Affiliation: University of Oxford
- Dimethyl sulfoxide (DMSO) exposure to human peripheral blood mononuclear cells (PBMCs) abolish T cell responses only in high concentrations and following coincubation for more than two hoursHenrik Kloverpris
Department of Virology, Statens Serum Institut, Denmark
J Immunol Methods 356:70-8. 2010..In contrast, >2% for >2 hours compromises these responses. These data are relevant in the design of immunotherapies based on pulsing a large number of peptides onto antigen presenting cells prior to reinfusion...
- HIV control through a single nucleotide on the HLA-B locusHenrik N Kløverpris
Department of Paediatrics, University of Oxford, Oxford, United Kingdom
J Virol 86:11493-500. 2012..This naturally controlled experiment represents perhaps the clearest demonstration of the direct impact of a particular HIV-specific CTL on disease control...
- HLA-B*57 Micropolymorphism shapes HLA allele-specific epitope immunogenicity, selection pressure, and HIV immune controlHenrik N Kloverpris
Department of Paediatrics, University of Oxford, Peter Medawar Building, Oxford, United Kingdom
J Virol 86:919-29. 2012..These findings are consistent with HLA class I alleles mediating effective immune control of HIV through the number of p24 Gag-specific CD8(+) T-cell responses generated that can drive significant selection pressure on the virus...
- HLA-A*7401-mediated control of HIV viremia is independent of its linkage disequilibrium with HLA-B*5703Philippa C Matthews
Department of Paediatrics, University of Oxford, Oxford OX1 3SY, United Kingdom
J Immunol 186:5675-86. 2011..In addition, these studies identify a factor contributing to different HIV disease outcomes in individuals expressing HLA-B*5703...
- Sequence analysis of HIV-1 isolates from Guinea-Bissau: selection of vaccine epitopes relevant in both West African and European countriesLasse Vinner
Virus Research and Development, Statens Serum Institut, Copenhagen, Denmark
APMIS 119:487-97. 2011..Our results warrant testing of the selected vaccine epitopes in both geographic locations...
- Induction of novel CD8+ T-cell responses during chronic untreated HIV-1 infection by immunization with subdominant cytotoxic T-lymphocyte epitopesHenrik Kloverpris
Department of Virology, Statens Serum Institut, University of Copenhagen, Denmark
AIDS 23:1329-40. 2009..To investigate the potential to induce additional cytotoxic T-lymphocyte (CTL) immunity during chronic HIV-1 infection...
- High frequency, sustained T cell responses to PARV4 suggest viral persistence in vivoRuth Simmons
Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
J Infect Dis 203:1378-87. 2011..The interaction of PARV4 with the cellular immune system has not been described. Consequently, we investigated whether T cell responses to PARV4 could be detected in individuals exposed to blood-borne viruses...