Elena Klenova

Summary

Affiliation: University of Essex
Country: UK

Publications

  1. ncbi request reprint YB-1 and CTCF differentially regulate the 5-HTT polymorphic intron 2 enhancer which predisposes to a variety of neurological disorders
    Elena Klenova
    Department of Biological Sciences, University of Essex, Essex CO4 3SQ, United Kingdom
    J Neurosci 24:5966-73. 2004
  2. ncbi request reprint Poly(ADP-ribosyl)ation and epigenetics. Is CTCF PARt of the plot?
    Elena Klenova
    Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, Essex, UK
    Cell Cycle 4:96-101. 2005
  3. pmc CTCF interacts with and recruits the largest subunit of RNA polymerase II to CTCF target sites genome-wide
    Igor Chernukhin
    Department of Biological Sciences, Central Campus, University of Essex, Wivenhoe Park, Colchester, Essex CO4 3SQ, United Kingdom
    Mol Cell Biol 27:1631-48. 2007
  4. pmc Mutational analysis of the poly(ADP-ribosyl)ation sites of the transcription factor CTCF provides an insight into the mechanism of its regulation by poly(ADP-ribosyl)ation
    Dawn Farrar
    Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, Essex CO4 3SQ, United Kingdom
    Mol Cell Biol 30:1199-216. 2010
  5. doi request reprint Decreased poly(ADP-ribosyl)ation of CTCF, a transcription factor, is associated with breast cancer phenotype and cell proliferation
    France Docquier
    Department of Biological Sciences, University of Essex, Essex, United Kingdom
    Clin Cancer Res 15:5762-71. 2009
  6. doi request reprint Generation of poly(ADP-ribosyl)ation deficient mutants of the transcription factor, CTCF
    Dawn Farrar
    Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, Essex, UK
    Methods Mol Biol 780:293-312. 2011
  7. pmc A Novel Mechanism for CTCF in the Epigenetic Regulation of Bax in Breast Cancer Cells
    Claudia Fabiola Mendez-Catala
    School of Biological Sciences, University of Essex, Colchester, Essex, United Kingdom
    Neoplasia 15:898-912. 2013
  8. doi request reprint BioVyon Protein A, an alternative solid-phase affinity matrix for chromatin immunoprecipitation
    Igor Chernukhin
    Department of Biological Sciences, University of Essex, Colchester, Essex CO4 3SQ, UK
    Anal Biochem 412:183-8. 2011
  9. ncbi request reprint The potential of BORIS detected in the leukocytes of breast cancer patients as an early marker of tumorigenesis
    Vivien D'Arcy
    Department of Biological Sciences, University of Essex, Colchester, Essex, United Kingdom
    Clin Cancer Res 12:5978-86. 2006
  10. ncbi request reprint Immunoprecipitation techniques for the analysis of transcription factor complexes
    Elena Klenova
    Department of Biological Sciences, Gene Regulation Laboratory, University of Essex, Wivenhoe Park, Colchester, Essex CO4 3SQ, UK
    Methods 26:254-9. 2002

Collaborators

  • Rolf Ohlsson
  • Yoko Ito
  • Adele Murrell
  • Alan Mackay
  • Sergei Vatolin
  • ROBERT ADRON HARRIS
  • L J Burke
  • C Kanduri
  • ANDREW FEINBERG
  • M S Sandhu
  • Maja Jagodic
  • Igor Chernukhin
  • Dawn Farrar
  • France Docquier
  • Victor Lobanenkov
  • Verónica Torrano
  • Claudia Fabiola Mendez-Catala
  • Svetlana Gretton
  • Vivien D'Arcy
  • Rituparna Mukhopadhyay
  • Wenqiang Yu
  • M Dolores Delgado
  • Joanne Whitehead
  • Georgia Xanthi Kita
  • Vinod Pant
  • Sung Yun Kang
  • Elena Pugacheva
  • Alexander Vostrov
  • Dmitri Loukinov
  • Julian Roberts
  • Anne L Hancock
  • Javier Leon
  • Shaharum Shamsuddin
  • Rainer Renkawitz
  • Ayman El-Kady
  • Svetlana Pack
  • Vasudeva Ginjala
  • Dave Cowieson
  • Sam Brown
  • Samer Yammine
  • Sushma Rai
  • Michael O'Hare
  • Louise Alldridge
  • Adhip Mandal
  • Parmjit Jat
  • Ian Morrison
  • Shwu Yuan Wu
  • Claes Holmgren
  • Vivien J Bubb
  • Sudhanshu H Mardikar
  • John P Quinn
  • Alison C Scott
  • Yoo Wook Kwon
  • Rosita Bergstrom
  • Keith W Brown
  • Gerome Breen
  • Kim Moorwood
  • Victor V Lobanenkov
  • Karim Malik
  • Hanlim Moon
  • Mark R Howard
  • Cheng Ming Chiang
  • Marc Vigneron
  • Anthony R Dallosso
  • Ru Zhang
  • Melissa Smart
  • Joaquin Navascues
  • Metodi Metodiev
  • Miguel Lafarga
  • Carlos Richard
  • Naresh Pore
  • Ziedulla K Abdullaev
  • Maria T Berciano
  • Nelson Fernandez
  • Abigail F Robinson
  • Heather Dorricott
  • Michael J O'Hare
  • Dmitry Loukinov
  • Meena Kanduri
  • Magda Lezcano
  • Gholamreza Tavoosidana
  • Junwang Xu
  • Piero Mariano
  • Wolfgang Quitschke
  • Sreenivasulu Kurukuti
  • Mitsuo Oshimura

