Josef T Kittler

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint Palmitoylation regulates the clustering and cell surface stability of GABAA receptors
    Jan Rathenberg
    Department of Pharmacology, University College, London WC1E 6BT, UK
    Mol Cell Neurosci 26:251-7. 2004
  2. pmc Delivery of GABAARs to synapses is mediated by HAP1-KIF5 and disrupted by mutant huntingtin
    Alison E Twelvetrees
    Department of Neuroscience, Physiology, and Pharmacology, University College London, Gower Street, London, WC1E 6BT, UK
    Neuron 65:53-65. 2010
  3. pmc Regulation of synaptic inhibition by phospho-dependent binding of the AP2 complex to a YECL motif in the GABAA receptor gamma2 subunit
    Josef T Kittler
    Department of Physiology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 105:3616-21. 2008
  4. pmc Identification and characterisation of a Maf1/Macoco protein complex that interacts with GABAA receptors in neurons
    Katharine R Smith
    Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London, WC1E 6BT, UK
    Mol Cell Neurosci 44:330-41. 2010
  5. pmc Regulation of inhibitory synaptic transmission by a conserved atypical interaction of GABA(A) receptor beta- and gamma-subunits with the clathrin AP2 adaptor
    Katharine R Smith
    Department of Neuroscience, University College London, London WC1E 6BT, UK
    Neuropharmacology 55:844-50. 2008
  6. pmc Phospho-dependent binding of the clathrin AP2 adaptor complex to GABAA receptors regulates the efficacy of inhibitory synaptic transmission
    Josef T Kittler
    Department of Physiology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 102:14871-6. 2005
  7. pmc Ubiquitin-dependent lysosomal targeting of GABA(A) receptors regulates neuronal inhibition
    I Lorena Arancibia-Carcamo
    Department of Neuroscience, Physiology, and Pharmacology, University College London, Gower Street, London, WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 106:17552-7. 2009
  8. ncbi request reprint Association of GRIP1 with a GABA(A) receptor associated protein suggests a role for GRIP1 at inhibitory synapses
    Josef T Kittler
    Department of Pharmacology, University College London, London WC1E 6BT, UK
    Biochem Pharmacol 68:1649-54. 2004
  9. pmc NMDA receptors regulate GABAA receptor lateral mobility and clustering at inhibitory synapses through serine 327 on the γ2 subunit
    James Muir
    Department of Neuroscience, Physiology, and Pharmacology, University College London, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 107:16679-84. 2010
  10. doi request reprint Stabilization of GABA(A) receptors at endocytic zones is mediated by an AP2 binding motif within the GABA(A) receptor β3 subunit
    Katharine R Smith
    Department of Neuroscience, Physiology, and Pharmacology, University College London, London WC1E 6BT, UK
    J Neurosci 32:2485-98. 2012

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Palmitoylation regulates the clustering and cell surface stability of GABAA receptors
    Jan Rathenberg
    Department of Pharmacology, University College, London WC1E 6BT, UK
    Mol Cell Neurosci 26:251-7. 2004
    ..Taken together, these results suggest that palmitoylation of GABAA receptors plays an essential role in regulating the clustering of these receptors at synaptic sites...
  2. pmc Delivery of GABAARs to synapses is mediated by HAP1-KIF5 and disrupted by mutant huntingtin
    Alison E Twelvetrees
    Department of Neuroscience, Physiology, and Pharmacology, University College London, Gower Street, London, WC1E 6BT, UK
    Neuron 65:53-65. 2010
    ..Its disruption by mutant huntingtin may explain some of the defects in brain information processing occurring in Huntington's disease and provides a molecular target for therapeutic approaches...
  3. pmc Regulation of synaptic inhibition by phospho-dependent binding of the AP2 complex to a YECL motif in the GABAA receptor gamma2 subunit
    Josef T Kittler
    Department of Physiology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 105:3616-21. 2008
    ..These data define a mechanism for tyrosine kinase regulation of GABA(A)R surface levels and synaptic inhibition...
