J C Knight

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi request reprint A polymorphism that affects OCT-1 binding to the TNF promoter region is associated with severe malaria
    J C Knight
    Molecular Infectious Diseases Group, Institute of Molecular Medicine, Oxford, UK
    Nat Genet 22:145-50. 1999
  2. ncbi request reprint The malarial fever response--pathogenesis, polymorphism and prospects for intervention
    D Kwiatkowski
    Department of Paediatrics, John Radcliffe Hospital, Oxford, U K
    Ann Trop Med Parasitol 91:533-42. 1997
  3. ncbi request reprint Complex NF-kappaB interactions at the distal tumor necrosis factor promoter region in human monocytes
    I A Udalova
    Oxford University Department of Paediatrics, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom
    J Biol Chem 273:21178-86. 1998
  4. ncbi request reprint Severe malarial anemia and cerebral malaria are associated with different tumor necrosis factor promoter alleles
    W McGuire
    Department of Paediatrics, John Radcliffe Hospital, Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom
    J Infect Dis 179:287-90. 1999
  5. ncbi request reprint Increased in vivo transcription of an IL-8 haplotype associated with respiratory syncytial virus disease-susceptibility
    D Hacking
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Genes Immun 5:274-82. 2004
  6. pmc Genetics and the general physician: insights, applications and future challenges
    J C Knight
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford, OX3 7BN, UK
    QJM 102:757-72. 2009
  7. ncbi request reprint Clustered organization of Krüppel zinc-finger genes at Xp11.23, flanking a translocation breakpoint at OATL1: a physical map with locus assignments for ZNF21, ZNF41, ZNF81, and ELK1
    J C Knight
    Department of Histopathology, St Thomas s Hospital, UMDS, London, United Kingdom
    Genomics 21:180-7. 1994
  8. pmc A third distinct tumor necrosis factor receptor of orthopoxviruses
    V N Loparev
    Poxvirus Section, Viral Exanthems and Herpesvirus Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Proc Natl Acad Sci U S A 95:3786-91. 1998

Collaborators

Detail Information

Publications8

  1. ncbi request reprint A polymorphism that affects OCT-1 binding to the TNF promoter region is associated with severe malaria
    J C Knight
    Molecular Infectious Diseases Group, Institute of Molecular Medicine, Oxford, UK
    Nat Genet 22:145-50. 1999
    ....
  2. ncbi request reprint The malarial fever response--pathogenesis, polymorphism and prospects for intervention
    D Kwiatkowski
    Department of Paediatrics, John Radcliffe Hospital, Oxford, U K
    Ann Trop Med Parasitol 91:533-42. 1997
    ..Our understanding of these processes, which are potentially of considerable therapeutic relevance, remains very limited at both the molecular and the epidemiological level...
  3. ncbi request reprint Complex NF-kappaB interactions at the distal tumor necrosis factor promoter region in human monocytes
    I A Udalova
    Oxford University Department of Paediatrics, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom
    J Biol Chem 273:21178-86. 1998
    ..These findings suggest that NF-kappaB acts in a complex manner to activate TNF transcription in human monocytes...
  4. ncbi request reprint Severe malarial anemia and cerebral malaria are associated with different tumor necrosis factor promoter alleles
    W McGuire
    Department of Paediatrics, John Radcliffe Hospital, Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom
    J Infect Dis 179:287-90. 1999
    ..5 (P<.001) after stratification for HLA type. These findings suggest that severe malarial anemia and cerebral malaria are influenced by separate genetic factors situated near the TNF gene...
  5. ncbi request reprint Increased in vivo transcription of an IL-8 haplotype associated with respiratory syncytial virus disease-susceptibility
    D Hacking
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Genes Immun 5:274-82. 2004
    ....
  6. pmc Genetics and the general physician: insights, applications and future challenges
    J C Knight
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford, OX3 7BN, UK
    QJM 102:757-72. 2009
    ..There is also a need for a broader debate about the ethical implications of current advances in genetics for medicine and society...
  7. ncbi request reprint Clustered organization of Krüppel zinc-finger genes at Xp11.23, flanking a translocation breakpoint at OATL1: a physical map with locus assignments for ZNF21, ZNF41, ZNF81, and ELK1
    J C Knight
    Department of Histopathology, St Thomas s Hospital, UMDS, London, United Kingdom
    Genomics 21:180-7. 1994
    ..ZNF41 maps to a 440-kb YAC spanning this region, while a more proximal cluster comprising the ZNF21 and ZNF81 genes lies 150 kb distal to the chromosome breakpoint associated with synovial sarcoma...
  8. pmc A third distinct tumor necrosis factor receptor of orthopoxviruses
    V N Loparev
    Poxvirus Section, Viral Exanthems and Herpesvirus Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Proc Natl Acad Sci U S A 95:3786-91. 1998
    ..Possessing up to three TNFRs, including CrmD, which is secreted as disulfide-linked complexes in varied amounts by CPV and ECT, likely enhances the dynamics of the immune modulating mechanisms of orthopoxviruses...