Detail Information

Publications20

  1. ncbi request reprint YB-1 and CTCF differentially regulate the 5-HTT polymorphic intron 2 enhancer which predisposes to a variety of neurological disorders
    Elena Klenova
    Department of Biological Sciences, University of Essex, Essex CO4 3SQ, United Kingdom
    J Neurosci 24:5966-73. 2004
    ..Our data suggest a novel mechanism that explains, in part, the ability of the distinct VNTR copy numbers to support differential reporter gene expression based on YB-1 binding sites...
  2. ncbi request reprint Poly(ADP-ribosyl)ation and epigenetics. Is CTCF PARt of the plot?
    Elena Klenova
    Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, Essex, UK
    Cell Cycle 4:96-101. 2005
    ....
  3. pmc CTCF interacts with and recruits the largest subunit of RNA polymerase II to CTCF target sites genome-wide
    Igor Chernukhin
    Department of Biological Sciences, Central Campus, University of Essex, Wivenhoe Park, Colchester, Essex CO4 3SQ, United Kingdom
    Mol Cell Biol 27:1631-48. 2007
    ..We discuss the possible implications of our observations with respect to plausible mechanisms of transcriptional regulation via a CTCF-mediated direct link of LS Pol II to the DNA...
  4. pmc Mutational analysis of the poly(ADP-ribosyl)ation sites of the transcription factor CTCF provides an insight into the mechanism of its regulation by poly(ADP-ribosyl)ation
    Dawn Farrar
    Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, Essex CO4 3SQ, United Kingdom
    Mol Cell Biol 30:1199-216. 2010
    ..By using bioinformatics tools, numerous sites of CTCF and PARP-1 colocalization were demonstrated, suggesting that such regulation of CTCF may take place at the genome level...
  5. doi request reprint Decreased poly(ADP-ribosyl)ation of CTCF, a transcription factor, is associated with breast cancer phenotype and cell proliferation
    France Docquier
    Department of Biological Sciences, University of Essex, Essex, United Kingdom
    Clin Cancer Res 15:5762-71. 2009
    ..This study was aimed to investigate differential poly(ADP-ribosyl)ation of CTCF in normal and tumor breast tissues...
  6. doi request reprint Generation of poly(ADP-ribosyl)ation deficient mutants of the transcription factor, CTCF
    Dawn Farrar
    Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, Essex, UK
    Methods Mol Biol 780:293-312. 2011
    ..Based on several general characteristics (nuclear distribution/localisation, stability and levels of expression in the cell), the PARylation-deficient mutant was comparable with the wild-type CTCF...
  7. pmc A Novel Mechanism for CTCF in the Epigenetic Regulation of Bax in Breast Cancer Cells
    Claudia Fabiola Mendez-Catala
    School of Biological Sciences, University of Essex, Colchester, Essex, United Kingdom
    Neoplasia 15:898-912. 2013
    ..In this context, CTCF functions as a transcriptional repressor counteracting influences of positive regulatory factors; depletion of breast cancer cells from CTCF therefore results in the activation of Bax and apoptosis. ..
  8. doi request reprint BioVyon Protein A, an alternative solid-phase affinity matrix for chromatin immunoprecipitation
    Igor Chernukhin
    Department of Biological Sciences, University of Essex, Colchester, Essex CO4 3SQ, UK
    Anal Biochem 412:183-8. 2011
    ..In summary, BioVyon Protein A provides a column-based assay method for ChIP and other immunoprecipitation-based procedures; the rigid porous structure of BioVyon enables a fast and robust protocol with higher ChIP enrichment ratios...
  9. ncbi request reprint The potential of BORIS detected in the leukocytes of breast cancer patients as an early marker of tumorigenesis
    Vivien D'Arcy
    Department of Biological Sciences, University of Essex, Colchester, Essex, United Kingdom
    Clin Cancer Res 12:5978-86. 2006
    ..The aim of this study was to investigate the expression of BORIS in the leukocytes of breast cancer patients and the correlation between BORIS levels and clinical/pathologic variables...
  10. ncbi request reprint Immunoprecipitation techniques for the analysis of transcription factor complexes
    Elena Klenova
    Department of Biological Sciences, Gene Regulation Laboratory, University of Essex, Wivenhoe Park, Colchester, Essex CO4 3SQ, UK
    Methods 26:254-9. 2002
    ..The importance of empirically establishing optimum conditions for cell lysis, selection of appropriate antibodies, conditions for immunoprecipitation, and detection of interacting partners are discussed...
  11. ncbi request reprint Heightened expression of CTCF in breast cancer cells is associated with resistance to apoptosis