  4. pmc Identification and characterisation of a Maf1/Macoco protein complex that interacts with GABAA receptors in neurons
    Katharine R Smith
    Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London, WC1E 6BT, UK
    Mol Cell Neurosci 44:330-41. 2010
    ..Expressing Macoco in neurons increases surface GABA(A)R levels. Our results suggest that Maf1 and Macoco are novel GABA(A)R interacting proteins important for regulating GABA(A)R surface expression and GABA(A)R signalling in the brain...
  5. pmc Regulation of inhibitory synaptic transmission by a conserved atypical interaction of GABA(A) receptor beta- and gamma-subunits with the clathrin AP2 adaptor
    Katharine R Smith
    Department of Neuroscience, University College London, London WC1E 6BT, UK
    Neuropharmacology 55:844-50. 2008
    ..These data suggest that multiple AP2 internalization signals control the levels of surface and synaptic GABA(A) receptors to regulate synaptic inhibition...
  6. pmc Phospho-dependent binding of the clathrin AP2 adaptor complex to GABAA receptors regulates the efficacy of inhibitory synaptic transmission
    Josef T Kittler
    Department of Physiology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 102:14871-6. 2005
    ..Therefore phospho-dependent regulation of AP2 binding to GABA(A)Rs provides a mechanism to specify receptor cell surface number and the efficacy of inhibitory synaptic transmission...
  7. pmc Ubiquitin-dependent lysosomal targeting of GABA(A) receptors regulates neuronal inhibition
    I Lorena Arancibia-Carcamo
    Department of Neuroscience, Physiology, and Pharmacology, University College London, Gower Street, London, WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 106:17552-7. 2009
    ..Together, our results establish a previously unknown mechanism for influencing inhibitory transmission under normal and pathological conditions...
  8. ncbi request reprint Association of GRIP1 with a GABA(A) receptor associated protein suggests a role for GRIP1 at inhibitory synapses
    Josef T Kittler
    Department of Pharmacology, University College London, London WC1E 6BT, UK
    Biochem Pharmacol 68:1649-54. 2004
    ..Our findings provide evidence that GRIP1 can associate with proteins important for regulating GABA(A) receptor function and suggest that GRIP1 may play a role at inhibitory synapses...
  9. pmc NMDA receptors regulate GABAA receptor lateral mobility and clustering at inhibitory synapses through serine 327 on the γ2 subunit
    James Muir
    Department of Neuroscience, Physiology, and Pharmacology, University College London, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 107:16679-84. 2010
    ..Thus, NMDAR signaling, via calcineurin and a key GABA(A)R phosphorylation site, controls the stability of synaptic GABA(A)Rs, with important implications for activity-dependent control of synaptic inhibition and neuronal plasticity...
  10. doi request reprint Stabilization of GABA(A) receptors at endocytic zones is mediated by an AP2 binding motif within the GABA(A) receptor β3 subunit
    Katharine R Smith
    Department of Neuroscience, Physiology, and Pharmacology, University College London, London WC1E 6BT, UK
    J Neurosci 32:2485-98. 2012
    ..Thus, AP2 binding to an RRR motif in the GABA(A)R β3-subunit ICD regulates GABA(A)R residency time at EZs, steady-state synaptic receptor levels, and pathological loss of GABA(A)Rs from synapses during simulated ischemia...
  11. ncbi request reprint Gephyrin regulates the cell surface dynamics of synaptic GABAA receptors
    Tija C Jacob
    Department of Pharmacology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 25:10469-78. 2005
    ....
  12. doi request reprint Disrupted in Schizophrenia 1 forms pathological aggresomes that disrupt its function in intracellular transport
    Talia A Atkin
    Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Hum Mol Genet 21:2017-28. 2012
    ..These data, therefore, show that DISC1 is recruited to aggresomes with negative effects on neuronal function, and suggests a novel DISC1-based mechanism for neuronal pathology...
