J C Knight
Affiliation: University of Oxford
- A polymorphism that affects OCT-1 binding to the TNF promoter region is associated with severe malariaJ C Knight
Molecular Infectious Diseases Group, Institute of Molecular Medicine, Oxford, UK
Nat Genet 22:145-50. 1999....
- The malarial fever response--pathogenesis, polymorphism and prospects for interventionD Kwiatkowski
Department of Paediatrics, John Radcliffe Hospital, Oxford, U K
Ann Trop Med Parasitol 91:533-42. 1997..Our understanding of these processes, which are potentially of considerable therapeutic relevance, remains very limited at both the molecular and the epidemiological level...
- Complex NF-kappaB interactions at the distal tumor necrosis factor promoter region in human monocytesI A Udalova
Oxford University Department of Paediatrics, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom
J Biol Chem 273:21178-86. 1998..These findings suggest that NF-kappaB acts in a complex manner to activate TNF transcription in human monocytes...
- Severe malarial anemia and cerebral malaria are associated with different tumor necrosis factor promoter allelesW McGuire
Department of Paediatrics, John Radcliffe Hospital, Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom
J Infect Dis 179:287-90. 1999..5 (P<.001) after stratification for HLA type. These findings suggest that severe malarial anemia and cerebral malaria are influenced by separate genetic factors situated near the TNF gene...
- Increased in vivo transcription of an IL-8 haplotype associated with respiratory syncytial virus disease-susceptibilityD Hacking
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
Genes Immun 5:274-82. 2004....
- Genetics and the general physician: insights, applications and future challengesJ C Knight
Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford, OX3 7BN, UK
QJM 102:757-72. 2009..There is also a need for a broader debate about the ethical implications of current advances in genetics for medicine and society...
- Clustered organization of Krüppel zinc-finger genes at Xp11.23, flanking a translocation breakpoint at OATL1: a physical map with locus assignments for ZNF21, ZNF41, ZNF81, and ELK1J C Knight
Department of Histopathology, St Thomas s Hospital, UMDS, London, United Kingdom
Genomics 21:180-7. 1994..ZNF41 maps to a 440-kb YAC spanning this region, while a more proximal cluster comprising the ZNF21 and ZNF81 genes lies 150 kb distal to the chromosome breakpoint associated with synovial sarcoma...
- A third distinct tumor necrosis factor receptor of orthopoxvirusesV N Loparev
Poxvirus Section, Viral Exanthems and Herpesvirus Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Proc Natl Acad Sci U S A 95:3786-91. 1998..Possessing up to three TNFRs, including CrmD, which is secreted as disulfide-linked complexes in varied amounts by CPV and ECT, likely enhances the dynamics of the immune modulating mechanisms of orthopoxviruses...