Lars Klinge

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. ncbi request reprint Severe phenotype in infantile facioscapulohumeral muscular dystrophy
    Lars Klinge
    Institute of Human Genetics, University of Newcastle upon Tyne, International Centre for Life, Central Parkway, Newcastle upon Tyne, NE1 3BZ, United Kingdom
    Neuromuscul Disord 16:553-8. 2006
  2. doi request reprint Late onset in dysferlinopathy widens the clinical spectrum
    L Klinge
    Institute of Human Genetics, University of Newcastle upon Tyne, International Centre for Life, Central Parkway, Newcastle upon Tyne, NE1 3BZ, United Kingdom
    Neuromuscul Disord 18:288-90. 2008
  3. doi request reprint Dysferlin associates with the developing T-tubule system in rodent and human skeletal muscle
    Lars Klinge
    Institute of Human Genetics, International Centre for Life, University of Newcastle, Newcastle upon Tyne NE1 3BZ, UK
    Muscle Nerve 41:166-73. 2010
  4. pmc New aspects on patients affected by dysferlin deficient muscular dystrophy
    Lars Klinge
    University of Newcastle, Institute of Human Genetics, The Institute of Human Genetics, International Centre for Life, Central Parkway, Newcastle upon Tyne, UK
    J Neurol Neurosurg Psychiatry 81:946-53. 2010
  5. doi request reprint Sarcoglycanopathies: can muscle immunoanalysis predict the genotype?
    Lars Klinge
    Institute of Human Genetics, University of Newcastle upon Tyne, International Centre for Life, Central Parkway, NE1 3BZ Newcastle upon Tyne, UK
    Neuromuscul Disord 18:934-41. 2008
  6. pmc Attenuated muscle regeneration is a key factor in dysferlin-deficient muscular dystrophy
    Yen Hui Chiu
    Institute of Human Genetics, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne NE1 3BZ, UK
    Hum Mol Genet 18:1976-89. 2009
  7. ncbi request reprint From T-tubule to sarcolemma: damage-induced dysferlin translocation in early myogenesis
    Lars Klinge
    Institute of Human Genetics, University of Newcastle upon Tyne, International Centre for Life, Central Pkwy, NE1 3BZ Newcastle upon Tyne, England, UK
    FASEB J 21:1768-76. 2007

Collaborators

Detail Information

Publications7

  1. ncbi request reprint Severe phenotype in infantile facioscapulohumeral muscular dystrophy
    Lars Klinge
    Institute of Human Genetics, University of Newcastle upon Tyne, International Centre for Life, Central Parkway, Newcastle upon Tyne, NE1 3BZ, United Kingdom
    Neuromuscul Disord 16:553-8. 2006
    ..However, our data also suggest that the risk to an individual with classical FSHD of having a child with the infantile form is low...
  2. doi request reprint Late onset in dysferlinopathy widens the clinical spectrum
    L Klinge
    Institute of Human Genetics, University of Newcastle upon Tyne, International Centre for Life, Central Parkway, Newcastle upon Tyne, NE1 3BZ, United Kingdom
    Neuromuscul Disord 18:288-90. 2008
    ..This case represents the eldest age of onset of dysferlinopathy reported so far and widens the clinical spectrum of this disease...
  3. doi request reprint Dysferlin associates with the developing T-tubule system in rodent and human skeletal muscle
    Lars Klinge
    Institute of Human Genetics, International Centre for Life, University of Newcastle, Newcastle upon Tyne NE1 3BZ, UK
    Muscle Nerve 41:166-73. 2010
    ..These findings indicate that dysferlin is necessary for correct T-tubule formation, and dysferlin-deficient skeletal muscle is characterized by abnormally configured T-tubules...
  4. pmc New aspects on patients affected by dysferlin deficient muscular dystrophy
    Lars Klinge
    University of Newcastle, Institute of Human Genetics, The Institute of Human Genetics, International Centre for Life, Central Parkway, Newcastle upon Tyne, UK
    J Neurol Neurosurg Psychiatry 81:946-53. 2010
    ....
  5. doi request reprint Sarcoglycanopathies: can muscle immunoanalysis predict the genotype?
    Lars Klinge
    Institute of Human Genetics, University of Newcastle upon Tyne, International Centre for Life, Central Parkway, NE1 3BZ Newcastle upon Tyne, UK
    Neuromuscul Disord 18:934-41. 2008
    ..A concomitant reduction of dystrophin and beta-dystroglycan was observed more frequently than previously reported and illustrates the important differential diagnosis of DMD and BMD for sarcoglycan deficient LGMD...
  6. pmc Attenuated muscle regeneration is a key factor in dysferlin-deficient muscular dystrophy
    Yen Hui Chiu
    Institute of Human Genetics, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne NE1 3BZ, UK
    Hum Mol Genet 18:1976-89. 2009
    ..This study reveals a novel pathomechanism affecting muscle regeneration and maintenance in dysferlinopathy and highlights enhancement of the neutrophil response as a potential therapeutic avenue in these disorders...
  7. ncbi request reprint From T-tubule to sarcolemma: damage-induced dysferlin translocation in early myogenesis
    Lars Klinge
    Institute of Human Genetics, University of Newcastle upon Tyne, International Centre for Life, Central Pkwy, NE1 3BZ Newcastle upon Tyne, England, UK
    FASEB J 21:1768-76. 2007
    ..These results shed light on the dynamics of muscle membrane repair and are highly indicative of a specific role of dysferlin in this process in early myogenesis...