  13. pmc Huntingtin-associated protein 1 regulates inhibitory synaptic transmission by modulating gamma-aminobutyric acid type A receptor membrane trafficking
    Josef T Kittler
    Department of Pharmacology, University College London, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 101:12736-41. 2004
    ..Together these observations have identified a role for HAP1 in regulating GABA(A)R sorting, suggesting an important role for this protein in the construction and maintenance of inhibitory synapses...
  14. ncbi request reprint A-kinase anchoring protein 79/150 facilitates the phosphorylation of GABA(A) receptors by cAMP-dependent protein kinase via selective interaction with receptor beta subunits
    Nicholas J Brandon
    MRC Laboratory for Molecular Cell Biology and Department of Pharmacology, University College London, Gower Street, London WCIE 6BT, UK
    Mol Cell Neurosci 22:87-97. 2003
    ..Therefore, the selective interaction of beta subunits with AKAP150 may facilitate GABA(A) receptor subtype-specific functional modulation by PKA activity which may have profound local effects on neuronal excitation...
  15. doi request reprint Control of mitochondrial transport and localization in neurons
    Andrew F Macaskill
    Department of Neuroscience, Physiology and Pharmacology, University College London, Gower St, London WC1E 6BT, UK
    Trends Cell Biol 20:102-12. 2010
    ....
  16. doi request reprint The cell biology of synaptic inhibition in health and disease
    Katharine R Smith
    Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London, WC1E 6BT, UK
    Curr Opin Neurobiol 20:550-6. 2010
    ..The regulatory pathways essential for the fine-tuning of synaptic inhibition have also emerged as key sites of vulnerability during pathological changes in cell excitability in disease states...
  17. doi request reprint Mitochondrial trafficking and the provision of energy and calcium buffering at excitatory synapses
    Andrew F Macaskill
    Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London, UK
    Eur J Neurosci 32:231-40. 2010
    ..We also consider some implications of this regulation for synaptic function and plasticity and discuss how this may contribute to synaptic dysfunction and signalling in neurological disease, with a focus on Alzheimer's disease...
  18. ncbi request reprint Modulation of GABAA receptor activity by phosphorylation and receptor trafficking: implications for the efficacy of synaptic inhibition
    Josef T Kittler
    Medical Research Council Laboratory of Molecular Cell Biology and Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Curr Opin Neurobiol 13:341-7. 2003
    ..Here, we discuss these regulatory mechanisms, and their consequences for the efficacy of GABA(A) receptor mediated synaptic inhibition...
  19. doi request reprint Regulation of GABA(A) receptor membrane trafficking and synaptic localization
    I Lorena Arancibia-Carcamo
    Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E6BT, UK
    Pharmacol Ther 123:17-31. 2009
    ....
  20. pmc The receptor subunits generating NMDA receptor mediated currents in oligodendrocytes
    Valeria Burzomato
    Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    J Physiol 588:3403-14. 2010
    ..These data are consistent with NMDA-evoked currents in oligodendrocytes reflecting the activation of receptors containing NR1, NR2C and NR3A subunits...
  21. pmc Miro1 is a calcium sensor for glutamate receptor-dependent localization of mitochondria at synapses
    Andrew F Macaskill
    Department of Neuroscience, Physiology, and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Neuron 61:541-55. 2009
    ..Thus, Miro1 is a key determinant of how energy supply is matched to energy usage in neurons...
  22. ncbi request reprint Mechanisms of GABAA receptor assembly and trafficking: implications for the modulation of inhibitory neurotransmission
    Josef T Kittler
    Department of Pharmacology, University College London, United Kingdom
    Mol Neurobiol 26:251-68. 2002
    ..These regulatory processes will be discussed within the context of the dynamic modulation of synaptic inhibition in the central nervous system (CNS)...
