FEBS Lett 396:293-7. 1996
    ....
  49. ncbi request reprint Identification of a leader exon and a core promoter for the rat tuberous sclerosis 2 (Tsc2) gene and structural comparison with the human homolog
    T Kobayashi
    Department of Experimental Pathology, Cancer Institute, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo 170, Japan
    Mamm Genome 8:554-8. 1997
    ..Characterization of the 5' region of Tsc2 and TSC2 will facilitate studies of the regulation of the gene and its disregulation in tumorigenesis...
  50. ncbi request reprint Construction of tumor-specific cells expressing a membrane-anchored single-chain Fv of anti-ErbB-2 antibody
    M Suzuki
    Department of Biotechnology, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, 464-8603, Nagoya, Japan
    Biochim Biophys Acta 1525:191-6. 2001
    ..The fabricated cells have the potential to serve as drug carriers in drug targeting applications...
  51. ncbi request reprint Enhanced nucleophilicity and depressed electrophilicity of peroxide by zinc(II), aluminum(III) and lanthanum(III) ions
    S Nishino
    Department of Chemistry, Faculty of Science, Yamagata University, Japan
    Z Naturforsch C 56:138-43. 2001
    ..This gives an important information to elucidate the fact that La3+ can enhance the growth of plants under certain conditions...
  52. ncbi request reprint Inhibition of pseudorabies virus replication by a dominant-negative mutant of early protein 0 expressed in a tetracycline-regulated system
    T Tasaki
    Laboratory of Animal Experiment for Disease Model, Institute for Genetic Medicine, Hokkaido University, 060-0815, Sapporo, Japan
    Vet Microbiol 78:195-203. 2001
    ..The present results suggest that the EP0 mutant may not alter the efficiency of the viral gene transcription but rather translation efficiency of the viral mRNA...
  53. ncbi request reprint p57(Kip2) regulates the proper development of labyrinthine and spongiotrophoblasts
    K Takahashi
    Molecular Oncology Group, Nippon Roche Research Center 200, Kajiwara, Kamakura, Kanagawa 247 8530, Japan
    Mol Hum Reprod 6:1019-25. 2000
    ..It is, therefore, suggested that p57(Kip2) protein might have an unknown role...
  54. ncbi request reprint An Aspergillus oryzae CCAAT-binding protein, AoCP, is involved in the high-level expression of the Taka-amylase A gene
    A Tanaka
    Department of Biological Mechanisms and Functions, Graduate School of Bioagricultural Sciences, Nagoya University, Japan
    Curr Genet 37:380-7. 2000
    ..nidulans eglA gene, encoding an endo-beta-1,4-glucanase, in the deletion strain. These results indicate functional interchangeability of the genes from two species...
  55. ncbi request reprint Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid
    K Bandoh
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Biol Chem 274:27776-85. 1999
    ....
  56. ncbi request reprint Pelizaeus-Merzbacher disease: three novel mutations and implication for locus heterogeneity
    H Osaka
    Department of Pediatrics, School of Medicine, Yokohama City University, Yokohama, Japan
    Ann Neurol 45:59-64. 1999
    ..Moreover, in one family 3 patients exhibited a intragenic polymorphism that did not segregate with the disease, suggesting a locus heterogeneity for Pelizaeus-Merzbacher disease...
  57. ncbi request reprint A novel immediate early response gene, IEX-1, is induced by ultraviolet radiation in human keratinocytes
    R Kumar
    Nephrology Research Unit, Mayo Clinic and Foundation, Rochester, Minnesota, 55905, USA
    Biochem Biophys Res Commun 253:336-41. 1998
    ..Epidermal growth factor (EGF), a major mitogen of keratinocytes, and a tumor-promoting phorbol ester increase IEX-1 mRNA expression. IEX-1 may play a role in keratinocyte proliferation especially following UVR...
  58. ncbi request reprint Tyrosinase stabilization by Tyrp1 (the brown locus protein)
    T Kobayashi
    Laboratory of Cell Biology, NCI, National Institutes of Health, Bethesda Maryland 20892, USA
    J Biol Chem 273:31801-5. 1998
    ..In sum, these results suggest that, in addition to its catalytic function in oxidizing DHICA, Tyrp1 may play an important role in stabilizing Tyr, a second potential role in the regulation of melanin formation...
  59. ncbi request reprint Regulation of a novel immediate early response gene, IEX-1, in keratinocytes by 1alpha,25-dihydroxyvitamin D3
    T Kobayashi
    Departments of Medicine, Molecular Biology, Mayo Clinic and Foundation, Rochester, Minnesota, 55905, USA
    Biochem Biophys Res Commun 251:868-73. 1998
    ....
  60. ncbi request reprint Point mutations (Thr240Arg and Gln311Stop) [correction of Thr240Arg and Ala311Stop] in the Parkin gene
    N Hattori
    Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
    Biochem Biophys Res Commun 249:754-8. 1998
    ..Identification of its mutation provides an important clue as to the role of the Parkin protein in degeneration of the substantia nigra in the brain of AR-JP patients...
  61. ncbi request reprint Cloning and characterization of the 5'-flanking region of the mouse diastrophic dysplasia sulfate transporter gene
    T Kobayashi
    Department of Medicine, Kobe University School of Medicine, Japan
    Biochem Biophys Res Commun 238:738-43. 1997
    ..The present data suggest that the DTDST gene expression in osteoblasts and differentiating precursor cells to osteoblast/chondrocyte lineage would be mainly regulated by undetermined XRE binding transcription factors...
  62. pmc Cloning of the cDNA encoding a novel rat mast-cell proteinase, rMCP-3, and its expression in comparison with other rat mast-cell proteinases
    H Ide
    Department of Parasitology, Miyazaki Medical College, Japan
    Biochem J 311:675-80. 1995
    ....