    France Docquier
    Department of Biological Sciences, Central Campus, University of Essex, Essex, United Kingdon
    Cancer Res 65:5112-22. 2005
    ..The observations reported in this study may lead to development of therapies based on selective reduction of CTCF in breast cancer cells...
  12. pmc Mutation of a single CTCF target site within the H19 imprinting control region leads to loss of Igf2 imprinting and complex patterns of de novo methylation upon maternal inheritance
    Vinod Pant
    Department of Development and Genetics, Evolution Biology Centre, Uppsala University, S 752 36 Uppsala, Sweden
    Mol Cell Biol 24:3497-504. 2004
    ..Considering many other CTCF targets, we propose that site-specific interactions between various DNA-bound CTCF molecules may provide general focal points in the organization of looped chromatin domains involved in gene regulation...
  13. pmc The binding sites for the chromatin insulator protein CTCF map to DNA methylation-free domains genome-wide
    Rituparna Mukhopadhyay
    Department of Development and Genetics, Evolution Biology Centre, Uppsala University, Norbyvagen 18A, S 752 36 Uppsala, Sweden
    Genome Res 14:1594-602. 2004
    ..As these targets are generally DNA methylation-free as determined by antibodies against 5-methylcytidine and a methyl-binding protein (MBD2), a CTCF-based network correlates with genome-wide epigenetic states...
  14. ncbi request reprint Poly(ADP-ribosyl)ation regulates CTCF-dependent chromatin insulation
    Wenqiang Yu
    Department of Development and Genetics, Evolution Biology Centre, Uppsala University, Norbyvagen 18A, S 752 36 Uppsala, Sweden
    Nat Genet 36:1105-10. 2004
    ..We suggest that poly(ADP-ribosyl)ation imparts chromatin insulator properties to CTCF at both imprinted and nonimprinted loci, which has implications for the regulation of expression domains and their demise in pathological lesions...
  15. ncbi request reprint Regulation of the transcription factor, CTCF, by phosphorylation with protein kinase CK2
    Ayman El-Kady
    Genetics Unit, Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK
    FEBS Lett 579:1424-34. 2005
    ..Mutation of the individual serines reveals that Serine 612 is a critical residue in regulation of CTCF by CK2...
  16. ncbi request reprint Targeting of CTCF to the nucleolus inhibits nucleolar transcription through a poly(ADP-ribosyl)ation-dependent mechanism
    Verónica Torrano
    Grupo de Biología Molecular del Cáncer, Departamento de Biologia Molecular, Universidad de Cantabria, 39011 Santander, Spain
    J Cell Sci 119:1746-59. 2006
    ..Notably, the labelling of active transcription sites by in situ run-on assays demonstrated that CTCF inhibits nucleolar transcription through a poly(ADP-ribosyl)ation-dependent mechanism...
  17. ncbi request reprint Differential regulation of the serotonin transporter gene by lithium is mediated by transcription factors, CCCTC binding protein and Y-box binding protein 1, through the polymorphic intron 2 variable number tandem repeat
    Julian Roberts
    Physiology Laboratory, School of Biomedical Science, University of Liverpool, Liverpool L69 3BX, United Kingdom
    J Neurosci 27:2793-801. 2007
    ....
  18. ncbi request reprint A CTCF-binding silencer regulates the imprinted genes AWT1 and WT1-AS and exhibits sequential epigenetic defects during Wilms' tumourigenesis
    Anne L Hancock
    Cancer and Leukaemia in Childhood, Sargent Research Unit, Department of Cellular and Molecular Medicine, School of Medical Sciences, University of Bristol, University Walk, Bristol, UK
    Hum Mol Genet 16:343-54. 2007
    ..We propose a model wherein imprinting defects at chromosome 11p13 may contribute to Wilms' tumourigenesis...
  19. ncbi request reprint CTCF regulates growth and erythroid differentiation of human myeloid leukemia cells
    Verónica Torrano
    Grupo de Biología Molecular del Cáncer, Departamento de Biologia Molecular, Unidad de Biomedicina CSIC, Universidad de Cantabria, 39011 Santander, Spain
    J Biol Chem 280:28152-61. 2005
    ..Taken together our results demonstrate that CTCF is involved in the control of myeloid cell growth and differentiation...
  20. pmc Somatically acquired hypomethylation of IGF2 in breast and colorectal cancer
    Yoko Ito
    Department of Oncology, University of Cambridge, CRUK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    Hum Mol Genet 17:2633-43. 2008
    ..These results indicate that IGF2 DMR0 hypomethylation has diagnostic potential for colon cancer rather than value as a surrogate biomarker for constitutive LOI...