  23. ncbi request reprint Censoring the editor in transient forebrain ischemia
    Josef T Kittler
    Department of Physiology, University College London, London WC1E 6BT, United Kingdom
    Neuron 49:646-8. 2006
    ....
  24. pmc Molecular determinants for the interaction between AMPA receptors and the clathrin adaptor complex AP-2
    Kathrin Kastning
    Department of Membrane Biochemistry, Institute of Chemistry and Biochemistry, Freie Universitat Berlin, Takustrasse 6, 14195 Berlin, Germany
    Proc Natl Acad Sci U S A 104:2991-6. 2007
    ..These data suggest that common mechanisms regulate AP-2-dependent internalization of pre- and postsynaptic membrane proteins...
  25. ncbi request reprint Phospholipase C-related inactive protein is implicated in the constitutive internalization of GABAA receptors mediated by clathrin and AP2 adaptor complex
    Takashi Kanematsu
    Laboratory of Molecular and Cellular Biochemistry, Faculty of Dental Science, and Station for Collaborative Research, Kyushu University, Fukuoka, Japan
    J Neurochem 101:898-905. 2007
    ..These results indicate that PRIP is primarily implicated in the constitutive internalization of GABA(A) receptor that requires clathrin and AP2 protein complex...
  26. ncbi request reprint Modulation of GABA(A) receptor phosphorylation and membrane trafficking by phospholipase C-related inactive protein/protein phosphatase 1 and 2A signaling complex underlying brain-derived neurotrophic factor-dependent regulation of GABAergic inhibition
    Takashi Kanematsu
    Laboratory of Molecular and Cellular Biochemistry, Faculty of Dental Science and Station for Collaborative Research, Kyushu University, Fukuoka 812 8582, Japan
    J Biol Chem 281:22180-9. 2006
    ..Together, the results suggest that PRIP plays an important role in BDNF-dependent regulation of GABA(A) receptors by mediating the specific association between beta subunits of these receptors with protein phosphatases...
  27. ncbi request reprint Dopamine D3 receptors regulate GABAA receptor function through a phospho-dependent endocytosis mechanism in nucleus accumbens
    Guojun Chen
    Department of Physiology and Biophysics, State University of New York, Buffalo, New York 14214, USA
    J Neurosci 26:2513-21. 2006
    ..Together, our results suggest that D3 receptor activation suppresses the efficacy of inhibitory synaptic transmission in NAc by increasing the phospho-dependent endocytosis of GABAA receptors...
  28. ncbi request reprint GABAA receptor phospho-dependent modulation is regulated by phospholipase C-related inactive protein type 1, a novel protein phosphatase 1 anchoring protein
    Miho Terunuma
    Laboratory of Molecular and Cellular Biochemistry, Faculty of Dental Science and Station for Collaborative Research, Kyushu University, Fukuoka 812 8582, Japan
    J Neurosci 24:7074-84. 2004
    ..Together, these results suggest an essential role for PRIP-1 in controlling GABA(A) receptor activity via regulating subunit phosphorylation and thereby the efficacy of neuronal inhibition mediated by these receptors...
  29. ncbi request reprint Brain-derived neurotrophic factor modulates fast synaptic inhibition by regulating GABA(A) receptor phosphorylation, activity, and cell-surface stability
    Jasmina N Jovanovic
    Department of Pharmacology, University College, London, WC1E 6BT, United Kingdom
    J Neurosci 24:522-30. 2004
    ..Thus, transient formation of GABA(A) receptor signaling complexes has the potential to provide a basis for acute changes in receptor function underlying GABAergic synaptic plasticity...
  30. ncbi request reprint Subunit specificity and interaction domain between GABA(A) receptor-associated protein (GABARAP) and GABA(A) receptors
    Jesper Nymann-Andersen
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, California, USA
    J Neurochem 80:815-23. 2002
    ....